Progress in brain research最新文献_第8页

Molecular targets of caffeine in the central nervous system. 咖啡因在中枢神经系统中的分子靶点

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-07-25 DOI: 10.1016/bs.pbr.2024.06.012

Ishita Bhardwaj, Atifa Haseeb Ansari, Swayam Prabha Rai, Sippy Singh, Durgesh Singh

{"title":"Molecular targets of caffeine in the central nervous system.","authors":"Ishita Bhardwaj, Atifa Haseeb Ansari, Swayam Prabha Rai, Sippy Singh, Durgesh Singh","doi":"10.1016/bs.pbr.2024.06.012","DOIUrl":"https://doi.org/10.1016/bs.pbr.2024.06.012","url":null,"abstract":"Caffeine is an alkaloid obtained from plants and is one of the most consumptive drug in the form of chocolate, coffee and beverages. The potential impact of caffeine within CNS can be easily understood by mechanism of action-antagonism of adenosine receptor, calcium influx, inhibits phosphodiesterases. Adenosine a neuromodulator for adenosine receptors, which are abundantly expressed within the central nervous system. Caffeine antagonized the adenosine receptor, hence stimulate expression of dopamine. It plays pivotal role in many metabolic pathways within the brain and nervous system, it reduced the amyloid-β-peptide (Aβ) accumulation, downregulation of tau protein phosphorylation, stimulate cholinergic neurons and inhibits the acetylcholinestrase (AChE). It also possess antioxidant and antiapoptotic activity. Caffeine act as nutraceutical product, improves mental health. It contains antioxidants, vitamins, minerals and dietary supplements, by reducing the risk factor of several neurodegenerations including Alzheimer's disease, migraine, gallstone, cancer, Huntington's disease and sclerosis. This act as a stimulant and have capability to increase the effectiveness of certain pain killer. Beside positive affects, over-consumption of caffeine leads to negative impact: change in sleep pattern, hallucinations, high blood pressure, mineral loss and even heartburn. This chapter highlights pros and cons of caffeine consumption.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"288 ","pages":"35-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 序言

4区医学

Progress in brain research Pub Date : 2024-01-01 DOI: 10.1016/S0079-6123(24)00138-9

Nasrollah Moradikor, Indranath Chatterjee

引用次数: 0

Predicting sports performance of elite female football players through smart wearable measurement platform. 通过智能可穿戴测量平台预测精英女足运动员的运动表现。

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-05-11 DOI: 10.1016/bs.pbr.2024.04.002

Chia-Kai Chang, Yu-Lun Chen, Chi-Hung Juan

{"title":"Predicting sports performance of elite female football players through smart wearable measurement platform.","authors":"Chia-Kai Chang, Yu-Lun Chen, Chi-Hung Juan","doi":"10.1016/bs.pbr.2024.04.002","DOIUrl":"https://doi.org/10.1016/bs.pbr.2024.04.002","url":null,"abstract":"Recent development of information technology and wearable devices has led to the analysis of multidimensional sports information and the enhancement of athletes' sports performance convenient and potentially more efficient. In this study, we present a novel data platform tailored for capturing athletes' cognitive, physiological, and body composition data. This platform incorporates diverse visualization modes, enabling athletes and coaches to access data seamlessly. Fourteen elite female football players (average age=20.6±1.3years; 3 forwards, 5 midfielders, 4 defenders, and 2 goalkeepers) were recruited from National Taiwan Normal University, Taiwan, as the primary observational group, and 12 female university students without regular sport/exercise habits (average age=21.6±1.3years) were recruited as control group. Through multidimensional data analysis, we identified significant differences in limb muscle mass and several cognitive function scores (e.g., reaction times of attention and working memory) between elite female football varsity team and general female university students. Furthermore, 1-month heart rate data obtained from wearable devices revealed a significant negative correlation between average heart rate median and cognitive function scores. Overall, this study demonstrates the potential of this platform as an efficient multidimensional data collection and analysis platform. Therefore, valuable insights between cognitive functions, physiological signals and body composition can be obtained via this multidimensional platform for facilitating sports performance.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"286 ","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sands of time: Discontinuity in time production, or inadequacy of psychophysical fit? 时间之沙：时间产生的不连续性，还是心理物理契合的不足？

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-05-29 DOI: 10.1016/bs.pbr.2024.05.001

Joseph Glicksohn, Tal Dotan Ben-Soussan

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Foreword. 前言

4区医学

Progress in brain research Pub Date : 2024-01-01 DOI: 10.1016/S0079-6123(24)00070-0

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Bioactive potential and chemical compounds of coffee. 咖啡的生物活性潜力和化学成分。

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-07-08 DOI: 10.1016/bs.pbr.2024.06.011

Roonak Amiri, Mohsen Akbari, Nasrollah Moradikor

引用次数: 0

Preface. 序言

4区医学

Progress in brain research Pub Date : 2024-01-01 DOI: 10.1016/S0079-6123(24)00149-3

Nasrollah Moradikor, Indranath Chatterjee

引用次数: 0

Brain functional networks and structures that categorize type 2 bipolar disorder and major depression. 划分 2 型躁狂症和重度抑郁症的大脑功能网络和结构。

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-06-25 DOI: 10.1016/bs.pbr.2024.05.008

Yen-Ling Chen, Jia-En Jhou, Ya-Mei Bai, Mu-Hong Chen, Pei-Chi Tu, Yu-Te Wu

{"title":"Brain functional networks and structures that categorize type 2 bipolar disorder and major depression.","authors":"Yen-Ling Chen, Jia-En Jhou, Ya-Mei Bai, Mu-Hong Chen, Pei-Chi Tu, Yu-Te Wu","doi":"10.1016/bs.pbr.2024.05.008","DOIUrl":"https://doi.org/10.1016/bs.pbr.2024.05.008","url":null,"abstract":"Background: Distinguishing between type 2 bipolar disorder (BD II) and major depressive disorder (MDD) poses a significant clinical challenge due to their overlapping symptomatology. This study aimed to investigate neurobiological markers that differentiate BD II from MDD using multimodal neuroimaging techniques.Methods: Fifty-nine individuals with BD II, 114 with MDD, and 117 healthy controls participated in the study, undergoing structural and functional magnetic resonance imaging. Functional connectivity (FC) analysis used regions from Shen's whole-brain FC-based atlas. Feature selection was carried out using independent t-tests and ReliefF algorithms, followed by classification using Support Vector Machine and wide neural network.Results: Significant differences in brain structure and function were observed among patients with BD II, MDD, and healthy controls. Both structural and functional alterations were more pronounced in BD II compared to MDD, particularly in regions associated with sensory processing, motor function, and the cerebellum. Classification based on neurobiological markers achieved a mean testing accuracy of 88.24%, with the t-test selected features outperforming those selected by ReliefF. Dysconnectivity patterns correlated with symptom severity and functioning in BD II but not MDD.Conclusion: Our findings suggest that neurobiological markers derived from multimodal imaging techniques can effectively differentiate patients with BD II from those with MDD. The identified alterations in brain structure and function, particularly in sensory-motor processing networks, may serve as potential biomarkers for distinguishing between these mood disorders. However, the influence of psychotropic medications and daily functioning severity on these neurobiological markers warrants further investigation.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"290 ","pages":"63-81"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Renaissance-Europe-17th Century. 文艺复兴-欧洲-17 世纪。

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-04-24 DOI: 10.1016/bs.pbr.2024.02.015

Jeremy C Ganz

{"title":"Renaissance-Europe-17th Century.","authors":"Jeremy C Ganz","doi":"10.1016/bs.pbr.2024.02.015","DOIUrl":"https://doi.org/10.1016/bs.pbr.2024.02.015","url":null,"abstract":"The authors of the texts described in this chapter will have had access to the anatomy of Vesalius; a marked step forward. However, there was no equivalent advance in physiology. Harvey's book on the circulation of the blood was published in 1628 but it took many years for its contents to be accepted as standard teaching. The century saw the development of instruments some of which look more like instruments a modern surgeon would recognize. The two major technical advances were the acceptance of a single-handed trephine and the design of crown trepans with a conical shape and blades extending up the sides. Moreover, the crown trepan had once again become the favored instrument for gaining access to the interior of the cranium. In terms of technique there was a worrying trend that surgeons could feel when they had penetrated the inner table of the skull without the need to probe. All the way back to Hippocrates, it had been customary to use probes to assess depth while trepanning. Thus, the abandonment of this safety measure if it was real, is cause for concern. However, it is not impossible that probing was continued and simply not mentioned as it was so obviously necessary as not to require comment. The lenticular illustrated remains of the triangular shape first illustrated by Vidius. It is important to note that it was not used to incise the skull but to smooth of rough edges and spicules.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"285 ","pages":"41-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aesthetic valence: Psychophysical perspectives. 审美价值：心理物理学视角

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-06-17 DOI: 10.1016/bs.pbr.2024.05.005

Åke Hellström

{"title":"Aesthetic valence: Psychophysical perspectives.","authors":"Åke Hellström","doi":"10.1016/bs.pbr.2024.05.005","DOIUrl":"10.1016/bs.pbr.2024.05.005","url":null,"abstract":"Comparisons of aesthetic valence and of sensory magnitude are subject to similar order effects, indicating an evolved mechanism that sharpens also aesthetic discrimination. As the foundation of pleasantness and aesthetic valence of an object, an optimal level of evoked arousal or, in more recent research, of information load, has been proposed. According to discrepancy theory, this evoked effect is modulated by the object's deviation from the current adaptation level (AL). The AL is built up and updated by pooling recent stimulation. A model based on these concepts is proposed here, and it is illustrated by results of empirical studies by the author's students. For everyday objects such as cars and ladies' clothes, rated beauty was related by a U-shaped function to rated modernity. Minimal beauty occurred for intermediate modernity. For ladies' clothes, this minimum was situated higher on the modernity scale for females and extraverts. As modernity can be seen as the amount of deviation from the AL which represents the usual, this shift could be explained by faster upward adjustment of the AL. In contrast, for paintings the relation between modernity and beauty was inversely U-shaped. This could be due to paintings intrinsically carrying more information than other objects, as indicated by ratings of hard-to-access, with which rated beauty had an inverse U-shaped relation. In a factor-analytic study of preference for 42 paintings four orthogonal factors were extracted, interpreted as High and Low modernity, and High and Low information content. This could yield a rudimentary empirical typology of art.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"287 ","pages":"45-70"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0