Progress in brain research最新文献_第9页

Physiological aspects of hormesis. 激效的生理方面。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-23 DOI: 10.1016/bs.pbr.2025.05.001

Elisa Mitiko Kawamoto, Cristoforo Scavone, Rosana Camarini

{"title":"Physiological aspects of hormesis.","authors":"Elisa Mitiko Kawamoto, Cristoforo Scavone, Rosana Camarini","doi":"10.1016/bs.pbr.2025.05.001","DOIUrl":"10.1016/bs.pbr.2025.05.001","url":null,"abstract":"Hormesis-the adaptive response of cells and organisms to moderate, intermittent stress-has emerged as a promising framework for treating neurological and neuropsychiatric disorders. This biphasic dose-response phenomenon can benefit biological systems by inducing neural plasticity, improving cognitive function, and enhancing antioxidant and anti-inflammatory responses. Hormetic interventions including intermittent fasting, physical exercise, and environmental enrichment, among others, work through common molecular pathways. These approaches collectively modulate essential transcription factors such as NF-κB, CREB, and Nrf2, and consequent increases in the expression of neuroprotective genes, such as BDNF and heat shock proteins. The relationship between stress and biological outcomes follows an inverted U-shaped curve, where moderate stress triggers beneficial adaptations while chronic or excessive stress leads to allostatic load and pathology. This mechanistic understanding bridges traditional concepts of homeostasis with modern views on neuroplasticity and resilience. By elucidating the cellular and molecular mechanisms of hormetic responses, researchers can develop precisely calibrated, personalized interventions that may lead to therapeutic approaches to neurodegenerative conditions, neuropsychiatric disorders, and age-related cognitive decline.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"295 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent fasting and ketone bodies. 间歇性禁食和酮体。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-21 DOI: 10.1016/bs.pbr.2025.05.002

Geovana Rosa Oliveira Dos Santos, Thiago Amorim de Souza Lima, Merle Gallus, Elisa Mitiko Kawamoto

{"title":"Intermittent fasting and ketone bodies.","authors":"Geovana Rosa Oliveira Dos Santos, Thiago Amorim de Souza Lima, Merle Gallus, Elisa Mitiko Kawamoto","doi":"10.1016/bs.pbr.2025.05.002","DOIUrl":"10.1016/bs.pbr.2025.05.002","url":null,"abstract":"Intermittent fasting (IF) is a dietary intervention based on time-restricted energy intake. Over the years, IF has been widely investigated as a non-pharmacological approach to increasing life expectancy and promoting brain health. The underlying mechanisms by which IF promotes its beneficial effects are attributed to hormesis, an evolutionary adaptive strategy that regulates cellular responses to stress. These effects include elevated levels of brain-derived neurotrophic factor (BDNF), enhanced neurogenesis and autophagy, increased synaptic plasticity, and improved cognitive functions such as memory and learning. The metabolic switch induced by IF promotes the production of ketone bodies (β-hydroxybutyrate, acetoacetate, and acetone), which serve as alternative energy substrate for the central nervous system (CNS) and modulator of vital processes, including cellular homeostasis, inflammation, and oxidative stress. The two most common neurodegenerative diseases, Alzheimer's Disease (AD) and Parkinson's Disease (PD), are characterized by mitochondrial dysfunction, neuroinflammation and energy deficits. IF has shown a promising therapeutic approach through its neuroprotective and anti-inflammatory effects, which need to be further assessed. Through similar mechanisms, IF appears to exert an antidepressant effect by regulating monoamines in limbic regions, and inhibiting neuroinflammation.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"295 ","pages":"39-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals and brain health: The effects of curcumin, isoflavonoids, and ouabain. 植物化学物质与大脑健康：姜黄素、异黄酮和豆蔻碱的作用。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-23 DOI: 10.1016/bs.pbr.2025.05.004

Arthur B Cantanzaro, Ana Maria Orellana

引用次数: 0

Chemical diversity, receptor binding affinity, and pharmacology of phytocannabinoids: Insights into neuronal mechanisms. 化学多样性，受体结合亲和力和植物大麻素药理学：对神经机制的见解。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-08-25 DOI: 10.1016/bs.pbr.2025.07.006

Claudio Marcos Queiroz, Laura de Oliveira Koren, Camila Rayane Pereira da Silva, Sidarta Ribeiro, Sérgio Ruschi Bergamachi Silva

{"title":"Chemical diversity, receptor binding affinity, and pharmacology of phytocannabinoids: Insights into neuronal mechanisms.","authors":"Claudio Marcos Queiroz, Laura de Oliveira Koren, Camila Rayane Pereira da Silva, Sidarta Ribeiro, Sérgio Ruschi Bergamachi Silva","doi":"10.1016/bs.pbr.2025.07.006","DOIUrl":"10.1016/bs.pbr.2025.07.006","url":null,"abstract":"Comparative studies of phytocannabinoids offer valuable insights into the therapeutic potential of cannabis. While Cannabis sativa can produce over 100 distinct phytocannabinoids, most are present only in trace amounts. This review examines the structural, biochemical, and pharmacological characteristics of five representative phytocannabinoids: cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (Δ9-THC), and cannabinol (CBN). We describe their biosynthetic pathways, abiotic transformations, and precursor roles in generating molecular diversity. Chemovar profiles are discussed based on seed bank data and chromatographic analyses of Brazilian-grown cultivars. Our findings suggest that high-CBD chemovars have recently emerged, possibly due to genetic drift from intensive hybridization. To evaluate the clinical relevance of these compounds, we conducted a systematic review and meta-analysis of binding affinities (Ki) for CB1, CB2, and other neuronal receptors. Δ9-THC and CBN showed high affinities for CB1 and CB2, while CBG, CBC, and CBD exhibited 10-100 times lower affinities. Statistical analysis confirmed significantly stronger CB1 and CB2 binding for Δ9-THC compared to CBD. These results support the hypothesis that non-psychotropic phytocannabinoids primarily act through non-canonical targets such as GPR55 (G Protein-Coupled Receptor 55), TRPV1 (Transient Receptor Potential Vanilloid 1), and TRPM8 (Transient Receptor Potential Melastatin 8), though affinity data for these receptors remain limited. Finally, we discuss preclinical pharmacological evidence highlighting how subtle structural differences yield distinct physiological effects. Our findings emphasize the need for expanded research into underexplored phytocannabinoids with unique therapeutic potential.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"1-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Music and art therapy in age-related neuropsychiatric disorders: Creative approaches to healing. 与年龄相关的神经精神疾病的音乐和艺术治疗：创造性的治疗方法。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-13 DOI: 10.1016/bs.pbr.2025.08.023

Elaheh Hajizadeh, Sara Salatin, Mehdi Sarailoo, Halimeh Amirazad, Maryam Azarfarin, Masoomeh Dadkhah

{"title":"Music and art therapy in age-related neuropsychiatric disorders: Creative approaches to healing.","authors":"Elaheh Hajizadeh, Sara Salatin, Mehdi Sarailoo, Halimeh Amirazad, Maryam Azarfarin, Masoomeh Dadkhah","doi":"10.1016/bs.pbr.2025.08.023","DOIUrl":"10.1016/bs.pbr.2025.08.023","url":null,"abstract":"Neuropsychiatric diseases are a serious disorders affecting an individual's life, which can constitute a great problem to health care systems and a reduced level of activity in elderly. These disorders mainly include schizophrenia (SCZ), anxiety, and depression. Art therapy (AT) as one of the non-pharmacological therapies seems to improve cognitive and behavioral symptoms in neuropsychiatric disorders in older adults but the exact neural mechanisms are not fully known. All these preventive methods contribute in decreasing psychological distress and promoting mental health in aging. Many different art media can be utilized by therapists for psychiatric and psychological conditions. AT, including music, painting, and architecture media as the most therapeutic processes can be served as a useful therapeutic option to alleviate disease related symptoms. Here, in this chapter we investigate the effectiveness of art therapies in age-related neuropsychiatric disorders adults. It's recommended for further research to stronger focus on processes and biological mechanisms underlying art related changes. We believe that this method has promoting potential in clinic on neuropsychiatric diseases to be further evaluated.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"111-134"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The science behind non-pharmacological interventions. 非药物干预背后的科学。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-02 DOI: 10.1016/bs.pbr.2025.08.020

Aaqil Ahamed Ayoubkhan, Sana Awan, Vaishali Jindal, Ruquiya Murtuzapurwala, Ali Fereidouni

{"title":"The science behind non-pharmacological interventions.","authors":"Aaqil Ahamed Ayoubkhan, Sana Awan, Vaishali Jindal, Ruquiya Murtuzapurwala, Ali Fereidouni","doi":"10.1016/bs.pbr.2025.08.020","DOIUrl":"10.1016/bs.pbr.2025.08.020","url":null,"abstract":"The elderly population is rising in number, and along with it, the distribution of neuropsychiatric disorders is also increasing. These disorders pose a challenge in treating them effectively in a timely manner. As most geriatric patients have comorbidities, the side effects of multiple medications, including drugs for neuropsychiatric disorders, cumulatively impair their well-being. To decrease the drug doses and hence the side effects, Non-Pharmacological Interventions (NPIs) pave a prominent pathway for the handling of patients. Cognitive stimulation therapy, mindfulness and meditation, music and art therapy, physical activity, social engagement, occupational therapy, reminiscence therapy, and technology-assisted interventions are the treatment modalities of neuropsychiatric disorders. In conjunction with the outcomes of these interventions on neuropsychiatric disorders, their limitations, challenges, and future directions are also explored. Though these evidence-based therapies are beneficial, optimal guidelines, a shortage of skilled therapy providers, long-term outcomes, and knowledge about the mechanism of action are inadequate. Finally, engaging in social interaction, daily exercise, and having a creative hobby, such as drawing and listening to music, delays the worsening of neuropsychiatric symptoms in the aging population. In this chapter, we aim to review the science behind NPIs for neuropsychiatric disorders extensively.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"45-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stress on neuronal cell: Morphological to molecular approach. 应激对神经细胞的影响：形态学到分子学的研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.1016/bs.pbr.2025.01.010

Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh

{"title":"Effect of stress on neuronal cell: Morphological to molecular approach.","authors":"Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh","doi":"10.1016/bs.pbr.2025.01.010","DOIUrl":"10.1016/bs.pbr.2025.01.010","url":null,"abstract":"Stress can be characterized as any perceived or actual threat that necessitates compensatory actions to maintain homeostasis. It can alter an organism's behavior over time by permanently altering the composition and functionality of brain circuitry. The amygdala and prefrontal cortex are two interrelated brain regions that have been the focus of initial research on stress and brain structural and functional plasticity, with the hippocampus serving as the entry point for most of this knowledge. Prolonged stress causes significant morphological alterations in important brain regions such as the hippocampus, amygdala, and prefrontal cortex. Memory, learning, and emotional regulation are among the cognitive functions that are adversely affected by these changes, including neuronal shrinkage, dendritic retraction, and synaptic malfunction. Stress perturbs the equilibrium of neurotransmitters, neuronal plasticity, and mitochondrial function at the molecular level. On the other hand, chronic stress negatively impacts physiology and can result in neuropsychiatric diseases. Recent molecular research has linked various epigenetic processes, such as DNA methylation, histone modifications, and noncoding RNAs, to the dysregulation of genes in the impacted brain circuits responsible for the pathophysiology of chronic stress. Numerous disorders, including neurodegenerative diseases (NDDs) including Alzheimer's, amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, multiple sclerosis, and Parkinson's disease, have been linked to oxidative stress as a possible cause.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"469-502"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment. 创伤后应激障碍（PTSD）的神经科学基础：从大脑到治疗。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1016/bs.pbr.2025.01.009

Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta

{"title":"The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment.","authors":"Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta","doi":"10.1016/bs.pbr.2025.01.009","DOIUrl":"10.1016/bs.pbr.2025.01.009","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a debilitating mental health condition resulting from exposure to traumatic events, marked by persistent psychological distress and impairment in daily functioning. Risk factors for PTSD include genetic predispositions, neurobiological factors, as well as psychosocial and environmental influences. Specific demographic groups, such as veterans, first responders, and individuals in high-risk environments, are more susceptible to developing the disorder. Despite growing research, there remain gaps in understanding the full pathophysiology of PTSD, and existing diagnostic methods and treatments are not universally effective, contributing to a significant public health burden. This chapter explores the pathophysiology of PTSD, focusing on its underlying mechanisms, associated risk factors, and high-risk populations. Biological biomarkers such as neuroimaging findings, hormonal imbalances, genetic predispositions, and physiological indicators are discussed in the context of their role in PTSD diagnosis and understanding. Both pharmacological treatments and non-pharmacological interventions, including Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), and mindfulness-based techniques, are reviewed for their effectiveness in symptom management. Further research is essential to advance individualized diagnostic techniques and optimize treatment strategies, ensuring more personalized care for PTSD patients.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"427-468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case studies of the migraine aura in the blind or partially sighted. 盲人或弱视者偏头痛先兆的个案研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-22 DOI: 10.1016/bs.pbr.2025.02.003

Ramiro M Joly-Mascheroni, Alex J Shepherd

{"title":"Case studies of the migraine aura in the blind or partially sighted.","authors":"Ramiro M Joly-Mascheroni, Alex J Shepherd","doi":"10.1016/bs.pbr.2025.02.003","DOIUrl":"10.1016/bs.pbr.2025.02.003","url":null,"abstract":"Visual Aura symptoms are particularly intriguing when manifesting in the severely visually impaired. Presented here are eight case reports of the migraine aura experienced by those who are blind or partially sighted. The migraine aura consists of fully reversible neurological symptoms that typically precede the migraine headache by approximately 30 min. The symptoms are commonly visual and include the classic fortification spectra, seeing flashing lights, stars or phosphenes, or experiencing distortions of the visual scene. Non-visual aura symptoms can also be experienced, including pins and needles or numbness on the face and/or limbs, allodynia, speech difficulties, auditory disturbances and distortions of the sense of smell and/or taste. Both visual and non-visual aura symptoms were assessed using an on-line questionnaire. All participants experienced visual symptoms associated with their headache. Six experienced non-visual aura symptoms, which is a higher proportion than usually found when people without visual loss are questioned. Migraine triggers were also assessed. Glare and stress were the most frequently endorsed (by six out of eight), followed by flickering lights, tiredness and hormonal factors (five out of eight). The relative weight or balance of activity in visual, somatosensory and motor cortices is suggested as a possible explanation for the higher rate of non-visual aura symptoms in those who are blind or partially sighted.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"143-155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Affect in the dark: Navigating the complex landscape of social cognition in blindness. 黑暗中的情感：在失明中导航社会认知的复杂景观。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI: 10.1016/bs.pbr.2025.02.002

Veronica Domenici, Olivier Collignon, Giada Lettieri

引用次数: 0