Plant and Cell Physiology最新文献

{"title":"Mirabilis jalapa mannanase-mediated mannose promotes root development in Arabidopsis via the MYB41-DWF4 module regulating brassinosteroid signaling pathways.","authors":"Hui Li, Xun Jin, Mengyao Rong, Sitong Guo, Caiyu Yang, Dongxu Wang, Hui Ma, Jingwei Lin, Shuisen Chen, Ming Zhong, Zhifu Guo","doi":"10.1093/pcp/pcag053","DOIUrl":"10.1093/pcp/pcag053","url":null,"abstract":"<p><p>Sugars serve both as nutritional sources and signaling entities in plant root systems, engaging in crosstalk with phytohormones to modulate root morphogenesis and growth. Previous investigations demonstrated that heterologous expression of the Mirabilis jalapa mannanase gene (MirMAN) in Arabidopsis thaliana significantly promotes root development. Nevertheless, the mechanistic basis and associated signaling networks underpinning this phenomenon remain poorly elucidated. In this study, we found that MirMAN-mediated mannose could significantly promote plant root development, participate in root morphogenesis by promoting lateral root emergence and root elongation. Moreover, MirMAN-mediated mannose could increase the content of endogenous auxin, elevated the expression of auxin transport genes (AtLAX3/AtPIN2) and the response factor (AtARF7/19), lateral root development-related genes (AtLBD16/29), cell cycle-related gene (AtGATA23), sugar signaling-related genes (AtSnRK1) to promote lateral root development. Furthermore, the expression of AtMYB41 was significantly increased by MirMAN-mediated mannose. We further found that MYB41 directly bound to the promoter of AtDWF4 (a BR biosynthetic gene) and positively regulates the transcription of AtDWF4. Consistent with these findings, the myb41 mutants exhibited fewer lateral roots, reduced AtDWF4 expression, and lower brassinosteroid content. Collectively, These results provide new perspectives for understanding the mechanisms of endogenous plant sugar signaling, and provide new ideas for exploiting the plastic developmental capacity of plant roots.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1489-1502"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rice phosphate transporter reduces the low phosphate response through jasmonate signaling.","authors":"Balaji Mani, Kanika Maurya, Lokesh Verma, Priya Gupta, Pawandeep S Kohli, Gagan Gupta, Aime Jaskolowski, Yves Poirier, Jitender Giri","doi":"10.1093/pcp/pcag070","DOIUrl":"10.1093/pcp/pcag070","url":null,"abstract":"<p><p>Phosphorus (P) is an essential macronutrient for plant growth, and its deficiency severely limits crop productivity. The PHOSPHATE1 (PHO1) protein family, defined by an N-terminal SPX (SYG1/Pho81/XPR1) domain, four transmembrane (4TM) domains, and a C-terminal EXS (ERD1/XPR1/SYG1) domain, mediates phosphate (Pi, the bioavailable form of P) loading into the xylem for root-to-shoot transport. In rice, OsPHO1;2 is critical for Pi export, and loss-of-function mutants exhibit severe growth retardation and Pi-deficiency symptoms despite sufficient external Pi. To dissect the functional contributions of PHO1, we generated CRISPR/Cas9 rice lines expressing either the EXS domain containing a part of the SPX domain (S-EXS) or the 4TM + EXS domains (T-EXS) of OsPHO1;2. Phenotypic analyses under Pi-sufficient and Pi-deficient conditions revealed that S-EXS lines displayed improved early growth compared to ospho1;2 mutants, despite similar shoot Pi levels. These plants exhibited reduced jasmonic acid accumulation and attenuated Pi starvation responses (PSRs), resembling wild-type hormone profiles. In contrast, T-EXS lines mirrored the growth defects of ospho1;2 mutants. Transcriptome profiling confirmed that defense and Pi starvation pathways were less activated in S-EXS lines relative to the mutants. However, both the S-EXS and T-EXS lines retained seed development defects and reduced seed P content, consistent with the ospho1;2 phenotypes. Heterozygous plants carrying one functional OsPHO1;2 allele exhibited normal growth and seed development, confirming the recessive nature of the mutation. Collectively, these findings demonstrate that the S-EXS domain of OsPHO1;2 promotes plant growth independently of Pi transport by modulating jasmonate signaling and suppressing PSRs. This highlights a signaling role for PHO1 domains, offering new insights into Pi homeostasis and potential strategies for breeding Pi-efficient crops.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1503-1519"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct concentration-dependent double-stranded DNA-binding modes of a dinoflagellate cold shock domain protein provide insight into mechanisms of nuclear regulation.","authors":"Shizue Yoshihara, Yohei Minakuchi, Atsushi Toyoda, Kota Higashi, Karin Fujimura, Jun Minagawa, Hayato Tokumoto","doi":"10.1093/pcp/pcag075","DOIUrl":"10.1093/pcp/pcag075","url":null,"abstract":"<p><p>Coral reef ecosystems depend on symbiotic dinoflagellates, yet the molecular mechanisms that regulate their growth remain poorly understood. Dinoflagellates possess unusually large genomes but remarkably few transcription factors, most of which contain a cold shock domain (CSD). In this study, we investigated the transcriptional responses associated with growth stimulation in the symbiotic dinoflagellate Breviolum minutum. Exposure to zinc oxide nanoparticles significantly promoted cell proliferation, and transcriptome analysis identified a CSD protein (CSP) gene, designated B. minutum CSP1 (BmCSP1) as one of the few upregulated genes encoding transcription-related proteins under this growth-promoting condition. Phylogenetic analysis revealed that BmCSP1 belongs to a highly divergent dinoflagellate CSD clade. To examine its biochemical properties, we analyzed the recombinant CSD of BmCSP1 and compared it with Escherichia coli CspA (EcCspA). BmCSP1 bound single-stranded DNA and RNA with apparent affinities similar to those of EcCspA but exhibited stronger apparent binding to double-stranded DNA (dsDNA). Electrophoretic mobility shift assays further revealed a distinctive concentration-dependent dsDNA-binding behavior: at lower concentrations, BmCSP1 formed sharp, discrete protein-DNA complexes, whereas at higher concentrations the electrophoretic behavior of the complexes became increasingly heterogeneous. Comparative analyses using supercoiled, open circular, and linearized plasmid DNA further demonstrated that BmCSP1-dsDNA interactions are strongly influenced by DNA topology. In addition, both BmCSP1- and EcCspA-dsDNA complexes remained stable after heating to 95°C, despite the loss of dsDNA-binding activity in the free proteins above 55°C. These findings identify BmCSP1 as a dinoflagellate CSP with unique topology-dependent dsDNA-binding modes and exceptional complex stability, providing new insights into how a limited repertoire of transcription factors may contribute to genome organization and transcriptional regulation in dinoflagellates.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1573-1586"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous γ-aminobutyric acid application delays onset of ripening in Grenache, Chardonnay, and Shiraz grape berries.","authors":"Chethana G Shekharappa, Nicholas J Booth, Vinay Pagay, Stephen D Tyerman, Sunita A Ramesh","doi":"10.1093/pcp/pcag078","DOIUrl":"10.1093/pcp/pcag078","url":null,"abstract":"<p><p>Physiological and biochemical changes in Vitis vinifera L. (grape) berries during development have been extensively studied; however, the role of γ-aminobutyric acid (GABA), a non-protein amino acid that changes during berry development, remains unknown. We hypothesized that GABA accumulation in the berry may have an osmoprotective role and increase the living tissue percentage during development. On this precedent, exogenous application of GABA (5 mM) to bunches may result in a delayed onset of ripening. GABA was observed to accumulate concomitantly with sugar accumulation commencing at veraison in Chardonnay, Shiraz, and Grenache grape berries sampled from the Coombe vineyard over two seasons (2018-20). Cultivar-dependent variability was noted in hydrogen peroxide and antioxidant capacity. In berries treated with exogenous GABA (5 mM) weekly from the pea-stage until veraison, decreases in berry mass, total soluble solids, and cell death, along with increased antioxidant capacity, and a delay in veraison were observed. These findings suggest that exogenous GABA may modulate ripening, although the exact mechanisms require further investigation. Elucidating these mechanisms may benefit growers by improving grape berry quality and enabling modification of ripening in response to a changing climate or adverse weather events.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1587-1602"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas9-mediated genome editing reveals the involvement of a polyphenol oxidase in the shikonin-specific biosynthesis in Lithospermum erythrorhizon.","authors":"Kohei Nakanishi, Yuki Takano, Kyoko Yamamoto, Yuki Matsuda, Mariko Yano, Koji Mito, Takuji Ichino, Kanade Tatsumi, Hao Li, Kazuaki Ohara, Ryosuke Munakata, Hideyuki Suzuki, Nozomu Sakurai, Daisuke Shibata, Keishi Osakabe, Bunta Watanabe, Takahiro Okada, Koichiro Shimomura, Kojiro Takanashi, Akifumi Sugiyama, Kazufumi Yazaki","doi":"10.1093/pcp/pcag074","DOIUrl":"10.1093/pcp/pcag074","url":null,"abstract":"<p><p>Shikonin, a 1,4-naphthoquinone derivative produced by some limited Boraginaceae species, exhibits unique pharmacological properties and is also used as a natural dye. The regulatory factors of shikonin production have been demonstrated using a cell culture system of Lithospermum erythrorhizon. Among these factors, copper is known to be the strongest enhancer of shikonin production, and the copper-requiring biosynthetic step is shikonin-specific, unlike the byproduct benzoquinones. Despite the long history of shikonin biosynthesis studies for over 40 years, the copper-involved reaction has been still unknown. Here, we explored candidate genes associated with shikonin production using a PCR-select subtraction experiment. Genes encoding PPO, a dicopper-dependent oxidoreductase, was highlighted by the strong synchronous expression with shikonin production. Transcriptome analysis of hairy roots and cultured cells of this plant revealed that, of the five PPO genes expressed in L. erythrorhizon (LePPOs), only LePPO1 showed a close correlation with shikonin production. Then, we generated genome-edited hairy roots of LePPO1 using CRISPR/Cas9-mediated mutagenesis to analyze its impact on shikonin derivative and other specialized metabolite production. The results showed that shikonin content was markedly reduced in all LePPO1-ge lines, while the content of deoxyshikonofuran, a hydroquinone-type shunt product that branches after 3''-hydroxygeranylhydroquinone in the shikonin biosynthetic pathway, remained unaffected in the LePPO1-ge lines. These findings address the question of why a copper ion is crucial for shikonin biosynthesis and suggest that LePPO1 participates in naphthalene ring formation. Interestingly, LePPO1 is localized in plastids, whereas shikonin accumulates in the apoplast.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1557-1572"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148056421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From mannose to root development: MYB41 links cell wall-derived sugars to brassinosteroid signalling.","authors":"Ryo Tachibana","doi":"10.1093/pcp/pcag093","DOIUrl":"10.1093/pcp/pcag093","url":null,"abstract":"","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1455-1457"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functions and interactions of important sulfur-containing metabolites in plant development and stress responses.","authors":"Zhigang Wang, Fan Chen, Yunfei Xu, Yijie Zang, Wenjia Chen, Yunxiang Zang, Huihui Fang","doi":"10.1093/pcp/pcag045","DOIUrl":"10.1093/pcp/pcag045","url":null,"abstract":"<p><p>Sulfur (S), an essential macroelement, plays important roles in numerous plant physiological processes. Through sulfur assimilation pathways, plants biosynthesize various S-containing compounds, including the gasotransimitter hydrogen sulfide (H2S), the primary organic S-containing amino acid cysteine (Cys), the master antioxidant glutathione (GSH), and characteristic secondary metabolites such as glucosinolates (GSLs). Current studies have established the wide involvement of S-containing metabolites in orchestrating plant development and stimuli responses, however, the interplay and crosstalk among these molecules in coordinating these processes remain limited. This review systematically synthesizes current knowledge on sulfur assimilation and the multifaceted functions of S-containing metabolites in plants, encompassing their roles in ROS and intracellular sulfur homeostasis, protein redox modifications, and as signaling molecules that interact with plant hormones and other growth regulators. We also specifically delineate the functional interactions and crosstalk among various metabolites, with a focus on the paired relationships between H2S and Cys, H2S and GSH, H2S and GSLs, Cys and GSLs, and GSH and GSLs, during plant development and stress adaptation. We expect that this review will establish a comprehensive framework for understanding the regulation of sulfur metabolism and elucidating the mechanistic basis of S-containing metabolites in physiological processes. By integrating recent advances in this field, we aim to provide not only fundamental insights into sulfur nutrient utilization efficiency, but also valuable theoretical support for developing innovative strategies for crop improvement and sustainable agriculture.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1461-1472"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The MADS-box transcription factor OfDEFA orchestrates floral aroma biosynthesis in Osmanthus fragrans flowers through a dual-layer transcriptional regulatory network.","authors":"Feiyan Ren, Jia Wang, Tingting Shi, Wuwei Zhu, Chenyu Wei, Chunling Zhang, Xiulian Yang, Lianggui Wang, Yuanzheng Yue","doi":"10.1093/pcp/pcag072","DOIUrl":"10.1093/pcp/pcag072","url":null,"abstract":"<p><p>Floral scent, primarily comprised of volatile organic compounds such as the monoterpene linalool, serves as a critical medium for plant-pollinator communication and determines ornamental value. Linalool is catalyzed by terpene synthases in plants through the methylerythritol 4-phosphate (MEP) pathway. In sweet Osmanthus (Osmanthus fragrans), linalool is a characteristic aroma compound, yet the transcriptional regulation of its biosynthesis remains largely unknown. Although MADS-box transcription factors (TFs) are known as master regulators of floral organ identity, their role in controlling terpenoid volatile production is largely unexplored. In this study, we elucidated the OfDEFA, a nucleus-localized MADS-box TF, which centrally regulates linalool biosynthesis through a sophisticated dual-layer mechanism. Using the key enhancer region of the linalool synthase gene OfTPS1a promoter as bait, we identified OfDEFA via yeast-one-hybrid screening. Transient overexpression and virus-induced gene silencing of OfDEFA in O. fragrans flowers confirmed its role as a positive regulator of linalool biosynthesis. We demonstrated that OfDEFA can directly bind to CArG-box motifs in the promoters of two linalool synthase genes, OfTPS1a and OfTPS7, to activate their expression. Furthermore, we uncovered that OfDEFA can also directly activate OfMYB21, a known positive regulator of OfTPS1a, thereby regulating the production of linalool. Our findings reveal a novel, elaborate regulatory module in which a floral homeotic MADS-box factor coordinates floral scent production by directly engaging structural genes and simultaneously reinforcing the regulatory network of the MEP pathway, providing new insights into the complex regulatory network underlying linalool biosynthesis in sweet Osmanthus.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1520-1532"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148056419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the ribosomal stress response pathway leading to cell cycle arrest in Arabidopsis thaliana.","authors":"Iwai Ohbayashi, Tai-Yin Hsu, Jenifer Faustine, Po-Chen Chiang, Takafumi Miyashita, Takaaki Yonekura, Akitoshi Iwamoto, Masahiko Furutani, Munetaka Sugiyama","doi":"10.1093/pcp/pcag096","DOIUrl":"10.1093/pcp/pcag096","url":null,"abstract":"<p><p>When ribosome biogenesis or function is perturbed, plant cells undergo ribosomal stress, leading to growth defects and developmental alterations. The plant ribosomal stress response has recently gained recognition, but its molecular mechanism remains elusive. Here, we characterized this response in Arabidopsis thaliana using ribosome biogenesis-impairing mutations [root initiation defective 2 (rid2) and rid3] and ribosome biogenesis/function-interfering drugs (5-fluorouracil and puromycin) as ribosomal stressors. These stressors repressed cell proliferation and increased ploidy levels indicative of endoreduplication. Under these ribosomal stress conditions, a subset of NAM, ATAF1/2, CUC (NAC) transcription factor genes and cyclin-dependent kinase (CDK) inhibitor genes were upregulated, while they tended to downregulate G2/M-specific genes. Overexpression of ANAC082, which encodes an Arabidopsis NAC (ANAC) factor implicated in the ribosomal stress response pathway, phenocopied the ribosomal stress response in terms of cellular behavior and gene expression. These results together indicate that, predominantly mediated by ANAC082, ribosomal stress arrests the cell cycle at G2 and promotes endoreduplication. A comparison of gene expression and genetic relations between the ribosomal and DNA damage stress responses, focusing on ANAC082 and the DNA damage stress response-mediating NAC factor SUPPRESSOR OF GAMMA RESPONSE1, revealed that these stress response pathways are distinct and largely independent of each other, although they have similar outputs in the control of cell proliferation and endoreduplication.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1642-1659"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional definition of leaf sink-to-source transition by 14C tracing reveals transcriptional reprogramming in soybean.","authors":"Ai Kaiho-Soma, Ryohei Sugita, Yuko Kurita, Natsuko I Kobayashi, Tomoko M Nakanishi, Keitaro Tanoi","doi":"10.1093/pcp/pcag090","DOIUrl":"10.1093/pcp/pcag090","url":null,"abstract":"<p><p>Immature leaves initially act as sinks that import photosynthates from mature leaves. As leaves develop, they gradually acquire source capacity-a developmental shift known as the sink-to-source transition. Although this transition is critical for increasing source number and yield potential, its molecular basis remains largely unclear. To investigate the underlying mechanisms in soybean, we combined carbon-14 (14C) tracer analysis with RNA-seq. At an early vegetative stage, the second trifoliate leaf was classified into sink, transition, or source states based on its 14C accumulation pattern. Autoradiographic analyses further indicated that regulation of photosynthate transport occurs at the nodal region, prompting parallel RNA-seq analysis of both leaf and node tissues. Transcriptome analysis revealed early induction of cytokinin negative regulators, A-type ARABIDOPSIS RESPONSE REGULATORs (ARRs), in leaf tissue, suggesting attenuation of cytokinin signaling at the onset of the sink-to-source transition. In contrast, genes involved in sugar transport, such as sugars will eventually be exported transporters and sucrose transporter family members, showed continuous upregulation across developmental stages in both leaf and node tissues. Together, these results provide a high-resolution view of transcriptional reprogramming accompanying the leaf sink-to-source transition in soybean.</p>","PeriodicalId":20575,"journal":{"name":"Plant and Cell Physiology","volume":" ","pages":"1628-1641"},"PeriodicalIF":4.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}