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[VEXAS syndrome - a chameleon of inflammatory syndromes]. [VEXAS综合征-炎症综合征的变色龙]。
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.009
Elisa Leggeri, Athina Pangalu, Florence Vallelian
{"title":"[VEXAS syndrome - a chameleon of inflammatory syndromes].","authors":"Elisa Leggeri, Athina Pangalu, Florence Vallelian","doi":"10.23785/PRAXIS.2025.02.009","DOIUrl":"10.23785/PRAXIS.2025.02.009","url":null,"abstract":"<p><strong>Introduction: </strong>The VEXAS syndrome is a systemic autoinflammatory disease first described in 2020. It primarily affects older men and is caused by a somatic mutation in the UBA1 gene on the X chromosome, leading to dysfunction of the innate immune system. Symptoms include fever, weight loss, various hematological manifestations, and a broad spectrum of clinical symptoms, often including ocular manifestations. Diagnosis is based on the detection of the mutation. There is currently no standardized therapy, and mortality can be as high as 40 %.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"75-79"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia]. [快速眼动睡眠行为障碍-不仅仅是简单的睡眠异常]。
Praxis Pub Date : 2025-02-01 DOI: 10.23785//PRAXIS.2025.02.004
Carolin Schäfer, Anne-Kathrin Brill, Marie-Angela Wulf, Markus Schmidt, Claudio L Bassetti
{"title":"[REM-Sleep-Behavior Disorder - More Than a Simple Parasomnia].","authors":"Carolin Schäfer, Anne-Kathrin Brill, Marie-Angela Wulf, Markus Schmidt, Claudio L Bassetti","doi":"10.23785//PRAXIS.2025.02.004","DOIUrl":"10.23785//PRAXIS.2025.02.004","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid-Eye-Movement (REM) sleep is an essential part of sleep dominating the second half of the night. A disturbance of the phy-siological muscle hypotonia of REM sleep can lead to dream enactment: REM sleep behavior disorder (RBD). In the absence of a disease of the central nervous system or provoking factors such as sleep apnea, alcohol consumption or antidepressants, isolated RBD (iRBD) may be present. IRBD is an early stage of alpha-synucleinopathies such as Parkinson's disease, dementia with Lewy bodies and multisystem atrophy. Medical history and polysomnography are the most important diagnostic tools. Clonazepam and melatonin are symptomatic treatments used to prevent injury. New technologies enable long-term monitoring of disease progression in iRBD and thus guide the targeted use of future disease-modifying therapies.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Two Different Courses of a Rare, Potentially Reversible Encephalopathy]. [一种罕见的、可能可逆的脑病的两种不同病程]。
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.007
Dominik Imhoff, Rolf Sturzenegger, Philip Went, Georgios Pantazis
{"title":"[Two Different Courses of a Rare, Potentially Reversible Encephalopathy].","authors":"Dominik Imhoff, Rolf Sturzenegger, Philip Went, Georgios Pantazis","doi":"10.23785/PRAXIS.2025.02.007","DOIUrl":"10.23785/PRAXIS.2025.02.007","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare form of cerebral amyloid angiopathy (CAA). This leads to amyloid deposits and inflammation in the vessel walls with cerebral microbleeds, white matter hyperintensities and edema. Major clinical manifestations vary and are non-specific. They include rapidly progressive dementia, headaches and epileptic seizures. MRI and histology are crucial for further diagnosis, although the definitive diagnosis can only be made in autopsy. Timely therapy, mainly with corticosteroids, is essential for successful healing.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Statins are not associated with an increased risk of cataracts in patients at risk of cardiovascular disease]. [他汀类药物与有心血管疾病风险的患者白内障风险增加无关]。
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.002
Thomas Rosemann, Andrea Rosemann
{"title":"[Statins are not associated with an increased risk of cataracts in patients at risk of cardiovascular disease].","authors":"Thomas Rosemann, Andrea Rosemann","doi":"10.23785/PRAXIS.2025.02.002","DOIUrl":"10.23785/PRAXIS.2025.02.002","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Brucellose as a travel souvenir]. [作为旅游纪念品的布鲁塞尔]。
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.010
Valentino Monaco, Michael Bodmer, Andrea Christina Frey
{"title":"[Brucellose as a travel souvenir].","authors":"Valentino Monaco, Michael Bodmer, Andrea Christina Frey","doi":"10.23785/PRAXIS.2025.02.010","DOIUrl":"10.23785/PRAXIS.2025.02.010","url":null,"abstract":"<p><strong>Introduction: </strong>Family with fever, asthenia, arthralgia and headache after travelling back from Kosovo. A precise exposure history led to the suspicion of an underlying zoonosis and allowed a diagnosis to be made. The treatment with doxycycline and gentamicin led to a restitutio ad integrum in all family members.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"80-82"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Summary of the 2024 ESC-Guidelines for the management of elevated blood pressure and hypertension]. 【2024年esc -高血压和高血压治疗指南摘要】。
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.003
Miklos Rohla, Emrush Rexhaj
{"title":"[Summary of the 2024 ESC-Guidelines for the management of elevated blood pressure and hypertension].","authors":"Miklos Rohla, Emrush Rexhaj","doi":"10.23785/PRAXIS.2025.02.003","DOIUrl":"10.23785/PRAXIS.2025.02.003","url":null,"abstract":"<p><strong>Introduction: </strong>This mini-review summarizes the new guideline recommendations of the European Society of Cardiology for the management of elevated blood pressure and hypertension - with particular focus on aspects relevant to daily clinical practice.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute Diverticulitis - Treatment without Antibiotics?] 急性憩室炎-不使用抗生素治疗？］
Praxis Pub Date : 2025-02-01 DOI: 10.23785/PRAXIS.2025.02.006
Ivana Heinimann, Philipp Busche, Éva Pozder, Gisela Etter, Cordula Gubler, Katia Boggian, Philip Tarr
{"title":"[Acute Diverticulitis - Treatment without Antibiotics?]","authors":"Ivana Heinimann, Philipp Busche, Éva Pozder, Gisela Etter, Cordula Gubler, Katia Boggian, Philip Tarr","doi":"10.23785/PRAXIS.2025.02.006","DOIUrl":"10.23785/PRAXIS.2025.02.006","url":null,"abstract":"<p><strong>Introduction: </strong>In patients with acute uncomplicated diverticulitis current guidelines recommend that antibiotics should not be used reflexively or routinely, but rather selectively: starting with Hinchey stage 1b, i.e. in the case of localized pericolic abscess. Antibiotic-free diverticulitis therapy is therefore generally possible up to Hinchey stage 1a. We recommend carefully evaluating the patient, taking exclusion criteria into account and re-examining the patient after 48-72 hours. Keywords: Diverticulitis, antibiotics, treatment without antibiotics, complications.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 2","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Non-alcoholic fatty liver: New name, but the challenge remains]. [非酒精性脂肪肝：新名字，但挑战依然存在]。
Praxis Pub Date : 2025-01-01 DOI: 10.23785/PRAXIS.2025.01.005
Miroslav Vána, Koray Fidan, Annalisa Berzigotti, Naomi F Lange
{"title":"[Non-alcoholic fatty liver: New name, but the challenge remains].","authors":"Miroslav Vána, Koray Fidan, Annalisa Berzigotti, Naomi F Lange","doi":"10.23785/PRAXIS.2025.01.005","DOIUrl":"10.23785/PRAXIS.2025.01.005","url":null,"abstract":"<p><strong>Introduction: </strong>Due to widespread diseases with increasing numbers of patients, such as metabolic syndrome, metabolic liver diseases are becoming the most common liver diseases of the future. The article explains key changes, including the nomenclature change from non-alcoholic fatty liver disease to metabolic dysfunction-associated steatotic liver disease.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Eosinophilic Lung Diseases: Time Pressure in the Maze of Differential Diagnoses]. 嗜酸性肺疾病：鉴别诊断迷宫中的时间压力
Praxis Pub Date : 2025-01-01 DOI: 10.23785/PRAXIS.2025.01.008
Sebastian Hahn, Elena Heizmann, Anne-Christin Stöwhas, Silvia Ulrich, Maurice Roeder
{"title":"[Eosinophilic Lung Diseases: Time Pressure in the Maze of Differential Diagnoses].","authors":"Sebastian Hahn, Elena Heizmann, Anne-Christin Stöwhas, Silvia Ulrich, Maurice Roeder","doi":"10.23785/PRAXIS.2025.01.008","DOIUrl":"10.23785/PRAXIS.2025.01.008","url":null,"abstract":"<p><strong>Introduction: </strong>We present a case with eosinophilic granulomatosis with polyangiitis (EGPA). We provide an overview of eosinophilic lung diseases and underline challenges in diagnosis and management of those diseases. Furthermore, we discuss the severity classification of EGPA and provide insight into the current treatment regimen.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Helicobacter pylori]. 幽门螺杆菌。
Praxis Pub Date : 2025-01-01 DOI: 10.23785/PRAXIS.2025.01.006
Fabian Egli, Dominik Dill, Baharak Babouee Flury, Magdalena Filipowicz Sinnreich, Anne Meynard, Gisela Etter, Philipp Busche, Franca Baggi Menozzi, Adrian Egli, Philip Tarr
{"title":"[Helicobacter pylori].","authors":"Fabian Egli, Dominik Dill, Baharak Babouee Flury, Magdalena Filipowicz Sinnreich, Anne Meynard, Gisela Etter, Philipp Busche, Franca Baggi Menozzi, Adrian Egli, Philip Tarr","doi":"10.23785/PRAXIS.2025.01.006","DOIUrl":"10.23785/PRAXIS.2025.01.006","url":null,"abstract":"<p><strong>Introduction: </strong>The guidelines on Helicobacter pylori (HP) have changed considerably. HP should always be considered a persistent and not a transient infection. A positive HP test should always be treated in order to prevent complications such as gastric or duodenal ulcers and gastric carcinoma. The prevalence of HP has been decreasing for many years but remains high among immigrants from many countries. Because the antimicrobial resistance situation has deteriorated significantly, we always recommend resistance testing before first-line therapy.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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