PraxisPub Date : 2026-01-01DOI: 10.23785/PRAXIS.2026.01.007
Barbara Songin, Markus Schneemann
{"title":"[Pulmonal Tularemia - a slightly different infection].","authors":"Barbara Songin, Markus Schneemann","doi":"10.23785/PRAXIS.2026.01.007","DOIUrl":"10.23785/PRAXIS.2026.01.007","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the numbers of tularemia cases have risen. The rarest but most lethal form is pulmonary. Diagnosis is particularly difficult in immunosuppressed patients because clinical symptoms and radiological findings are nonspecific. Clinically and radiologically, the disease can mimic other causes of atypical pneumonia or pulmonary infiltrates, especially bacterial or viral pneumonia. Due to these nonspecific features, diagnosis is often delayed. More accurate diagnostics and properly administered therapy prevents complications and lowers lethal courses.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 1","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-01-01DOI: 10.23785/PRAXIS.2026.01.004
Irene Bosma, Elena Crisman, Lukas Wildi, Karl Frontzek, Bernd Klaeser, Michael Osthoff
{"title":"[Tiger man: diagnosis at a glance in F18-FDG-PET-CT for the evaluation of muscle weakness and hypercalcemia].","authors":"Irene Bosma, Elena Crisman, Lukas Wildi, Karl Frontzek, Bernd Klaeser, Michael Osthoff","doi":"10.23785/PRAXIS.2026.01.004","DOIUrl":"10.23785/PRAXIS.2026.01.004","url":null,"abstract":"<p><strong>Introduction: </strong>A 68-year-old patient presented with weakness, recurrent falls, unintentional weight loss, and confusion. Symptomatic hypercalcemia secondary to a Vitamin D intoxication was initially identified as cause. Over time, proximal myopathy, edema of the forearms, persistent hypercalcemia with elevated 1,25 Vitamin D and increased inflammatory markers developed. A PET-CT showed disseminated linear uptake in the skeletal muscles («tiger man sign»). After muscular biopsy the suspicion of muscular sarcoidosis was confirmed. High-dose steroid therapy resulted in rapid clinical improvement.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-01-01DOI: 10.23785/PRAXIS.2026.01.002
Joseph Osterwalder
{"title":"[Moderate alcohol consumption - healthy or risky? A critical perspective on existing research and WHO guidelines].","authors":"Joseph Osterwalder","doi":"10.23785/PRAXIS.2026.01.002","DOIUrl":"10.23785/PRAXIS.2026.01.002","url":null,"abstract":"<p><strong>Introduction: </strong>The health effects of moderate alcohol consumption are controversially discussed in the scientific community. Older studies suggested cardiovascular benefits, but newer data indicate these are likely overestimated due to methodological biases. At the same time, there is growing evidence that even small amounts of alcohol increase the risk of cancer. Therefore, the WHO emphasizes in its new guidelines 2023, that there is no safe level of alcohol consumption. However, this view is challenged by recent research from groups like the AHA and the USA NASEM as well as concerns over possible conflicts of interest and lack of transparency in WHO's decision-making. Therefore, any potential changes to Swiss recommendations should await the results of the ongoing prospective, randomized UNATI trial.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 1","pages":"2-6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[No mistakes with Schnitzler syndrome].","authors":"Elisa Leggeri, Federica Foglia, Florence Vallelian","doi":"10.23785/PRAXIS.2025.12.007","DOIUrl":"10.23785/PRAXIS.2025.12.007","url":null,"abstract":"<p><strong>Introduction: </strong>Schnitzler syndrome is a rare autoinflammatory disease that primarily manifests in adulthood. In cases presenting with chronic urticaria and paraproteinemia, Schnitzler syndrome should be considered in the differential diagnosis, and the Strassburg criteria should be applied to establish the diagnosis. IL-1 inhibitors have proven to be an effective long-term treatment for Schnitzler syndrome. Patients should be moni-tored for the potential development of lymphoproliferative disorders and/or amyloidosis.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"434-437"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2025-12-01DOI: 10.23785/PRAXIS.2025.12.001
Andrea Rosemann, Thomas Rosemann
{"title":"Vorhofflimmern: Nach Ablation auf Antikoagulation verzichten?","authors":"Andrea Rosemann, Thomas Rosemann","doi":"10.23785/PRAXIS.2025.12.001","DOIUrl":"10.23785/PRAXIS.2025.12.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"410-411"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2025-12-01DOI: 10.23785/PRAXIS.2025.12.005
Ueli Käch, Sofia Boscher, Alexander Turk, Lilian Weiss
{"title":"[Zinc-ed Up and knocked down: alternative causes of bicytopenia].","authors":"Ueli Käch, Sofia Boscher, Alexander Turk, Lilian Weiss","doi":"10.23785/PRAXIS.2025.12.005","DOIUrl":"10.23785/PRAXIS.2025.12.005","url":null,"abstract":"<p><strong>Introduction: </strong>We present the case of a severe bicytopenia as a complication of uncontrolled zinc supplementation and consequent copper deficiency in a young female patient. Following rapid diagnosis, discontinuation of zinc intake and initiation of copper supplementation led to a complete regression of the findings in the blood count and bone marrow, which had initially been interpreted as potentially malignant.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"425-428"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hidden danger: a tare cause of painful muscle spasms after long-lie].","authors":"Barbara Schürch, Cédric Hirzel, Claudine Kocher, Florian Schuler, Plamena Todorova, Christine Roten, Kristina Tänzler","doi":"10.23785/PRAXIS.2025.12.006","DOIUrl":"10.23785/PRAXIS.2025.12.006","url":null,"abstract":"<p><strong>Introduction: </strong>The introduction of systematic vaccination programs since the 1940s has led to a significant reduction in prevalence of tetanus in Western countries. However, tetanus cases still occur sporadically, especially in older people with inadequate immunisation status. The diagnosis is primarily clinical. Microbiological isolation of the gram-positive, anaerobic rod-shaped bacteria is often unsuccessful (not necessarily required for diagnosis). Specific treatment includes wound debridement, administration of tetanus immunoglobulin, tetanus vaccination and antibiotic therapy. Moreover, supportive measures up to invasive ventilation are used.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"429-433"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2025-12-01DOI: 10.23785/PRAXIS.2025.12.002
Andreas Disko, Frauke Johannes, Anna-Maria Pekacka-Egli, Magdalena Bujan, Bartosz Bujan
{"title":"[Swallowing disorder after stroke - diagnosis and therapy in primary care].","authors":"Andreas Disko, Frauke Johannes, Anna-Maria Pekacka-Egli, Magdalena Bujan, Bartosz Bujan","doi":"10.23785/PRAXIS.2025.12.002","DOIUrl":"10.23785/PRAXIS.2025.12.002","url":null,"abstract":"<p><strong>Introduction: </strong>Dysphagia is a common consequence of stroke, affecting a significant proportion of patients especially during the acute phase. They carry a substantial risk of complications such as aspiration pneumonia, malnutrition, and dehydration, and can considerably impair both quality of life and rehabilitation outcomes. In general practice, where many stroke survivors receive follow-up care, early identification of dysphagia is essential to prevent serious consequences like pneumonia or nutritional deficits. This article provides an overview of the pathophysiology and clinical symptoms of post-stroke dysphagia (PSD). It outlines established screening tools and diagnostic approaches, as well as therapeutic options that can be applied in primary care settings. Special emphasis is placed on interprofessional collaboration and the role of general practitioners in coordinating therapy and long-term management. The article offers practical recommendations for the care of affected patients and supports primary care providers in delivering competent and comprehensive treatment.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"412-416"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2025-12-01DOI: 10.23785/PRAXIS.2025.12.003
Elisa Bally, Thilo Burkard, Matthias Betz, Annina S Vischer
{"title":"[Primary hyperaldosteronism - screening, work-up, treatment].","authors":"Elisa Bally, Thilo Burkard, Matthias Betz, Annina S Vischer","doi":"10.23785/PRAXIS.2025.12.003","DOIUrl":"10.23785/PRAXIS.2025.12.003","url":null,"abstract":"<p><strong>Introduction: </strong>Primary hyperaldosteronism is a common and treatable cause of secondary arterial hypertension. Case finding with the aldosterone-to-renin ratio is recommended in all patients with arterial hypertension. If the case finding test is positive, a confirmatory test should be performed, followed by imaging of the adrenal glands and adrenal vein sampling. Treatment depends on the cause. Laparoscopic adrenalectomy is the treatment of choice for unilateral secretion and medical therapy with mineral corticoid receptor antagonists for bilateral secretion.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"417-420"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2025-12-01DOI: 10.23785/PRAXIS.2025.12.004
Natalie Grob, Markus Koster, Stefan Bilz
{"title":"[Diagnostic steps and management of a rare cause of hypercalcemia].","authors":"Natalie Grob, Markus Koster, Stefan Bilz","doi":"10.23785/PRAXIS.2025.12.004","DOIUrl":"10.23785/PRAXIS.2025.12.004","url":null,"abstract":"<p><strong>Introduction: </strong>Background: Distinguishing familial hypocalciuric hypercalcemia (FHH) a rare cause of usually mild, parathyroid hormone-dependent hypercalcemia from other causes is central for management due to its benign and usually mild course. Case: Diagnostic approach to a mild hypercalcemia in a 36-years-old female with FHH. Conclusion: This case highlights the importance of a precise and stepwise diagnostic approach to identify rare causes of hypercalcemia like FHH, an autosomal-dominant inherited, pathogenic variant of the calcium sensing receptor.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"114 12","pages":"421-424"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}