{"title":"[Chronic diarrhea in Parkinson's disease during Levodopa therapy].","authors":"Annina Macht, Gieri Cathomas, Eveline Bauer, Manfred Essig, Miriam Flückiger","doi":"10.23785/PRAXIS.2026.05.006","DOIUrl":"10.23785/PRAXIS.2026.05.006","url":null,"abstract":"<p><strong>Introduction: </strong>Microscopic colitis is a chronic inflammatory bowel disease characterized by a macroscopically normal colonoscopy and typical histological findings. Drug-associated forms are common, but only rarely reported in association with Levodopa plus Dopa decarboxylase inhibitor therapy. This case report describes a 73-year-old patient with Parkinson's disease and chronic diarrhea in whom complete symptom resolution occurred after discontinuation of Levodopa/Benserazide and switching to Levodopa/Carbidopa. The case highlights the importance of medication review in Parkinson's patients with chronic diarrhea.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 5","pages":"145-148"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-05-01DOI: 10.23785/PRAXIS.2026.05.001
Sarina Mäder, Thomas Rosemann
{"title":"Die pränatale Paracetamol-Einnahme ist ohne negativen Einfluss auf die kindliche Entwicklung.","authors":"Sarina Mäder, Thomas Rosemann","doi":"10.23785/PRAXIS.2026.05.001","DOIUrl":"10.23785/PRAXIS.2026.05.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 5","pages":"124"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-05-01DOI: 10.23785/PRAXIS.2026.05.003
Nadja Widmer, Andrea Stillhard, Thomas Kündig, Severin Läuchli
{"title":"[Retrospective analysis of epidemiology, clinical characteristics and management of 300 Scabies cases].","authors":"Nadja Widmer, Andrea Stillhard, Thomas Kündig, Severin Läuchli","doi":"10.23785/PRAXIS.2026.05.003","DOIUrl":"10.23785/PRAXIS.2026.05.003","url":null,"abstract":"<p><strong>Introduction: </strong>Scabies is a common, highly infectious skin condition that is becoming increasingly prevalent in our society, as well as in communal settings. The aim of this retrospective data analysis was to investigate the epidemiology, clinical presentation and treatment outcomes of scabies cases at the Triemli City Hospital in Zurich. A total of 300 cases of scabies were analysed over the period from 1 February 2023 to 21 September 2023. Purely topical treatment showed a significantly higher rate of treatment failure than combination therapy with permethrin cream and ivermectin tablets (RR = 3.52; 95%-CI = 1.94-6.33; p 0.001). The results support the use of systemic components to reduce treatment failure. Patients with contact to a mass-accommodation facility did not have a significantly increased risk of treatment failure compared with those without contact to such a facility (RR = 0.82; 95%-CI = 0.60-1.11; p > 0.05).</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 5","pages":"132-136"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148034549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.001
Andreas Nadig, Thomas Rosemann
{"title":"Schützt der Konsum von fettreichem Käse vor Demenz?","authors":"Andreas Nadig, Thomas Rosemann","doi":"10.23785/PRAXIS.2026.04.001","DOIUrl":"10.23785/PRAXIS.2026.04.001","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.004
David Jutzi, Robert Escher, Gabriel Waldegg
{"title":"[Slowly progressive, non-traumatic swelling of the left ankle. What does this have to do with rice grains?]","authors":"David Jutzi, Robert Escher, Gabriel Waldegg","doi":"10.23785/PRAXIS.2026.04.004","DOIUrl":"10.23785/PRAXIS.2026.04.004","url":null,"abstract":"<p><strong>Introduction: </strong>This case illustrates the diagnostic approach to chronic arthropathy or tendinopathy. Based on the most common causes, initial evaluation should primarily include imaging and rheumatological assessment. Depending on the results, patients may be managed in primary care or referred to an appropriate specialist. In this patient, extended investigations revealed tuberculous rice body tenosynovitis. After surgical treatment and nine months of antituberculous therapy, an excellent clinical outcome was achieved.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"107-110"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vorstellung unseres Redaktionsmitglieds Prof. Dr. med. Philipp Tarr.","authors":"Dagmar Keller Lang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong></p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.003
Sasha Mukhija, Franz Lehner, Hans H Jung
{"title":"[Amyotrophic lateral sclerosis (ALS): current perspectives and the Swiss ALS Registry].","authors":"Sasha Mukhija, Franz Lehner, Hans H Jung","doi":"10.23785/PRAXIS.2026.04.003","DOIUrl":"10.23785/PRAXIS.2026.04.003","url":null,"abstract":"<p><strong>Introduction: </strong>Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease leading to muscle weakness, atrophy, and ultimately death. In addition to mutations in ALS-related genes, environmental and lifestyle factors may increase disease risk. Diagnosis is based on clinical evaluation, supplemented by electroneuromyography, imaging, and molecular genetic testing. No curative therapy exists, but Riluzole and Edaravone can slow progression, and genetic therapies offer promising perspectives in certain genetically determined forms. In practice, diagnosis is often delayed. The Swiss ALS Registry collects comprehensive data on environmental, lifestyle, clinical, genetic, and biomarker factors, aiming to improve understanding of risk, disease progression, and therapeutic approaches.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.005
Pascale Hösli, Marino Quarella Quarella, Raphael Jeker, Giatgen Spinas, Thomas Neumann, Michael Brändle
{"title":"[Orbital pathology, not always caused by endocrine factors].","authors":"Pascale Hösli, Marino Quarella Quarella, Raphael Jeker, Giatgen Spinas, Thomas Neumann, Michael Brändle","doi":"10.23785/PRAXIS.2026.04.005","DOIUrl":"10.23785/PRAXIS.2026.04.005","url":null,"abstract":"<p><strong>Introduction: </strong>Not all cases of Exophthalmos are related to Graves' disease. Normal thyroid function test results should prompt extended differential diagnostics. IgG4-related disease (IgG4-RD) mimics various inflammatory, infectious, or neoplastic conditions. Diagnosis requires integration of clinical, laboratory, imaging, and histopathological findings. Early glucocorticoid therapy can reduce organ involvement and improve patient outcomes.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.007
Angela Mettler, Tomas Klail, Martin Müller, Elisa Ferrazzini
{"title":"[When the brain starves: A life-threatening neurological complication following bariatric surgery].","authors":"Angela Mettler, Tomas Klail, Martin Müller, Elisa Ferrazzini","doi":"10.23785/PRAXIS.2026.04.007","DOIUrl":"10.23785/PRAXIS.2026.04.007","url":null,"abstract":"<p><strong>Introduction: </strong>In this case report, we describe a 31-year-old female patient who presented with intermittent diplopia, progressive gait instability, dizziness and forgetfulness. Clinical examination revealed decreased level of consciousness (Glasgow Coma Scale score of 14), horizontal and vertical gaze-evoked nystagmus, bilateral abducens nerve palsy, and severe truncal and gait ataxia. Laboratory analyses did not reveal any diagnostic findings. Brain magnetic resonance imaging (MRI) showed bilateral FLAIR-hyperintensities in the dorsomedial thal-amus, mammillary bodies, and around the third ventricle extending into the quadrigeminal plate of the midbrain, findings indicative of Wernicke's encephalopathy. Given the patient's history of sleeve gastrectomy performed three months earlier, and the presumed thiamine (vitamin B1) deficiency due to malabsorption, reduced nutritional intake, and lack of micro-nutrient supplementation, the diagnosis of Wernicke's encephalopathy was established and high-dose intravenous thiamine therapy was initiated.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"119-122"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PraxisPub Date : 2026-04-01DOI: 10.23785/PRAXIS.2026.04.002
Daniel Franzen, Ingo Hülter, Alexander Turk
{"title":"[Oxygen in medicine - basics, applications and risks].","authors":"Daniel Franzen, Ingo Hülter, Alexander Turk","doi":"10.23785/PRAXIS.2026.04.002","DOIUrl":"10.23785/PRAXIS.2026.04.002","url":null,"abstract":"<p><strong>Introduction: </strong>Oxygen is a central component in the treatment of acute and chronic diseases associated with hypoxemia. Nevertheless, in everyday clinical practice it is often administered reflexively, even when documented or clearly suspected hypoxemia - the most important prerequisite for appropriate oxygen therapy - is absent. Dyspnea alone is not an indication, as patients with breathlessness but without hypoxaemia ge-nerally do not benefit from oxygen administration. Controlled titration with clearly defined target ranges is essential in order to avoid risks such as hypercapnia, coronary and cerebral vasoconstriction, oxygen toxicity, absorption atelectasis, or even increased mortality. Long-term oxygen therapy remains a prognostically relevant intervention in patients with stable chronic hypoxaemia. This article summarizes the physiological principles, indications, risks, technical delivery systems, and reimbursement considerations relevant to primary care practice.</p>","PeriodicalId":20494,"journal":{"name":"Praxis","volume":"115 4","pages":"96-99"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}