Polymer Journal最新文献_第10页

Molecular dynamics simulation of the relationship between hydration and water mobilities around piperazine-immobilized polyvinyl alcohol membranes for CO2 capture 用于捕获二氧化碳的哌嗪固定化聚乙烯醇膜周围水合与水流动性之间关系的分子动力学模拟

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-07-25 DOI: 10.1038/s41428-024-00936-3

Ryo Nagumo, Ayami Shibata, Ikuo Taniguchi, Shuichi Iwata

引用次数: 0

Advances in injectable hydrogels with biological and physicochemical functions for cell delivery 用于细胞输送的具有生物和理化功能的可注射水凝胶的研究进展

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-07-09 DOI: 10.1038/s41428-024-00934-5

Akihiro Nishiguchi

{"title":"Advances in injectable hydrogels with biological and physicochemical functions for cell delivery","authors":"Akihiro Nishiguchi","doi":"10.1038/s41428-024-00934-5","DOIUrl":"10.1038/s41428-024-00934-5","url":null,"abstract":"Injectable hydrogels that can be administered via syringes have enormous potential as cell delivery carriers for cell transplantation therapy. Owing to their beneficial properties, including biocompatibility, biodegradability, tissue adhesion, and scaffold functions, injectable hydrogels can be used to improve the delivery efficacy and survival of transplanted cells posttransplantation. Moreover, delivery via injection does not require culture or invasive surgical procedures, leading to reduced costs, processing time, and patient burden. To develop injectable hydrogels for clinical translation, hydrogels have been functionalized using various biological and physicochemical engineering approaches to induce angiogenesis, suppress immune rejection, provide viscoelasticity, and allow pore formation for cell infiltration. This focus review discusses the design of optimal injectable hydrogels for cell delivery. Moreover, this focus review summarizes the different approaches available to improve the biological and physicochemical features of hydrogels, lists their impacts on cellular functions, and highlights their therapeutic efficacy. Injectable hydrogels hold promise as cell delivery carriers for cell transplantation therapy in regenerative medicine. Injectable hydrogels possess various benefits, including biocompatibility, biodegradability, tissue adhesive properties, scaffold functions, and minimal invasiveness. To overcome the barriers in clinical translation, biological and physicochemical functionalization, which can improve delivery efficacy to the target and graft survival posttransplantation, is desirable. This review discusses the strategies to design injectable hydrogels for cell delivery and summarizes the approaches available to improve the biological and physicochemical features of hydrogels.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"895-903"},"PeriodicalIF":2.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141568635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled synthesis of cylindrical micelles via crystallization-driven self-assembly (CDSA) and applications 通过结晶驱动自组装 (CDSA) 受控合成圆柱形胶束及其应用

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-07-09 DOI: 10.1038/s41428-024-00931-8

Sipradip Mahapatra, Pradip Dey, Goutam Ghosh

{"title":"Controlled synthesis of cylindrical micelles via crystallization-driven self-assembly (CDSA) and applications","authors":"Sipradip Mahapatra, Pradip Dey, Goutam Ghosh","doi":"10.1038/s41428-024-00931-8","DOIUrl":"10.1038/s41428-024-00931-8","url":null,"abstract":"Recently, crystallization-driven living self-assembly (CDSA) has attracted much attention for its ability to generate 1D cylindrical micelles and mimic chain growth polymerization using seed micelles as nuclei, as this process allows for the continuous growth of polymeric micelles with well-defined and controlled 1D nanostructures. Researchers have developed different techniques, including self-seeding and seeded growth, to form cylindrical block comicelles using the principle of living CDSA. This method is beneficial for the generation of complex nanostructures, such as pentablock comicelles or patchy comicelles, with very low polydispersity. This review sheds light on the living CDSA method, which can be used to precisely control length, shape, and branching during the self-assembly of amphiphilic block copolymers (BCPs) in the solution phase, leading to the creation of monodisperse 1D micelles with a crystalline core and solvated corona in a modular fashion. This paper also highlights the growth kinetics underlying the synthesis of cylindrical micelles via CDSA and its application in various fields, such as drug delivery, optoelectronics, and catalysis, which have been discovered recently. Lastly, the prospects of CDSA and its potential impact on materials science and nanotechnology are discussed. This review sheds light on the living CDSA method, which can be used to precisely control length, shape, and branching during the self-assembly of amphiphilic block copolymers (BCPs) in the solution phase, leading to the creation of monodisperse 1D micelles with a crystalline core and solvated corona in a modular fashion. This paper also highlights the growth kinetics underlying the synthesis of cylindrical micelles via CDSA and its application in various fields, such as drug delivery, optoelectronics, and catalysis, which have been discovered recently.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 11","pages":"949-975"},"PeriodicalIF":2.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00931-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141568633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile and efficient synthesis of N-benzyl chitosan via a one-pot reductive amination utilizing 2-picoline borane 利用 2-甲基吡啶硼烷进行单锅还原胺化，简便高效地合成 N-苄基壳聚糖

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-07-05 DOI: 10.1038/s41428-024-00933-6

Junpei Miyake

{"title":"Facile and efficient synthesis of N-benzyl chitosan via a one-pot reductive amination utilizing 2-picoline borane","authors":"Junpei Miyake","doi":"10.1038/s41428-024-00933-6","DOIUrl":"10.1038/s41428-024-00933-6","url":null,"abstract":"In this paper, the use of 2-picoline borane (pic-BH3) as a reducing agent for the reductive amination of chitosan is reported for the first time. By optimizing the feed molar ratio of chitosan, benzaldehyde and pic-BH3, a high yield of isolated N-benzyl chitosan with a nearly perfect degree of substitution is successfully obtained. This material has rarely been obtained with previous methods. The newly developed synthetic method herein has many advantages, including being more facile, more efficient, and less harmful than conventional methods; thus, this method is applicable to other aldehydes or ketones, leading to wide varieties of N-modified chitosan in the future. For the first time, this paper revealed that 2-picoline borane (pic-BH3) functioned well in the reductive amination of chitosan. Therefore, N-benzyl chitosan with a nearly perfect degree of substitution was successfully obtained, which has rarely been achieved by other synthetic methods. The new method herein has many advantages, including being more facile, more efficient, and less harmful than conventional methods; thus, this method is applicable to other aldehydes or ketones, leading to a wide variety of N-modified chitosan specimens with desirable degrees of substitution in the future.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"925-931"},"PeriodicalIF":2.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00933-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141548144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semiautomated experiment with a robotic system and data generation by foundation models for synthesis of polyamic acid particles 利用机器人系统进行半自动实验，并通过基础模型生成数据，用于合成聚酰胺酸颗粒

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-07-01 DOI: 10.1038/s41428-024-00930-9

Kan Hatakeyama-Sato, Hiroki Ishikawa, Shinya Takaishi, Yasuhiko Igarashi, Yuta Nabae, Teruaki Hayakawa

引用次数: 0

Improvement in the physical properties of poly(lactic acid)/thermoplastic starch blends using oligo(lactic acid)-grafted starch 使用低聚（乳酸）接枝淀粉改善聚（乳酸）/热塑性淀粉混合物的物理性质

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-06-18 DOI: 10.1038/s41428-024-00918-5

Kazuki Shibasaki, Yu-I Hsu, Hiroshi Uyama

{"title":"Improvement in the physical properties of poly(lactic acid)/thermoplastic starch blends using oligo(lactic acid)-grafted starch","authors":"Kazuki Shibasaki, Yu-I Hsu, Hiroshi Uyama","doi":"10.1038/s41428-024-00918-5","DOIUrl":"10.1038/s41428-024-00918-5","url":null,"abstract":"General-purpose petroleum-derived plastic remains in the environment for long periods and has significant impacts on oceans and land. Biodegradable and biomass plastics are being developed around the world as countermeasures. A poly(lactic acid) (PLA)/thermoplastic starch (TPS) blend is a promising ecofriendly alternative to biodegradable plastic made from plants. However, owing to the hydrophilicity of starch and the hydrophobicity of PLA, phase separation occurs between PLA and starch. Furthermore, PLA/TPS blends have poor water resistance because of the presence of starch, limiting their applications. In this study, to improve the affinity of PLA for starch, oligo(lactic acid)-grafted starch (OLAgSt) was synthesized as a compatibilizer for PLA/TPS blends, and the effect of its addition to PLA/TPS blends was evaluated. OLAgSt with different OLA molecular weights and degrees of substitution (DS) were synthesized, and their effects on PLA/TPS were compared. The results indicated that OLAgSt functioned as a good compatibilizer, improving the dispersibility of TPS in PLA with 4 wt% OLAgSt added to PLA/TPS and improving the water resistance. Moreover, the OLA molecular weight of OLAgSt was greater than that of DS. These results are expected to facilitate the development of PLA/TPS applications in the food packaging and biomedical fields. Blends of poly(lactic acid) (PLA) and thermoplastic starch (TPS) are promising biodegradable plastics, although their poor compatibility results in poor physical properties. In this study, oligo(lactic acid)-grafted starch (OLAgSt) was synthesized and added to PLA/TPS blends as a compatibilizer, and the physical properties of the obtained blends were evaluated. OLAgSt was synthesized by ring-opening polymerization of L-lactide using the hydroxy group of tapioca starch as an initiator. OLAgSt not only enhanced the dispersion of TPS within PLA, but also improved the biodegradability of the blend in a seawater environment.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"905-913"},"PeriodicalIF":2.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00918-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141528869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase diagram for the gelation of temperature-responsive and biocompatible poly(oligo ethylene glycol methyl ether methacrylate) polymers in aqueous free-radical polymerization reactions 水基自由基聚合反应中温度响应型生物兼容聚（低聚乙二醇甲醚甲基丙烯酸酯）聚合物凝胶化的相图

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-06-18 DOI: 10.1038/s41428-024-00929-2

Takuma Kureha, Takuto Hirayama, Taichi Nishi

{"title":"Phase diagram for the gelation of temperature-responsive and biocompatible poly(oligo ethylene glycol methyl ether methacrylate) polymers in aqueous free-radical polymerization reactions","authors":"Takuma Kureha, Takuto Hirayama, Taichi Nishi","doi":"10.1038/s41428-024-00929-2","DOIUrl":"10.1038/s41428-024-00929-2","url":null,"abstract":"In this study, gel-phase diagrams of temperature-responsive and biocompatible polymers were obtained, and the characteristic gelation behaviors of the polymers were examined. The polymers are based on three oligoethylene glycol methyl ether methacrylate (OEGMA) monomers with different numbers of ethylene oxide (EO) units, i.e., with side chains that differ in length. The gelation thresholds depend on the OEGMA and crosslinker concentrations as well as the side chain length. Long EO side chains fill the polymerization system and reduce the concentration of polymer overlap, resulting in a high ability to occupy the system. Furthermore, the EO side chains may engage in self-crosslinking, i.e., polymers can branch and grow from the side chains depending on their length, resulting in a high bond probability. Based on these unique behavior patterns, gelation occurs more readily as the length of the side chains increases. We also synthesized ultralow crosslinked pOEGMA gels by tuning the gelation conditions; these gels exhibited improved swelling capacity and temperature responsiveness. These results should facilitate the development of a synthesis strategy to control the physical properties and structures of these materials for advanced applications, such as biofilms, actuators, and carriers. The gel-phase diagrams of temperature-responsive and biocompatible polymers with ethylene oxide (EO) side chains that differ in length were obtained. The gelation thresholds of the polymers depend not only on the monomer and crosslinker concentrations but also on the EO side chain lengths. Long EO side chains reduce the polymer overlap concentration. Furthermore, the EO side chains can engage in self-crosslinking, i.e., polymers can grow from the side chains depending on their length. These unique behaviors indicate that gelation occurs more readily with increasing the side chain length.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 11","pages":"1017-1029"},"PeriodicalIF":2.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00929-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon nanotubes functionalized with α-aminoisobutyric acid-containing peptide increase gene delivery efficiency in plant mitochondria 含有α-氨基异丁酸肽的功能化碳纳米管提高了植物线粒体中的基因传递效率

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-06-14 DOI: 10.1038/s41428-024-00927-4

Simon Sau Yin Law, Mako Kuzumoto, Seiya Fujita, Tsuyohiko Fujigaya, Keiji Numata

{"title":"Carbon nanotubes functionalized with α-aminoisobutyric acid-containing peptide increase gene delivery efficiency in plant mitochondria","authors":"Simon Sau Yin Law, Mako Kuzumoto, Seiya Fujita, Tsuyohiko Fujigaya, Keiji Numata","doi":"10.1038/s41428-024-00927-4","DOIUrl":"10.1038/s41428-024-00927-4","url":null,"abstract":"Functionalized carbon nanotubes have shown tremendous promise in the field of plant biotechnology for genetic engineering and cargo delivery; recent findings have shown that they can be delivered within specific organelles, such as mitochondria and chloroplasts, in intact plants. 2-Aminoisobutyric acid is an unnatural amino acid that promotes helical conformation and has been demonstrated to increase membrane permeability. Rational substitution of this amino acid into a mitochondrial targeting peptide induced a helical conformation that, when functionalized onto polymer-coated carbon nanotubes, conferred increased membrane permeability compared with that of the native peptide. The secondary structure was maintained on the surface and, when used to deliver pDNA, led to an increase in gene expression, suggesting that this method may be used to enhance the delivery efficiency of existing functional peptides. Induction of helical structures in peptides have been shown to increase their membrane permeability and facilitate cargo delivery applications. Our study has shown that substitution of an unnatural amino acid into a mitochondrial-targeting peptide induces a helical conformation that is maintained even after conjugation onto carbon nanotubes and confers increased membrane permeability. This led to an increase in DNA delivery efficiencies and gene expression into the mitochondria of intact plants when used as a DNA delivery system.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"915-924"},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00927-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular methodologies for the assembly of optical microresonators from functional organic materials 用功能有机材料组装光学微谐振器的超分子方法学

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-06-12 DOI: 10.1038/s41428-024-00925-6

Hiroshi Yamagishi

{"title":"Supramolecular methodologies for the assembly of optical microresonators from functional organic materials","authors":"Hiroshi Yamagishi","doi":"10.1038/s41428-024-00925-6","DOIUrl":"10.1038/s41428-024-00925-6","url":null,"abstract":"An optical microresonator is a micrometer-scale object that can confine light inside its body via total internal reflection at the boundary. In addition to well-established applications, including laser oscillators, optical sensors, and quantum memory, optical resonators have attracted renewed attention in chemistry and biology as minute and highly sensitive sensors that work in the environment and inside biological tissues and cells without any connected wires. Optical resonators should be functional for facilitating molecular interactions and biological compatibility, which is, however, challenging with conventional materials and processing techniques. In contrast, the authors have been tackling this issue by using supramolecular chemistry, which enables the assembly of optical resonators from chemically and biologically functional organic materials in solution. This article reviews our recent progress on the methodologies for making organic optical resonators and their emergent optical properties. Optical resonators have attracted renewed attention in chemistry and biology as minute and highly sensitive sensors that work in the environment and inside biological tissues and cells without any connected wires. Optical resonators should be functional for facilitating molecular interactions and biological compatibility, which is, however, challenging with conventional materials and processing techniques. In contrast, the authors have been tackling this issue by using supramolecular chemistry. This article reviews our recent progress on the methodologies for making organic optical resonators and their emergent optical properties.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"887-894"},"PeriodicalIF":2.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41428-024-00925-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing crystal transitions in low-temperature, low-concentration NaOH solutions to prepare cellulose I and II composite materials 优化低温、低浓度 NaOH 溶液中的晶体转变，制备纤维素 I 和 II 复合材料

IF 2.3 4区化学

Polymer Journal Pub Date : 2024-06-12 DOI: 10.1038/s41428-024-00928-3

Yuki Kugo, Takuya Isono, Masashi Fujiwara, Toshifumi Sato, Hirofumi Tani, Tomoki Erata, Kenji Tajima

{"title":"Optimizing crystal transitions in low-temperature, low-concentration NaOH solutions to prepare cellulose I and II composite materials","authors":"Yuki Kugo, Takuya Isono, Masashi Fujiwara, Toshifumi Sato, Hirofumi Tani, Tomoki Erata, Kenji Tajima","doi":"10.1038/s41428-024-00928-3","DOIUrl":"10.1038/s41428-024-00928-3","url":null,"abstract":"Cellulose II exhibits exceptional attributes, including flexibility, high stainability, and gloss. However, its strength is lower than that of cellulose I due to reduced crystallinity during the crystal transition. In this study, we devised a novel method to regulate the proportion and distribution of cellulose I and II crystals. This was achieved by employing a low-concentration alkaline solution and liquid nitrogen, resulting in a high-strength composite material that retained the excellent properties of cellulose II. When cellulose powder was immersed in an 8 wt% NaOH solution and quenched with liquid nitrogen, the crystal transition from cellulose I to II occurred outward from the sample periphery to its center. The percentage of cellulose II increased proportionally with treatment time. This technique was extended to cellulose I-rich cotton fibers, facilitating the creation of a composite fiber with cellulose I at the core and cellulose II on the surface. The tensile strength and Young’s modulus of the composite fiber were greater than those of the mercerized cellulose II fiber. Additionally, the elongation at break and toughness of these fibers surpassed those of conventional cotton fibers. This innovative method allows for the preparation of cellulose I and II composite materials with diverse properties. This study developed a novel method for the control of the cellulose crystal of cellulose I and II. The crystal transition from cellulose I to II was tracked when cellulose I, which is soaked in a low-concentration NaOH aqueous solution, was quenched using liquid nitrogen. The crystal transition progressed from the surface to the center of the sample. This quench treatment has the potential to fabricate new cellulose materials with a cellulose I core and a cellulose II surface.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":"56 10","pages":"939-943"},"PeriodicalIF":2.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0