Placenta最新文献

{"title":"Maternal-fetal interface favors a specific neutrophil type characterized by a long-lived, immunosuppressive phenotype, able to enhance EVT motility","authors":"Anna-Lena Höbler , Andreas Ian Lackner , Peter Haslinger , Gudrun Meinhardt , Hanna Waldhäusl , Theresa Maxian , Sandra Haider , Martin Knöfler , Raimund Oberle , Jürgen Pollheimer","doi":"10.1016/j.placenta.2024.10.048","DOIUrl":"10.1016/j.placenta.2024.10.048","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 151"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maternal inflammation during obese pregnancy on placental nutrient transport and fetal growth","authors":"Cindy XW. Zhang , Samantha Lean , Alejandro A. Candia , Edina Horvath-Gulasci , Amanda Sferruzzi-Perri","doi":"10.1016/j.placenta.2024.10.041","DOIUrl":"10.1016/j.placenta.2024.10.041","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 149"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal exposure to a mixture of food chemical compounds on fetoplacental development","authors":"Jeanne Bozec , Delphine Rousseau-Ralliard , Louise Angrand , Donya Popping , Michèle Dahirel , Gwendoline Morin , Louise Lemarie , Christophe Richard , Valérie Gelin , Claire Philippat , Véronique Gayrard , Anne Couturier-Tarrade","doi":"10.1016/j.placenta.2024.10.027","DOIUrl":"10.1016/j.placenta.2024.10.027","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 144"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome","authors":"Alison Paquette ,&nbsp;Mariana Parenti ,&nbsp;Samantha Lapehn ,&nbsp;Chaini Konwar ,&nbsp;Leena Kadam ,&nbsp;Evan J. Firsick ,&nbsp;Emily S. Barrett ,&nbsp;Julie MacIsaac ,&nbsp;James MacDonald ,&nbsp;Theo Bammler ,&nbsp;Kecia Carroll ,&nbsp;Daniel Enquobahrie ,&nbsp;Michael Kobor ,&nbsp;Kaja Z. LeWinn ,&nbsp;Ruby Nguyen ,&nbsp;Roger Smith ,&nbsp;Adam Spirzo ,&nbsp;Qi Zhao ,&nbsp;Leslie Myatt ,&nbsp;Nicole R. Bush ,&nbsp;Sheela Sathyanarayana","doi":"10.1016/j.placenta.2024.12.021","DOIUrl":"10.1016/j.placenta.2024.12.021","url":null,"abstract":"<div><h3>Introduction</h3><div>The placenta produces corticotrophin releasing hormone (CRH), which rises exponentially in maternal plasma across pregnancy. CRH plays a functional role in fetal development, labor initiation, and the regulation of gestational length. We aimed to understand how maternal plasma CRH during pregnancy reflects placental physiology during parturition by characterizing placental transcriptomic signatures of maternal plasma CRH and comparing to transcriptomic signatures of gestational age at birth.</div></div><div><h3>Methods</h3><div>Maternal plasma CRH concentrations were measured via radioimmunoassay at two timepoints and the placental transcriptome was quantified via RNA sequencing in 516 pregnant participants enrolled in the CANDLE cohort. Robust linear models were fitted to estimate associations between CRH and placental gene expression at birth. We conducted a functional validation in primary trophoblast cells before and after syncytialization.</div></div><div><h3>Results</h3><div>Plasma CRH concentrations in the mid-pregnancy visit were associated with placental expression of 8 differentially expressed genes (DEGs), and concentrations in late pregnancy were associated with 283 DEGs. These genes were involved in several metabolic pathways. Seven genes were significantly associated with both plasma CRH and gestational length. Four genes were concordantly decreased and 7 genes were concordantly increased in primary trophoblasts treated with CRH.</div></div><div><h3>Discussion</h3><div>Overall, this study reveals potential novel transcriptional mechanisms by which CRH may regulate metabolic pathways important for placental function and identifies genes associated with both CRH and gestational length.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 29-38"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental alkaline phosphatase (PLAP): Is it exclusively placental?","authors":"Awanit Kumar ,&nbsp;Sourabh Sharma ,&nbsp;Maged M. Costantine ,&nbsp;Kara Rood ,&nbsp;Rheanna Urrabaz-Garza ,&nbsp;Jeena Jacob ,&nbsp;Lauren S. Richardson ,&nbsp;Ananth Kumar Kammala ,&nbsp;Ramkumar Menon","doi":"10.1016/j.placenta.2025.01.001","DOIUrl":"10.1016/j.placenta.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Adverse pregnancies outcomes present a clinical dilemma in Perinatal medicine. This is partly due to lack of accuracy of current biomarkers to predict high-risk pregnancies at an earlier stage. The placental alkaline phosphatase (PLAP) carrying extracellular vesicles (EVs), and their cargo have been reported as a source of biomarkers for placental health and an indication of pre-eclampsia progression.</div></div><div><h3>Objectives</h3><div>We postulate that PLAP is not only placental but also expressed in other fetal organs, suggesting that PLAP + ve EVs are not only a functional indicator of placental function alone.</div></div><div><h3>Methods</h3><div>We evaluated PLAP in the placenta, fetal membranes, maternal decidua, myometrial cells, and the EVs derived from them. Various bioanalytical techniques were used to detect PLAP expressions in the cells and EVs. The EVs were characterized by size/quantity, PLAP as a cargo, and canonical EV protein markers.</div></div><div><h3>Results</h3><div>PLAP expression was determined in the chorion trophoblast cells (CTCs) of the fetal membranes and the placental trophoblasts; however, it was absent in the amnion layer of the fetal membranes and the maternal uterine cells used in this study. Using multiple experimental approaches, we further verified the cellular sources of PLAP and confirmed that the EVs from the chorion and placental trophoblasts contain PLAP.</div></div><div><h3>Conclusion</h3><div>Our studies suggest that PLAP is not truly placental. Instead, cells of trophoblast lineage in both fetal membranes and the placenta express PLAP in cells and their EVs. Although PLAP + ve EVs for biomarkers are not exclusively placental, they still represent real-time fetal-specific tissues conditions during pregnancy.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 118-125"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antenatal melatonin supplementation increases fetal weight and reduces placental oxidative damage in a mouse model of advanced maternal age","authors":"Jessica Dalton-O’Reilly ,&nbsp;Michelle Desforges ,&nbsp;Alexander E.P. Heazell ,&nbsp;Susan Greenwood ,&nbsp;Mark R. Dilworth","doi":"10.1016/j.placenta.2024.10.063","DOIUrl":"10.1016/j.placenta.2024.10.063","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 156"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuregulin plays a multifaceted role in the extravillous trophoblast lineage of the human placenta","authors":"J. Wächter ,&nbsp;G. Meinhardt ,&nbsp;S. Lugmayr ,&nbsp;H. Waldhäusl ,&nbsp;A.-L. Höbler ,&nbsp;T. Maxian ,&nbsp;A.-M. Prandstetter ,&nbsp;J. Pollheimer ,&nbsp;S. Haider ,&nbsp;M. Knöfler","doi":"10.1016/j.placenta.2024.10.054","DOIUrl":"10.1016/j.placenta.2024.10.054","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 153"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of syncytiotrophoblast-derived cf-RNA OPA1 to predict the occurrence of preeclampsia","authors":"Zhongrui Pei ,&nbsp;Huirong Tang ,&nbsp;Jing Wu ,&nbsp;Jie Wang ,&nbsp;Dan Liu ,&nbsp;Chenrui Cao ,&nbsp;Weichen Pan ,&nbsp;Taishun Li ,&nbsp;Honglei Duan ,&nbsp;Zhiyin Wang ,&nbsp;Mingming Zheng ,&nbsp;Yali Hu ,&nbsp;Guangfeng Zhao","doi":"10.1016/j.placenta.2024.12.022","DOIUrl":"10.1016/j.placenta.2024.12.022","url":null,"abstract":"<div><h3>Background</h3><div>Pre-eclampsia (PE) poses a significant threat to mothers and infants worldwide. Studies indicate that taking low-dose aspirin before the 16th week of pregnancy may prevent approximately 70 % of PE cases, highlighting the importance of predicting PE. Cell-free RNA (cf-RNA) exhibits significant changes in the maternal peripheral blood during early pregnancy, making cf-RNA analysis a promising and less invasive method for predicting PE.</div></div><div><h3>Methods</h3><div>The two datasets, GSE192902 and GSE149440, were analyzed to identify differentially expressed cf-RNAs, followed by the calculation of their AUC values Subsequently, these cf-RNAs were validated using placental tissues, as well as late- and early-stage plasma samples collected from both healthy individuals and patients with PE. Furthermore, we performed tissue localization and functional analyses on the ultimate candidate gene.</div></div><div><h3>Results</h3><div>Mitochondrial Dynamin-Like GTPase (OPA1) emerged as the molecule with the most consistent and statistically significant alterations in placental tissues and serum samples from patients with PE across various gestational weeks. Notably, the combination of OPA1 levels and mean arterial pressure (MAP) yielded an AUC of 0.825 (95 % CI: 0.759–0.879) for predicting PE. Additionally, we verified that OPA1 is predominantly expressed in placental syncytiotrophoblast (STB) cells, and its downregulation negatively impacts STB mitochondrial function, angiogenic potential, and cell proliferation.</div></div><div><h3>Conclusions</h3><div>OPA1 holds the potential to emerge as a novel cf-RNA for predicting PE.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A positive association between postpartum electrohysterography parameters and blood loss after vaginal delivery: A prospective study","authors":"Maria Wilhelmina Elisabeth Frenken ,&nbsp;Daisy Adriana Anne-Jan van der Woude ,&nbsp;Bettine Geertrude van Willigen ,&nbsp;Jeanne Petra Dieleman ,&nbsp;Swan Gie Oei ,&nbsp;Judith Octavia Elisabeth Helena van Laar","doi":"10.1016/j.placenta.2024.12.018","DOIUrl":"10.1016/j.placenta.2024.12.018","url":null,"abstract":"<div><h3>Introduction</h3><div>The postpartum period can be complicated by hemorrhage, frequently caused by uterine atony. Electrohysterography, allowing continuous monitoring of uterine activity, may be a promising alternative for early detection of uterine atony, and thereby contribute to the prevention of postpartum hemorrhage. Associations between electrohysterographic parameters postpartum and total blood loss were studied.</div></div><div><h3>Methods</h3><div>In this prospective explorative study, women were included with a vaginal delivery between 36⁺⁰ and 42⁺⁰ weeks of gestation. Linear regression analysis was used to describe the association between electrohysterographic parameters (i.e. area under the contraction curve (AUC) total (in arbitrary units), AUC from baseline (in arbitrary units), maximum amplitude (in arbitrary units) and baseline tone (in arbitrary units)) and total blood loss (in mL) during the first 30 min postpartum.</div></div><div><h3>Results</h3><div>In total, 25 women were included for analysis, of whom three had postpartum hemorrhage. A moderate positive linear correlation was found between the logarithmically transformed total blood loss and the AUC total (r = 0.44, p = 0.03), AUC from baseline (r = 0.43, p = 0.03) and baseline tone (r = 0.43, p = 0.03). There was no significant linear correlation between the logarithmically transformed total blood loss and maximum amplitude. Explorative analysis revealed a significantly higher AUC total, AUC from baseline and baseline tone in women with postpartum hemorrhage compared to women without postpartum hemorrhage. (p = 0.02, p = 0.02 and p = 0.03, respectively).</div></div><div><h3>Discussion</h3><div>There is a moderate positive correlation between the logarithmically transformed total blood loss and the AUC total, AUC from baseline and baseline tone. Also, these parameters were all significantly higher in women with postpartum hemorrhage compared to women without postpartum hemorrhage.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 11-19"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIG1 triggers placental senescence in preeclampsia through LMNA/p53 axis activation","authors":"Yanxuan Xiao ,&nbsp;Maliang Tao ,&nbsp;Jiexing He ,&nbsp;Jiaqi Li ,&nbsp;Qiuyu Huang ,&nbsp;Yiqi Yu ,&nbsp;Mingze Gao ,&nbsp;Qian Chen ,&nbsp;Zhijian Wang","doi":"10.1016/j.placenta.2024.12.023","DOIUrl":"10.1016/j.placenta.2024.12.023","url":null,"abstract":"<div><h3>Introduction</h3><div>The mechanism behind abnormal placental aging in preeclampsia (PE) is unclear. Although TIG1 is widely expressed in the human placenta, its function hasn't been well understood. Our previous study found a significant elevation of TIG1 in the placentas of PE patients. In this study, we focused on the molecular mechanism by which TIG1 functions in PE.</div></div><div><h3>Methods</h3><div>TIG1 expression of placentas from PE patients and L-NAME mice were analyzed using qRT-PCR, Western blot, and immunohistochemistry. TIG1-overexpressed HTR-8/SVneo cells were constructed for transcriptomic sequencing. Senescence in the placenta was evaluated by biomarkers of p16, p21, and p53. TIG1 binding proteins were identified via co-immunoprecipitation. A co-culture system of HTR-8/SVneo and human endometrial stromal cells was developed to study the change in trophoblasts’ function.</div></div><div><h3>Results</h3><div>TIG1 expression was significantly increased in the PE placentas. Elevated expression of TIG1 was associated with abnormal senescence of trophoblasts. TIG1 induced trophoblasts’ senescence by regulating LMNA/p53 axis. The senescence of trophoblasts can be manifested as reduced invasion ability in the co-culture system.</div></div><div><h3>Discussion</h3><div>Our study indicated that TIG1 was crucial in the development of PE by causing the senescence of trophoblasts and reducing their invasiveness, offering insights into the molecular mechanisms of placental dysfunction in PE.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 39-50"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}