IF 3.1 2区医学

Placenta Pub Date : 2026-09-29 DOI: 10.1016/j.placenta.2026.09.024

Rohan M Lewis, Victoria Hj Roberts

引用次数: 0

Biomechanical modelling of the feto-placental and utero-placental circulations; where to from here? 胎儿-胎盘和子宫-胎盘循环的生物力学建模；从这里到哪里？

IF 3.1 2区医学

Placenta Pub Date : 2026-09-09 DOI: 10.1016/j.placenta.2026.08.341

Sahan Jayatissa, Joanna L James, Alys R Clark

{"title":"Biomechanical modelling of the feto-placental and utero-placental circulations; where to from here?","authors":"Sahan Jayatissa, Joanna L James, Alys R Clark","doi":"10.1016/j.placenta.2026.08.341","DOIUrl":"https://doi.org/10.1016/j.placenta.2026.08.341","url":null,"abstract":"<p><p>Biomechanical computational modelling has been used since the 1980s to understand the health of the placenta, and to interpret clinical imaging in pregnancy. In the last few decades, alongside rapid advances in computing power and imaging technologies, biomechanical computational models have been developed that enable researchers to link anatomy to function across temporal and spatial scales. Blood flow through the feto-placental or utero-placental circulations has been a key focus of many of these models, due to the functional importance of these dynamically linked circulations in facilitating exchange of nutrients, oxygen and wastes, and in turn ensuring healthy fetal growth. This review aims to analyse the current state-of-the-art biomechanical models of fetal and maternal blood flow in the placenta, including lumped parameter, computational fluid dynamics, and network models. We consider how different models have been parameterized by data from an array of imaging technologies, from in vivo ultrasound or magnetic resonance imaging, to ex vivo computed tomography and histology data. Building on this, we incorporate learnings from the wider field of cardiovascular biomechanics to suggest future focus areas to further improve the insight gained from computational modelling approaches in pregnancy, and improve future interpretation of diagnostic imaging in this setting.</p>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cleavage of HSP90 Chaperone Occurs in Malaria Infected Placenta and a Placental Model of Ferroptosis 疟疾感染的胎盘和铁下垂胎盘模型中HSP90伴侣蛋白发生裂解

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.068

Demba Sarr, Ashish Shukla, Stephen` Mwalimu, Julie Moore

引用次数: 0

Placental release of sFlt-1 and PlGF is not increased in acute fatty liver of pregnancy 妊娠急性脂肪肝患者胎盘释放sFlt-1和PlGF未增加

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.030

Ceylan Tjoe-A-On, Jurgen Janse, Madhavi Harhangi, Langeza Saleh, Rugina Neuman, Koen Verdonk, Willy Visser, Henk Russcher, Jan Danser

引用次数: 0

iPSC-based Preeclampsia Model Reveals Inflammation Induced Trophoblast Invasion Defects and Pharmacologic Rescue Strategy 基于ipsc的子痫前期模型揭示炎症诱导的滋养细胞侵袭缺陷及药物救援策略

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.075

Ryuta Miyake, Robert Morey, Zhongyang Xie, Alexis Kozminski, Sampada Kallol, Virginia Cheung, Mariko Horii

引用次数: 0

NAT10-mediated mRNA N4-acetylcytidine in amnion fibroblasts drives lipid peroxidation and inflammation at parturition nat10介导的羊膜成纤维细胞mRNA n4 -乙酰胞苷在分娩时驱动脂质过氧化和炎症

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.019

Mengdie Li, Wangsheng Wang, Gang Sun

引用次数: 0

Combined inhibition of DOT1L and BRD9 promotes proliferation and impedes differentiation of human trophoblast stem cells DOT1L和BRD9的联合抑制可促进人滋养细胞干细胞的增殖并阻碍其分化

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.076

Shuhiba Mohammad, Alexa Krala, Xiao Li, Xiang Zhao, Wendy Dean, Myriam Hemberger

引用次数: 0

Gestational week 13 – a critical window for pre-eclampsia pathogenesis: A cell-free RNA gene expression study 妊娠第13周——子痫前期发病的关键窗口期：一项无细胞RNA基因表达研究

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-09-17 DOI: 10.1016/j.placenta.2026.09.008

Suhirthakumar Puvanendran, Obed Brew

{"title":"Gestational week 13 – a critical window for pre-eclampsia pathogenesis: A cell-free RNA gene expression study","authors":"Suhirthakumar Puvanendran, Obed Brew","doi":"10.1016/j.placenta.2026.09.008","DOIUrl":"10.1016/j.placenta.2026.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Pre-eclampsia (PE) is a hypertensive pregnancy disorder associated with significant maternal and foetal morbidity, with symptoms typically emerging late, highlighting the need to identify early molecular changes for effective screening and management.</div></div><div><h3>Methods</h3><div>We analysed 228 maternal plasma cfRNA samples from GSE154377 and GSE192902 spanning GW8–16 for gestational-week-specific differential expression. We additionally analysed available later-gestation samples in three windows, 17–20, 24–26, and 27–39 weeks, using the same differential expression framework. Differential expression was assessed using DESeq2, with Gene Ontology (GO) and KEGG pathway enrichment and long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs). characterisation, alongside severity comparisons across normotensive, PE, and severe PE groups.</div></div><div><h3>Results</h3><div>A major transcriptomic shift occurred at GW 13, with 2894 differentially expressed genes, highlighting immune activation, mitochondrial regulation, apoptosis, and NOD-like receptor and Th1/Th2 signalling pathways. Non-coding RNAs (ncRNA), particularly lncRNAs and snoRNAs, were strongly implicated in immune dysregulation and vascular dysfunction. Key genes, including MYZAP, CAV2, OXTR, and GBP1, emerged as potential early biomarkers, while later gestation showed fewer DEGs and less transcriptomic disruption than GW 13, with stronger changes observed in severe PE.</div></div><div><h3>Discussion</h3><div>GW 13 represents a critical molecular window for PE pathogenesis, while cfRNA profiling offers a non-invasive approach to detect early changes and support first-trimester screening strategies, pending prospective validation. The identification of regulatory ncRNA and protein-coding biomarkers offers translational opportunities for diagnostics and targeted interventions to improve maternal-foetal outcomes.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 166-176"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndecan-1 polymorphisms are associated with preeclampsia Syndecan-1多态性与先兆子痫有关。

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-09-11 DOI: 10.1016/j.placenta.2026.09.004

Tzu-Yang Chang, Yi-Yung Chen, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen

{"title":"Syndecan-1 polymorphisms are associated with preeclampsia","authors":"Tzu-Yang Chang, Yi-Yung Chen, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen","doi":"10.1016/j.placenta.2026.09.004","DOIUrl":"10.1016/j.placenta.2026.09.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Preeclampsia (PE), a major obstetrical challenge, involves intricate inflammatory and oxidative stress pathways. In this study, we investigated the genetic association between the syndecan-1 (<em>SDC1</em>) gene, a key regulator in these mechanisms, and PE risk.</div></div><div><h3>Methods</h3><div>A hospital-based case-control study including 130 pregnant women with PE and 1300 healthy pregnant women (controls) was conducted. <em>SDC1 rs2</em>230924 C/T and <em>rs1</em>131351 C/G polymorphisms were genotyped. Plasma SDC1 and placental SDC1 expression levels were measured using ELISA and Western blotting.</div></div><div><h3>Results</h3><div>We identified that the <em>SDC1 rs2</em>230924 C/T genotype and the <em>T</em> allele were associated with an increased risk of PE (odds ratios: 1.65 and 1.61; <em>P</em> = 0.02 and 0.01; <em>P</em><sub><em>c</em></sub> = 0.04 and 0.02). Moreover, the <em>rs2230924 T-rs1131351 C</em> haplotype significantly increases the risk of developing PE (odds ratio: 2.12, <em>P</em> = 0.007, <em>P</em><sub><em>c</em></sub> = 0.03). PE women had lower plasma SDC1 levels than controls (<em>P</em> = 0.032). Plasma SDC1 levels were lower in controls with the <em>rs2</em>230924 C/T and <em>T/T</em> genotypes than in those with the <em>C/C</em> genotype (<em>P</em> = 0.002 and <em>P</em> = 0.025). A significant reduction of SDC1 protein expression was also observed in placentae from PE cases (<em>P</em> = 0.03).</div></div><div><h3>Discussion</h3><div>The <em>SDC1 rs2</em>230924 C/T genotype and <em>T</em> allele may increase PE risk in pregnant women. Validation in larger and multi-ethnic cohorts is necessary before clinical application.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 152-157"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of PIEZO1 in placental and embryonic development PIEZO1在胎盘和胚胎发育中的作用

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.064

Jill Witvrouwen, Pilar Van Mechelen, Seppe Gevaert, Katrien Luyten, Inge Bongaers, Joris Vriens, Katrien De Clercq

引用次数: 0

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