Placenta最新文献_第6页

TIG1 triggers placental senescence in preeclampsia through LMNA/p53 axis activation TIG1通过LMNA/p53轴激活引发子痫前期胎盘衰老。

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.12.023

Yanxuan Xiao , Maliang Tao , Jiexing He , Jiaqi Li , Qiuyu Huang , Yiqi Yu , Mingze Gao , Qian Chen , Zhijian Wang

{"title":"TIG1 triggers placental senescence in preeclampsia through LMNA/p53 axis activation","authors":"Yanxuan Xiao , Maliang Tao , Jiexing He , Jiaqi Li , Qiuyu Huang , Yiqi Yu , Mingze Gao , Qian Chen , Zhijian Wang","doi":"10.1016/j.placenta.2024.12.023","DOIUrl":"10.1016/j.placenta.2024.12.023","url":null,"abstract":"<div><h3>Introduction</h3><div>The mechanism behind abnormal placental aging in preeclampsia (PE) is unclear. Although TIG1 is widely expressed in the human placenta, its function hasn't been well understood. Our previous study found a significant elevation of TIG1 in the placentas of PE patients. In this study, we focused on the molecular mechanism by which TIG1 functions in PE.</div></div><div><h3>Methods</h3><div>TIG1 expression of placentas from PE patients and L-NAME mice were analyzed using qRT-PCR, Western blot, and immunohistochemistry. TIG1-overexpressed HTR-8/SVneo cells were constructed for transcriptomic sequencing. Senescence in the placenta was evaluated by biomarkers of p16, p21, and p53. TIG1 binding proteins were identified via co-immunoprecipitation. A co-culture system of HTR-8/SVneo and human endometrial stromal cells was developed to study the change in trophoblasts’ function.</div></div><div><h3>Results</h3><div>TIG1 expression was significantly increased in the PE placentas. Elevated expression of TIG1 was associated with abnormal senescence of trophoblasts. TIG1 induced trophoblasts’ senescence by regulating LMNA/p53 axis. The senescence of trophoblasts can be manifested as reduced invasion ability in the co-culture system.</div></div><div><h3>Discussion</h3><div>Our study indicated that TIG1 was crucial in the development of PE by causing the senescence of trophoblasts and reducing their invasiveness, offering insights into the molecular mechanisms of placental dysfunction in PE.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 39-50"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human differentiated and undifferentiated trophoblast organoids as a novel model for human cytomegalovirus congenital infection

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.060

Karolina Radziun , Michael Nevels , David Turner , Aras Kadioglu , Marie Yang

引用次数: 0

Vasoactivity of cannabis components in human placental arteries

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.031

M.S. Harhangi , S.H.P. Simons , I.K.M. Reiss , A.H.J. Danser , M. Broekhuizen

引用次数: 0

Investigating the effects of beta blockers on fetal vasculature

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.032

Doaa Babaeer , Jenny Myers , Paul Brownbill

引用次数: 0

Human-based placenta-embryo chip for developmental toxicity assessment of nanoparticles and drugs

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.026

Manon Murdeu , Vera Kissling , Jacob Folz , Andreas Hierlemann , Julia Alicia Boos , Tina Buerki-Thurnherr

引用次数: 0

Crosstalk between extravillous trophoblasts and decidual glands in early human pregnancy

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.061

Anna-Maria Prandstetter , Theresa Maxian , Hanna Waldhäusl , Jasmin Wächter , Anna-Lena Höbler , Gudrun Meinhardt , Jürgen Pollheimer , Martin Knöfler , Sandra Haider

引用次数: 0

Modulation of thrombopoiesis by placenta-derived factors: Insights from MEG-01 cells

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.046

Kaja Ujčič , Lena Neuper , Désirée Forstner , Freya Lyssy , Nadja Kupper , Julian Krappinger , Cornelia Missbrenner , Beatrice Brugger , Christine Daxboeck , Stefan Wernitznig , Barbara Obermayer-Pietsch , Julia Kargl , Julia Feichtinger , Andreas Reinisch , Udo Markert , Martin Gauster

引用次数: 0

Nebivolol induced relaxation of human chorionic plate arteries is dependent on the NOS/NO/SGC pathway

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.033

Teresa Tropea , Paul Brownbill , Anthony M. Heagerty , Jenny E. Myers

引用次数: 0

The proinflammatory cytokines IFN-α and TNF-α inhibit extravillous trophoblast invasion

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.049

Jantine van Voorden , Fangxu Lin , Souad Boussata , Remco Keijser , Liana Barenbrug , Bente Horselenberg , Wendy Dankers , Ans van Pelt , Gijs Afink

引用次数: 0

Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential 胎盘细胞外囊泡在体外移植模型中诱导卵巢肿瘤细胞死亡：可能的治疗潜力。

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.12.028

Xinyi Sun , Jiayi Wan , Yi Zhang , Ye Shen , Yunhui Tang , Yongxiang Yin , Lawrence W. Chamley , Min Zhao , Qi Chen

{"title":"Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential","authors":"Xinyi Sun , Jiayi Wan , Yi Zhang , Ye Shen , Yunhui Tang , Yongxiang Yin , Lawrence W. Chamley , Min Zhao , Qi Chen","doi":"10.1016/j.placenta.2024.12.028","DOIUrl":"10.1016/j.placenta.2024.12.028","url":null,"abstract":"<div><h3>Introduction</h3><div>Placental extracellular vesicles (EVs), lipid-enclosed particles released from the placenta, can facilitate intercellular communication and are classified as micro- or nano-EVs depending on size. Placental EVs contain molecules associated with cell proliferation and death. In this study, we investigated whether treating human ovarian tumour explants with placental EVs could induce ovarian tumour cell death.</div></div><div><h3>Methods</h3><div>Human ovarian tumours were collected. After directly treating human ovarian tumour explants with placental EVs, cellular necrosis was observed in ovarian tumour explants by HE stains. Cell death-associated miRNAs were measured.</div></div><div><h3>Results</h3><div>Expression of apoptosis and senescence-associated proteins, including NF-<span><math><mrow><mi>κ</mi><mi>β</mi></mrow></math></span> and <span><math><mrow><mi>γ</mi></mrow></math></span> H2AX, were significantly increased, while proliferation-associated proteins were significantly reduced in the explants after exposure to placental EVs. Furthermore, miRNA-519a-5p, miRNA-512–3p and miRNA-143–3p, which were reported to promote ovarian cancer cell apoptosis or inhibition of ovarian cancer cell growth, were significantly increased, and the target genes of miRNA-519a-5p and miRNA-512–3p were significantly reduced in the explants after exposure to placental EVs. Transfection of SK-OV-3 ovarian cancer cells with a mimic of miRNA-519a-5p or miRNA-143–3p reduced the viability of these cells.</div></div><div><h3>Discussion</h3><div>Our study demonstrated that placental EVs could induce necrosis in ovarian tumour explants. Increased levels of apoptosis and senescence-associated proteins and miRNAs could contribute to this change in ovarian tumour cell phenotype after exposure to placental EVs.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 20-28"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0