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Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.12.024
Ana Rita Pinheiro , Adriana Raquel Rodrigues , Liliana Matos , José Júlio Costa , Sara Ricardo , Luís Guedes-Martins , Henrique Almeida , Elisabete Silva
{"title":"Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation","authors":"Ana Rita Pinheiro ,&nbsp;Adriana Raquel Rodrigues ,&nbsp;Liliana Matos ,&nbsp;José Júlio Costa ,&nbsp;Sara Ricardo ,&nbsp;Luís Guedes-Martins ,&nbsp;Henrique Almeida ,&nbsp;Elisabete Silva","doi":"10.1016/j.placenta.2024.12.024","DOIUrl":"10.1016/j.placenta.2024.12.024","url":null,"abstract":"<div><h3>Background and aim</h3><div>Pregnancy after the age of 35 is correlated with an increased risk of impaired placentation and the development of pregnancy-associated complications. Changes in uterine redox balance seem to play a role in these settings. In this work, we hypothesized that local redox dysregulation impacts the placenta metabolic profile. Thus, we aimed to study the expression of enzymes/transporters related to nutrient uptake during reproductive aging and the effect of antioxidant supplementation.</div></div><div><h3>Methods</h3><div>Placenta samples were collected from pregnant women aged between 22 and 41 years, and from mice of different reproductive ages (8–12 and 38–42 weeks). A subgroup of 38–42 weeks-old mice was treated with apocynin (5 mM) in the drinking water. Real-time PCR was carried out to assess gene expression, and immunohistochemistry or western blotting to assess protein expression.</div></div><div><h3>Results</h3><div>A significant age-related decrease in the expression of glucose transporter type 1 (GLUT-1) was observed in both species. Regarding lipid metabolism, there was a strong negative and significant correlation between the gene expression of fatty-acid transporter type 4 and maternal age, in the human placenta. Perilipin isoform 2 (PLIN-2) decreased significantly with maternal age, in both models. Additionally, a significant age-related decrease in the gene expression of large neutral amino acid transporter type 4 with reproductive age was observed in the mice placenta. Supplementation with apocynin attenuated the observed alterations in GLUT-1 and PLIN-2. The observed changes suggest an age-related placenta metabolic dysfunction, likely associated with oxidative stress, that may negatively impact fetal and placental development.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 60-66"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of calcium signals in trophoblast fusion
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.055
Pilar Van Mechelen , Amitesh Panda , Joris Vriens , Katrien De Clercq
{"title":"The role of calcium signals in trophoblast fusion","authors":"Pilar Van Mechelen ,&nbsp;Amitesh Panda ,&nbsp;Joris Vriens ,&nbsp;Katrien De Clercq","doi":"10.1016/j.placenta.2024.10.055","DOIUrl":"10.1016/j.placenta.2024.10.055","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 153"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of methotrexate nanoparticles for the treatment of gestational trophoblastic neoplasia
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.035
Doha Boukaoui , Rim Atioui , Nathalie Boulens , Pierre-Adrien Bolze , Florence Delie- Salmon , Manuela Undurraga , Marie-Benoîte Cohen
{"title":"Development of methotrexate nanoparticles for the treatment of gestational trophoblastic neoplasia","authors":"Doha Boukaoui ,&nbsp;Rim Atioui ,&nbsp;Nathalie Boulens ,&nbsp;Pierre-Adrien Bolze ,&nbsp;Florence Delie- Salmon ,&nbsp;Manuela Undurraga ,&nbsp;Marie-Benoîte Cohen","doi":"10.1016/j.placenta.2024.10.035","DOIUrl":"10.1016/j.placenta.2024.10.035","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 147"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization and in vitro modeling of trophoblast and villous core networks of human first trimester placental cells
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.059
Theresa Maxian , Andreas Lackner , Hanna Waldhäusl , Anna-Lena Höbler , Anna-Maria Prandstetter , Jasmin Wächter , Gudrun Meinhardt , Jürgen Pollheimer , Martin Knöfler , Sandra Haider
{"title":"Characterization and in vitro modeling of trophoblast and villous core networks of human first trimester placental cells","authors":"Theresa Maxian ,&nbsp;Andreas Lackner ,&nbsp;Hanna Waldhäusl ,&nbsp;Anna-Lena Höbler ,&nbsp;Anna-Maria Prandstetter ,&nbsp;Jasmin Wächter ,&nbsp;Gudrun Meinhardt ,&nbsp;Jürgen Pollheimer ,&nbsp;Martin Knöfler ,&nbsp;Sandra Haider","doi":"10.1016/j.placenta.2024.10.059","DOIUrl":"10.1016/j.placenta.2024.10.059","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 154-155"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decidual macrophage efferocytosis of trophoblasts in full term human placenta
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.051
Kylie Belchamber , Katie Morris , Shakila Thangaratinum , Jennifer Tamblyn
{"title":"Decidual macrophage efferocytosis of trophoblasts in full term human placenta","authors":"Kylie Belchamber ,&nbsp;Katie Morris ,&nbsp;Shakila Thangaratinum ,&nbsp;Jennifer Tamblyn","doi":"10.1016/j.placenta.2024.10.051","DOIUrl":"10.1016/j.placenta.2024.10.051","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 152"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of air pollutant sulfur dioxide exposure syncytialization and invasion processes in trophoblast cells: role of er stress
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.039
Sunil Singh , Swati Ajmeriya , Ruby Dhar , Subhradip Karmakar
{"title":"Impact of air pollutant sulfur dioxide exposure syncytialization and invasion processes in trophoblast cells: role of er stress","authors":"Sunil Singh ,&nbsp;Swati Ajmeriya ,&nbsp;Ruby Dhar ,&nbsp;Subhradip Karmakar","doi":"10.1016/j.placenta.2024.10.039","DOIUrl":"10.1016/j.placenta.2024.10.039","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 148"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decript - deciphering the human prenatal chemical exposome using high-resolution mass spectrometry
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.028
Thomas Contini , Rémi Béranger , Luc Multigner , Jana Klánová , Elliott Price , Arthur David
{"title":"Decript - deciphering the human prenatal chemical exposome using high-resolution mass spectrometry","authors":"Thomas Contini ,&nbsp;Rémi Béranger ,&nbsp;Luc Multigner ,&nbsp;Jana Klánová ,&nbsp;Elliott Price ,&nbsp;Arthur David","doi":"10.1016/j.placenta.2024.10.028","DOIUrl":"10.1016/j.placenta.2024.10.028","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 144-145"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a fluidic in vitro model to investigate maternal-fetal drug transfer
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.030
Barbara Fuenzalida , Nadja Koechli , Edgar Otsouka , Michael Luethi , Rona Karahoda , Martin Müller , Chennakesava Cuddapah , Bram Sengers , Frantisek Staud , Christiane Albrecht
{"title":"Development of a fluidic in vitro model to investigate maternal-fetal drug transfer","authors":"Barbara Fuenzalida ,&nbsp;Nadja Koechli ,&nbsp;Edgar Otsouka ,&nbsp;Michael Luethi ,&nbsp;Rona Karahoda ,&nbsp;Martin Müller ,&nbsp;Chennakesava Cuddapah ,&nbsp;Bram Sengers ,&nbsp;Frantisek Staud ,&nbsp;Christiane Albrecht","doi":"10.1016/j.placenta.2024.10.030","DOIUrl":"10.1016/j.placenta.2024.10.030","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 145"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The combined levels of CREBBP and EP300 affect EVT differentiation
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.053
Fangxu Lin , Jantine van Voorden , Remco Keijser , Gijs Afink
{"title":"The combined levels of CREBBP and EP300 affect EVT differentiation","authors":"Fangxu Lin ,&nbsp;Jantine van Voorden ,&nbsp;Remco Keijser ,&nbsp;Gijs Afink","doi":"10.1016/j.placenta.2024.10.053","DOIUrl":"10.1016/j.placenta.2024.10.053","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 152-153"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin treatment during pregnancy does not negatively impact placental mitochondrial function
IF 3 2区 医学
Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.034
Eleasha Calloway , Lucy Higgins , Jenny E. Myers , Michelle Desforges
{"title":"Metformin treatment during pregnancy does not negatively impact placental mitochondrial function","authors":"Eleasha Calloway ,&nbsp;Lucy Higgins ,&nbsp;Jenny E. Myers ,&nbsp;Michelle Desforges","doi":"10.1016/j.placenta.2024.10.034","DOIUrl":"10.1016/j.placenta.2024.10.034","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 146-147"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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