Placenta最新文献

{"title":"Temporal emergence of aspirin-associated transcriptomic changes and their cellular origin in early human placental villi","authors":"Akihito Sagara, Masaru Kobayashi, Osamu Shimokawa, Hiroyasu Ohashi, Munekage Yamaguchi, Ritsuko Pooh, Eiji Kondoh","doi":"10.1016/j.placenta.2026.08.042","DOIUrl":"10.1016/j.placenta.2026.08.042","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e199"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Immune Cell Trafficking Across the Human Placenta Using Complementary Ex Vivo Perfusion and Villous Explant Models","authors":"Wenting Cao, Lea Dietrich, Paulina Fuentes-Zacarias, Jana Pastuschek, Diana M. Morales-Prieto, Udo R. Markert","doi":"10.1016/j.placenta.2026.08.034","DOIUrl":"10.1016/j.placenta.2026.08.034","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages e196-e197"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NRIP1 Dosage Drives Estrogen Resistance and Syncytiotrophoblast Defects in Trisomy 21","authors":"Deirdre Logsdon, Kindyll Wetta, Isabela Pereira, Brian Niemeyer, John Rinn, Matthew Galbraith, Joaquin Espinosa, Justin Brumbaugh","doi":"10.1016/j.placenta.2026.08.050","DOIUrl":"10.1016/j.placenta.2026.08.050","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e202"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental fitness in advanced maternal age: insights from trophoblast organoids","authors":"Violeta Stojanovska, Adela Burianova, Shivangi Ghosh, Parth Singh, Ana Claudia Zenclussen","doi":"10.1016/j.placenta.2026.08.028","DOIUrl":"10.1016/j.placenta.2026.08.028","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e195"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149204777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placenta accreta spectrum: Detection using quantitative analysis of diffusion MRI-based myometrial tractography","authors":"Guohui Yan,&nbsp;Kui Li,&nbsp;Weizeng Zheng,&nbsp;Yongqing Zhang,&nbsp;Meixiang Deng,&nbsp;Xiaomin Liu,&nbsp;Yuhan Lin,&nbsp;Yikan Feng,&nbsp;Wei Bian,&nbsp;Yu Zou","doi":"10.1016/j.placenta.2026.08.337","DOIUrl":"10.1016/j.placenta.2026.08.337","url":null,"abstract":"<div><h3>Objectives</h3><div>Prenatal diagnosis of the placenta accreta spectrum (PAS) relies on subjective anatomical MRI interpretation and lacks objective quantitative biomarkers. This study aimed to validate diffusion MRI myometrial tractography for PAS detection and compare its performance with conventional visual MRI diagnosis.</div></div><div><h3>Materials and methods</h3><div>This prospective study enrolled 154 pregnant women with suspected PAS. All subjects underwent routine MRI and DTI. Tractography-derived FA, fiber density and ADC were measured. Diagnosis was confirmed by 2023 FIGO criteria; participants were stratified into a 70% training set and independent 30% test set. Statistical analyses included group comparisons, ROC analyses with DeLong's test, and ICC for interobserver reliability.</div></div><div><h3>Results</h3><div>PAS patients exhibited lower FA (<em>p</em> &lt; 0.001), reduced fiber density (<em>p</em> &lt; 0.001) and higher ADC (<em>p</em> = 0.044). The clinically adjusted FA + fiber density model reached an AUC of 0.86 in the training set (conventional MRI AUC = 0.81) and maintained an AUC of 0.82 in the test set, comparable to conventional MRI. Combined parameters yielded an AUC of 0.82 for differentiating PAS grade 1 and grade 2. ICCs (0.788–0.948) indicated excellent interobserver agreement.</div></div><div><h3>Conclusion</h3><div>Quantitative diffusion MRI tractography provides objective biomarkers for prenatal PAS evaluation. The combined FA and fiber density model yields stable diagnostic performance and delivers complementary quantitative information to mitigate subjectivity in conventional anatomical-MRI assessment. This proof-of-concept work requires further external multicenter validation before clinical adoption.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 94-102"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging cotyledon histopathology and perfusion in healthy primate pregnancy","authors":"Logan T. Keding,&nbsp;Ruo-Yu Liu,&nbsp;Taylor J. Keding,&nbsp;Jessica Vazquez,&nbsp;Crystal G. Bockoven,&nbsp;Dinesh M. Shah,&nbsp;Thaddeus G. Golos,&nbsp;Oliver Wieben,&nbsp;Aleksandar K. Stanic","doi":"10.1016/j.placenta.2026.08.340","DOIUrl":"10.1016/j.placenta.2026.08.340","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthy and diseased placentae alike often display some degree of histopathology. However, quantitative techniques to characterize common placental lesions and their relationship to local maternal hemodynamics in healthy pregnancy are currently limited.</div></div><div><h3>Methods</h3><div>Seven pregnant macaques with healthy fetoplacental biometrics were recruited for study. Placentae were imaged by MRI at three time points across mid-to late-gestation to quantify volume, blood flow, and perfusion of maternal blood across pregnancy. Near term, we collected placental cotyledons, imaged hematoxylin/eosin-stained slides, then annotated major histopathological features (sub-tissues, intervillous gaps, fibrin deposition, villous agglutination, inflammatory agglutination, and stromal mineralization) within each cotyledon. Histopathological lesions were assessed in relation to each other and MRI-based perfusion metrics, in a cotyledon-specific manner. Parallel analyses were performed to investigate both basic (Spearman correlation) and animal variance-conditioned (dimensionality-reduction) relationships.</div></div><div><h3>Results</h3><div>Dimensionality reduction analysis revealed maternal vascular malperfusion-associated histopathology as the main contributor to dataset variance and was positively associated with increased maternal blood perfusion across gestation. Cotyledons with increased stromal mineralization demonstrated low blood perfusion across pregnancy, alongside changes potentially indicative of maternal compensation. Additionally, histopathology associated with healthy placental function demonstrated low cotyledon blood flow at all timepoints.</div></div><div><h3>Conclusions</h3><div>We revealed several relationships connecting histopathology and perfusion in the healthy pregnancy, such as maternal vascular malperfusion-associated lesions increasing with increased maternal blood perfusion - all accomplished at the smallest functional unit of the placenta. This methodological framework embeds pathologist-refined morphological expertise into a quantitative, spatially resolved format that can better ground unsupervised computational approaches to placental analysis.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 103-112"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The syncytin-like ERVV-2 regulates trophoblast differentiation and HDP-related gene expression","authors":"Tomoka Shimooki,&nbsp;Kazuya Kusama,&nbsp;Atsuya Tsuru,&nbsp;Mikihiro Yoshie,&nbsp;Junya Kojima,&nbsp;Hirotaka Nishi,&nbsp;Kazuhiro Tamura","doi":"10.1016/j.placenta.2026.08.044","DOIUrl":"10.1016/j.placenta.2026.08.044","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages e199-e200"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenge to the extracellular vesicle–centric paradigm of placental–maternal communication by trophoblast-derived extracellular nanoparticles as important extracellular immunoregulatory cargo carriers","authors":"Toshihiro Takizawa,&nbsp;Syunya Noguchi,&nbsp;Yasuyuki Negishi,&nbsp;Shohei Tozawa,&nbsp;Takuji Kosuge,&nbsp;Takami Takizawa,&nbsp;Rimpei Morita,&nbsp;Hiroyuki Fujiwara,&nbsp;Akihide Ohkuchi,&nbsp;Hironori Takahashi","doi":"10.1016/j.placenta.2026.08.035","DOIUrl":"10.1016/j.placenta.2026.08.035","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e197"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPV2-Mediated Calcium Entry Marks Syncytiotrophoblast Differentiation in the Placenta","authors":"Pilar Van Mechelen,&nbsp;Seppe Gevaert,&nbsp;Jill Witvrouwen,&nbsp;Ana Ferrero Micó,&nbsp;Inge Bongaers,&nbsp;Thomas Voets,&nbsp;Joris Vriens,&nbsp;Katrien De Clercq","doi":"10.1016/j.placenta.2026.08.057","DOIUrl":"10.1016/j.placenta.2026.08.057","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e204"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell-derived extracellular vesicles modulate inflammatory signaling at the maternal-fetal interface","authors":"Brett Vahkal,&nbsp;Liza Konnikova","doi":"10.1016/j.placenta.2026.08.017","DOIUrl":"10.1016/j.placenta.2026.08.017","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e191"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}