Placenta最新文献

{"title":"Trophoblast extracellular vesicles, regulators of maternal and life-long physiology","authors":"Larry Chamley","doi":"10.1016/j.placenta.2026.08.005","DOIUrl":"10.1016/j.placenta.2026.08.005","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e188"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Links between Inositol Content, Tissue Acylcarnitines and Strength of Fetal Membranes","authors":"Melissa KH. Lee, Hannah EJ. Yong, Hai Ning Wee, Ashwin Seetharaman, Yong Peh, Le Xuan Sam, Amaury Cazenave-Gassiot, Han Zhang, Anita S. Kale, Mahesh Choolani, Hwa Liang Leo, Shiao-Yng Chan","doi":"10.1016/j.placenta.2026.08.038","DOIUrl":"10.1016/j.placenta.2026.08.038","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e198"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal sex and growth restriction program tumor microenvironmental response to pancreatic cancer","authors":"Gianna Paulucci, Mayu Morita, Terry Morgan","doi":"10.1016/j.placenta.2026.08.024","DOIUrl":"10.1016/j.placenta.2026.08.024","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages e193-e194"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining normal placental histology: histopathologic findings and interobserver reproducibility in clinically uncomplicated term pregnancies","authors":"Sandra Zekic Tomas,&nbsp;Thomas Menter,&nbsp;Stipe Dumancic,&nbsp;Maria Linda Rocha,&nbsp;Saeed Azadkhah,&nbsp;Raluca Mihai,&nbsp;Eumenia Castro,&nbsp;Barbara Ciolka,&nbsp;Heather L. Keir,&nbsp;Martyna Trzeszcz,&nbsp;Carmen Severens-Rijvers,&nbsp;Bettina Neumayer,&nbsp;Jakub Kelbl,&nbsp;Maria Orsaria,&nbsp;Hélder Oliveira Coelho,&nbsp;Rosete Nogueira,&nbsp;Line Raaby,&nbsp;Gitta Turowski","doi":"10.1016/j.placenta.2026.09.006","DOIUrl":"10.1016/j.placenta.2026.09.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The Amsterdam consensus criteria have standardized placental lesion classification; however, the histopathologic spectrum of clinically uncomplicated pregnancies and the reproducibility of placental assessment remain incompletely defined. We aimed to characterize histopathologic findings in term placentas from uncomplicated pregnancies with favorable outcomes and assess interobserver reproducibility.</div></div><div><h3>Methods</h3><div>In this multi-rater observational study, 35 placentas from physiologic term singleton pregnancies were evaluated by 14 perinatal pathologists. Three full-thickness sections per case were digitized at ×40 magnification and independently assessed. Twenty-seven variables encompassed Amsterdam-defined lesion categories, findings often associated with adverse pregnancy outcomes, and morphologic characteristics of uncertain clinical significance. Interobserver agreement was assessed using intraclass correlation coefficients and Krippendorff's alpha.</div></div><div><h3>Results</h3><div>Findings from all three categories occurred in placentas with favorable outcomes. Agreement was low for villous maturation (α = 0.129), fetal vascular malperfusion (α = 0.161), chorangiosis (α = 0.178), and syncytial knotting (α = 0.181), while maternal vascular malperfusion showed minimal reproducibility (α = 0.016). Giant multinucleated extravillous trophoblast cell counts showed the highest reproducibility (ICC = 0.633).</div></div><div><h3>Discussion</h3><div>Placental histopathologic findings in uncomplicated pregnancies vary in standardization, clinical relevance, and reproducibility. Consensus-defined lesions may require refined operational thresholds, findings often associated with adverse outcomes require attention to extent and distribution, and morphologic characteristics of uncertain clinical significance require outcome-based validation. These findings support contextual interpretation and continued refinement of diagnostic criteria and normal placental morphology.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 158-165"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of postpartum depression in low- and middle-income countries in Asia","authors":"Eiko Yamamoto","doi":"10.1016/j.placenta.2026.08.040","DOIUrl":"10.1016/j.placenta.2026.08.040","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages e198-e199"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP-citrate lyase regulates nuclear acetyl-coA levels to promote histone acetylation and is essential to maintain human trophoblast stemness and mouse placental and fetal growth","authors":"Irving Aye,&nbsp;Giulia Avellino,&nbsp;Stephanie Rogers,&nbsp;Delia Hawkes,&nbsp;Eleanor Ward,&nbsp;Jacqueline Guettler,&nbsp;Dafina Angelova,&nbsp;Gordon Smith,&nbsp;Stephen Charnock-Jones","doi":"10.1016/j.placenta.2026.08.058","DOIUrl":"10.1016/j.placenta.2026.08.058","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e204"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision cut placenta slices – a novel, advanced model of the human placenta and decidua","authors":"Kylie Belchamber","doi":"10.1016/j.placenta.2026.08.041","DOIUrl":"10.1016/j.placenta.2026.08.041","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e199"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saireito attenuates inflammatory and oxidative stress signaling and preserves trophoblast function in models relevant to preeclampsia","authors":"Saya Watanabe,&nbsp;Takahiro Seyama,&nbsp;Kei Hashimoto,&nbsp;MIki Nishizawa,&nbsp;Kazuyuki Shigekawa,&nbsp;Ryo Watanabe,&nbsp;Mai Yoshiyama,&nbsp;Chikara Kihira,&nbsp;Yuko Takahashi,&nbsp;Haruka Nishida,&nbsp;Mana Hirano,&nbsp;Hideo Kamata,&nbsp;Yukifumi Sasamori,&nbsp;Haruko Hiraike,&nbsp;Yutaka Osuga,&nbsp;Kazunori Nagasaka","doi":"10.1016/j.placenta.2026.08.054","DOIUrl":"10.1016/j.placenta.2026.08.054","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e203"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational Study of Inflammatory and Immune Regulatory Markers in Obese and Non-Obese Women with Recurrent Pregnancy Loss at a Large Tertiary Hospital in South Africa.","authors":"Inge Smit,&nbsp;Matamela Mabugana,&nbsp;Nadia Ikumi,&nbsp;Mushi Matjila","doi":"10.1016/j.placenta.2026.08.049","DOIUrl":"10.1016/j.placenta.2026.08.049","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e201"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aryl hydrocarbon Receptor signaling in the human trophoblast links environmental sensing with placental immune and endocrine functions","authors":"Romane Person,&nbsp;Gaëlle Deval,&nbsp;Marie-Léone Vignaud,&nbsp;Théo Jamay,&nbsp;Raja Djelidi,&nbsp;Audrey Chissey,&nbsp;Lucie Adoux,&nbsp;Didier Borderie,&nbsp;Frank Giton,&nbsp;Thierry Fournier,&nbsp;Xavier Coumoul,&nbsp;Ioana Ferecatu","doi":"10.1016/j.placenta.2026.08.051","DOIUrl":"10.1016/j.placenta.2026.08.051","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e202"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}