Placenta最新文献_第9页

The role of calcium signals in trophoblast fusion 钙信号在滋养细胞融合中的作用

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.055

Pilar Van Mechelen , Amitesh Panda , Joris Vriens , Katrien De Clercq

引用次数: 0

Development of methotrexate nanoparticles for the treatment of gestational trophoblastic neoplasia 甲氨蝶呤纳米颗粒治疗妊娠滋养细胞瘤的研究进展

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.035

Doha Boukaoui , Rim Atioui , Nathalie Boulens , Pierre-Adrien Bolze , Florence Delie- Salmon , Manuela Undurraga , Marie-Benoîte Cohen

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Characterization and in vitro modeling of trophoblast and villous core networks of human first trimester placental cells 人妊娠早期胎盘细胞滋养细胞和绒毛核心网络的表征和体外建模

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.059

Theresa Maxian , Andreas Lackner , Hanna Waldhäusl , Anna-Lena Höbler , Anna-Maria Prandstetter , Jasmin Wächter , Gudrun Meinhardt , Jürgen Pollheimer , Martin Knöfler , Sandra Haider

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Decidual macrophage efferocytosis of trophoblasts in full term human placenta 足月人胎盘中滋养细胞的蜕膜巨噬细胞efferocyte

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.051

Kylie Belchamber , Katie Morris , Shakila Thangaratinum , Jennifer Tamblyn

引用次数: 0

Impact of air pollutant sulfur dioxide exposure syncytialization and invasion processes in trophoblast cells: role of er stress 空气污染物二氧化硫暴露对滋养细胞合胞和侵袭过程的影响：er应激的作用

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.039

Sunil Singh , Swati Ajmeriya , Ruby Dhar , Subhradip Karmakar

引用次数: 0

Decript - deciphering the human prenatal chemical exposome using high-resolution mass spectrometry 记录-破译人类产前化学暴露使用高分辨率质谱

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.028

Thomas Contini , Rémi Béranger , Luc Multigner , Jana Klánová , Elliott Price , Arthur David

引用次数: 0

Development of a fluidic in vitro model to investigate maternal-fetal drug transfer 研究母体-胎儿药物转移的流体体外模型的建立

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.030

Barbara Fuenzalida , Nadja Koechli , Edgar Otsouka , Michael Luethi , Rona Karahoda , Martin Müller , Chennakesava Cuddapah , Bram Sengers , Frantisek Staud , Christiane Albrecht

引用次数: 0

Antioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation 抗氧化处理可减弱与年龄相关的胎盘GLUT-1和PLIN-2下调

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.12.024

Ana Rita Pinheiro , Adriana Raquel Rodrigues , Liliana Matos , José Júlio Costa , Sara Ricardo , Luís Guedes-Martins , Henrique Almeida , Elisabete Silva

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引用次数: 0

Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential 胎盘细胞外囊泡在体外移植模型中诱导卵巢肿瘤细胞死亡：可能的治疗潜力。

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.12.028

Xinyi Sun , Jiayi Wan , Yi Zhang , Ye Shen , Yunhui Tang , Yongxiang Yin , Lawrence W. Chamley , Min Zhao , Qi Chen

{"title":"Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential","authors":"Xinyi Sun , Jiayi Wan , Yi Zhang , Ye Shen , Yunhui Tang , Yongxiang Yin , Lawrence W. Chamley , Min Zhao , Qi Chen","doi":"10.1016/j.placenta.2024.12.028","DOIUrl":"10.1016/j.placenta.2024.12.028","url":null,"abstract":"<div><h3>Introduction</h3><div>Placental extracellular vesicles (EVs), lipid-enclosed particles released from the placenta, can facilitate intercellular communication and are classified as micro- or nano-EVs depending on size. Placental EVs contain molecules associated with cell proliferation and death. In this study, we investigated whether treating human ovarian tumour explants with placental EVs could induce ovarian tumour cell death.</div></div><div><h3>Methods</h3><div>Human ovarian tumours were collected. After directly treating human ovarian tumour explants with placental EVs, cellular necrosis was observed in ovarian tumour explants by HE stains. Cell death-associated miRNAs were measured.</div></div><div><h3>Results</h3><div>Expression of apoptosis and senescence-associated proteins, including NF-<span><math><mrow><mi>κ</mi><mi>β</mi></mrow></math></span> and <span><math><mrow><mi>γ</mi></mrow></math></span> H2AX, were significantly increased, while proliferation-associated proteins were significantly reduced in the explants after exposure to placental EVs. Furthermore, miRNA-519a-5p, miRNA-512–3p and miRNA-143–3p, which were reported to promote ovarian cancer cell apoptosis or inhibition of ovarian cancer cell growth, were significantly increased, and the target genes of miRNA-519a-5p and miRNA-512–3p were significantly reduced in the explants after exposure to placental EVs. Transfection of SK-OV-3 ovarian cancer cells with a mimic of miRNA-519a-5p or miRNA-143–3p reduced the viability of these cells.</div></div><div><h3>Discussion</h3><div>Our study demonstrated that placental EVs could induce necrosis in ovarian tumour explants. Increased levels of apoptosis and senescence-associated proteins and miRNAs could contribute to this change in ovarian tumour cell phenotype after exposure to placental EVs.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 20-28"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The combined levels of CREBBP and EP300 affect EVT differentiation CREBBP和EP300的联合水平影响EVT分化

IF 3 2区医学

Placenta Pub Date : 2025-02-01 DOI: 10.1016/j.placenta.2024.10.053

Fangxu Lin , Jantine van Voorden , Remco Keijser , Gijs Afink

引用次数: 0