发布求助
文献互助 智能选刊 最新文献

Placenta最新文献

筛选
英文 中文
Proteomic Analysis of Anaerobic Glycolysis in the Placenta Across Gestation 妊娠期胎盘厌氧糖酵解的蛋白质组学分析
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.046
Caitlan R. Dodd, Veronica B. Botha, Heather C. Murray, Anya L. Arthurs, John E. Schjenken, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher
{"title":"Proteomic Analysis of Anaerobic Glycolysis in the Placenta Across Gestation","authors":"Caitlan R. Dodd, Veronica B. Botha, Heather C. Murray, Anya L. Arthurs, John E. Schjenken, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher","doi":"10.1016/j.placenta.2026.08.046","DOIUrl":"10.1016/j.placenta.2026.08.046","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e200"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p300 acts as a placental nutrient sensor through mTOR signaling p300通过mTOR信号传导作为胎盘营养传感器
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.066
Maryam Khelil, Souad Boussata, Remco Keijser, Gijs Afink
{"title":"p300 acts as a placental nutrient sensor through mTOR signaling","authors":"Maryam Khelil, Souad Boussata, Remco Keijser, Gijs Afink","doi":"10.1016/j.placenta.2026.08.066","DOIUrl":"10.1016/j.placenta.2026.08.066","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e207"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Glycemic Stress Disrupts the Autophagic Mechanism and Differentiation Kinetics of Human Trophoblast Stem Cells 慢性血糖应激破坏人滋养细胞干细胞的自噬机制和分化动力学
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.067
Chloe Lee, Hoi Kit Matthew Leung, Cheuk-Lun Lee, Ka Wang Cheung, Philip C.N. Chiu
{"title":"Chronic Glycemic Stress Disrupts the Autophagic Mechanism and Differentiation Kinetics of Human Trophoblast Stem Cells","authors":"Chloe Lee, Hoi Kit Matthew Leung, Cheuk-Lun Lee, Ka Wang Cheung, Philip C.N. Chiu","doi":"10.1016/j.placenta.2026.08.067","DOIUrl":"10.1016/j.placenta.2026.08.067","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e207"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental transcriptomics identifies a candidate HLA-DQA2-FGL2 immune signature in gestational diabetes mellitus 胎盘转录组学鉴定妊娠期糖尿病的候选HLA-DQA2-FGL2免疫标记。
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-08-29 DOI: 10.1016/j.placenta.2026.08.339
Shuyu Liu, Jingxiang Feng, Youde Ding, Weizhang Liang
{"title":"Placental transcriptomics identifies a candidate HLA-DQA2-FGL2 immune signature in gestational diabetes mellitus","authors":"Shuyu Liu,&nbsp;Jingxiang Feng,&nbsp;Youde Ding,&nbsp;Weizhang Liang","doi":"10.1016/j.placenta.2026.08.339","DOIUrl":"10.1016/j.placenta.2026.08.339","url":null,"abstract":"<div><h3>Introduction</h3><div>Gestational diabetes mellitus (GDM) is a major public health challenge characterized by placental immunometabolic dysregulation. This study aimed to identify molecular signatures associated with GDM-related placental pathology and evaluate their diagnostic and therapeutic implications.</div></div><div><h3>Methods</h3><div>Two bulk placental transcriptomic datasets (GSE70493 and GSE263483) and one single-cell dataset (GSE173193) were analyzed. Differential expression analysis, WGCNA, and machine-learning feature selection (LASSO and SVM-RFE) were used to identify candidate gene signatures. A two-gene logistic regression model was constructed and externally validated. Immune-cell correlation rewiring and single-cell <em>in silico</em>perturbation analysis explored immune-network alterations and regulatory roles of identified genes. A drug-prioritization framework was used for therapeutic screening.</div></div><div><h3>Results</h3><div>Intersecting WGCNA modules with differentially expressed genes identified 29 candidates enriched in antigen presentation and mononuclear phagocyte functions. Dual-algorithm selection converged on HLA-DQA2 and FGL2. The two-gene model achieved an AUC of 0.786 in the discovery cohort and 0.813 in the external validation cohort. Immune rewiring analysis indicated a shift toward M1 macrophage polarization. Single-cell perturbation analysis supported regulatory roles of HLA-DQA2 and FGL2 within the macrophage lineage. Drug analysis reaffirmed insulin, metformin, and glyburide as stable therapeutic anchors.</div></div><div><h3>Discussion</h3><div>The HLA-DQA2/FGL2 signature captures key aspects of placental immunometabolic dysregulation in GDM, including altered antigen presentation and macrophage-associated immune rewiring. This integrated framework provides candidate biomarkers for GDM risk stratification and generates computational hypotheses for future mechanistic and therapeutic studies.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 82-93"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinated gene networks reveal distinct evolutionary selection pressures shaping human trophoblast cell states. 协调的基因网络揭示了形成人类滋养细胞状态的不同进化选择压力。
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.027
Jemima Chukwu Shaibu, Evgenii Martirosian, Peter Ruane, John Aplin, Adam Stevens
{"title":"Coordinated gene networks reveal distinct evolutionary selection pressures shaping human trophoblast cell states.","authors":"Jemima Chukwu Shaibu,&nbsp;Evgenii Martirosian,&nbsp;Peter Ruane,&nbsp;John Aplin,&nbsp;Adam Stevens","doi":"10.1016/j.placenta.2026.08.027","DOIUrl":"10.1016/j.placenta.2026.08.027","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e194"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149204680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of Classical HLA Expression in Human Trophoblast Stem Cells 人滋养细胞干细胞经典HLA表达的调控
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.081
Hannah Witmer, Sampada Kallol, Virginia Chu Cheung, Francesca Soncin, Mana Parast, Mariko Horii
{"title":"Modulation of Classical HLA Expression in Human Trophoblast Stem Cells","authors":"Hannah Witmer,&nbsp;Sampada Kallol,&nbsp;Virginia Chu Cheung,&nbsp;Francesca Soncin,&nbsp;Mana Parast,&nbsp;Mariko Horii","doi":"10.1016/j.placenta.2026.08.081","DOIUrl":"10.1016/j.placenta.2026.08.081","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e211"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149204933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA sensing induces a sterile interferon response in the placenta that correlates with increased HERV expression RNA感应在胎盘中诱导与HERV表达增加相关的无菌干扰素反应
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.060
Sabine de Lange, Eloisa Vega Quiroz, Julia van der Weerd, Thomas den Hamer, Marielle Kuijt, Marco Gugliemi, Carin van der Keur, Michael Eikmans, Leon Mei, Annemarthe van der Veen
{"title":"RNA sensing induces a sterile interferon response in the placenta that correlates with increased HERV expression","authors":"Sabine de Lange,&nbsp;Eloisa Vega Quiroz,&nbsp;Julia van der Weerd,&nbsp;Thomas den Hamer,&nbsp;Marielle Kuijt,&nbsp;Marco Gugliemi,&nbsp;Carin van der Keur,&nbsp;Michael Eikmans,&nbsp;Leon Mei,&nbsp;Annemarthe van der Veen","doi":"10.1016/j.placenta.2026.08.060","DOIUrl":"10.1016/j.placenta.2026.08.060","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e205"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning–enhanced placental ultrasound for first-trimester prediction of pre-eclampsia: development and external validation of multivariable models using OxNNet biomarkers in the FirstPLUS and OxPLUS studies 机器学习增强胎盘超声用于早期子痫前期预测：在FirstPLUS和OxPLUS研究中使用OxNNet生物标志物的多变量模型的开发和外部验证
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.022
Sam Mathewlynn, Sally Collins
{"title":"Machine learning–enhanced placental ultrasound for first-trimester prediction of pre-eclampsia: development and external validation of multivariable models using OxNNet biomarkers in the FirstPLUS and OxPLUS studies","authors":"Sam Mathewlynn,&nbsp;Sally Collins","doi":"10.1016/j.placenta.2026.08.022","DOIUrl":"10.1016/j.placenta.2026.08.022","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e193"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetate metabolism regulates human trophoblast stem cell differentiation into extravillous trophoblasts 醋酸盐代谢调节人滋养层干细胞向外滋养层细胞分化
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.011
Eleanor G. Ward, Stephanie Rogers, D. Stephen Charnock-Jones, Gordon C.S. Smith, Irving L.M. H. Aye
{"title":"Acetate metabolism regulates human trophoblast stem cell differentiation into extravillous trophoblasts","authors":"Eleanor G. Ward,&nbsp;Stephanie Rogers,&nbsp;D. Stephen Charnock-Jones,&nbsp;Gordon C.S. Smith,&nbsp;Irving L.M. H. Aye","doi":"10.1016/j.placenta.2026.08.011","DOIUrl":"10.1016/j.placenta.2026.08.011","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e190"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arrayed CRISPR screening reveals novel regulators of trophoblast cell-cell fusion and hCG secretion 阵列CRISPR筛选揭示滋养层细胞-细胞融合和hCG分泌的新调节因子
IF 3.1 2区 医学
Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.013
Meagan Esbin, Rituja Bhowmik, Hanqin Li, Andrew Cearlock, Jiayu Chen, Tomy Tran, Dirk Hockemeyer, Xavier Darzacq, Fyodor Urnov, Robert Tjian, Min Yang
{"title":"Arrayed CRISPR screening reveals novel regulators of trophoblast cell-cell fusion and hCG secretion","authors":"Meagan Esbin,&nbsp;Rituja Bhowmik,&nbsp;Hanqin Li,&nbsp;Andrew Cearlock,&nbsp;Jiayu Chen,&nbsp;Tomy Tran,&nbsp;Dirk Hockemeyer,&nbsp;Xavier Darzacq,&nbsp;Fyodor Urnov,&nbsp;Robert Tjian,&nbsp;Min Yang","doi":"10.1016/j.placenta.2026.08.013","DOIUrl":"10.1016/j.placenta.2026.08.013","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Page e190"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149199449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书