Placenta最新文献_第4页

Comprehensive Lysosomal Enzyme Profiling of Human Amniotic Epithelial Cells for Therapeutic Applications 人羊膜上皮细胞溶酶体酶谱分析及其治疗应用

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.082

Millei Kaga, Chika Takano, Yutaka Furuta, Isamu Taiko, Toshio Miki

引用次数: 0

Disruption of GAS6/AXL Signaling-Driven Amniotic Intercellular Communication Triggers Labor by Activating Endoplasmic Reticulum Stress GAS6/AXL信号驱动的羊膜细胞间通讯中断通过激活内质网应激触发分娩

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.074

Li-Jun Ling, Yu-Ping Tang, Yuan-hui Jia, Han Xie, Wang-sheng Wang, Kang Sun, Hao Ying

引用次数: 0

Lipid nanoparticle conjugation methods for placental targeted delivery of short interfering RNA to treat placental dysfunction 脂质纳米颗粒偶联方法用于胎盘靶向递送短干扰RNA治疗胎盘功能障碍

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.023

Maya Robertson, Qingqing Fan, Natasha de Alwis, Zoe Kodila, Christina Cortez-Hugo, Natalie Hannan

引用次数: 0

Single-cell transcriptomics on FFPE placenta: A novel method for comprehensive exploration of an entire placental section FFPE胎盘的单细胞转录组学：一种全面探索整个胎盘切片的新方法

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-09-05 DOI: 10.1016/j.placenta.2026.09.001

Zambiasi Aymeric, Aziza Jacqueline, Clementine Decamps, Emeline Sarot, Carine Valle, Ousselin Jessie, Reboul Hadrien, Courtade-Saidi Monique, Nicaise Yvan, Hamdi M. Safouane, Dubucs Charlotte

{"title":"Single-cell transcriptomics on FFPE placenta: A novel method for comprehensive exploration of an entire placental section","authors":"Zambiasi Aymeric, Aziza Jacqueline, Clementine Decamps, Emeline Sarot, Carine Valle, Ousselin Jessie, Reboul Hadrien, Courtade-Saidi Monique, Nicaise Yvan, Hamdi M. Safouane, Dubucs Charlotte","doi":"10.1016/j.placenta.2026.09.001","DOIUrl":"10.1016/j.placenta.2026.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>The placenta's complex cellular diversity challenges traditional transcriptomic analyses. Single-cell RNA sequencing (scRNA-seq) offers breakthrough capabilities by enabling transcriptome profiling at the single-cell level. However, traditional scRNA-seq relies on fresh or frozen samples, which present practical storage and quality challenges. Applying scRNA-seq to Formalin-Fixed, Paraffin-Embedded (FFPE) placentas could harness archived samples for clinical insights.</div></div><div><h3>Methods</h3><div>We used 10x Genomics Flex technology to analyze 8 non-pathological placentas ranging from 21 + 6 weeks of gestation (WoG) to 39 + 4 WoG.</div></div><div><h3>Results</h3><div>Our approach identifies diverse cell populations and allows us to discern maternal from fetal cells. Despite sample size limitations, the method yields comparable data to prior fresh/frozen tissue studies and we complete these data by integrating new molecular markers. The potential to correlate single-cell results with histopathology enables us to conduct an in-depth analysis across entire placental sections by concurrently addressing both fetal and maternal cells. We could thus confirm molecular markers like KRT5/6 using immunohistochemistry by revisiting the slide.</div></div><div><h3>Discussion</h3><div>This innovation could aid in understanding focal anomalies observed on standard histology slides, thereby enhancing traditional histopathological assessments. Given its practicality, integrating our method into routine practice is both feasible and promising.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 113-126"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148935349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental calcineurin/NFATc1 expression and angiogenic profiles in isolated fetal growth restriction: A prospective longitudinal study 胎盘钙调神经磷酸酶/NFATc1表达和血管生成特征在分离的胎儿生长受限：一项前瞻性纵向研究。

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-09-10 DOI: 10.1016/j.placenta.2026.09.005

Berivan Guzelbag, Melike Punduk Yılmaz, Emine Yılmaz Guler, Sevilay Yavuz Dogu, Alireza Maghsoudi, Cagseli Goksu Ozgun Selcuk, Melik Selcuk, Ali Cetin

{"title":"Placental calcineurin/NFATc1 expression and angiogenic profiles in isolated fetal growth restriction: A prospective longitudinal study","authors":"Berivan Guzelbag, Melike Punduk Yılmaz, Emine Yılmaz Guler, Sevilay Yavuz Dogu, Alireza Maghsoudi, Cagseli Goksu Ozgun Selcuk, Melik Selcuk, Ali Cetin","doi":"10.1016/j.placenta.2026.09.005","DOIUrl":"10.1016/j.placenta.2026.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The calcineurin/nuclear factor of activated T-cells (NFAT) signaling pathway regulates soluble fms-like tyrosine kinase-1 (sFlt-1) expression in placental tissue; however, its role in isolated fetal growth restriction (FGR) has not been investigated.</div></div><div><h3>Methods</h3><div>This prospective longitudinal cohort study enrolled 39 women with isolated FGR (15 early-onset <32 weeks, 24 late-onset ≥32 weeks). Placental calcineurin and NFATc1 were quantified by ELISA at delivery. Serum sFlt-1, placental growth factor (PlGF), and vascular endothelial growth factor (VEGF), together with urinary sFlt-1 and PlGF, were measured at antepartum presentation (T1) and 24 ± 2 h postpartum (T3).</div></div><div><h3>Results</h3><div>Placental calcineurin was significantly higher in early-onset versus late-onset FGR (3.23 ± 0.93 vs. 2.63 ± 0.85 ng/mg protein, p = 0.038). A significant positive correlation was observed between placental calcineurin and NFATc1 (r = 0.409, 95% CI [0.107–0.642], p = 0.010). Early-onset FGR exhibited markedly elevated serum sFlt-1/PlGF ratios (151.4 ± 55.6 vs. 86.1 ± 46.2, p < 0.001; Cohen's d = 1.28), higher placental sFlt-1 (p = 0.036), and lower placental PlGF (p = 0.014). Following delivery, serum sFlt-1 declined by 78% in both groups (p < 0.001), while VEGF remained stable. Urinary biomarkers did not discriminate between phenotypes at antepartum presentation.</div></div><div><h3>Conclusions</h3><div>Placental calcineurin is elevated in early-onset FGR and positively correlates with NFATc1, suggesting coordinated pathway involvement in placental insufficiency. Postpartum normalization of sFlt-1 and PlGF confirms the predominantly placental origin of the angiogenic imbalance. The serum sFlt-1/PlGF ratio discriminates between FGR phenotypes and may complement clinical decision-making.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"183 ","pages":"Pages 127-135"},"PeriodicalIF":3.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transglutaminase activity contributes to trophoblast cell behavior in vitro 谷氨酰胺转胺酶活性影响滋养细胞的体外行为

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.053

Camila Tosar, Victoria Nuñez, Avril Toledo, Paula Arbildi

引用次数: 0

NI1.8 - Withdrawn NI1.8 -撤回

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.016

引用次数: 0

Sca-1 expression in mouse trophoblast stem cells is dynamic, and the expression level alters self-renewal characteristics Sca-1在小鼠滋养细胞干细胞中的表达是动态的，其表达水平改变了细胞的自我更新特性

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.079

Matthew Tang, Bryony Natale, Megan MacRae, Scott Lindsay, Curtis Noordhof, Avery McGinnis, Tiziana Cotechini, Patricia Lima, Louise Laurent, David Natale

引用次数: 0

TET3 contributes to epigenetic activation of TGFβ pathway and metabolic regulation in preeclampsia TET3参与子痫前期TGFβ通路的表观遗传激活和代谢调节

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.029

Yetao Xu, Dan Wu, Qing Zuo, Viktoriia Kolesnyk, Foram Gandhi, Yang Yang-Hartwich

引用次数: 0

Establishment of human trophoblast stem cells from term smooth chorion 足月平滑膜培养人滋养细胞干细胞的建立

IF 3.1 2区医学

Placenta Pub Date : 2026-09-01 Epub Date: 2026-10-16 DOI: 10.1016/j.placenta.2026.08.009

Takako Hoshiyama, Masanaga Muto, Masatsugu Ema, Shunichiro Tsuji

引用次数: 0