Placenta最新文献

{"title":"Antenatal melatonin supplementation increases fetal weight and reduces placental oxidative damage in a mouse model of advanced maternal age","authors":"Jessica Dalton-O’Reilly , Michelle Desforges , Alexander E.P. Heazell , Susan Greenwood , Mark R. Dilworth","doi":"10.1016/j.placenta.2024.10.063","DOIUrl":"10.1016/j.placenta.2024.10.063","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 156"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of syncytiotrophoblast-derived cf-RNA OPA1 to predict the occurrence of preeclampsia","authors":"Zhongrui Pei ,&nbsp;Huirong Tang ,&nbsp;Jing Wu ,&nbsp;Jie Wang ,&nbsp;Dan Liu ,&nbsp;Chenrui Cao ,&nbsp;Weichen Pan ,&nbsp;Taishun Li ,&nbsp;Honglei Duan ,&nbsp;Zhiyin Wang ,&nbsp;Mingming Zheng ,&nbsp;Yali Hu ,&nbsp;Guangfeng Zhao","doi":"10.1016/j.placenta.2024.12.022","DOIUrl":"10.1016/j.placenta.2024.12.022","url":null,"abstract":"<div><h3>Background</h3><div>Pre-eclampsia (PE) poses a significant threat to mothers and infants worldwide. Studies indicate that taking low-dose aspirin before the 16th week of pregnancy may prevent approximately 70 % of PE cases, highlighting the importance of predicting PE. Cell-free RNA (cf-RNA) exhibits significant changes in the maternal peripheral blood during early pregnancy, making cf-RNA analysis a promising and less invasive method for predicting PE.</div></div><div><h3>Methods</h3><div>The two datasets, GSE192902 and GSE149440, were analyzed to identify differentially expressed cf-RNAs, followed by the calculation of their AUC values Subsequently, these cf-RNAs were validated using placental tissues, as well as late- and early-stage plasma samples collected from both healthy individuals and patients with PE. Furthermore, we performed tissue localization and functional analyses on the ultimate candidate gene.</div></div><div><h3>Results</h3><div>Mitochondrial Dynamin-Like GTPase (OPA1) emerged as the molecule with the most consistent and statistically significant alterations in placental tissues and serum samples from patients with PE across various gestational weeks. Notably, the combination of OPA1 levels and mean arterial pressure (MAP) yielded an AUC of 0.825 (95 % CI: 0.759–0.879) for predicting PE. Additionally, we verified that OPA1 is predominantly expressed in placental syncytiotrophoblast (STB) cells, and its downregulation negatively impacts STB mitochondrial function, angiogenic potential, and cell proliferation.</div></div><div><h3>Conclusions</h3><div>OPA1 holds the potential to emerge as a novel cf-RNA for predicting PE.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A positive association between postpartum electrohysterography parameters and blood loss after vaginal delivery: A prospective study","authors":"Maria Wilhelmina Elisabeth Frenken ,&nbsp;Daisy Adriana Anne-Jan van der Woude ,&nbsp;Bettine Geertrude van Willigen ,&nbsp;Jeanne Petra Dieleman ,&nbsp;Swan Gie Oei ,&nbsp;Judith Octavia Elisabeth Helena van Laar","doi":"10.1016/j.placenta.2024.12.018","DOIUrl":"10.1016/j.placenta.2024.12.018","url":null,"abstract":"<div><h3>Introduction</h3><div>The postpartum period can be complicated by hemorrhage, frequently caused by uterine atony. Electrohysterography, allowing continuous monitoring of uterine activity, may be a promising alternative for early detection of uterine atony, and thereby contribute to the prevention of postpartum hemorrhage. Associations between electrohysterographic parameters postpartum and total blood loss were studied.</div></div><div><h3>Methods</h3><div>In this prospective explorative study, women were included with a vaginal delivery between 36⁺⁰ and 42⁺⁰ weeks of gestation. Linear regression analysis was used to describe the association between electrohysterographic parameters (i.e. area under the contraction curve (AUC) total (in arbitrary units), AUC from baseline (in arbitrary units), maximum amplitude (in arbitrary units) and baseline tone (in arbitrary units)) and total blood loss (in mL) during the first 30 min postpartum.</div></div><div><h3>Results</h3><div>In total, 25 women were included for analysis, of whom three had postpartum hemorrhage. A moderate positive linear correlation was found between the logarithmically transformed total blood loss and the AUC total (r = 0.44, p = 0.03), AUC from baseline (r = 0.43, p = 0.03) and baseline tone (r = 0.43, p = 0.03). There was no significant linear correlation between the logarithmically transformed total blood loss and maximum amplitude. Explorative analysis revealed a significantly higher AUC total, AUC from baseline and baseline tone in women with postpartum hemorrhage compared to women without postpartum hemorrhage. (p = 0.02, p = 0.02 and p = 0.03, respectively).</div></div><div><h3>Discussion</h3><div>There is a moderate positive correlation between the logarithmically transformed total blood loss and the AUC total, AUC from baseline and baseline tone. Also, these parameters were all significantly higher in women with postpartum hemorrhage compared to women without postpartum hemorrhage.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 11-19"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuregulin plays a multifaceted role in the extravillous trophoblast lineage of the human placenta","authors":"J. Wächter ,&nbsp;G. Meinhardt ,&nbsp;S. Lugmayr ,&nbsp;H. Waldhäusl ,&nbsp;A.-L. Höbler ,&nbsp;T. Maxian ,&nbsp;A.-M. Prandstetter ,&nbsp;J. Pollheimer ,&nbsp;S. Haider ,&nbsp;M. Knöfler","doi":"10.1016/j.placenta.2024.10.054","DOIUrl":"10.1016/j.placenta.2024.10.054","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 153"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIG1 triggers placental senescence in preeclampsia through LMNA/p53 axis activation","authors":"Yanxuan Xiao ,&nbsp;Maliang Tao ,&nbsp;Jiexing He ,&nbsp;Jiaqi Li ,&nbsp;Qiuyu Huang ,&nbsp;Yiqi Yu ,&nbsp;Mingze Gao ,&nbsp;Qian Chen ,&nbsp;Zhijian Wang","doi":"10.1016/j.placenta.2024.12.023","DOIUrl":"10.1016/j.placenta.2024.12.023","url":null,"abstract":"<div><h3>Introduction</h3><div>The mechanism behind abnormal placental aging in preeclampsia (PE) is unclear. Although TIG1 is widely expressed in the human placenta, its function hasn't been well understood. Our previous study found a significant elevation of TIG1 in the placentas of PE patients. In this study, we focused on the molecular mechanism by which TIG1 functions in PE.</div></div><div><h3>Methods</h3><div>TIG1 expression of placentas from PE patients and L-NAME mice were analyzed using qRT-PCR, Western blot, and immunohistochemistry. TIG1-overexpressed HTR-8/SVneo cells were constructed for transcriptomic sequencing. Senescence in the placenta was evaluated by biomarkers of p16, p21, and p53. TIG1 binding proteins were identified via co-immunoprecipitation. A co-culture system of HTR-8/SVneo and human endometrial stromal cells was developed to study the change in trophoblasts’ function.</div></div><div><h3>Results</h3><div>TIG1 expression was significantly increased in the PE placentas. Elevated expression of TIG1 was associated with abnormal senescence of trophoblasts. TIG1 induced trophoblasts’ senescence by regulating LMNA/p53 axis. The senescence of trophoblasts can be manifested as reduced invasion ability in the co-culture system.</div></div><div><h3>Discussion</h3><div>Our study indicated that TIG1 was crucial in the development of PE by causing the senescence of trophoblasts and reducing their invasiveness, offering insights into the molecular mechanisms of placental dysfunction in PE.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 39-50"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human differentiated and undifferentiated trophoblast organoids as a novel model for human cytomegalovirus congenital infection","authors":"Karolina Radziun ,&nbsp;Michael Nevels ,&nbsp;David Turner ,&nbsp;Aras Kadioglu ,&nbsp;Marie Yang","doi":"10.1016/j.placenta.2024.10.060","DOIUrl":"10.1016/j.placenta.2024.10.060","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 155"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasoactivity of cannabis components in human placental arteries","authors":"M.S. Harhangi ,&nbsp;S.H.P. Simons ,&nbsp;I.K.M. Reiss ,&nbsp;A.H.J. Danser ,&nbsp;M. Broekhuizen","doi":"10.1016/j.placenta.2024.10.031","DOIUrl":"10.1016/j.placenta.2024.10.031","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 145-146"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of beta blockers on fetal vasculature","authors":"Doaa Babaeer ,&nbsp;Jenny Myers ,&nbsp;Paul Brownbill","doi":"10.1016/j.placenta.2024.10.032","DOIUrl":"10.1016/j.placenta.2024.10.032","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 146"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-based placenta-embryo chip for developmental toxicity assessment of nanoparticles and drugs","authors":"Manon Murdeu ,&nbsp;Vera Kissling ,&nbsp;Jacob Folz ,&nbsp;Andreas Hierlemann ,&nbsp;Julia Alicia Boos ,&nbsp;Tina Buerki-Thurnherr","doi":"10.1016/j.placenta.2024.10.026","DOIUrl":"10.1016/j.placenta.2024.10.026","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 144"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk between extravillous trophoblasts and decidual glands in early human pregnancy","authors":"Anna-Maria Prandstetter ,&nbsp;Theresa Maxian ,&nbsp;Hanna Waldhäusl ,&nbsp;Jasmin Wächter ,&nbsp;Anna-Lena Höbler ,&nbsp;Gudrun Meinhardt ,&nbsp;Jürgen Pollheimer ,&nbsp;Martin Knöfler ,&nbsp;Sandra Haider","doi":"10.1016/j.placenta.2024.10.061","DOIUrl":"10.1016/j.placenta.2024.10.061","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 155"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}