Placenta最新文献

{"title":"A vascularized 3d placenta-on-a-chip to study barrier dysfunction in pre-eclampsia","authors":"Marta Cherubini , Defne Cobanoglu , Kristina Haase","doi":"10.1016/j.placenta.2024.10.045","DOIUrl":"10.1016/j.placenta.2024.10.045","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 150"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“GPI signal lost”: Implications for preeclampsia","authors":"Andrea Álvarez-Sánchez , Johanna Grinat , Paula Doria-Borrell , Marta Malenchini , Maravillas Mellado-López , Salvador Meseguer , Myriam Hemberger , Vicente Pérez-García","doi":"10.1016/j.placenta.2024.10.043","DOIUrl":"10.1016/j.placenta.2024.10.043","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 149"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of xanthine oxidase in pregnancy’s outcomes","authors":"Lorenzo Annesi , Giovanni Tossetta , Claudio Borghi , Federica Piani","doi":"10.1016/j.placenta.2024.10.064","DOIUrl":"10.1016/j.placenta.2024.10.064","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 156"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HAPLN3 is involved in trophoblast differentiation and invasion","authors":"Ana Ferrero-Micó , Sergio Navarro-Serna , Paula Doria-Borrell , Maravillas Mellado-López , Vicente Pérez-García","doi":"10.1016/j.placenta.2024.10.052","DOIUrl":"10.1016/j.placenta.2024.10.052","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 152"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the generation of human induced trophoblast stem cells from term umbilical cord","authors":"Jantine van Voorden , Souad Boussata , Remco Keijser , Marloes Vermij , Wessel Ganzevoort , Gijs Afink","doi":"10.1016/j.placenta.2024.10.058","DOIUrl":"10.1016/j.placenta.2024.10.058","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 154"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal-fetal interface favors a specific neutrophil type characterized by a long-lived, immunosuppressive phenotype, able to enhance EVT motility","authors":"Anna-Lena Höbler , Andreas Ian Lackner , Peter Haslinger , Gudrun Meinhardt , Hanna Waldhäusl , Theresa Maxian , Sandra Haider , Martin Knöfler , Raimund Oberle , Jürgen Pollheimer","doi":"10.1016/j.placenta.2024.10.048","DOIUrl":"10.1016/j.placenta.2024.10.048","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 151"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maternal inflammation during obese pregnancy on placental nutrient transport and fetal growth","authors":"Cindy XW. Zhang , Samantha Lean , Alejandro A. Candia , Edina Horvath-Gulasci , Amanda Sferruzzi-Perri","doi":"10.1016/j.placenta.2024.10.041","DOIUrl":"10.1016/j.placenta.2024.10.041","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 149"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal exposure to a mixture of food chemical compounds on fetoplacental development","authors":"Jeanne Bozec , Delphine Rousseau-Ralliard , Louise Angrand , Donya Popping , Michèle Dahirel , Gwendoline Morin , Louise Lemarie , Christophe Richard , Valérie Gelin , Claire Philippat , Véronique Gayrard , Anne Couturier-Tarrade","doi":"10.1016/j.placenta.2024.10.027","DOIUrl":"10.1016/j.placenta.2024.10.027","url":null,"abstract":"","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Page 144"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome","authors":"Alison Paquette ,&nbsp;Mariana Parenti ,&nbsp;Samantha Lapehn ,&nbsp;Chaini Konwar ,&nbsp;Leena Kadam ,&nbsp;Evan J. Firsick ,&nbsp;Emily S. Barrett ,&nbsp;Julie MacIsaac ,&nbsp;James MacDonald ,&nbsp;Theo Bammler ,&nbsp;Kecia Carroll ,&nbsp;Daniel Enquobahrie ,&nbsp;Michael Kobor ,&nbsp;Kaja Z. LeWinn ,&nbsp;Ruby Nguyen ,&nbsp;Roger Smith ,&nbsp;Adam Spirzo ,&nbsp;Qi Zhao ,&nbsp;Leslie Myatt ,&nbsp;Nicole R. Bush ,&nbsp;Sheela Sathyanarayana","doi":"10.1016/j.placenta.2024.12.021","DOIUrl":"10.1016/j.placenta.2024.12.021","url":null,"abstract":"<div><h3>Introduction</h3><div>The placenta produces corticotrophin releasing hormone (CRH), which rises exponentially in maternal plasma across pregnancy. CRH plays a functional role in fetal development, labor initiation, and the regulation of gestational length. We aimed to understand how maternal plasma CRH during pregnancy reflects placental physiology during parturition by characterizing placental transcriptomic signatures of maternal plasma CRH and comparing to transcriptomic signatures of gestational age at birth.</div></div><div><h3>Methods</h3><div>Maternal plasma CRH concentrations were measured via radioimmunoassay at two timepoints and the placental transcriptome was quantified via RNA sequencing in 516 pregnant participants enrolled in the CANDLE cohort. Robust linear models were fitted to estimate associations between CRH and placental gene expression at birth. We conducted a functional validation in primary trophoblast cells before and after syncytialization.</div></div><div><h3>Results</h3><div>Plasma CRH concentrations in the mid-pregnancy visit were associated with placental expression of 8 differentially expressed genes (DEGs), and concentrations in late pregnancy were associated with 283 DEGs. These genes were involved in several metabolic pathways. Seven genes were significantly associated with both plasma CRH and gestational length. Four genes were concordantly decreased and 7 genes were concordantly increased in primary trophoblasts treated with CRH.</div></div><div><h3>Discussion</h3><div>Overall, this study reveals potential novel transcriptional mechanisms by which CRH may regulate metabolic pathways important for placental function and identifies genes associated with both CRH and gestational length.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 29-38"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental alkaline phosphatase (PLAP): Is it exclusively placental?","authors":"Awanit Kumar ,&nbsp;Sourabh Sharma ,&nbsp;Maged M. Costantine ,&nbsp;Kara Rood ,&nbsp;Rheanna Urrabaz-Garza ,&nbsp;Jeena Jacob ,&nbsp;Lauren S. Richardson ,&nbsp;Ananth Kumar Kammala ,&nbsp;Ramkumar Menon","doi":"10.1016/j.placenta.2025.01.001","DOIUrl":"10.1016/j.placenta.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Adverse pregnancies outcomes present a clinical dilemma in Perinatal medicine. This is partly due to lack of accuracy of current biomarkers to predict high-risk pregnancies at an earlier stage. The placental alkaline phosphatase (PLAP) carrying extracellular vesicles (EVs), and their cargo have been reported as a source of biomarkers for placental health and an indication of pre-eclampsia progression.</div></div><div><h3>Objectives</h3><div>We postulate that PLAP is not only placental but also expressed in other fetal organs, suggesting that PLAP + ve EVs are not only a functional indicator of placental function alone.</div></div><div><h3>Methods</h3><div>We evaluated PLAP in the placenta, fetal membranes, maternal decidua, myometrial cells, and the EVs derived from them. Various bioanalytical techniques were used to detect PLAP expressions in the cells and EVs. The EVs were characterized by size/quantity, PLAP as a cargo, and canonical EV protein markers.</div></div><div><h3>Results</h3><div>PLAP expression was determined in the chorion trophoblast cells (CTCs) of the fetal membranes and the placental trophoblasts; however, it was absent in the amnion layer of the fetal membranes and the maternal uterine cells used in this study. Using multiple experimental approaches, we further verified the cellular sources of PLAP and confirmed that the EVs from the chorion and placental trophoblasts contain PLAP.</div></div><div><h3>Conclusion</h3><div>Our studies suggest that PLAP is not truly placental. Instead, cells of trophoblast lineage in both fetal membranes and the placenta express PLAP in cells and their EVs. Although PLAP + ve EVs for biomarkers are not exclusively placental, they still represent real-time fetal-specific tissues conditions during pregnancy.</div></div>","PeriodicalId":20203,"journal":{"name":"Placenta","volume":"160 ","pages":"Pages 118-125"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}