Phytochemistry最新文献_第4页

Guaianolide sesquiterpenoids from Chrysanthemum indicum L. alleviate rheumatoid arthritis by targeting of NLRP3 inflammasome pathway 菊花中的愈创木酚内酯倍半萜。靶向NLRP3炎性体通路缓解类风湿关节炎。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-05-01 Epub Date: 2026-01-03 DOI: 10.1016/j.phytochem.2026.114768

Gui-Min Xue , Hao Feng , Dong-Rong Zhu , Xin-Xin Guo , Ding-Qiao Xu , Yan-Jun Sun , Yan-Le Zhi , Zhi-Qiang Zhang , Guo-Sheng Li , Wu-Fa Dong , Jin-Feng Xue

{"title":"Guaianolide sesquiterpenoids from Chrysanthemum indicum L. alleviate rheumatoid arthritis by targeting of NLRP3 inflammasome pathway","authors":"Gui-Min Xue , Hao Feng , Dong-Rong Zhu , Xin-Xin Guo , Ding-Qiao Xu , Yan-Jun Sun , Yan-Le Zhi , Zhi-Qiang Zhang , Guo-Sheng Li , Wu-Fa Dong , Jin-Feng Xue","doi":"10.1016/j.phytochem.2026.114768","DOIUrl":"10.1016/j.phytochem.2026.114768","url":null,"abstract":"<div><div>Thirteen undescribed guaianolide lactones chryguaialactones A−M (1−13), together with ten known analogues (14−23), were isolated from the flowers of Chrysanthemum indicum L. The previously unreported structures including their absolute configurations were determined through spectroscopic techniques, combined with DP4+ NMR analysis, X-ray crystallography and calculated ECD methods. All compounds were screened on their IL-1β inhibitory activity in THP-1 cells, and most of them (1, 3−5, 7−8, 10, 12−17, and 19−23) displayed inhibitory effects with IC50 values in the range 0.31–15.95 μM. Besides, compound 13 showed the most potential activity with IC50 value of 0.31 ± 0.15 μM. Mechanismly, 13 inhibited the NLRP3 assembly and the activation of its downstream proteins. Furthermore, 13 could interact with NLRP3 protein illustrated by CETSA, DARTS and IP assays. Molecular docking revealed the covalent binding between the α, β unsaturated ketone in 13 and the NACHT domain of NLRP3. The suppression of 13 on NLRP3 inflammasome pathway was further proved in HFLS-RA cells. Hence, these findings uncovered an unrecognized role of 13 exerting anti rheumatoid arthritis activity in the regulation of NLRP3 inflammasome pathway.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"245 ","pages":"Article 114768"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dibenzocyclooctadiene lignans from Kadsura coccinea and their immunosuppressive activities 二苯并环二烯木脂素及其免疫抑制活性

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-05-01 Epub Date: 2026-01-13 DOI: 10.1016/j.phytochem.2026.114780

An Jin , Zhuocan Huang , Hui Li , Jinling Chang , Hanli Ruan , Wenming Wu

{"title":"Dibenzocyclooctadiene lignans from Kadsura coccinea and their immunosuppressive activities","authors":"An Jin , Zhuocan Huang , Hui Li , Jinling Chang , Hanli Ruan , Wenming Wu","doi":"10.1016/j.phytochem.2026.114780","DOIUrl":"10.1016/j.phytochem.2026.114780","url":null,"abstract":"<div><div>A detailed phytochemical analysis of the dried, ripe fruits of Kadsura coccinea led to the isolation and structural characterization of eleven undescribed lignans, designated kadcolignan K–U (1–11), together with thirteen previously documented compounds (12–24). Notably, kadcolignan U (11) is particularly distinctive, representing a rare dearomatized lignan with a dienone moiety and an uncommon 7, 2′–oxygen bridge. Mechanistic evaluation of the most potent isolates, kadcolignan O (5) and kadcolignan Q (7), revealed their capacity to trigger apoptosis in activated mice B lymphocytes through mitochondrial-dependent pathways, as evidenced by dose-dependent elevation of pro-apoptotic Bax, suppression of anti-apoptotic Bcl-2/Bcl-xL, and release of cleaved caspase-3 and caspase-9. Additionally, both metabolites were found to disrupt the PI3K/AKT/mTOR signaling axis by inhibiting the phosphorylation of PI3K, AKT, and mTOR in a dose-dependent manner. Our findings highlight K. coccinea as a source of B cell-targeted immunosuppressants, with 5 and 7 emerging as promising candidates for further development in autoimmune disease therapy.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"245 ","pages":"Article 114780"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Undescribed triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bge. and their neuroprotective effects 黄芪叶中未描述的三萜皂苷。知母。以及它们的神经保护作用。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-05-01 Epub Date: 2026-01-22 DOI: 10.1016/j.phytochem.2026.114788

Wenxiang Xu , Qian Zhang , Xinyuan Li , Zhenyun Liu , Peng Jiang , Yiqiang Zhang , Yumeng Luo , Wei Guan , Mengmeng Li , Qingyue Bu , Qingshan Chen , Lili Zhang , Xiaochi Ma , Haixue Kuang , Yan Liu

{"title":"Undescribed triterpenoid saponins from the leaves of Astragalus membranaceus (Fisch.) Bge. and their neuroprotective effects","authors":"Wenxiang Xu , Qian Zhang , Xinyuan Li , Zhenyun Liu , Peng Jiang , Yiqiang Zhang , Yumeng Luo , Wei Guan , Mengmeng Li , Qingyue Bu , Qingshan Chen , Lili Zhang , Xiaochi Ma , Haixue Kuang , Yan Liu","doi":"10.1016/j.phytochem.2026.114788","DOIUrl":"10.1016/j.phytochem.2026.114788","url":null,"abstract":"<div><div>In total, 14 undescribed triterpenoid saponins (1–14), along with three known ones (15–17), were isolated from the leaves of Astragalus membranaceus (Fisch.) Bge. In the case of previously unknown compounds, it was observed that dehydration occurred between the hydroxyl group at C-24 and the hydroxyl group at C-16 in compounds 1–3. This resulted in the formation of an ether bond, leading to the creation of a previously undescribed seven-membered structure. The structures were elucidated based on comprehensive spectroscopic analysis, encompassing HRESIMS, 1D and 2D NMR data, X-ray diffraction, DP4+ analysis, electron circular dichroism (ECD) calculations as well as comparison with published literature data. Additionally, HT22 cells induced with d-galactose were employed to evaluate the neuroprotective potential of all isolated triterpenoids. Results showed that triterpenoids 1–3 as well as 12–14 demonstrated notable neuroprotective benefits.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"245 ","pages":"Article 114788"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anti-leukemia steroidal saponins from Paris polyphylla var. yunnanensis 云南何首乌抗白血病甾体皂苷。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-05-01 Epub Date: 2026-01-22 DOI: 10.1016/j.phytochem.2026.114787

Yu Zhang , Yu-Chen Zhang , Yu-Chen Fan , Chen-Sen Xu , Hao-Lin Yu , Chao Wang , Jing Zhang , Yi-Lin Liu , Yi-Bo Shen , Chao Liu , Jin-Yue Sun , Jin-Zhong Hu , Zhi-Xin Liao

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Richard Robins – a Life in Phytochemistry 理查德·罗宾斯——植物化学的一生

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-05-01 Epub Date: 2026-01-30 DOI: 10.1016/j.phytochem.2026.114782

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Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei 封闭系统培养软珊瑚中briarane型二萜。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-04-01 Epub Date: 2025-12-24 DOI: 10.1016/j.phytochem.2025.114760

Lo-Yun Chen , Bo-Rong Peng , Thanh Hao Huynh , You-Ying Chen , Yu-Cheng Chen , Ngoc-Thac Pham , Huong-Giang Le , Quoc-Vu Pham , Phuong Vu Luu , Ying-Mi Lai , Mohamed El-Shazly , Tsong-Long Hwang , Kuei-Hung Lai

{"title":"Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei","authors":"Lo-Yun Chen , Bo-Rong Peng , Thanh Hao Huynh , You-Ying Chen , Yu-Cheng Chen , Ngoc-Thac Pham , Huong-Giang Le , Quoc-Vu Pham , Phuong Vu Luu , Ying-Mi Lai , Mohamed El-Shazly , Tsong-Long Hwang , Kuei-Hung Lai","doi":"10.1016/j.phytochem.2025.114760","DOIUrl":"10.1016/j.phytochem.2025.114760","url":null,"abstract":"<div><div>In this study, by using untargeted LC-MS/MS-based multi-informative molecular networking, 12 briarane diterpenoids were isolated from a closed-system cultured soft coral Briareum stechei. Among them, six unreported compounds were identified and named briastechols A–F (1–6). Notably, briastechols A (1) and B (2) possess a rare 11,14-ether bridge, while briastechols C (3) and D (4) feature a tetrahydrofuran moiety with an ether linkage between C-5 and C-8. Additionally, the absolute configurations of briastechol F (6) and briarenol H (10) were determined for the first time via X-ray crystallographic analysis. Evaluation of bioactivity indicated that the crude extract exerted pronounced anti-inflammatory effects, as reflected in the inhibition of superoxide anion formation and elastase secretion in human neutrophils triggered by N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB). Among the isolated compounds, briastechol E (5) showed significant anti-inflammatory potential, with IC50 values of 7.89 ± 0.38 μM and 4.53 ± 0.68 μM against superoxide anion generation and elastase release, respectively. These findings underscore the structural novelty and chemical diversity of metabolites from cultured B. stechei using a closed system, highlighting its potential as a sustainable source of anti-inflammatory agents and further supporting the viability of closed aquaculture systems for marine natural product research.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"244 ","pages":"Article 114760"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi 硬核人蛋白G-L：软珊瑚中具有4/9融合环系统的选择性细胞毒性二萜类化合物。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.phytochem.2025.114756

Phuong Vu Luu , Thuy-Tien Thi Phan , Ngoc-Thac Pham , Huong-Giang Le , Lo-Yun Chen , Huong Lien Ton-Nu , Mei-Hsien Lee , Yao-An Shen , Yu-Jui Fan , Yu-Chia Chang , Jui-Hsin Su , Bo-Rong Peng , Kuei-Hung Lai

{"title":"Sclerohumins G-L: Selective cytotoxic diterpenoids featuring a 4/9-fused ring system from the soft coral Sclerophytum humesi","authors":"Phuong Vu Luu , Thuy-Tien Thi Phan , Ngoc-Thac Pham , Huong-Giang Le , Lo-Yun Chen , Huong Lien Ton-Nu , Mei-Hsien Lee , Yao-An Shen , Yu-Jui Fan , Yu-Chia Chang , Jui-Hsin Su , Bo-Rong Peng , Kuei-Hung Lai","doi":"10.1016/j.phytochem.2025.114756","DOIUrl":"10.1016/j.phytochem.2025.114756","url":null,"abstract":"<div><div>Eight previously undescribed terpenoids, including six xeniaphyllane-derived diterpenoids, sclerohumins G-L (1–6), and two norcaryophyllene-type sesquiterpene isomers, norsclerohumins M and N (7 and 8), were isolated from the soft coral Sclerophytum humesi by MIMN-guided isolation. These compounds feature a 4/9-fused ring system, which was first isolated from the genus Sclerophytum. Moreover, compound 6 possesses a 20-exomethylene moiety, which is uncommon among xeniaphyllane-type diterpenoids. Their structures were elucidated through their spectroscopic analysis, including NMR, HR-ESI-MS, ECD, and DP4+ probability assessments. All isolates were tested for their cytotoxic activities, revealing that compounds 1–5 exhibited selective cytotoxicity in the MIA PaCa-2 cell line with IC50 values ranging from 9.0 to 26.1 μM and selective index (SI) greater than 3. The structure-activity relationships (SARs) of these active compounds were further investigated, providing insights into the molecular features that modulate cytotoxic efficacy. Additionally, a plausible biosynthetic pathway of compounds 1–6 was proposed, demonstrating the soft coral Sclerophytum humesi as a rich source of novel natural products.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"244 ","pages":"Article 114756"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Gingerols and their derivatives from ginger oleoresin and the anti-melanogenic effect in IBMX-stimulated B16F10 melanoma cells 姜辣素及其衍生物在ibmx刺激的B16F10黑色素瘤细胞中的抗黑素作用。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-04-01 Epub Date: 2025-12-26 DOI: 10.1016/j.phytochem.2025.114762

Jiarui Wu, Siyang Fan, Man Yang, Huali Wu, Fujiang Guo, Kaixian Chen, Liuqiang Zhang, Yiming Li

{"title":"Gingerols and their derivatives from ginger oleoresin and the anti-melanogenic effect in IBMX-stimulated B16F10 melanoma cells","authors":"Jiarui Wu, Siyang Fan, Man Yang, Huali Wu, Fujiang Guo, Kaixian Chen, Liuqiang Zhang, Yiming Li","doi":"10.1016/j.phytochem.2025.114762","DOIUrl":"10.1016/j.phytochem.2025.114762","url":null,"abstract":"<div><div>Ginger (Zingiber officinale Roscoe), a widely used culinary and medicinal plant, has recently gained significant attention for its whitening properties. While gingerols are the primary components of ginger, the whitening effects of their numerous, structurally similar gingerols remain underexplored, particularly with insufficient structure-activity relationship (SAR) analyses. This study aimed to comprehensively investigate the anti-melanogenic effects and SAR of diverse gingerols and their derivatives. Thirty-five gingerols and their derivatives were isolated from ginger oleoresin, including two rare monoterpene-gingerol conjugates (1–2), two unreported isogingerols (3–4), and one shogaol derivative (5). Compounds 6–9 were isolated from a natural source for the first time. Structural elucidation via spectroscopic analysis, specific rotation, and electronic circular dichroism confirmed their structures and configurations, with zingerol A (1) featuring an unprecedented 1-phenyl-2-geranyl-decane scaffold. Twenty-five isolates (1–2, 4–17, 19–21, 23, 25–26, and 32–34) demonstrated dose-dependent inhibition of melanogenesis in B16F10 cells. Shogaols (19–21) exhibited equivalent anti-melanogenic activity to hydroquinone at ≤ 2.5 μM. SAR studies revealed that geranyl substitution at C-2 and aliphatic chain elongation enhanced the bioactivity, with the C-3 carbonyl group serving as a critical pharmacophore.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"244 ","pages":"Article 114762"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Structurally specialised metabolites with antimicrobial and enzyme inhibitory activities from Hadal Trench-derived Nigrocephalum sp. SCSIO41049 Hadal沟源Nigrocephalum sp. SCSIO41049具有抗菌和酶抑制活性的结构特异性代谢物。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-04-01 Epub Date: 2025-12-12 DOI: 10.1016/j.phytochem.2025.114749

Qinlin Cao , Xiaoyan Pang , Mengjing Cong , Ziqing Li , Junfeng Wang , Xuefeng Zhou , Bin Yang , Weijia Zhang , Yonghong Liu

{"title":"Structurally specialised metabolites with antimicrobial and enzyme inhibitory activities from Hadal Trench-derived Nigrocephalum sp. SCSIO41049","authors":"Qinlin Cao , Xiaoyan Pang , Mengjing Cong , Ziqing Li , Junfeng Wang , Xuefeng Zhou , Bin Yang , Weijia Zhang , Yonghong Liu","doi":"10.1016/j.phytochem.2025.114749","DOIUrl":"10.1016/j.phytochem.2025.114749","url":null,"abstract":"<div><div>Two undescribed triterpene glycosides (1–2), one undescribed sesquiterpene glycoside (3), three undescribed α-pyrone derivatives (4–6) and one undescribed aliphatic hydrocarbon (7), along with twelve known compounds (8–19), were obtained from a culture of the fungus Nigrocephalum sp. SCSIO41049, separated from Mariana Trench sediment. Compounds 1 and 2 were the first discovered lanostane-type triterpenes with a d-mannose attached at the C-23. Compound 14 was isolated from nature for the first time. Their structures were elucidated based on 1D, 2D NMR and HR-ESI-MS spectral data analysis, followed by electronic circular dichroism (ECD) calculations, single-crystal X-ray diffraction analysis and acid hydrolysis reaction. All compounds were tested for their antimicrobial, enzyme inhibition and antitumor effects. Compound 1 displayed the potent inhibitory effect on Fusarium oxysporum HNM1003 with MIC value of 4 μg/mL. Compounds 6, 8, 11 and 15 demonstrated moderate inhibitory effects on Curvularia australiensis. Compounds 1, 2 and 10 exhibited significant neuraminidase inhibitory activity with IC50 values ranging from 33.02 to 43.55 μM.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"244 ","pages":"Article 114749"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cissatriterpenoids D-L, nine undescribed polyhydroxylated oleanane triterpenoids from Cissampelos pareira var. hirsuta 顺三萜D-L， 9个未描述的多羟基齐墩烷三萜。

IF 3.4 2区生物学

Phytochemistry Pub Date : 2026-04-01 Epub Date: 2025-12-16 DOI: 10.1016/j.phytochem.2025.114750

Shuang-Qin Cao , Ru-Yi Pan , Tong-Tong Zhang , Jian-Hong Gong , Meng Li , Hui Chen , Jing-Ke Zhang , Zhi-You Hao , Xiao-Ke Zheng , Yan-Jun Sun , Wei-Sheng Feng

{"title":"Cissatriterpenoids D-L, nine undescribed polyhydroxylated oleanane triterpenoids from Cissampelos pareira var. hirsuta","authors":"Shuang-Qin Cao , Ru-Yi Pan , Tong-Tong Zhang , Jian-Hong Gong , Meng Li , Hui Chen , Jing-Ke Zhang , Zhi-You Hao , Xiao-Ke Zheng , Yan-Jun Sun , Wei-Sheng Feng","doi":"10.1016/j.phytochem.2025.114750","DOIUrl":"10.1016/j.phytochem.2025.114750","url":null,"abstract":"<div><div>Nine undescribed polyhydroxylated oleanane triterpenoids (cissatriterpenoids D-L, 1–9) were isolated from the roots of Cissampelos pareira var. hirsuta. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis (HR-ESI-MS, UV, IR, NMR), and compared with the spectral data reported in the literature. All the compounds were tested for their cytotoxicity against MGC-803 and B16F10 cell lines, and inhibitory activity against nitric oxide (NO) release in LPS-induced RAW 264.7 cells. Among the tested compounds, compound 3 demonstrated the most potent cytotoxicity against the B16F10 cell line, with an IC50 value of 28.58 μM (etoposide, 23.51 μM). Moreover, it also exhibited the strongest inhibition of NO production in LPS-stimulated RAW 264.7 cells with an IC50 value of 17.73 μM, and was equivalent to that of the control drug dexamethasone (17.95 μM, P > 0.05). Compared with etoposide (47.77 μM), compounds 3 and 4 showed more potent cytotoxicities against the MGC-803 cell line with IC50 values of 42.21 μM and 38.28 μM, respectively. The preliminary study of structure-activity relationship indicated that esterification of 28-OH by tiglic acid may enhance the cytotoxic activity against two cell lines and NO inhibition effect in LPS-stimulated RAW 264.7 cells of polyhydroxylated oleanane triterpenoids. In contrast, benzoylation of 28-OH was found to increase the cytotoxic activity of those compounds against MGC-803 cell line. These results revealed the potential of polyhydroxylated oleanane triterpenoids as lead compounds for anti-tumor and anti-inflammatory applications.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"244 ","pages":"Article 114750"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0