Phytochemistry最新文献_第4页

Euphebranes A−G: higher diterpenoids from the radix of Euphorbia ebracteolata 大戟膜A−G：大戟根中的高级二萜

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-27 DOI: 10.1016/j.phytochem.2025.114657

Shu-Qi Wu , Lei-Ming Wu , Jia-Qian Chen , Fang-Yu Yuan , Dong Huang , Jia-Luo Huang , Yun-Yun Chen , Tao Yuan , Xin Chen , Zhang-Hua Sun , Gui-Hua Tang , Sheng Yin

{"title":"Euphebranes A−G: higher diterpenoids from the radix of Euphorbia ebracteolata","authors":"Shu-Qi Wu , Lei-Ming Wu , Jia-Qian Chen , Fang-Yu Yuan , Dong Huang , Jia-Luo Huang , Yun-Yun Chen , Tao Yuan , Xin Chen , Zhang-Hua Sun , Gui-Hua Tang , Sheng Yin","doi":"10.1016/j.phytochem.2025.114657","DOIUrl":"10.1016/j.phytochem.2025.114657","url":null,"abstract":"<div><div>Phytochemical investigation of roots of Euphorbia ebracteolata Hayata led to ten higher diterpenoids including seven undescribed ones (1–7) and three analogues (8−10), accompanied by four derivatives (7a and 9a−9c) obtained via chemical correlation. Notably, compound 1 represents a rare dinor-ent-isopimarane diterpenoid. Their structures were fully characterized using a combination of spectroscopic, ECD, chemical, and single-crystal X-ray diffraction means. Cytotoxicity screening suggested that the oxidized derivative of 7 (7a) displayed the most potent activity against non-small-cell lung cancer (NSCLC) cell line HCC827, comparable to the positive control, cisplatin. Mechanistic study revealed that 7a could arrest cell cycle at G1/S phase and induce apoptosis.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114657"},"PeriodicalIF":3.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight previously undescribed flavonoids and four previously undescribed bibenzyls from Macaranga kurzii and their potential antiviral activities 八种黄酮类化合物和四种联苯类化合物及其潜在的抗病毒活性

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-27 DOI: 10.1016/j.phytochem.2025.114654

Yan-Zi Ma , Ding-Cheng Zhang , Liu Yang , Xue-Wen Wu , Bo Li , Muhammad Aurang Zeb , Yuan-Lin Kong , Xue-Mei Zhou , Wei-Lie Xiao , Chang-Bo Zheng , Xiao-Li Li

{"title":"Eight previously undescribed flavonoids and four previously undescribed bibenzyls from Macaranga kurzii and their potential antiviral activities","authors":"Yan-Zi Ma , Ding-Cheng Zhang , Liu Yang , Xue-Wen Wu , Bo Li , Muhammad Aurang Zeb , Yuan-Lin Kong , Xue-Mei Zhou , Wei-Lie Xiao , Chang-Bo Zheng , Xiao-Li Li","doi":"10.1016/j.phytochem.2025.114654","DOIUrl":"10.1016/j.phytochem.2025.114654","url":null,"abstract":"<div><div>Eight previously undescribed flavonoids, named makurziis A-H (1–8), four previously undescribed bibenzyls, named mayankurziis A-D (9–12), as well as nine known compounds were isolated from the ethyl acetate extract of dried stems and leaves of Macaranga kurzii. Their structures were thoroughly elucidated through detailed spectroscopic analysis and comparison with existing literature data. Additionally, the structures of compounds 3 and 7 were further confirmed by single-crystal X-ray diffraction analysis. Biological testing revealed that compound 1 exhibited low cytotoxicity and potent anti-Zika virus (ZIKV) activity, with an EC50 value of 2.546 μM. Similarly, compound 8 displayed low cytotoxicity and strong potential against dengue virus (DENV), with an EC50 value of 3.092 μM. The quantitative real-time PCR and immunofluorescence analysis collectively showed that compounds 1 and 8 exhibited good in vitro antiviral activity at both the protein and RNA levels by suppressing the expression of ZIKV and DENV envelope protein.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114654"},"PeriodicalIF":3.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic compounds with anti-neuroinflammatory activities from the heartwood of Caesalpinia sappan L. (Sappan Lignum) 杉木心材中具有抗神经炎活性的酚类化合物

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-25 DOI: 10.1016/j.phytochem.2025.114656

Qi-Qi Wang , Yang Guo , Guo-Qing Qin , Xiang-Yang Liu , Feng Ye , Maisuti Tuerhong , Ming-Bo Zhao , Qing-Ying Zhang , Ke-Wu Zeng , Peng-Fei Tu

{"title":"Phenolic compounds with anti-neuroinflammatory activities from the heartwood of Caesalpinia sappan L. (Sappan Lignum)","authors":"Qi-Qi Wang , Yang Guo , Guo-Qing Qin , Xiang-Yang Liu , Feng Ye , Maisuti Tuerhong , Ming-Bo Zhao , Qing-Ying Zhang , Ke-Wu Zeng , Peng-Fei Tu","doi":"10.1016/j.phytochem.2025.114656","DOIUrl":"10.1016/j.phytochem.2025.114656","url":null,"abstract":"<div><div>Caesappanols G−Q (1−11), eleven undescribed phenolic compounds, including seven homoisoflavans and derivatives (1−7), two protosappanins (8−9), one phenylacylphenol (10), and one chalcone (11), along with nine known compounds (12−20), were isolated from Sappan Lignum, the heartwood of Caesalpinia sappan L. Structural elucidation of these compounds was accomplished through a combination of 1D and 2D NMR spectroscopy, mass spectrometry, NMR calculations, and ECD calculations. Furthermore, the anti-neuroinflammatory potential of these compounds was assessed by measuring their ability to inhibit NO production. All isolated compounds exhibited inhibitory effects on NO production in LPS-induced BV-2 cells. Among them, compounds 18, 19, and 20 demonstrated the most potent activity, with IC50 values of 19.63, 15.84, and 11.01 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114656"},"PeriodicalIF":3.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochalasins from the marine-derived fungus Acremonium implicatum DFFSCS001 and their anti-inflammatory activities 海洋源真菌Acremonium implicatum DFFSCS001的细胞松弛素及其抗炎活性

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-25 DOI: 10.1016/j.phytochem.2025.114655

Yu-Qian Tang , Chu-Xing Liang , Hui Cui , Xiao Liang , Shu-Hua Qi

{"title":"Cytochalasins from the marine-derived fungus Acremonium implicatum DFFSCS001 and their anti-inflammatory activities","authors":"Yu-Qian Tang , Chu-Xing Liang , Hui Cui , Xiao Liang , Shu-Hua Qi","doi":"10.1016/j.phytochem.2025.114655","DOIUrl":"10.1016/j.phytochem.2025.114655","url":null,"abstract":"<div><div>Nine undescribed cytochalasins, acrechalasins A‒I, together with three known analogs 21-O-deacetyl-L-696,474 and diaporthichalasins B and A were isolated from the marine-derived fungus Acremonium implicatum DFFSCS001. Their structures were elucidated by spectroscopic methods, and the absolute configurations of acrechalasins C and D and diaporthichalasin B were determined by single-crystal X-ray diffractions. Among them, acrechalasins A and B had a rare open-chain cytochalasin skeleton with a monocyclic butyrolactam group. Biologically, acrechalasins A‒I and 21-O-deacetyl-L-696,474 exhibited significant inhibitory activity against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 1.30 to 20.31 μM. Their structure−bioactivity relationship was also discussed. Especially, acrechalasins A and D also significantly suppressed the protein expression of iNOS at the concentration of 10 μM. This is the first report on the anti-inflammatory activities of open-chain cytochalasins featuring a monocyclic butyrolactam group.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114655"},"PeriodicalIF":3.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diterpenoids and sesquiterpenoids from Euphorbia helioscopia and their neuroprotective activity 大戟二萜和倍半萜及其神经保护活性

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-23 DOI: 10.1016/j.phytochem.2025.114653

Dong-Kun Zheng , Xue-Jin Liu , Xi Chen , Lin Liu , Shui-Chun Mao

{"title":"Diterpenoids and sesquiterpenoids from Euphorbia helioscopia and their neuroprotective activity","authors":"Dong-Kun Zheng , Xue-Jin Liu , Xi Chen , Lin Liu , Shui-Chun Mao","doi":"10.1016/j.phytochem.2025.114653","DOIUrl":"10.1016/j.phytochem.2025.114653","url":null,"abstract":"<div><div>Euphorbia helioscopia L., also known as “Zeqi” in China, has been used for decades as a traditional Chinese medicine to treat various diseases. In this study, a phytochemical investigation of the whole plant of E. helioscopia resulted in the isolation and structural elucidation of two undescribed lathyrane-type diterpenoids, euphohelioscopids A (1) and B (2), and one unreported megastigmane-type sesquiterpenoid, euphohelioscopid C (3), along with 20 known congeners (4−23). Their structures with absolute configurations were elucidated, based on a combination of extensive spectroscopic data analyses, ECD, and calculated NMR with the STS strategy, as well as comparison with previously reported NMR data. The isolated compounds were evaluated for their neuroprotective activities against glutamate-induced damage in HT22 cells. Compounds 1, 3, 5−8, 13, and 17 exhibited varying degrees of neuroprotective effects. Notably, compound 1, at a low concentration of 5 μM, demonstrated potent activity comparable to that of the positive control, D/L-3-n-butylphthalide (racemic NBP), elevating the cell survival rate from 48.4 % to 82.6 %. Further biological evaluations, including flow cytometric analysis and assessments of the expression of apoptosis-related proteins Bcl-2 and Bax, revealed that compound 1 mitigated glutamate-induced neuronal cell death through an anti-apoptotic pathway. These findings suggested that compound 1 may serve as a valuable lead scaffold for the development of novel neuroprotective agents.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114653"},"PeriodicalIF":3.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochalasans from the fungus Chaetomium globosum with cytotoxic activities against HepG2 cell line 对HepG2细胞系具有细胞毒活性的球形毛藻细胞链

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-23 DOI: 10.1016/j.phytochem.2025.114651

Hong-Fei Li , Tian Jin , Jiao-Xian Du , Xin-Wen Luo , Guo Zhang , Wang-Qiu Deng , Juan He , Tao Feng

引用次数: 0

Effects of exogenous GR24 on the growth and gene expression of maize seedlings under drought stress 外源GR24对干旱胁迫下玉米幼苗生长及基因表达的影响

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-21 DOI: 10.1016/j.phytochem.2025.114652

Ziyan Yu , Anqi Su , Yuqi Zhang , Wenbo Chai , Xiao Wei , Yuxian Yang , Wenhui Rao , Yan Zou , Youyang Qin , Zeyuan Liang , Yang Zhao , Jun Wang , Rongrong Sun , Xiaojian Peng

{"title":"Effects of exogenous GR24 on the growth and gene expression of maize seedlings under drought stress","authors":"Ziyan Yu , Anqi Su , Yuqi Zhang , Wenbo Chai , Xiao Wei , Yuxian Yang , Wenhui Rao , Yan Zou , Youyang Qin , Zeyuan Liang , Yang Zhao , Jun Wang , Rongrong Sun , Xiaojian Peng","doi":"10.1016/j.phytochem.2025.114652","DOIUrl":"10.1016/j.phytochem.2025.114652","url":null,"abstract":"<div><div>The growth and production of maize (Zea mays L.) are severely impaired by drought stress. Strigolactones (SLs), a novel class of phytohormones, play key roles in regulating plant development and adaptation to drought stress. However, little is known regarding how GR24 (a synthetic SL analog) modulates the growth and gene expression of maize seedlings to drought stress (DS). In this study, we conducted physiological analysis and transcriptome sequencing to investigate the mechanisms by which GR24 alleviates DS-induced effects on maize seedlings. Our results revealed that compared to seedlings subjected to DS alone, GR24 application significantly increased leaf fresh weight, leaf dry weight, root fresh weight, root dry weight, and leaf relative water content. Furthermore, chlorophyll a, b, and total chlorophyll content increased. Conversely, malondialdehyde (MDA), hydrogen peroxide (H2O2), and proline (Pro) content decreased. Following 10 days of rewatering, GR24-treated seedlings exhibited 100 % survival; leaf and root fresh weight increased by 223 % and 203 %, respectively, and leaf relative water content increased by 53 %. Meanwhile, MDA and proline content decreased by 87 % and 96 %, respectively. Transcriptome analysis indicated that exogenous GR24 enhanced maize drought tolerance by modulating plant hormone signal transduction and MAPK signaling pathway. Thus, exogenous GR24 effectively improves the drought tolerance and post-stress recovery capacity in maize seedlings.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114652"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Labdane-type diterpenoids from Hypoestes phyllostachya inhibit pancreatic cancer stem cells 从竹竹中提取的labdane型二萜抑制胰腺癌干细胞

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-21 DOI: 10.1016/j.phytochem.2025.114650

Tong Yan , Lin-Fen Ding , Ya Chen , Guo-Xian Hu , Lu Qu , Ming Hu , Ya-Xuan Ma , Rong-Qing Yuan , Lin Jia , Mei-Ju Zhao , Liu-Dong Song , Jia Su , Xing-De Wu

{"title":"Labdane-type diterpenoids from Hypoestes phyllostachya inhibit pancreatic cancer stem cells","authors":"Tong Yan , Lin-Fen Ding , Ya Chen , Guo-Xian Hu , Lu Qu , Ming Hu , Ya-Xuan Ma , Rong-Qing Yuan , Lin Jia , Mei-Ju Zhao , Liu-Dong Song , Jia Su , Xing-De Wu","doi":"10.1016/j.phytochem.2025.114650","DOIUrl":"10.1016/j.phytochem.2025.114650","url":null,"abstract":"<div><div>Ten previously undescribed labdane diterpenoids, hypochins A-J (1–10), were isolated from the aerial parts of Hypoestes phyllostachya with white spots. Their structures and absolute configurations were elucidated through comprehensive spectroscopic characterization, including IR, HRMS, NMR, electronic circular dichroism analysis, single-crystal X-ray diffraction, and biosynthetic considerations. Notably, compound 10 represents a rare labdane diterpenoid incorporating 16,15;19,6-dilactone units. Compound 1 exhibited potent inhibition of sphere formation in pancreatic cancer stem cells (PCSCs), which are known to drive tumor growth and contribute to resistance against cancer therapies. The suppression of PCSCs by 1 was confirmed by the down-regulation of cancer stem cell markers CD44, CD133, Oct-4, Sox-2, ALDH1A1, Musashi1, CXCR4, and PON1. Further investigations demonstrated that 1 suppressed the self-renewal of PANC-1 cells and inhibited their migration and invasion by suppressing epithelial-mesenchymal transition. Moreover, the selectivity of 1 against PCSCs and pancreatic cancer cells was evaluated through apoptosis analysis. Compared to paclitaxel, which is effective against cancer cells but inactive on PCSCs, compound 1 induced marked apoptosis in PCSCs, demonstrating its selectivity as a PCSC-targeted inhibitor. These results address the critical need for therapies that specifically target PCSCs, which play a crucial role in pancreatic cancer progression.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114650"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three rare verbascoside conjugated with iridoid glycosides and a diacylated iridoid diglycoside from Gmelina elliptica 三种与环烯醚萜苷缀合的稀有毛蕊花苷和一种二酰化环烯醚萜二糖苷

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-20 DOI: 10.1016/j.phytochem.2025.114649

Jedsada Maliwong , Nitirat Chimnoi , Somsak Ruchirawat , Tripetch Kanchanapoom

{"title":"Three rare verbascoside conjugated with iridoid glycosides and a diacylated iridoid diglycoside from Gmelina elliptica","authors":"Jedsada Maliwong , Nitirat Chimnoi , Somsak Ruchirawat , Tripetch Kanchanapoom","doi":"10.1016/j.phytochem.2025.114649","DOIUrl":"10.1016/j.phytochem.2025.114649","url":null,"abstract":"<div><div>Three rare verbascoside conjugated with iridoid glucosides linked by an ester bond, termed songmaeosides A-C (1–3), in addition to an unreported diacylated iridoid diglycoside, songmaeoside D (8), were isolated from the leaves of Gmelina elliptica. Additionally, premcoryoside (4), 6-α-L-(2ʺ-caffeoyl)-rhamnopyranosylcatalpol (5), saccatoside (6), scorodioside (7), verbascoside (9), syringalide A 3ʹ-α-l-rhamnopyranoside (10), isoverbascoside (11), icariside F2 (12), and sericoside (13) were also isolated. The isolation of verbascoside conjugated with iridoid glucosides through an ester linkage from this species is an uncommon phenomenon in plant sources. Premcoryoside was the first chemical recorded for this class in 1993. This study reveals a new discovery on this class of compounds, which has remained unpublished for almost 30 years.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"240 ","pages":"Article 114649"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunosuppressive spirocyclic labdane diterpenoids from Holocheila longipedunculata 长柄海棠的免疫抑制螺环唇丹二萜

IF 3.4 2区生物学

Phytochemistry Pub Date : 2025-08-20 DOI: 10.1016/j.phytochem.2025.114644

Xiu-Ying Bai , Shu-Xi Jing , Ting-Ting Zhou , Yu Zheng , Yan Liu , Sheng-Hong Li

{"title":"Immunosuppressive spirocyclic labdane diterpenoids from Holocheila longipedunculata","authors":"Xiu-Ying Bai , Shu-Xi Jing , Ting-Ting Zhou , Yu Zheng , Yan Liu , Sheng-Hong Li","doi":"10.1016/j.phytochem.2025.114644","DOIUrl":"10.1016/j.phytochem.2025.114644","url":null,"abstract":"<div><div>Phytochemical study on Holocheila longipedunculata has revealed twenty previously undescribed spirocyclic labdane diterpenoids, named hololabdanes (1–20). Their chemical structures were elucidated through comprehensive spectroscopic analysis, and the absolute configuration of hololabdane A (1) was determined via single-crystal X-ray diffraction. Notably, hololabdane I (17) and 16-epi-hololabdane I (18) feature a rare pyrrolo [2,1-b] oxazolidinone moiety, while hololabdane J (19) and 2′-epi-hololabdane J (20) possess a distinctive peroxide bridge. Biological evaluations revealed that these spirocyclic labdanes exhibit potential immunosuppressive activity. In particular, compounds 5, 7, and 11 exhibited potent inhibition effects against IFN-γ secretion from T cells, with IC50 values of 1.21, 4.50, and 2.88 μM, respectively. Additionally, compounds 5 and 11 inhibited T cell proliferation, with IC50 values of 1.30 and 9.27 μM, respectively.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"241 ","pages":"Article 114644"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0