Physiology international最新文献_第4页

RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2. RACGAP1 通过抑制 SIRT1/Mfn2 推动胃癌细胞的增殖、迁移和侵袭并抑制自噬。

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-22 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00235

Tingting Yan, Guangxin Lu, Rui Shang, Junhua Hu, Chaobei Zhu, Lingli Jin

{"title":"RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.","authors":"Tingting Yan, Guangxin Lu, Rui Shang, Junhua Hu, Chaobei Zhu, Lingli Jin","doi":"10.1556/2060.2023.00235","DOIUrl":"10.1556/2060.2023.00235","url":null,"abstract":"Objective: Gastric cancer is the most frequent gastrointestinal malignancy with a poor prognosis. Rac GTPase activation protein 1 (RACGAP1) is a novel tumor promotor, whose detailed effect on gastric cancer remains to be further elucidated. Hence, this study identifies the action of RACGAP1 on gastric cancer and investigates the potential mechanism.Methods: RACGAP1 expression in gastric cancer was analyzed based on the data of The Cancer Genome Atlas (TCGA) database. Cell proliferation was measured by CCK-8 and colony formation assay. Cell migration and invasion were evaluated by transwell assay. Cell apoptosis was assessed by flow cytometry. Cell autophagy was evaluated via determining LC3.Results: RACGAP1 presented at high level in gastric cancer cells. Overexpressed RACGAP1 potentiated gastric cancer cell proliferation, migration, and invasion. Besides, silenced RACGAP1 induced cell apoptosis and autophagy. Furthermore, RACGAP1 suppressed the expression of SIRT1 and Mfn2.Conclusion: RACGAP1 was overexpressed in gastric cancer. RACGAP1 potentiated aggressive behaviors of gastric cancer, and suppressed cell apoptosis and autophagy via modulating SIRT1/Mfn2. RACGAP1 may be a valuable target in the treatment of gastric cancer.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"35-46"},"PeriodicalIF":1.4,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of folic acid on isoprenaline-induced myocardial injury in rats. 叶酸对异丙肾上腺素诱发的大鼠心肌损伤的影响

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-22 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00291

Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric

{"title":"Effect of folic acid on isoprenaline-induced myocardial injury in rats.","authors":"Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric","doi":"10.1556/2060.2023.00291","DOIUrl":"10.1556/2060.2023.00291","url":null,"abstract":"Background: Isoprenaline (ISO), a synthetic catecholamine and a β-adrenoceptor agonist, is widely used to develop an experimental model of myocardial injury (MI) in rats. The leading hypothesis for ISO-induced MI in rats is that it results from catecholamine overstimulation, oxidative stress, inflammatory responses, and development of cardiomyopathy during ISO administration. Folic acid (FA) reduces oxidative stress, improves endothelial function and prevents apoptosis, thereby contributing to cardiovascular protection. This study aimed to investigate the potentially protective effect of FA pretreatment on ISO-induced MI in rats.Methods: For 7 days, adult male Wistar albino rats were pretreated with 5 mg/kg/day of FA. On the sixth and seventh days, MI in rats was induced by administering 85 mg/kg/day of ISO. Prooxidant markers in plasma samples, antioxidant capacity in erythrocyte lysates, cardiac damage markers, lipid profile, electrocardiography (ECG) and histopathological analysis were evaluated.Results: FA pretreatment significantly alleviated changes induced by ISO; it decreased the homocysteine and high-sensitivity troponin I level. FA moderately decreased the reactive oxygen species (ROS) levels (superoxide anion radical, hydrogen peroxide and thiobarbituric acid reactive substances) and improved the antioxidant activities of catalase, superoxide dismutase and reduced glutathione. ISO reduced the nitrite level and FA significantly alleviated this change.Conclusion: It can be concluded that FA, as a mild antioxidant, could be an appropriate cardioprotective substance in the rat model of ISO-induced MI.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"80-96"},"PeriodicalIF":1.4,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-arginine supplementation attenuates ovarian oxidative stress in female rats subjected to chronic intermittent hypoxia. 补充l -精氨酸可减轻慢性间歇缺氧雌性大鼠卵巢氧化应激。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-22 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00257

Amira Abdel-Rhman, Wessam Morsy, Nermeen Selim, Enas A Abdel-Hady

{"title":"L-arginine supplementation attenuates ovarian oxidative stress in female rats subjected to chronic intermittent hypoxia.","authors":"Amira Abdel-Rhman, Wessam Morsy, Nermeen Selim, Enas A Abdel-Hady","doi":"10.1556/2060.2023.00257","DOIUrl":"10.1556/2060.2023.00257","url":null,"abstract":"Background: Systemic and organ-specific oxidative stress triggered by hypoxia is suggested to play a key role in germ cell apoptosis and DNA damage. This study was designed to investigate the impact of chronic intermittent hypoxia (CIH) on female fertility and evaluate the potential antioxidant effect of L-arginine (L-Arg) supplementation.Methods: Adult female rats were allocated into three groups: controls (normoxic), hypoxic and hypoxic supplemented with L-Arg. After 12 weeks; hematocrit value was determined, body weight (BW) and ovarian weight were measured for the calculation of the gonado-somatic index. Plasma levels of luteinizing hormone (LH) and progesterone were estimated. Ovarian tissue malondialdehyde (MDA) and catalase were assessed, and caspase-3 enzyme expression was detected by immunohistochemistry.Results: Compared to controls, CIH resulted in increased oxidative stress in the ovarian tissue, decreased ovarian weight, and increased frequency of irregular cycles and higher plasma level of LH in rats with either regular or irregular ovarian cycles. Histological examination of ovarian sections revealed areas of degeneration, atretic follicles, interstitial edema, congested vessels and inflammatory cell infiltration. Immunohistochemistry confirmed the presence of apoptosis by increased caspase-3 expression. Hypoxic rats pre-treated with L-Arg showed increased BW and ovarian weight, decreased ovarian tissue MDA and plasma LH accompanied by a lower incidence of irregular cycles and mortality. The histological picture was improved and caspase-3 expression was reduced.Conclusion: Oxidative stress caused by CIH is detrimental to the structure and function of the corpus luteum with an increased risk of reduced fertility. L-Arg supplementation increases antioxidant capacity and improves hypoxia-induced fertility disorders.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"326-341"},"PeriodicalIF":1.4,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension. 毛细血管前肺动脉高压的循环apelin、IL22RA2和VEGF。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-17 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00264

Györgyi Csósza, Gergő Szűcs, Zsolt Rozgonyi, Balázs Csoma, György Losonczy, Veronika Müller, Kristóf Karlócai, Zsófia Lázár

{"title":"Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.","authors":"Györgyi Csósza, Gergő Szűcs, Zsolt Rozgonyi, Balázs Csoma, György Losonczy, Veronika Müller, Kristóf Karlócai, Zsófia Lázár","doi":"10.1556/2060.2023.00264","DOIUrl":"10.1556/2060.2023.00264","url":null,"abstract":"Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = -0.34, P = 0.04), and right ventricular stroke work index (r = -0.47, P = 0.003). IL22RA2 concentration correlated with mean PAP (r = -0.32, P = 0.04) and serum N-terminal pro B-type natriuretic peptide level (r = -0.42, P = 0.01). VEGF concentration increased in patients upon clinical improvement (N = 16, P = 0.02). Circulating apelin is a novel biomarker of pre-capillary PH. Apelin and IL22RA2 levels are related to right ventricular function upon diagnosis of PH.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"356-370"},"PeriodicalIF":1.4,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the acute illness: Exploring long COVID and its impact on multiple organ systems. 超越急性疾病：探索长期新冠肺炎及其对多器官系统的影响。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-09 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00256

Nandini Bhattacharjee, Parantap Sarkar, Tania Sarkar

{"title":"Beyond the acute illness: Exploring long COVID and its impact on multiple organ systems.","authors":"Nandini Bhattacharjee, Parantap Sarkar, Tania Sarkar","doi":"10.1556/2060.2023.00256","DOIUrl":"10.1556/2060.2023.00256","url":null,"abstract":"Unprecedented worldwide health catastrophe due to the COVID-19 pandemic has ended up resulting in high morbidity and mortality rates. Even though many people recover from acute infection, there is rising concern regarding post-COVID-19 conditions (PCCs), often referred to as post-acute sequelae of SARS-CoV-2 infection (PASC) or \"long COVID.\" The respiratory, cardiovascular, neurological, and endocrine systems are just a few of the many organ systems that can be impacted by this multifarious, complicated illness. The clinical manifestations of long COVID can vary among individuals and may include fatigue, dyspnea, chest pain, cognitive impairment, and new-onset diabetes, among others. Although the underlying processes of long COVID are not fully understood, they probably involve unregulated immune response, persistent generation of pro-inflammatory cytokines (chronic inflammation), autoimmune-like reactions, persistent viral replication, and micro-clot formation. To create successful treatments and care plans, it is essential to comprehend the immunological mechanisms causing these difficulties. The pathogenesis of long COVID should be clarified and potential biomarkers to help with diagnosis and treatment should be sought after. To reduce the burden of long COVID on people and healthcare systems around the world, the need for long-term monitoring and management of long COVID problems should be emphasized. It also underscores the significance of a multidisciplinary approach to patient care. The goal of this review is to carefully evaluate the clinical signs and symptoms of long COVID, their underlying causes, and any potential immunological implications.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"291-310"},"PeriodicalIF":1.4,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71522261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination. ATXN3通过调节S100A8泛素化促进透明细胞肾癌细胞的增殖、干性和运动性。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-08 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00247

Jixiang Bai, Jieru Han, Jiayi Fan, Jing Song, Shuhui Wang

{"title":"ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination.","authors":"Jixiang Bai, Jieru Han, Jiayi Fan, Jing Song, Shuhui Wang","doi":"10.1556/2060.2023.00247","DOIUrl":"10.1556/2060.2023.00247","url":null,"abstract":"Background: Clear cell renal cell carcinoma (ccRCC) is a dominant subtype of kidney cancer with a dismal outcome at advanced stages. Ataxin 3 (ATXN3) has been proven to play a cancer-promoting role in several tumors and is upregulated in the patients with renal cell carcinoma. Thus, the objective of this research is to examine the biological roles and underlying mechanisms of ATXN3 in ccRCC.Methods: Bioinformatics analysis was carried out to analyze ATXN3 expression in ccRCC tissues and patient survival. Gain- and loss-of-function assays were applied to explore the effect of ATXN3 on ccRCC cell malignant behavior in vitro. The effect of ATXN3 on the NF-κB pathway was assessed by Western blot and immunofluorescence staining. The binding between ATXN3 and S100A8 and the effect of ATXN3 on S100A8 ubiquitination were verified using coimmunoprecipitation.Results: ATXN3 was upregulated in ccRCC tissues and correlated with adverse patient outcome. ATXN3 overexpression facilitated the proliferation, stemness, invasion and migratory capacity of ccRCC cells, whereas silencing had the opposite effect. ATXN3 enhanced the activity of the NF-κB pathway. Silencing ATXN3 facilitated S100A8 ubiquitination. Rescue experiments demonstrated that S100A8 downregulation reversed the promoting effect of ATXN3 on malignant behavior and NF-κB pathway activation in ccRCC cells.Conclusion: ATXN3 exerts a cancer-promoting effect in ccRCC by regulating S100A8 ubiquitination. Therefore, targeting the ATXN3/S100A8/NF-κB axis may provide a novel underlying therapeutic strategy for ccRCC.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"311-325"},"PeriodicalIF":1.4,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stent composition and immune response after long-term coronary angioplasty. 支架成分与长期冠状动脉血管成形术后的免疫反应。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-07 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00162

Viviane A R Sant'Anna, Adriano H P Barbosa, Rodrigo A Souza, José M A Sousa, Frederico Monfardini, Magnus Gidlund, Henrique A R Fonseca

{"title":"Stent composition and immune response after long-term coronary angioplasty.","authors":"Viviane A R Sant'Anna, Adriano H P Barbosa, Rodrigo A Souza, José M A Sousa, Frederico Monfardini, Magnus Gidlund, Henrique A R Fonseca","doi":"10.1556/2060.2023.00162","DOIUrl":"10.1556/2060.2023.00162","url":null,"abstract":"Background: There are limited data about the influence of stent composition on immune responses after percutaneous coronary intervention (PCI).Objective: The aim was to compare the effects of PCI with conventional cobalt-chromium bare metal stent (BMS) and drug-eluting stent (DES) implantation on the modulation of humoral and cellular immune responses.Methods: A randomised, single-centre, open pilot study involving patients with stable coronary artery disease eligible for PCI was performed. Blood samples were collected from the peripheral artery (PA) and the coronary sinus (CS) at baseline and 40 weeks following PCI. IgM and IgG autoantibodies (Abs), anti-oxLDL and anti-ApoB-D, as well as cytokine levels were evaluated by enzyme-linked immunosorbent assay.Results: A total of 30 patients of 60 years mean age were included, 68% of whom were men. At the nine-month follow-up, a modulation in the levels of cytokines and autoantibodies was observed in both stent type groups. However, no difference was observed in the modulation of these markers between stents.Conclusion: The stent type promotes modulations in cellular and humoral immune responses in the long-term, with differences in the magnitude of effects in specific immune responses.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":" ","pages":"371-384"},"PeriodicalIF":1.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of an mHealth intervention on diabetes risk factors and body composition 移动健康干预对糖尿病危险因素和身体成分的有效性

4区医学

Physiology international Pub Date : 2023-10-12 DOI: 10.1556/2060.2023.00209

Georgina Simkó, Martina Uvacsek

{"title":"The effectiveness of an mHealth intervention on diabetes risk factors and body composition","authors":"Georgina Simkó, Martina Uvacsek","doi":"10.1556/2060.2023.00209","DOIUrl":"https://doi.org/10.1556/2060.2023.00209","url":null,"abstract":"Abstract Early identification and lifestyle intervention is beneficial for people with risk for diabetes. The aim of this study was to evaluate the risk of type 2 diabetes (T2D) in healthy overweight or obese women using the FINDRISC score and a twelve-week long mobile app-based lifestyle intervention. Fifty-four subjects were involved and forty-eight were analysed, n = 28 in the intervention group (online group: OG) and n = 20 in the control group (CG). Body composition was assessed using the InBody 720 device and diabetes risk was evaluated with the Finnish Diabetes Risk Questionnaire. The calorie intake and macronutrients were evaluated by a 3-day diary. Group differences and pre- and post-results were analysed using student t -tests by TIBCO Statistica 13.40.14. Significantly decreased body mass index (28.0 ± 2.5 kg m −2 vs 25.8 ± 4.3 kg m −2 , P = 0.00), body fat percentage (37.5 ± 6.3% vs 34.1 ± 5.9%, P = 0.03), waist circumference (100.8 ± 7.2 cm vs 94.7 ± 8.2 cm, P = 0.00) and visceral fat (124.0 ± 29.2 cm³ vs 109.0 ± 24.6 cm³, P = 0.04) were found in the OG. By the end of the programme, both groups showed significant decrease in food consumption, daily calorie intake (OG: 2,348.6 ± 348.0 vs 1,483.1 ± 114.4, CG: 2,372.4 ± 464.2 vs 1,654.1 ± 201.3 kcal day −1 , P = 0.00), fibre (OG: 19.5 ± 3.7 vs 26.1 ± 3.4, CG: 17.8 ± 3.9 vs 22.0 ± 4.8 g day −1 , P = 0.00) and cholesterol consumption (OG: 365.2 ± 58.9 vs 266.2 ± 65.8, CG: 377.4 ± 72.1 vs 269.2 ± 42.7 mg day −1 , P = 0.00). OG had a more significant reduction in body mass index ( P = 0.03) and body fat percentage ( P = 0.04) values at the end of the programme compared to the control group. In this study, it was found that mHealth intervention is a useful and effective method in the Hungarian female population. Further studies are needed to investigate modifications of this intervention to achieve more health-related effects.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal changes in the first 24 postoperative hours after cardiac surgical procedures. 心脏外科手术后24小时内的激素变化。

IF 1.4 4区医学

Physiology international Pub Date : 2023-09-05 DOI: 10.1556/2060.2023.00219

Balázs Szécsi, Krisztina Tóth, András Szabó, Csaba Eke, Rita Szentgróti, Orsolya Dohán, Kálmán Benke, Tamás Radovits, Miklós Pólos, Béla Merkely, János Gál, Andrea Székely

{"title":"Hormonal changes in the first 24 postoperative hours after cardiac surgical procedures.","authors":"Balázs Szécsi, Krisztina Tóth, András Szabó, Csaba Eke, Rita Szentgróti, Orsolya Dohán, Kálmán Benke, Tamás Radovits, Miklós Pólos, Béla Merkely, János Gál, Andrea Székely","doi":"10.1556/2060.2023.00219","DOIUrl":"https://doi.org/10.1556/2060.2023.00219","url":null,"abstract":"Background: Hormone level changes after heart surgeries are a widely observed phenomenon due to neurohormonal feedback mechanisms that may affect postoperative morbidity and mortality. The current study aimed to analyze the changes in thyroid and sex hormones in the first 24 postoperative hours after heart surgery.Methods: This prospective, observational study (registered on ClinicalTrials.gov: NCT03736499; 09/11/2018) included 49 patients who underwent elective cardiac surgical procedures at a tertiary heart center between March 2019 and December 2019. Thyroid hormones, including thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and sex hormones, including prolactin (PRL) and total testosterone, were measured preoperatively and at 24 h postoperatively.Results: Significant decreases in serum TSH (P < 0.001), T3 (P < 0.001) and total testosterone (P < 0.001) levels were noted, whereas T4 (P = 0.554) and PRL (P = 0.616) did not significantly change. Intensive care unit (ICU) hours (P < 0.001), mechanical ventilation (P < 0.001) and Vasoactive-Inotropic Score (VIS) (P = 0.006) were associated with postoperative T3 level. ICU hours were associated with postoperative T4 level (P = 0.028). Postoperative and delta testosterone levels were in connection with lengths of stay in ICU (P = 0.032, P = 0.010 respectively). Model for End-Stage Liver Disease (MELD) scores were associated with thyroid hormone levels and serum testosterone.Conclusions: T3 may represent a marker of nonthyroidal illness syndrome and testosterone may reflect hepatic dysfunction. In addition, PRL may act as a stress hormone in female patients.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"110 3","pages":"251-266"},"PeriodicalIF":1.4,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10161914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Academic stress, hair and saliva cortisol, and their relationship with body mass index and fat percentage in first year medical students. 一年级医学生学业压力、毛发和唾液皮质醇及其与体重指数和脂肪率的关系

IF 1.4 4区医学

Physiology international Pub Date : 2023-09-05 DOI: 10.1556/2060.2023.00178

Emilio Romero-Romero, Estela Guerreo De León, Juan Morán-Pinzón, Rigoberto Salado-Castillo, Armando Castillo-Pimentel

{"title":"Academic stress, hair and saliva cortisol, and their relationship with body mass index and fat percentage in first year medical students.","authors":"Emilio Romero-Romero, Estela Guerreo De León, Juan Morán-Pinzón, Rigoberto Salado-Castillo, Armando Castillo-Pimentel","doi":"10.1556/2060.2023.00178","DOIUrl":"https://doi.org/10.1556/2060.2023.00178","url":null,"abstract":"Introduction\u0000Although a large part of the population may be exposed to various pressures that can lead to mental or eating problems and increased perceived stress, the transition from adolescence to adulthood has been shown to be a crucial stage. Medical students are particularly vulnerable during the transition period as they must adapt to new circumstances, which may contribute to increased perceived stress. Cortisol plays an important role between stress, weight gain, and the development of obesity. We designed a study to investigate the association between stress, eating behaviour, cortisol, and body weight in a sample of first-year medical students.\u0000\u0000\u0000Methods\u0000We determined 75 first-year medical students' hair and salivary cortisol concentrations by ELISA and related it to self-reported stress, eating behaviour, and anthropometric measurements throughout the academic period. The prevalence of overweight and obesity in females was 25% and 10%, and in males was 35% and 6%, respectively. We report an increase in hair cortisol, higher self-reported stress scores, and BMI mainly in females. Finally, we found evidence of positive associations between hair cortisol and BMI in females (r = 0.348) and males (r = 0.423).\u0000\u0000\u0000Conclusion\u0000There is a low association between short-term single-point cortisol measures and long-term cortisol, mainly in males. Hence, short-term cortisol reactivity is moderately associated with long-term cortisol reactivity when both are evaluated simultaneously. These results support the previous evidence of positive associations between cortisol with body fat percentage and BMI, and finally, that eating behaviours are modified by academic stress perception, mainly in females.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"110 3","pages":"277-290"},"PeriodicalIF":1.4,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1