Physiology international最新文献_第10页

Differences in cardiorespiratory responses of young and senior male endurance athletes to maximal graded exercise test. 青年和老年男性耐力运动员心肺反应对最大分级运动试验的差异。

IF 1.4 4区医学

Physiology international Pub Date : 2020-09-29 Print Date: 2020-10-17 DOI: 10.1556/2060.2020.00032

M Michalis, K J Finn, R Podstawski, S Gabnai, Á Koller, A Cziráki, M Szántó, Z Alföldi, F Ihász

{"title":"Differences in cardiorespiratory responses of young and senior male endurance athletes to maximal graded exercise test.","authors":"M Michalis, K J Finn, R Podstawski, S Gabnai, Á Koller, A Cziráki, M Szántó, Z Alföldi, F Ihász","doi":"10.1556/2060.2020.00032","DOIUrl":"https://doi.org/10.1556/2060.2020.00032","url":null,"abstract":"Within recent years the popularity of sportive activities amongst older people, particularly competitive activities within certain age groups has increased. The purpose of this study was to assess the differences in the cardiorespiratory output at anaerobic threshold and at maximal power, output during an incremental exercise, among senior and young athletes. Ten elderly male subjects [mean (SD) age: 68.45 ± 9.32 years] and eight young male subjects [mean (SD) age: 25.87 ± 5.87 years] performed an incremental exercise test on a treadmill ergometer. No significant differences in body size were evident; however, the differences between the groups for peak power (451.62 ± 49 vs. 172.4 ± 32.2 W), aerobic capacity (57.97 ± 7.5 vs. 40.36 ± 8.6 mL kg-1 min-1), maximal heart rate (190.87 ± 9.2 vs. 158.5 ± 9.1 beats min-1), peak blood lactate (11 ± 1.7 vs. 7.3 ± 1.4 mmol L-1), and % VO2max at ventilatory thresholds (93.18 ± 4.3 vs. 79.29 ± 9.9%) were significantly lower in the senior athletes. The power output at anaerobic threshold was also higher (392 ± 48 vs. 151 ± 23 W) in the young athletes, explaining the significant difference in terms of performance between these groups. We have observed an evident deterioration in some of the cardiovascular parameters; however, the submaximal exercise economy seems to be preserved with aging. Exercise economy (i.e. metabolic cost of sustained submaximal exercise) was not different considerably with age in endurance-trained adults.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 3","pages":"444-454"},"PeriodicalIF":1.4,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Experimental effects of acute exercise on forgetting. 急性运动对遗忘的实验影响。

IF 1.4 4区医学

Physiology international Pub Date : 2020-09-29 Print Date: 2020-10-17 DOI: 10.1556/2060.2020.00033

D C Moore, S Ryu, P D Loprinzi

{"title":"Experimental effects of acute exercise on forgetting.","authors":"D C Moore, S Ryu, P D Loprinzi","doi":"10.1556/2060.2020.00033","DOIUrl":"https://doi.org/10.1556/2060.2020.00033","url":null,"abstract":"Objective: Prior research has evaluated the effects of acute exercise on episodic memory function. These studies have, on occasion, demonstrated that acute exercise may enhance both short- and long-term memory. It is uncertain as to whether the acute exercise improvements in long-term memory are a result of acute exercise attenuating declines in long-term memory, or rather, are driven by the enhancement effects of acute exercise on short-term memory. The present empirical study evaluates whether the decline from short- to long-term is influenced by acute exercise. This relationship is plausible as exercise has been shown to activate neurophysiological pathways (e.g., RAC1) that are involved in the mechanisms of forgetting.Methods: To evaluate the effects of acute exercise on forgetting, we used data from 12 of our laboratory's prior experiments (N = 538). Across these 12 experiments, acute exercise ranged from 10 to 15 mins in duration (moderate-to-vigorous intensity). Episodic memory was assessed from word-list or paragraph-based assessments. Short-term memory was assessed immediately after encoding, with long-term memory assessed approximately 20-min later. Forgetting was calculated as the difference in short- and long-term memory performance.Results: Acute exercise (vs. seated control) was not associated with an attenuated forgetting effect (d = 0.10; 95% CI: -0.04, 0.25, P = 0.17). We observed no evidence of a significant moderation effect (Q = 6.16, df = 17, P = 0.17, I2 = 0.00) for any of the evaluated parameters, including study design, exercise intensity and delay period.Conclusion: Across our 12 experimental studies, acute exercise was not associated with an attenuated forgetting effect. We discuss these implications for future research that evaluates the effects of acute exercise on long-term memory function.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 3","pages":"359-375"},"PeriodicalIF":1.4,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway. 胰岛素通过Akt/mTORC2通路对近端小管H+- atp酶的刺激作用

IF 1.4 4区医学

Physiology international Pub Date : 2020-09-29 Print Date: 2020-10-17 DOI: 10.1556/2060.2020.00030

M Nakamura, N Satoh, H Tsukada, T Mizuno, W Fujii, A Suzuki, S Horita, M Nangaku, M Suzuki

{"title":"Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway.","authors":"M Nakamura, N Satoh, H Tsukada, T Mizuno, W Fujii, A Suzuki, S Horita, M Nangaku, M Suzuki","doi":"10.1556/2060.2020.00030","DOIUrl":"https://doi.org/10.1556/2060.2020.00030","url":null,"abstract":"Purpose: Acid-base transport in renal proximal tubules (PTs) is mainly sodium-dependent and conducted in coordination by the apical Na+/H+ exchanger (NHE3), vacuolar H+-adenosine triphosphatase (V-ATPase), and the basolateral Na+/HCO3- cotransporter. V-ATPase on PTs is well-known to play an important role in proton excretion. Recently we reported a stimulatory effect of insulin on these transporters. However, it is unclear whether insulin is involved in acid-base balance in PTs. Thus, we assessed the role of insulin in acid-base balance in PTs.Methods: V-ATPase activity was evaluated using freshly isolated PTs obtained from mice, and specific inhibitors were then used to assess the signaling pathways involved in the observed effects.Results: V-ATPase activity in PTs was markedly enhanced by insulin, and its activation was completely inhibited by bafilomycin (a V-ATPase-specific inhibitor), Akt inhibitor VIII, and PP242 (an mTORC1/2 inhibitor), but not by rapamycin (an mTORC1 inhibitor). V-ATPase activity was stimulated by 1 nm insulin by approximately 20% above baseline, which was completely suppressed by Akt1/2 inhibitor VIII. PP242 completely suppressed the insulin-mediated V-ATPase stimulation in mouse PTs, whereas rapamycin failed to influence the effect of insulin. Insulin-induced Akt phosphorylation in the mouse renal cortex was completely suppressed by Akt1/2 inhibitor VIII and PP242, but not by rapamycin.Conclusion: Our results indicate that stimulation of V-ATPase activity by insulin in PTs is mediated via the Akt2/mTORC2 pathway. These results reveal the mechanism underlying the complex signaling in PT acid-base balance, providing treatment targets for renal disease.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 3","pages":"376-389"},"PeriodicalIF":1.4,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis. 运动、臭氧和间充质干细胞联合治疗可改善膝骨关节炎大鼠软骨组织中HIF1和SOX9的表达。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00024

Sara Asadi, Parvin Farzanegi, Mohammad Ali Azarbayjani

{"title":"Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis.","authors":"Sara Asadi, Parvin Farzanegi, Mohammad Ali Azarbayjani","doi":"10.1556/2060.2020.00024","DOIUrl":"https://doi.org/10.1556/2060.2020.00024","url":null,"abstract":"Purpose: Knee osteoarthritis (OA) is a common type of degenerative joint disease which decreases the quality of life. Sex-determining region Y box 9 (SOX9) and hypoxia-inducible factor-1 (HIF1) are considered as the key regulators of OA. We investigated the effect of combined therapies with mesenchymal stem cells (MSCs), ozone (O3) and exercise training on SOX9 and HIF1 expression in the cartilage of rats with knee OA.Methods: Knee OA was induced by surgical method. OA rats were divided into model, MSCs, ozone, exercise, MSCs + ozone, MSCs + exercise, ozone + exercise and MSCs + ozone + exercise groups. Rats in the MSCs group received intraarticular injection of 1 × 106 cells/kg. Rats in the ozone group received O3 at the concentration of 20 μg/mL, once weekly for 3 weeks. Rats in the exercise group were trained on rodent treadmill three times per week. 48 hours after the programs, cartilage tissues were isolated and the expression of SOX9 and HIF1 was determined using Real-Time PCR.Results: Significant differences were found in the expression of SOX9 and HIF1 between groups (P < 0.0001). Although combined therapies with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 in the cartilage tissue of rats with knee OA, combination of exercise with O3 was significantly more effective compared to the other combined therapies (P < 0.001).Conclusions: Combined therapy with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 genes in the cartilage of rats with knee OA; however, exercise + O3 was significantly more effective.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"231-242"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Salivary dysfunction caused by medication usage. 药物使用引起的唾液功能障碍。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00019

O M Einhorn, K Georgiou, A Tompa

引用次数: 14

Aspirin protects human coronary artery endothelial cells by inducing autophagy. 阿司匹林通过诱导自噬保护人冠状动脉内皮细胞。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00029

J Chen, L Wang, W H Liu, J Shi, Y Zhong, S J Liu, S M Liu

{"title":"Aspirin protects human coronary artery endothelial cells by inducing autophagy.","authors":"J Chen, L Wang, W H Liu, J Shi, Y Zhong, S J Liu, S M Liu","doi":"10.1556/2060.2020.00029","DOIUrl":"https://doi.org/10.1556/2060.2020.00029","url":null,"abstract":"Although the use of aspirin has substantially reduced the risks of cardiovascular events and death, its potential mechanisms have not been fully elucidated. In a previous study, we found that aspirin triggers cellular autophagy. In the present study, we aimed to determine the protective effects of aspirin on human coronary artery endothelial cells (HCAECs) and explore its underlying mechanisms. HCAECs were treated with oxidized low-density lipoprotein (ox-LDL), angiotensin II (Ang-II), or high glucose (HG) with or without aspirin stimulation. The expression levels of endothelial nitric oxide (NO) synthase (eNOS), p-eNOS, LC3, p62, phosphor-nuclear factor kappa B (p-NF-κB), p-p38 mitogen-activated protein kinase (p-p38 MAPK), and Beclin-1 were detected via immunoblotting analysis. Concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured via ELISA. NO levels were determined using the Griess reagent. Autophagic flux was tracked by tandem mRFP-GFP-tagged LC3. Results showed that aspirin increased eNOS level and reduced injury to the endothelial cells (ECs) caused by ox-LDL, Ang-II, and HG treatment in a dose-dependent manner. Aspirin also increased the LC3II/LC3I ratio, decreased p62 expression, and enhanced autophagic flux (autophagosome and autolysosome puncta) in the HCAECs. p-NF-κB and p-p38 mitogen-activated protein kinase inhibition, sVCAM-1 and sICAM-1 secretion, and eNOS activity promotion by aspirin treatment were found to be dependent on Beclin-1. These results suggested that aspirin can protect ECs from ox-LDL-, Ang-II-, and HG-induced injury by activating autophagy in a Beclin-1-dependent manner.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"294-305"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prenatal urban traffic noise exposure impairs spatial learning and memory and reduces glucocorticoid receptor expression in the hippocampus of male rat offspring. 产前城市交通噪声暴露损害雄性大鼠后代的空间学习和记忆，降低海马糖皮质激素受体的表达。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00022

F S Sajjadi, F Aghighi, Z Vahidinia, A Azami-Tameh, M Salami, S A Talaei

{"title":"Prenatal urban traffic noise exposure impairs spatial learning and memory and reduces glucocorticoid receptor expression in the hippocampus of male rat offspring.","authors":"F S Sajjadi, F Aghighi, Z Vahidinia, A Azami-Tameh, M Salami, S A Talaei","doi":"10.1556/2060.2020.00022","DOIUrl":"https://doi.org/10.1556/2060.2020.00022","url":null,"abstract":"Introduction\u0000Exposure to noise stress during early life may permanently affect the structure and function of the central nervous system. The aim of this study was to evaluate the effects of prenatal exposure to urban traffic noise on the spatial learning and memory of the rats' offspring and the expression of glucocorticoid receptors (GRs) in their hippocampi.\u0000\u0000\u0000Methods\u0000Three groups of pregnant rats were exposed to recorded urban traffic noise for 1, 2 or 4 h/day during the last week of pregnancy. At the age of 45 days, their male offspring were introduced to the Morris water maze (MWM) for assessment of spatial learning and memory. The corticosterone levels were measured in the offspring's sera by radioimmunoassay, and the relative expression of glucocorticoid and mineralocorticoid receptors (MRs) in their hippocampi was evaluated via RT-PCR.\u0000\u0000\u0000Results\u0000Facing urban traffic noise for 2 and 4 h/day during the third trimester of pregnancy caused the offspring to spend more time and to travel a larger distance than the controls to find the target platform. Analogously, these two groups were inferior to their control counterparts in the probe test. Also, prenatal noise stress elevated the corticosterone concentration in the sera of the rats' offspring and dose-dependently decreased the relative expression of the mRNA of both GRs and MRs in their hippocampi.\u0000\u0000\u0000Conclusions\u0000Urban traffic noise exposure during the last trimester of pregnancy impairs spatial learning and memory of rat offspring and reduces GRs and MRs gene expression in the hippocampus.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"209-219"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The role of age in post-cardiac arrest therapy in an elderly patient population. 年龄在老年患者心脏骤停后治疗中的作用。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-20 DOI: 10.1556/2060.2020.00027

E Kovács, D Pilecky, Z Szakál-Tóth, A Fekete-Győr, V A Gyarmathy, L Gellér, B Hauser, J Gál, B Merkely, E Zima

{"title":"The role of age in post-cardiac arrest therapy in an elderly patient population.","authors":"E Kovács, D Pilecky, Z Szakál-Tóth, A Fekete-Győr, V A Gyarmathy, L Gellér, B Hauser, J Gál, B Merkely, E Zima","doi":"10.1556/2060.2020.00027","DOIUrl":"https://doi.org/10.1556/2060.2020.00027","url":null,"abstract":"Aim: We investigated the effect of age on post-cardiac arrest treatment outcomes in an elderly population, based on a local database and a systemic review of the literature.Methods: Data were collected retrospectively from medical charts and reports. Sixty-one comatose patients, cooled to 32-34 °C for 24 h, were categorized into three groups: younger group (≤65 years), older group (66-75 years), and very old group (>75 years). Circumstances of cardiopulmonary resuscitation (CPR), patients' characteristics, post-resuscitation treatment, hemodynamic monitoring, neurologic outcome and survival were compared across age groups. Kruskal-Wallis test, Chi-square test and binary logistic regression (BLR) were applied. In addition, a literature search of PubMed/Medline database was performed to provide a background.Results: Age was significantly associated with having a cardiac arrest on a monitor and a history of hypertension. No association was found between age and survival or neurologic outcome. Age did not affect hemodynamic parameter changes during target temperature management (TTM), except mean arterial pressure (MAP). Need of catecholamine administration was the highest among very old patients. During the literature review, seven papers were identified. Most studies had a retrospective design and investigated interventions and outcome, but lacked unified age categorization. All studies reported worse survival in the elderly, although old survivors showed a favorable neurologic outcome in most of the cases.Conclusion: There is no evidence to support the limitation of post-cardiac arrest therapy in the aging population. Furthermore, additional prospective studies are needed to investigate the characteristics and outcome of post-cardiac arrest therapy in this patient group.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"319-336"},"PeriodicalIF":1.4,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38183965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Growth factors in pulmonary arterial hypertension: Focus on preserving right ventricular function. 生长因子在肺动脉高压中的作用:重点保护右心室功能。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00021

G Csósza, K Karlócai, G Losonczy, V Müller, Z Lázár

引用次数: 4

The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism. 肥胖抑制素对消炎痛引起的急性溃疡的胃保护作用是通过迷走神经机制介导的。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00025

Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen

{"title":"The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism.","authors":"Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen","doi":"10.1556/2060.2020.00025","DOIUrl":"https://doi.org/10.1556/2060.2020.00025","url":null,"abstract":"In order to investigate the role of the vagus nerve in the possible gastroprotective effect of obestatin on the indomethacin-induced acute oxidative gastric injury, Sprague-Dawley rats of both sexes were injected subcutaneously with indomethacin (25 mg/kg, 5% NaHCO3) followed by obestatin (10, 30 or 100 μg/kg). In other sets of rats, surgical vagotomy (Vx) or selective degeneration of vagal afferent fibers by perivagal capsaicin was performed before the injections of indomethacin or indomethacin + obestatin (30 μg/kg). Gastric serosal blood flow was measured, and 4 h after ulcer induction gastric tissue samples were taken for histological and biochemical assays. Obestatin reduced the severity of indomethacin-induced acute ulcer via the reversal of reactive hyperemia, by inhibiting ulcer-induced neutrophil infiltration and lipid peroxidation along with the replenishment of glutathione (GSH) stores, whereas Vx abolished the inhibitory effect of obestatin on blood flow and lipid peroxidation, and worsened the severity of ulcer. On the other hand, serosal blood flow was even amplified by the selective denervation of the capsaicin-sensitive vagal afferent fibers, but obestatin-induced reduction in ulcer severity was not altered. In conclusion, the gastroprotective effect of obestatin on indomethacin-induced ulcer appears to involve the activation of the vagovagal pathway.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"243-255"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2