Physiology international最新文献_第10页

The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism. 肥胖抑制素对消炎痛引起的急性溃疡的胃保护作用是通过迷走神经机制介导的。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00025

Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen

{"title":"The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism.","authors":"Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen","doi":"10.1556/2060.2020.00025","DOIUrl":"https://doi.org/10.1556/2060.2020.00025","url":null,"abstract":"In order to investigate the role of the vagus nerve in the possible gastroprotective effect of obestatin on the indomethacin-induced acute oxidative gastric injury, Sprague-Dawley rats of both sexes were injected subcutaneously with indomethacin (25 mg/kg, 5% NaHCO3) followed by obestatin (10, 30 or 100 μg/kg). In other sets of rats, surgical vagotomy (Vx) or selective degeneration of vagal afferent fibers by perivagal capsaicin was performed before the injections of indomethacin or indomethacin + obestatin (30 μg/kg). Gastric serosal blood flow was measured, and 4 h after ulcer induction gastric tissue samples were taken for histological and biochemical assays. Obestatin reduced the severity of indomethacin-induced acute ulcer via the reversal of reactive hyperemia, by inhibiting ulcer-induced neutrophil infiltration and lipid peroxidation along with the replenishment of glutathione (GSH) stores, whereas Vx abolished the inhibitory effect of obestatin on blood flow and lipid peroxidation, and worsened the severity of ulcer. On the other hand, serosal blood flow was even amplified by the selective denervation of the capsaicin-sensitive vagal afferent fibers, but obestatin-induced reduction in ulcer severity was not altered. In conclusion, the gastroprotective effect of obestatin on indomethacin-induced ulcer appears to involve the activation of the vagovagal pathway.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"243-255"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cerebral and peripheral muscle oxygenation and perfusion: Course in moderate and late preterm neonates during the first day after birth. 脑和周围肌肉氧合和灌注:中晚期早产儿出生后第一天的病程。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00028

N Hoeller, N Baik-Schneditz, B Schwaberger, L Mileder, B Urlesberger, G Pichler

{"title":"Cerebral and peripheral muscle oxygenation and perfusion: Course in moderate and late preterm neonates during the first day after birth.","authors":"N Hoeller, N Baik-Schneditz, B Schwaberger, L Mileder, B Urlesberger, G Pichler","doi":"10.1556/2060.2020.00028","DOIUrl":"https://doi.org/10.1556/2060.2020.00028","url":null,"abstract":"Aim: To investigate the ratio of cerebral tissue oxygenation index (cTOI) to peripheral muscle tissue oxygenation index (pTOI) measured by near-infrared spectroscopy (NIRS) in cardio-circulatory stable preterm neonates without signs of inflammation/infection on the first day after birth.Methods: Observational study analysing secondary outcome parameters of the 'Avoiding Hypotension in Preterm Neonates (AHIP)' trial (ClinicalTrials.gov identifier: NCT01910467). Preterm neonates, who had cTOI and pTOI measurements during 24 h after birth, were included. In each neonate the mean of the cTOI/pTOI-ratio, cTOI, pTOI and routine monitoring parameters were calculated for each hour and for the 24-h measuring period. Courses of all measured parameters were analysed.Results: Eighty-seven stable preterm neonates (33.1 [32.1-34.1] weeks of gestation) were included. The mean value over the 24-h measuring period for the cTOI/pTOI-ratio was 0.96 ± 0.02, for cTOI 70.1 ± 1.4 and for pTOI 73.4 ± 0.9. Routine monitoring parameters were in the normal ranges over 24 h. The courses of the cTOI/pTOI-ratio and cTOI showed significantly lower values from hour 5 to 15 compared to the first hours after birth. Heart rate decreased significantly over time, whereas mean arterial blood pressure increased significantly. pTOI, arterial oxygen saturation and body temperature showed no significant change over time.Conclusion: We are the first to report on cTOI/pTOI-ratios for cardio-circulatory stable preterm neonates over a 24-h period after birth, showing significantly lower values from hour 5 to 15 compared to the first hours after birth.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"267-279"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma. 大肠杆菌赖氨酸脱羧酶(LdcC)在e -钙粘蛋白阴性的小叶乳腺癌中表达下调。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00016

Zs Sári, T Kovács, T Csonka, M Török, É Sebő, J Toth, D Tóth, E Mikó, B Kiss, D Szeőcs, K Uray, Zs Karányi, I Kovács, G Méhes, P Árkosy, P Bai

{"title":"Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma.","authors":"Zs Sári, T Kovács, T Csonka, M Török, É Sebő, J Toth, D Tóth, E Mikó, B Kiss, D Szeőcs, K Uray, Zs Karányi, I Kovács, G Méhes, P Árkosy, P Bai","doi":"10.1556/2060.2020.00016","DOIUrl":"https://doi.org/10.1556/2060.2020.00016","url":null,"abstract":"Breast cancer is characterized by oncobiosis, the abnormal composition of the microbiome in neoplastic diseases. The biosynthetic capacity of the oncobiotic flora in breast cancer is suppressed, as suggested by metagenomic studies. The microbiome synthesizes a set of cytostatic and antimetastatic metabolites that are downregulated in breast cancer, including cadaverine, a microbiome metabolite with cytostatic properties. We set out to assess how the protein expression of constitutive lysine decarboxylase (LdcC), a key enzyme for cadaverine production, changes in the feces of human breast cancer patients (n = 35). We found that the fecal expression of Escherichia coli LdcC is downregulated in lobular cases as compared to invasive carcinoma of no special type (NST) cases. Lobular breast carcinoma is characterized by low or absent expression of E-cadherin. Fecal E. coli LdcC protein expression is downregulated in E-cadherin negative breast cancer cases as compared to positive ones. Receiver operating characteristic (ROC) analysis of LdcC expression in lobular and NST cases revealed that fecal E. coli LdcC protein expression might have predictive values. These data suggest that the oncobiotic transformation of the microbiome indeed leads to the downregulation of the production of cytostatic and antimetastatic metabolites. In E-cadherin negative lobular carcinoma that has a higher potential for metastasis formation, the protein levels of enzymes producing antimetastatic metabolites are downregulated. This finding represents a new route that renders lobular cases permissive for metastasis formation. Furthermore, our findings underline the role of oncobiosis in regulating metastasis formation in breast cancer.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"349-358"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Oral saline consumption and pressor responses to acute physical stress. 口服生理盐水的消耗和对急性生理应激的压力反应。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-16 DOI: 10.1556/2060.2020.00018

J J Del Vecchio, P A Hosick, E L Matthews

{"title":"Oral saline consumption and pressor responses to acute physical stress.","authors":"J J Del Vecchio, P A Hosick, E L Matthews","doi":"10.1556/2060.2020.00018","DOIUrl":"https://doi.org/10.1556/2060.2020.00018","url":null,"abstract":"Sodium induced volume loading may alter pressor responses to physical stress, an early symptom of cardiovascular disease.Purpose: Study 1: Determine the time point where total blood volume and serum sodium were elevated following saline consumption. Study 2: Examine the BP response to isometric handgrip (HG) and the cold pressor test (CPT) following saline consumption.Methods: Study 1: Eight participants drank 423 mL of normal saline (sodium 154 mmol/L) and had blood draws every 30 min for 3 h. Study 2: Sixteen participants underwent two randomized data collection visits; a control and experimental visit 90 min following saline consumption. Participants underwent 2 min of isometric HG, post exercise ischemia (PEI), and CPT.Results: Study 1: Total blood volume (3.8 ± 3.0 Δ%) and serum sodium (3.5 ± 3.6 Δ%) were elevated (P < 0.05) by the 90 min time point. Study 2: There were no differences in mean arterial pressure (MAP) during HG (EXP: 17.4 ± 8.2 ΔmmHg; CON: 19.1 ± 6.0 ΔmmHg), PEI (EXP: 16.9 ± 11.7 ΔmmHg; CON: 16.9 ± 7.8 ΔmmHg), or the CPT (EXP: 20.3 ± 10.8 ΔmmHg; CON: 20.9 ± 11.7 ΔmmHg) between conditions (P > 0.05). MAP recovery from the CPT was slower following saline consumption (1 min recovery: EXP; 15.7 ± 7.9 ΔmmHg, CON; 12.3 ± 8.9 ΔmmHg, P < 0.05).Conclusion: Data showed no difference in cardiovascular responses during HG or the CPT between conditions. BP recovery was delayed by saline consumption following the CPT.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"306-318"},"PeriodicalIF":1.4,"publicationDate":"2020-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38162147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T cell responses to an HLA-A2-restricted adipophilin peptide correlate with BMI in patients with atherosclerosis. 动脉粥样硬化患者T细胞对hla - a2限制性亲脂蛋白肽的反应与BMI相关

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-13 DOI: 10.1556/2060.2020.00023

K Kalantar, Z Farzaneh, M Eshkevar Vakili, M H Karimi, M Asadi, S Khosropanah, M Doroudchi

{"title":"T cell responses to an HLA-A2-restricted adipophilin peptide correlate with BMI in patients with atherosclerosis.","authors":"K Kalantar, Z Farzaneh, M Eshkevar Vakili, M H Karimi, M Asadi, S Khosropanah, M Doroudchi","doi":"10.1556/2060.2020.00023","DOIUrl":"https://doi.org/10.1556/2060.2020.00023","url":null,"abstract":"Introduction: Atherosclerosis is an inflammatory disease causing a vast array of cardiovascular diseases. Adipophilin has been reported to be highly expressed in atherosclerotic lesions. This study investigated the possible existence of auto-reactive T cells against an HLA-A02-restricted adipophilin-derived peptide as well as peptides from Epstein-barr virus (EBV), Cytomegalovirus (CMV) and influenza (Flu) virus in patients with atherosclerosis.Methods: HLA-A02 expression on peripheral blood mononuclear cells (PBMCs) was examined by flow cytometry. PBMCs from HLA-A02 individuals were stimulated with adipophilin, CMV, EBV, and Flu peptides at a concentration of 10 µM. Interferon (IFN)-γ production was evaluated in the culture supernatant using a commercial ELISA test.Results: The levels of IFN-γ production against an HLA-A02-restricted adipophilin peptide and peptides from CMV, EBV, and Flu revealed no statistically significant differences between patients and healthy controls. However, we found a positive correlation between IFN-γ production against adipophilin and Body mass index (BMI) of patients (R = 0.8, P = 0.003), whereas no significant correlation was found in healthy controls (R = -0.267, P = 0.378). No correlation between BMI and IFN-γ production against CMV, EBV, or Flu peptides was found.Discussion: Atherosclerotic patients with higher BMIs might have greater numbers of T cells against adipophilin that is highly expressed in atherosclerotic plaques. Therefore, autoimmune reactions may have a greater role in the development of atherosclerosis in individuals with higher BMI.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"280-293"},"PeriodicalIF":1.4,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-intensity interval training-induced hypertrophy in gastrocnemius muscle via improved IGF-I/Akt/FoxO and myostatin/Smad signaling pathways in rats. 高强度间歇训练通过改善IGF-I/Akt/FoxO和肌生长抑制素/Smad信号通路诱导大鼠腓肠肌肥大

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-07 DOI: 10.1556/2060.2020.00020

Soheil Biglari, Alireza Ghardashi Afousi, Farnoosh Mafi, Fatemeh Shabkhiz

{"title":"High-intensity interval training-induced hypertrophy in gastrocnemius muscle via improved IGF-I/Akt/FoxO and myostatin/Smad signaling pathways in rats.","authors":"Soheil Biglari, Alireza Ghardashi Afousi, Farnoosh Mafi, Fatemeh Shabkhiz","doi":"10.1556/2060.2020.00020","DOIUrl":"https://doi.org/10.1556/2060.2020.00020","url":null,"abstract":"Objective: It has been shown that high-intensity interval training (HIIT) leads to skeletal muscle hypertrophy; however, its mechanisms of cellular and molecular regulation are still unclear. The purpose of this study was to investigate the effect of HIIT on muscle hypertrophy and major signal transduction pathways.Design: 12 male rats were randomly divided into two groups: control and HIIT. The exercise group performed 30-min HIIT in each session (5 × 4-min intervals running at 85-95% VO2max separated by 2-min active rest at 55-60% VO2max), 3 days/week for 8 weeks. Muscle fiber cross-sectional area (CSA) and the expression of signal transduction pathway proteins were determined in the gastrocnemius muscle.Results: In the HIIT group, the expression of IGF-I, IGF-IR Akt, p-Akt, AMPKα, p-AMPKα and follistatin increased significantly, whereas a significant decrease was observed in the expression of FoxO1, p-FoxO1, myostatin, ActRIIB, Smad2/3 and p-Smad2/3 (P < 0.05). However, there were no significant differences between the HIIT and control groups in the expression of mTOR, p-mTOR, P70S6K, and p-P70S6K (P > 0.05). In addition, CSA and gastrocnemius muscle weight increased significantly in the HIIT group (P < 0.05).Conclusions: HIIT induced muscle hypertrophy by improving IGF-I/Akt/FoxO and myostatin/Smad signal transduction pathways.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"220-230"},"PeriodicalIF":1.4,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38136895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Combined effects of acute exercise and hypoxia on memory. 急性运动和缺氧对记忆的联合影响。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-02 DOI: 10.1556/2060.2020.00017

M Jung, I Brizes, S Wages, P Ponce, M Kang, P D Loprinzi

引用次数: 0

Pro- and anti-inflammatory factors, vascular stiffness and outcomes in chronic hemodialysis patients. 慢性血液透析患者的促炎因子、抗炎因子、血管僵硬度和预后。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-02 DOI: 10.1556/2060.2020.00026

B Sági, A Peti, O Lakatos, T Gyimesi, E Sulyok, I Wittmann, Botond Csiky

{"title":"Pro- and anti-inflammatory factors, vascular stiffness and outcomes in chronic hemodialysis patients.","authors":"B Sági, A Peti, O Lakatos, T Gyimesi, E Sulyok, I Wittmann, Botond Csiky","doi":"10.1556/2060.2020.00026","DOIUrl":"https://doi.org/10.1556/2060.2020.00026","url":null,"abstract":"Objective In this observational study we addressed accelerated arteriosclerosis (AS) in patients with chronic renal failure (CRF) on hemodialysis (HD) by measuring vascular stiffness (VS) parameters and attempted to relate them to pro-inflammatory and protective factors. Patients 96 consecutive patients receiving regular HD were included. 20 adult patients without major renal, cardiovascular or metabolic morbidities served as controls. Methods AS parameters (carotid-femoral pulse wave velocity - PWV, aortic augmentation index - Aix) were measured by using applanation tonometry (SphygmoCor, AtCor Medical, Sidney). In addition to routine laboratory tests 25(OH) vitamin D3 (vitamin D3) and high-sensitivity C-reactive protein (hsCRP) were quantified by immunometric assay; whereas fetuin-A, α-Klotho, tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) were determined by ELISA. Results Pro-inflammatory biomarkers (hsCRP, TNF-α and TGF-β1) were markedly elevated (P < 0.01), while anti-inflammatory factors (fetuin-A: P < 0.05, α-Klotho: P < 0.01, vitamin D3: P < 0.01) significantly depressed in HD patients when compared to controls. PWV was significantly affected only by total cholesterol, fetuin-A and dialysis time. Multiple linear regression analyses revealed that several clinical and laboratory parameters were associated with pro- and anti-inflammatory biomarkers rather than VS. The impact of baseline clinical and biochemical variables on outcome measures were also analyzed after three-year follow-up, and it was demonstrated that low levels of vitamin D, α-Klotho protein and fetuin-A were related to adverse cardiovascular outcomes, whereas all-cause mortality was associated with elevated hsCRP and depressed vitamin D. Conclusions Our results provide additional information on the pathomechanism of accelerated AS in patients with CRF, and documented direct influence of pro- and anti-inflammatory biomarkers on major outcome measures.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"256-266"},"PeriodicalIF":1.4,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38120167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Maturation of NMDA receptor-mediated spontaneous postsynaptic currents in the rat locus coeruleus neurons. 大鼠蓝斑神经元NMDA受体介导的自发突触后电流的成熟。

IF 1.4 4区医学

Physiology international Pub Date : 2020-04-23 Print Date: 2020-03-01 DOI: 10.1556/2060.2020.00010

M Kourosh-Arami, S Hajizadeh

{"title":"Maturation of NMDA receptor-mediated spontaneous postsynaptic currents in the rat locus coeruleus neurons.","authors":"M Kourosh-Arami, S Hajizadeh","doi":"10.1556/2060.2020.00010","DOIUrl":"https://doi.org/10.1556/2060.2020.00010","url":null,"abstract":"Introduction: During mammalian brain development, neural activity leads to maturation of glutamatergic innervations to locus coeruleus. In this study, fast excitatory postsynaptic currents mediated by N-methyl-d-aspartate (NMDA) receptors were evaluated to investigate the maturation of excitatory postsynaptic currents in locus coeruleus (LC) neurons.Methods: NMDA receptor-mediated synaptic currents in LC neurons were evaluated using whole-cell voltage-clamp recording during the primary postnatal weeks. This technique was used to calculate the optimum holding potential for NMDA receptor-mediated currents and the best frequency for detecting spontaneous excitatory postsynaptic currents (sEPSC).Results: The optimum holding potential for detecting NMDA receptor-mediated currents was + 40 to + 50 mV in LC neurons. The frequency, amplitude, rise time, and decay time constant of synaptic responses depended on the age of the animal and increased during postnatal maturation.Conclusion: These findings suggest that most nascent glutamatergic synapses express functional NMDA receptors in the postnatal coerulear neurons, and that the activities of the neurons in this region demonstrate an age-dependent variation.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 1","pages":"18-29"},"PeriodicalIF":1.4,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38101203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Left ventricular apical rotation is associated with mitral annular function in healthy subjects. Results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study. 健康受试者左心室尖顶旋转与二尖瓣环功能相关。三维斑点跟踪超声心动图magyar健康研究结果。

IF 1.4 4区医学

Physiology international Pub Date : 2020-04-23 Print Date: 2020-03-01 DOI: 10.1556/2060.2020.00002

A Nemes, Z Kovács, Á Kormányos, P Domsik, A Kalapos, Z Ajtay, C Lengyel

{"title":"Left ventricular apical rotation is associated with mitral annular function in healthy subjects. Results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study.","authors":"A Nemes, Z Kovács, Á Kormányos, P Domsik, A Kalapos, Z Ajtay, C Lengyel","doi":"10.1556/2060.2020.00002","DOIUrl":"https://doi.org/10.1556/2060.2020.00002","url":null,"abstract":"Introduction: Left ventricular (LV) twist is considered an essential part of LV function due to oppositely directed LV basal and apical rotations. Several factors could play a role in determining LV rotational mechanics in normal circumstances. This study aimed to investigate the relationship between LV rotational mechanics and mitral annular (MA) size and function in healthy subjects.Methods: The study comprised 118 healthy adult volunteers (mean age: 31.5 ± 11.8 years, 50 males). All subjects had undergone complete two-dimensional (2D) Doppler echocardiography and three-dimensional speckle-tracking echocardiography (3DSTE) at the same time by the same echocardiography equipment.Results: The normal mean LV apical and basal rotations proved to be 9.57 ± 3.33 and -3.75 ± 1.98°, respectively. LV apical rotation correlated with end-systolic MA diameter, area, perimeter, fractional area change, and fractional shortening, but did not correlate with any end-diastolic mitral annular morphologic parameters. The logistic regression model identified MA fractional area change as an independent predictor of ≤6° left ventricular apical rotation (P < 0.003).Conclusions: Correlations could be detected between apical LV rotation and end-systolic MA size and function, suggesting relationships between MA dimensions and function and LV rotational mechanics.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 1","pages":"145-154"},"PeriodicalIF":1.4,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38096135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1