Physiology international最新文献_第9页

Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway. 胰岛素通过Akt/mTORC2通路对近端小管H+- atp酶的刺激作用

IF 1.4 4区医学

Physiology international Pub Date : 2020-09-29 Print Date: 2020-10-17 DOI: 10.1556/2060.2020.00030

M Nakamura, N Satoh, H Tsukada, T Mizuno, W Fujii, A Suzuki, S Horita, M Nangaku, M Suzuki

{"title":"Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway.","authors":"M Nakamura, N Satoh, H Tsukada, T Mizuno, W Fujii, A Suzuki, S Horita, M Nangaku, M Suzuki","doi":"10.1556/2060.2020.00030","DOIUrl":"https://doi.org/10.1556/2060.2020.00030","url":null,"abstract":"Purpose: Acid-base transport in renal proximal tubules (PTs) is mainly sodium-dependent and conducted in coordination by the apical Na+/H+ exchanger (NHE3), vacuolar H+-adenosine triphosphatase (V-ATPase), and the basolateral Na+/HCO3- cotransporter. V-ATPase on PTs is well-known to play an important role in proton excretion. Recently we reported a stimulatory effect of insulin on these transporters. However, it is unclear whether insulin is involved in acid-base balance in PTs. Thus, we assessed the role of insulin in acid-base balance in PTs.Methods: V-ATPase activity was evaluated using freshly isolated PTs obtained from mice, and specific inhibitors were then used to assess the signaling pathways involved in the observed effects.Results: V-ATPase activity in PTs was markedly enhanced by insulin, and its activation was completely inhibited by bafilomycin (a V-ATPase-specific inhibitor), Akt inhibitor VIII, and PP242 (an mTORC1/2 inhibitor), but not by rapamycin (an mTORC1 inhibitor). V-ATPase activity was stimulated by 1 nm insulin by approximately 20% above baseline, which was completely suppressed by Akt1/2 inhibitor VIII. PP242 completely suppressed the insulin-mediated V-ATPase stimulation in mouse PTs, whereas rapamycin failed to influence the effect of insulin. Insulin-induced Akt phosphorylation in the mouse renal cortex was completely suppressed by Akt1/2 inhibitor VIII and PP242, but not by rapamycin.Conclusion: Our results indicate that stimulation of V-ATPase activity by insulin in PTs is mediated via the Akt2/mTORC2 pathway. These results reveal the mechanism underlying the complex signaling in PT acid-base balance, providing treatment targets for renal disease.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 3","pages":"376-389"},"PeriodicalIF":1.4,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38431842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis. 运动、臭氧和间充质干细胞联合治疗可改善膝骨关节炎大鼠软骨组织中HIF1和SOX9的表达。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00024

Sara Asadi, Parvin Farzanegi, Mohammad Ali Azarbayjani

{"title":"Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis.","authors":"Sara Asadi, Parvin Farzanegi, Mohammad Ali Azarbayjani","doi":"10.1556/2060.2020.00024","DOIUrl":"https://doi.org/10.1556/2060.2020.00024","url":null,"abstract":"Purpose: Knee osteoarthritis (OA) is a common type of degenerative joint disease which decreases the quality of life. Sex-determining region Y box 9 (SOX9) and hypoxia-inducible factor-1 (HIF1) are considered as the key regulators of OA. We investigated the effect of combined therapies with mesenchymal stem cells (MSCs), ozone (O3) and exercise training on SOX9 and HIF1 expression in the cartilage of rats with knee OA.Methods: Knee OA was induced by surgical method. OA rats were divided into model, MSCs, ozone, exercise, MSCs + ozone, MSCs + exercise, ozone + exercise and MSCs + ozone + exercise groups. Rats in the MSCs group received intraarticular injection of 1 × 106 cells/kg. Rats in the ozone group received O3 at the concentration of 20 μg/mL, once weekly for 3 weeks. Rats in the exercise group were trained on rodent treadmill three times per week. 48 hours after the programs, cartilage tissues were isolated and the expression of SOX9 and HIF1 was determined using Real-Time PCR.Results: Significant differences were found in the expression of SOX9 and HIF1 between groups (P < 0.0001). Although combined therapies with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 in the cartilage tissue of rats with knee OA, combination of exercise with O3 was significantly more effective compared to the other combined therapies (P < 0.001).Conclusions: Combined therapy with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 genes in the cartilage of rats with knee OA; however, exercise + O3 was significantly more effective.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"231-242"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Salivary dysfunction caused by medication usage. 药物使用引起的唾液功能障碍。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00019

O M Einhorn, K Georgiou, A Tompa

引用次数: 14

Aspirin protects human coronary artery endothelial cells by inducing autophagy. 阿司匹林通过诱导自噬保护人冠状动脉内皮细胞。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00029

J Chen, L Wang, W H Liu, J Shi, Y Zhong, S J Liu, S M Liu

{"title":"Aspirin protects human coronary artery endothelial cells by inducing autophagy.","authors":"J Chen, L Wang, W H Liu, J Shi, Y Zhong, S J Liu, S M Liu","doi":"10.1556/2060.2020.00029","DOIUrl":"https://doi.org/10.1556/2060.2020.00029","url":null,"abstract":"Although the use of aspirin has substantially reduced the risks of cardiovascular events and death, its potential mechanisms have not been fully elucidated. In a previous study, we found that aspirin triggers cellular autophagy. In the present study, we aimed to determine the protective effects of aspirin on human coronary artery endothelial cells (HCAECs) and explore its underlying mechanisms. HCAECs were treated with oxidized low-density lipoprotein (ox-LDL), angiotensin II (Ang-II), or high glucose (HG) with or without aspirin stimulation. The expression levels of endothelial nitric oxide (NO) synthase (eNOS), p-eNOS, LC3, p62, phosphor-nuclear factor kappa B (p-NF-κB), p-p38 mitogen-activated protein kinase (p-p38 MAPK), and Beclin-1 were detected via immunoblotting analysis. Concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured via ELISA. NO levels were determined using the Griess reagent. Autophagic flux was tracked by tandem mRFP-GFP-tagged LC3. Results showed that aspirin increased eNOS level and reduced injury to the endothelial cells (ECs) caused by ox-LDL, Ang-II, and HG treatment in a dose-dependent manner. Aspirin also increased the LC3II/LC3I ratio, decreased p62 expression, and enhanced autophagic flux (autophagosome and autolysosome puncta) in the HCAECs. p-NF-κB and p-p38 mitogen-activated protein kinase inhibition, sVCAM-1 and sICAM-1 secretion, and eNOS activity promotion by aspirin treatment were found to be dependent on Beclin-1. These results suggested that aspirin can protect ECs from ox-LDL-, Ang-II-, and HG-induced injury by activating autophagy in a Beclin-1-dependent manner.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"294-305"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prenatal urban traffic noise exposure impairs spatial learning and memory and reduces glucocorticoid receptor expression in the hippocampus of male rat offspring. 产前城市交通噪声暴露损害雄性大鼠后代的空间学习和记忆，降低海马糖皮质激素受体的表达。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-24 Print Date: 2020-06-01 DOI: 10.1556/2060.2020.00022

F S Sajjadi, F Aghighi, Z Vahidinia, A Azami-Tameh, M Salami, S A Talaei

{"title":"Prenatal urban traffic noise exposure impairs spatial learning and memory and reduces glucocorticoid receptor expression in the hippocampus of male rat offspring.","authors":"F S Sajjadi, F Aghighi, Z Vahidinia, A Azami-Tameh, M Salami, S A Talaei","doi":"10.1556/2060.2020.00022","DOIUrl":"https://doi.org/10.1556/2060.2020.00022","url":null,"abstract":"Introduction\u0000Exposure to noise stress during early life may permanently affect the structure and function of the central nervous system. The aim of this study was to evaluate the effects of prenatal exposure to urban traffic noise on the spatial learning and memory of the rats' offspring and the expression of glucocorticoid receptors (GRs) in their hippocampi.\u0000\u0000\u0000Methods\u0000Three groups of pregnant rats were exposed to recorded urban traffic noise for 1, 2 or 4 h/day during the last week of pregnancy. At the age of 45 days, their male offspring were introduced to the Morris water maze (MWM) for assessment of spatial learning and memory. The corticosterone levels were measured in the offspring's sera by radioimmunoassay, and the relative expression of glucocorticoid and mineralocorticoid receptors (MRs) in their hippocampi was evaluated via RT-PCR.\u0000\u0000\u0000Results\u0000Facing urban traffic noise for 2 and 4 h/day during the third trimester of pregnancy caused the offspring to spend more time and to travel a larger distance than the controls to find the target platform. Analogously, these two groups were inferior to their control counterparts in the probe test. Also, prenatal noise stress elevated the corticosterone concentration in the sera of the rats' offspring and dose-dependently decreased the relative expression of the mRNA of both GRs and MRs in their hippocampi.\u0000\u0000\u0000Conclusions\u0000Urban traffic noise exposure during the last trimester of pregnancy impairs spatial learning and memory of rat offspring and reduces GRs and MRs gene expression in the hippocampus.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"209-219"},"PeriodicalIF":1.4,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38225403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The role of age in post-cardiac arrest therapy in an elderly patient population. 年龄在老年患者心脏骤停后治疗中的作用。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-20 DOI: 10.1556/2060.2020.00027

E Kovács, D Pilecky, Z Szakál-Tóth, A Fekete-Győr, V A Gyarmathy, L Gellér, B Hauser, J Gál, B Merkely, E Zima

{"title":"The role of age in post-cardiac arrest therapy in an elderly patient population.","authors":"E Kovács, D Pilecky, Z Szakál-Tóth, A Fekete-Győr, V A Gyarmathy, L Gellér, B Hauser, J Gál, B Merkely, E Zima","doi":"10.1556/2060.2020.00027","DOIUrl":"https://doi.org/10.1556/2060.2020.00027","url":null,"abstract":"Aim: We investigated the effect of age on post-cardiac arrest treatment outcomes in an elderly population, based on a local database and a systemic review of the literature.Methods: Data were collected retrospectively from medical charts and reports. Sixty-one comatose patients, cooled to 32-34 °C for 24 h, were categorized into three groups: younger group (≤65 years), older group (66-75 years), and very old group (>75 years). Circumstances of cardiopulmonary resuscitation (CPR), patients' characteristics, post-resuscitation treatment, hemodynamic monitoring, neurologic outcome and survival were compared across age groups. Kruskal-Wallis test, Chi-square test and binary logistic regression (BLR) were applied. In addition, a literature search of PubMed/Medline database was performed to provide a background.Results: Age was significantly associated with having a cardiac arrest on a monitor and a history of hypertension. No association was found between age and survival or neurologic outcome. Age did not affect hemodynamic parameter changes during target temperature management (TTM), except mean arterial pressure (MAP). Need of catecholamine administration was the highest among very old patients. During the literature review, seven papers were identified. Most studies had a retrospective design and investigated interventions and outcome, but lacked unified age categorization. All studies reported worse survival in the elderly, although old survivors showed a favorable neurologic outcome in most of the cases.Conclusion: There is no evidence to support the limitation of post-cardiac arrest therapy in the aging population. Furthermore, additional prospective studies are needed to investigate the characteristics and outcome of post-cardiac arrest therapy in this patient group.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"319-336"},"PeriodicalIF":1.4,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38183965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Growth factors in pulmonary arterial hypertension: Focus on preserving right ventricular function. 生长因子在肺动脉高压中的作用:重点保护右心室功能。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00021

G Csósza, K Karlócai, G Losonczy, V Müller, Z Lázár

引用次数: 4

The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism. 肥胖抑制素对消炎痛引起的急性溃疡的胃保护作用是通过迷走神经机制介导的。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00025

Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen

{"title":"The gastroprotective effect of obestatin on indomethacin-induced acute ulcer is mediated by a vagovagal mechanism.","authors":"Leyla Semiha Şen, Zarife Nigar Özdemir Kumral, Gülsün Memi, Feriha Ercan, Berrak C Yeğen, Cumhur Yeğen","doi":"10.1556/2060.2020.00025","DOIUrl":"https://doi.org/10.1556/2060.2020.00025","url":null,"abstract":"In order to investigate the role of the vagus nerve in the possible gastroprotective effect of obestatin on the indomethacin-induced acute oxidative gastric injury, Sprague-Dawley rats of both sexes were injected subcutaneously with indomethacin (25 mg/kg, 5% NaHCO3) followed by obestatin (10, 30 or 100 μg/kg). In other sets of rats, surgical vagotomy (Vx) or selective degeneration of vagal afferent fibers by perivagal capsaicin was performed before the injections of indomethacin or indomethacin + obestatin (30 μg/kg). Gastric serosal blood flow was measured, and 4 h after ulcer induction gastric tissue samples were taken for histological and biochemical assays. Obestatin reduced the severity of indomethacin-induced acute ulcer via the reversal of reactive hyperemia, by inhibiting ulcer-induced neutrophil infiltration and lipid peroxidation along with the replenishment of glutathione (GSH) stores, whereas Vx abolished the inhibitory effect of obestatin on blood flow and lipid peroxidation, and worsened the severity of ulcer. On the other hand, serosal blood flow was even amplified by the selective denervation of the capsaicin-sensitive vagal afferent fibers, but obestatin-induced reduction in ulcer severity was not altered. In conclusion, the gastroprotective effect of obestatin on indomethacin-induced ulcer appears to involve the activation of the vagovagal pathway.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"243-255"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cerebral and peripheral muscle oxygenation and perfusion: Course in moderate and late preterm neonates during the first day after birth. 脑和周围肌肉氧合和灌注:中晚期早产儿出生后第一天的病程。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00028

N Hoeller, N Baik-Schneditz, B Schwaberger, L Mileder, B Urlesberger, G Pichler

{"title":"Cerebral and peripheral muscle oxygenation and perfusion: Course in moderate and late preterm neonates during the first day after birth.","authors":"N Hoeller, N Baik-Schneditz, B Schwaberger, L Mileder, B Urlesberger, G Pichler","doi":"10.1556/2060.2020.00028","DOIUrl":"https://doi.org/10.1556/2060.2020.00028","url":null,"abstract":"Aim: To investigate the ratio of cerebral tissue oxygenation index (cTOI) to peripheral muscle tissue oxygenation index (pTOI) measured by near-infrared spectroscopy (NIRS) in cardio-circulatory stable preterm neonates without signs of inflammation/infection on the first day after birth.Methods: Observational study analysing secondary outcome parameters of the 'Avoiding Hypotension in Preterm Neonates (AHIP)' trial (ClinicalTrials.gov identifier: NCT01910467). Preterm neonates, who had cTOI and pTOI measurements during 24 h after birth, were included. In each neonate the mean of the cTOI/pTOI-ratio, cTOI, pTOI and routine monitoring parameters were calculated for each hour and for the 24-h measuring period. Courses of all measured parameters were analysed.Results: Eighty-seven stable preterm neonates (33.1 [32.1-34.1] weeks of gestation) were included. The mean value over the 24-h measuring period for the cTOI/pTOI-ratio was 0.96 ± 0.02, for cTOI 70.1 ± 1.4 and for pTOI 73.4 ± 0.9. Routine monitoring parameters were in the normal ranges over 24 h. The courses of the cTOI/pTOI-ratio and cTOI showed significantly lower values from hour 5 to 15 compared to the first hours after birth. Heart rate decreased significantly over time, whereas mean arterial blood pressure increased significantly. pTOI, arterial oxygen saturation and body temperature showed no significant change over time.Conclusion: We are the first to report on cTOI/pTOI-ratios for cardio-circulatory stable preterm neonates over a 24-h period after birth, showing significantly lower values from hour 5 to 15 compared to the first hours after birth.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"267-279"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma. 大肠杆菌赖氨酸脱羧酶(LdcC)在e -钙粘蛋白阴性的小叶乳腺癌中表达下调。

IF 1.4 4区医学

Physiology international Pub Date : 2020-07-17 DOI: 10.1556/2060.2020.00016

Zs Sári, T Kovács, T Csonka, M Török, É Sebő, J Toth, D Tóth, E Mikó, B Kiss, D Szeőcs, K Uray, Zs Karányi, I Kovács, G Méhes, P Árkosy, P Bai

{"title":"Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma.","authors":"Zs Sári, T Kovács, T Csonka, M Török, É Sebő, J Toth, D Tóth, E Mikó, B Kiss, D Szeőcs, K Uray, Zs Karányi, I Kovács, G Méhes, P Árkosy, P Bai","doi":"10.1556/2060.2020.00016","DOIUrl":"https://doi.org/10.1556/2060.2020.00016","url":null,"abstract":"Breast cancer is characterized by oncobiosis, the abnormal composition of the microbiome in neoplastic diseases. The biosynthetic capacity of the oncobiotic flora in breast cancer is suppressed, as suggested by metagenomic studies. The microbiome synthesizes a set of cytostatic and antimetastatic metabolites that are downregulated in breast cancer, including cadaverine, a microbiome metabolite with cytostatic properties. We set out to assess how the protein expression of constitutive lysine decarboxylase (LdcC), a key enzyme for cadaverine production, changes in the feces of human breast cancer patients (n = 35). We found that the fecal expression of Escherichia coli LdcC is downregulated in lobular cases as compared to invasive carcinoma of no special type (NST) cases. Lobular breast carcinoma is characterized by low or absent expression of E-cadherin. Fecal E. coli LdcC protein expression is downregulated in E-cadherin negative breast cancer cases as compared to positive ones. Receiver operating characteristic (ROC) analysis of LdcC expression in lobular and NST cases revealed that fecal E. coli LdcC protein expression might have predictive values. These data suggest that the oncobiotic transformation of the microbiome indeed leads to the downregulation of the production of cytostatic and antimetastatic metabolites. In E-cadherin negative lobular carcinoma that has a higher potential for metastasis formation, the protein levels of enzymes producing antimetastatic metabolites are downregulated. This finding represents a new route that renders lobular cases permissive for metastasis formation. Furthermore, our findings underline the role of oncobiosis in regulating metastasis formation in breast cancer.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":"107 2","pages":"349-358"},"PeriodicalIF":1.4,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38178444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10