Physiology international最新文献_第2页

Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. 在各种形式的突触可塑性中，基于激酶和磷酸酶活性的 tau 蛋白磷酸化。

IF 1.4 4区医学

Physiology international Pub Date : 2024-03-04 Print Date: 2024-03-21 DOI: 10.1556/2060.2024.00344

Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süer

引用次数: 0

Innovative prophylactic and therapeutic approaches in liver cirrhosis. 肝硬化的创新预防和治疗方法。

IF 1.4 4区医学

Physiology international Pub Date : 2024-02-29 Print Date: 2024-03-21 DOI: 10.1556/2060.2024.00339

Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan

{"title":"Innovative prophylactic and therapeutic approaches in liver cirrhosis.","authors":"Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan","doi":"10.1556/2060.2024.00339","DOIUrl":"10.1556/2060.2024.00339","url":null,"abstract":"Liver cirrhosis is the consequence of chronicisation and of the evolution of untreated liver diseases. The complexity of the disease and the complications it can cause have been and are still intensively researched, aiming to discover new therapies or improve existing ones for the effective management of liver cirrhosis. Currently, the treatment used is directed against the cause that caused the disease, if it is known; in advanced cases, liver transplantation is the only valid therapeutic option. Hepatoprotectors that are currently on the market are numerous, having as common properties the antioxidant, anti-inflammatory, stabilizing properties of the hepatocytic membrane; A few examples: the ethanolic extract of Curcuma longa, the extract from the plant called Sophora flavescens, the extract of Glycyrrhiza glabra, silymarin (extracted from Sylibum marianum), the extract of Ganoderma lucidum, etc. Liver cirrhosis is accompanied by generalized hypovitaminosis, so supplementing the diet with hydro- and liposoluble vitamins is mandatory. Protein-caloric malnutrition can be prevented by a hyperprotein diet, especially beneficial being the supplementation with branched-chain amino acids, which are also applicable in the prophylaxis and treatment of hepatic encephalopathy. Nanoparticles are a state-of-the-art therapeutic option, proving increased bioavailability, for example polydopamine nanoparticles loaded with l-arginine have been tested as therapy in liver cirrhosis. Among the innovative treatment directions in liver cirrhosis are hybrid products (e.g. hybrid polymer nanoparticles loaded with caffeic acid), cell cultures and artificial or bioartificial liver support.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of endogenous analgesia triggered by acupuncture, stress, or noxious stimulation on REM sleep-deprived rats. 针灸、压力或有害刺激引发的内源性镇痛对快速眼动睡眠障碍大鼠的影响

IF 1.4 4区医学

Physiology international Pub Date : 2024-02-28 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00273

Natalia F Sardi, Priscila Natume, Thainá Watanabe, Ana Carolina Pescador, Karla E Torres-Chavez, Glaucia Tobaldini, Luana Fischer

{"title":"Impact of endogenous analgesia triggered by acupuncture, stress, or noxious stimulation on REM sleep-deprived rats.","authors":"Natalia F Sardi, Priscila Natume, Thainá Watanabe, Ana Carolina Pescador, Karla E Torres-Chavez, Glaucia Tobaldini, Luana Fischer","doi":"10.1556/2060.2023.00273","DOIUrl":"10.1556/2060.2023.00273","url":null,"abstract":"Poor sleep increases pain, at least in part, by disrupting endogenous pain modulation. However, the efficacy of endogenous analgesia in sleep-deprived subjects has never been tested. To assess this issue, we chose three different ways of triggering endogenous analgesia: (1) acupuncture, (2) acute stress, and (3) noxious stimulation, and compared their ability to decrease the pronociceptive effect induced by REM-SD (Rapid Eye Movement Sleep Deprivation) with that to decrease inflammatory hyperalgesia in the classical carrageenan model. First, we tested the ability of REM-SD to worsen carrageenan-induced hyperalgesia: A low dose of carrageenan (30 µg) in sleep-deprived Wistar rats resulted in a potentiated hyperalgesic effect that was more intense and longer-lasting than that induced by a higher standard dose of carrageenan (100 µg) or by REM-SD alone. Then, we found that (1) acupuncture, performed at ST36, completely reversed the pronociceptive effect induced by REM-SD or by carrageenan; (2) immobilization stress completely reversed the pronociceptive effect of REM-SD, while transiently inhibited carrageenan-induced hyperalgesia; (3) noxious stimulation of the forepaw by capsaicin also reversed the pronociceptive effect of REM-SD and persistently increased the nociceptive threshold above the baseline in carrageenan-treated animals. Therefore, acupuncture, stress, or noxious stimulation reversed the pronociceptive effect of REM-SD, while each intervention affected carrageenan-induced hyperalgesia differently. This study has shown that while sleep loss may disrupt endogenous pain modulation mechanisms, it does not prevent the activation of these mechanisms to induce analgesia in sleep-deprived individuals.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats. 大鼠有氧运动时 GPR81 在调节肌肉内甘油三酯储存中的作用。

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-31 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00238

Yihan Ni, Xiangdeng Lai, Lin Li, Jingquan Sun, Yaqian Qu, Siyu Chen, Hao Zhang

{"title":"Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats.","authors":"Yihan Ni, Xiangdeng Lai, Lin Li, Jingquan Sun, Yaqian Qu, Siyu Chen, Hao Zhang","doi":"10.1556/2060.2023.00238","DOIUrl":"10.1556/2060.2023.00238","url":null,"abstract":"Lactate, a metabolite of exercise, plays a crucial role in the body. In these studies, we aimed to investigate the role of G protein-coupled receptor 81 (GPR81), a specific receptor for lactate, in regulating lipid storage in the gastrocnemius muscle of rats. To achieve this, we measured the impact of sodium 3-hydroxybutyrate (3-OBA) concentration and time on the cAMP-PKA signaling pathway in the gastrocnemius muscles of rats. Our investigation involved determining the effects of administering 3-OBA at a concentration of 3 mmol L-1 just 15 min before exercise. As expected, exercise led to a notable increase in intramuscular lactate concentration in rats. However, injecting 3-OBA prior to exercise yielded intriguing results. It not only further augmented the cAMP-PKA signaling pathway but also boosted the expression of lipolysis-related proteins such as hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL). Simultaneously, it decreased the expression of fat-synthesizing proteins, including acetyl CoA carboxylase (ACC) and fatty acid synthase (FAS), while increasing the protein expression of cytochrome c oxidase subunit Ⅳ(COX Ⅳ) and the activity of citrate synthetase (CS). Unfortunately, there was no significant change observed in intramuscular triglyceride (IMTG) content. In summary, our findings shed light on the role of lactate in partially regulating intramuscular triglycerides during exercise.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visually evoked local field potential changes in the caudate nucleus are remarkably more frequent in awake, behaving cats than in anaesthetized animals. 尾状核中视觉诱发的局部场电位变化在清醒状态下的行为猫中比在麻醉状态下的行为猫中更为频繁。

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-31 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00240

Diána Nyujtó, Ádám Kiss, Balázs Bodosi, Gabriella Eördegh, Kálmán Tót, András Kelemen, Attila Nagy

{"title":"Visually evoked local field potential changes in the caudate nucleus are remarkably more frequent in awake, behaving cats than in anaesthetized animals.","authors":"Diána Nyujtó, Ádám Kiss, Balázs Bodosi, Gabriella Eördegh, Kálmán Tót, András Kelemen, Attila Nagy","doi":"10.1556/2060.2023.00240","DOIUrl":"10.1556/2060.2023.00240","url":null,"abstract":"Previous results show that halothane gas anaesthesia has a suppressive effect on the visually evoked single-cell activities in the feline caudate nucleus (CN). In this study, we asked whether the low-frequency neuronal signals, the local field potentials (LFP) are also suppressed in the CN of anaesthetized animals.To answer this question, we compared the LFPs recorded from the CN of two halothane-anaesthetized (1.0%), paralyzed, and two awake, behaving cats during static and dynamic visual stimulation. The behaving animals were trained to perform a visual fixation task.Our results denoted a lower proportion of significant power changes to visual stimulation in the CN of the anesthetized cats in each frequency range (from delta to beta) of the LFPs, except gamma. These differences in power changes were more obvious in static visual stimulation, but still, remarkable differences were found in dynamic stimulation, too. The largest differences were found in the alpha and beta frequency bands for static stimulation. Concerning dynamic stimulation, the differences were the biggest in the theta, alpha and beta bands.Similar to the single-cell activities, remarkable differences were found between the visually evoked LFP changes in the CN of the anaesthetized, paralyzed and awake, behaving cats. The halothane gas anaesthesia and the immobilization suppressed the significant LFP power alterations in the CN to both static and dynamic stimulation. These results suggest the priority of the application of behaving animals even in the analysis of the visually evoked low-frequency electric signals, the LFPs recorded from the CN.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis. THAP9-AS1 通过靶向调控 miR-185-5p/SOX13 轴促进鼻咽癌的进展。

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-25 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00232

Jinhua Mo, Zengyi Gong, Hong Liu, Lian Zhou, Yanguang Zhao

{"title":"THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis.","authors":"Jinhua Mo, Zengyi Gong, Hong Liu, Lian Zhou, Yanguang Zhao","doi":"10.1556/2060.2023.00232","DOIUrl":"10.1556/2060.2023.00232","url":null,"abstract":"Background: It has been reported that long non-coding RNA THAP9-AS1 exerts carcinogenic role by mediating miRNAs and target genes in various human cancers. However, whether THAP9-AS1 influences the progression of nasopharyngeal carcinoma (NPC) remains unknown.Methods: The transcriptional levels of THAP9-AS1 and miR-185-5p were estimated via quantitative real time polymerase chain reaction (qRT-PCR) assay. The protein level of SOX13 was detected with western blotting assay. Additionally, methyl thiazolyl tetrazolium (MTT) assay as well as colony formation assay were utilized to measure cell growth. The apoptotic cells were observed by employing Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling (TUNEL) staining analysis, and transwell assay was introduced to test cell migration in addition to invasion. Moreover, the relationship between miR-185-5p and THAP9-AS1 or SOX13 was estimated through dual-luciferase reporter gene assay.Results: THAP9-AS1 was overexpressed in head and neck squamous cell carcinoma (HNSCC) tissues and NPC cells. Besides, silencing of THAP9-AS1 depressed the life processes of NPC cells including cell growth, migration as well as invasion but facilitated cell apoptosis. Further investigation proved that miR-185-5p was the direct target of THAP9-AS1. Besides, the knockdown of THAP9-AS1 notably reduced the transcriptional level of miR-185-5p. Furthermore, THAP9-AS1 served as a sponge of miR-185-5p to modulate the expression of SOX13, which regulated the development of NPC cells.Conclusion: This work verified that THAP9-AS1 promoted NPC cell progression at least partly by mediating the miR-185-5p/SOX13 axis.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2. RACGAP1 通过抑制 SIRT1/Mfn2 推动胃癌细胞的增殖、迁移和侵袭并抑制自噬。

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-22 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00235

Tingting Yan, Guangxin Lu, Rui Shang, Junhua Hu, Chaobei Zhu, Lingli Jin

{"title":"RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.","authors":"Tingting Yan, Guangxin Lu, Rui Shang, Junhua Hu, Chaobei Zhu, Lingli Jin","doi":"10.1556/2060.2023.00235","DOIUrl":"10.1556/2060.2023.00235","url":null,"abstract":"Objective: Gastric cancer is the most frequent gastrointestinal malignancy with a poor prognosis. Rac GTPase activation protein 1 (RACGAP1) is a novel tumor promotor, whose detailed effect on gastric cancer remains to be further elucidated. Hence, this study identifies the action of RACGAP1 on gastric cancer and investigates the potential mechanism.Methods: RACGAP1 expression in gastric cancer was analyzed based on the data of The Cancer Genome Atlas (TCGA) database. Cell proliferation was measured by CCK-8 and colony formation assay. Cell migration and invasion were evaluated by transwell assay. Cell apoptosis was assessed by flow cytometry. Cell autophagy was evaluated via determining LC3.Results: RACGAP1 presented at high level in gastric cancer cells. Overexpressed RACGAP1 potentiated gastric cancer cell proliferation, migration, and invasion. Besides, silenced RACGAP1 induced cell apoptosis and autophagy. Furthermore, RACGAP1 suppressed the expression of SIRT1 and Mfn2.Conclusion: RACGAP1 was overexpressed in gastric cancer. RACGAP1 potentiated aggressive behaviors of gastric cancer, and suppressed cell apoptosis and autophagy via modulating SIRT1/Mfn2. RACGAP1 may be a valuable target in the treatment of gastric cancer.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of folic acid on isoprenaline-induced myocardial injury in rats. 叶酸对异丙肾上腺素诱发的大鼠心肌损伤的影响

IF 1.4 4区医学

Physiology international Pub Date : 2024-01-22 Print Date: 2024-03-21 DOI: 10.1556/2060.2023.00291

Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric

{"title":"Effect of folic acid on isoprenaline-induced myocardial injury in rats.","authors":"Tanja Sobot, Zorislava Bajic, Ranko Skrbic, Snezana Uletilovic, Nebojsa Mandic-Kovacevic, Tanja Cvjetkovic, Ugljesa Malicevic, Djordje Djukanovic, Milica Gajic Bojic, Sanja Jovicic, Maja Barudzija, Milos P Stojiljkovic, Dragan M Djuric","doi":"10.1556/2060.2023.00291","DOIUrl":"10.1556/2060.2023.00291","url":null,"abstract":"Background: Isoprenaline (ISO), a synthetic catecholamine and a β-adrenoceptor agonist, is widely used to develop an experimental model of myocardial injury (MI) in rats. The leading hypothesis for ISO-induced MI in rats is that it results from catecholamine overstimulation, oxidative stress, inflammatory responses, and development of cardiomyopathy during ISO administration. Folic acid (FA) reduces oxidative stress, improves endothelial function and prevents apoptosis, thereby contributing to cardiovascular protection. This study aimed to investigate the potentially protective effect of FA pretreatment on ISO-induced MI in rats.Methods: For 7 days, adult male Wistar albino rats were pretreated with 5 mg/kg/day of FA. On the sixth and seventh days, MI in rats was induced by administering 85 mg/kg/day of ISO. Prooxidant markers in plasma samples, antioxidant capacity in erythrocyte lysates, cardiac damage markers, lipid profile, electrocardiography (ECG) and histopathological analysis were evaluated.Results: FA pretreatment significantly alleviated changes induced by ISO; it decreased the homocysteine and high-sensitivity troponin I level. FA moderately decreased the reactive oxygen species (ROS) levels (superoxide anion radical, hydrogen peroxide and thiobarbituric acid reactive substances) and improved the antioxidant activities of catalase, superoxide dismutase and reduced glutathione. ISO reduced the nitrite level and FA significantly alleviated this change.Conclusion: It can be concluded that FA, as a mild antioxidant, could be an appropriate cardioprotective substance in the rat model of ISO-induced MI.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-arginine supplementation attenuates ovarian oxidative stress in female rats subjected to chronic intermittent hypoxia. 补充l -精氨酸可减轻慢性间歇缺氧雌性大鼠卵巢氧化应激。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-22 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00257

Amira Abdel-Rhman, Wessam Morsy, Nermeen Selim, Enas A Abdel-Hady

{"title":"L-arginine supplementation attenuates ovarian oxidative stress in female rats subjected to chronic intermittent hypoxia.","authors":"Amira Abdel-Rhman, Wessam Morsy, Nermeen Selim, Enas A Abdel-Hady","doi":"10.1556/2060.2023.00257","DOIUrl":"10.1556/2060.2023.00257","url":null,"abstract":"Background: Systemic and organ-specific oxidative stress triggered by hypoxia is suggested to play a key role in germ cell apoptosis and DNA damage. This study was designed to investigate the impact of chronic intermittent hypoxia (CIH) on female fertility and evaluate the potential antioxidant effect of L-arginine (L-Arg) supplementation.Methods: Adult female rats were allocated into three groups: controls (normoxic), hypoxic and hypoxic supplemented with L-Arg. After 12 weeks; hematocrit value was determined, body weight (BW) and ovarian weight were measured for the calculation of the gonado-somatic index. Plasma levels of luteinizing hormone (LH) and progesterone were estimated. Ovarian tissue malondialdehyde (MDA) and catalase were assessed, and caspase-3 enzyme expression was detected by immunohistochemistry.Results: Compared to controls, CIH resulted in increased oxidative stress in the ovarian tissue, decreased ovarian weight, and increased frequency of irregular cycles and higher plasma level of LH in rats with either regular or irregular ovarian cycles. Histological examination of ovarian sections revealed areas of degeneration, atretic follicles, interstitial edema, congested vessels and inflammatory cell infiltration. Immunohistochemistry confirmed the presence of apoptosis by increased caspase-3 expression. Hypoxic rats pre-treated with L-Arg showed increased BW and ovarian weight, decreased ovarian tissue MDA and plasma LH accompanied by a lower incidence of irregular cycles and mortality. The histological picture was improved and caspase-3 expression was reduced.Conclusion: Oxidative stress caused by CIH is detrimental to the structure and function of the corpus luteum with an increased risk of reduced fertility. L-Arg supplementation increases antioxidant capacity and improves hypoxia-induced fertility disorders.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension. 毛细血管前肺动脉高压的循环apelin、IL22RA2和VEGF。

IF 1.4 4区医学

Physiology international Pub Date : 2023-11-17 Print Date: 2023-12-18 DOI: 10.1556/2060.2023.00264

Györgyi Csósza, Gergő Szűcs, Zsolt Rozgonyi, Balázs Csoma, György Losonczy, Veronika Müller, Kristóf Karlócai, Zsófia Lázár

{"title":"Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.","authors":"Györgyi Csósza, Gergő Szűcs, Zsolt Rozgonyi, Balázs Csoma, György Losonczy, Veronika Müller, Kristóf Karlócai, Zsófia Lázár","doi":"10.1556/2060.2023.00264","DOIUrl":"10.1556/2060.2023.00264","url":null,"abstract":"Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = -0.34, P = 0.04), and right ventricular stroke work index (r = -0.47, P = 0.003). IL22RA2 concentration correlated with mean PAP (r = -0.32, P = 0.04) and serum N-terminal pro B-type natriuretic peptide level (r = -0.42, P = 0.01). VEGF concentration increased in patients upon clinical improvement (N = 16, P = 0.02). Circulating apelin is a novel biomarker of pre-capillary PH. Apelin and IL22RA2 levels are related to right ventricular function upon diagnosis of PH.","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136398681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0