{"title":"Vitamin K deficiency bleeding and optimal prophylaxis methods in biliary atresia: A surveillance study in Japan.","authors":"Ryuji Okubo, Chiyoe Shirota, Motoshi Wada, Masato Shinkai, Hirofumi Tomita, Satoshi Umeda, Hiromu Miyake, Toshiharu Matsuura, Shigehisa Fumino, Akio Odaka, Taizo Hibi, Toshio Harumatsu, Akiko Yokoi, Tomoro Hishiki, Shigeru Ono, Kohei Matsushita","doi":"10.1111/ped.70075","DOIUrl":"10.1111/ped.70075","url":null,"abstract":"<p><strong>Background: </strong>Vitamin K (VK) prophylaxis refers to the administration of VK to newborns to prevent neonatal VK deficiency bleeding (VKDB), which is characterized by intracranial hemorrhage (ICH). This study investigated the relationship between VK prophylaxis methods and VKDB in biliary atresia (BA).</p><p><strong>Methods: </strong>The survey targeted 497 cases in the Japanese Biliary Atresia Registry between 2015 and 2019, of which 395 (79.5%) returned the questionnaire. Of the 395 patients, 289 were selected after excluding cases in which the gestational age was <36 weeks or the VK prophylaxis methods/feeding contents were unknown. The patients were categorized into two groups according to VK prophylaxis methods. We conducted a comparative study using propensity score matching. The prognosis of patients with or without ICH was also investigated.</p><p><strong>Results: </strong>In the analysis, no VKDB occurred in patients using the 3-month method. In the propensity score matching analysis, age at first visit and age at surgery were later in the three-times method (p = 0.018 and p = 0.022, respectively); VKDB was higher in the three-times method than in the 3-month method (p = 0.029). ICH, jaundice disappearance, cholangitis, and native liver survival rates (NLSRs) were not significantly different between groups. When examining the prognosis based on ICH occurrence, the two groups showed no significant differences in jaundice disappearance, cholangitis, and NLSRs. The ICH group had a greater number of cases of delayed mental and/or motor development.</p><p><strong>Conclusions: </strong>In BA, the 3-month method is effective in preventing VKDB, and early diagnosis is crucial.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70075"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Congenital diaphragmatic hernia with congenital heart disease including ventricular septal defect: Risk factors.","authors":"Yuichi Hirano, Keita Terui, Wataru Kudo, Ayako Takenouchi, Shugo Komatsu, Satoru Oita, Hiroko Yoshizawa, Takashi Fumita, Yusaku Yoshino, Tomoro Hishiki","doi":"10.1111/ped.70126","DOIUrl":"10.1111/ped.70126","url":null,"abstract":"<p><strong>Background: </strong>Congenital diaphragmatic hernia (CDH) with congenital heart disease (CHD) has a poor prognosis. This study aimed to establish the prognostic factors of CDH associated with ventricular septal defect (VSD), which is the most commonly encountered CHD.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective observational study including neonatal cases of CDH with CHD managed at our hospital between 2000 and 2022. The risk factors for CDH in patients with VSD were established by comparing survivors and non-survivors.</p><p><strong>Results: </strong>Among the 84 infants with CDH, 14 (17%) were associated with CHD, including 11 cases of VSD (79% of CHD). The survival rate of patients with CDH prenatally diagnosed with left-sided disease and VSD was 56% (four of nine patients died). The rate of low lung volume (observed/expected lung area-to-head circumference ratio ≤ 35%) was significantly higher in non-survivors than in survivors (75% vs. 0%, p = 0.048). All non-survivors had associated severe CHD (n = 3) or severe pulmonary hypertension (n = 1).</p><p><strong>Conclusion: </strong>Low lung volume was a risk factor for CDH with at least moderate to small size of VSD, which was comparable with that in patients with isolated CDH.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70126"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jo Uemura, Ryoji Aoki, Masako Aoki, Nobuhiko Nagano, Aya Okahashi, Osamu Miyazaki, Ichiro Morioka
{"title":"Early diagnosis by newborn physique index and femoral-pelvic radiologic score in an infant with hypochondroplasia.","authors":"Jo Uemura, Ryoji Aoki, Masako Aoki, Nobuhiko Nagano, Aya Okahashi, Osamu Miyazaki, Ichiro Morioka","doi":"10.1111/ped.15856","DOIUrl":"https://doi.org/10.1111/ped.15856","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15856"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sex education to an adolescent male with Down syndrome in a single-mother family in Japan.","authors":"Amuna Saito, Takeshi Sato, Haruko Shima, Hiroyuki Yamagishi, Satoshi Narumi, Tomohiro Ishii, Tomonobu Hasegawa","doi":"10.1111/ped.15896","DOIUrl":"10.1111/ped.15896","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15896"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Par Khin, Nobutoshi Nawa, Yui Yamaoka, Floret Maame Owusu, Aya Abe, Takeo Fujiwara
{"title":"Association between elementary and middle school children with mixed/foreign parents and influenza vaccination in Japan.","authors":"Yu Par Khin, Nobutoshi Nawa, Yui Yamaoka, Floret Maame Owusu, Aya Abe, Takeo Fujiwara","doi":"10.1111/ped.15851","DOIUrl":"https://doi.org/10.1111/ped.15851","url":null,"abstract":"<p><strong>Background: </strong>The number of children with foreign parents is increasing in Japan; however, the percentage of these children receiving the recommended annual influenza vaccination, which must be paid for voluntarily, may be quite low. Socioeconomic status may influence voluntary vaccination decisions. This study explored the association between elementary and middle school children with mixed (either of the parents was non-Japanese) /foreign parents (both parents were non-Japanese) and influenza vaccination in Japan, stratified by household income and maternal education.</p><p><strong>Methods: </strong>We used combined data from eight cities in the Greater Tokyo area for the period from 2016 to 2019, which included 16,368 elementary and middle school students and their caregivers. Caregivers responded to questions about whether their children received influenza vaccination in the previous year and their foreign-born status. Multilevel Poisson regression was applied and further stratified by income status and maternal education.</p><p><strong>Results: </strong>Three hundred ninety-one children (2.4%) had mixed parents, and 91 (0.6%) had foreign parents. When compared with Japanese children, children with mixed (incidence risk ratio, IRR: 0.80, confidence Interval, CI: 0.71, 0.90) and foreign parents (IRR: 0.70, CI: 0.56, 0.88) were less likely to receive influenza vaccination. After stratification, children with mixed/foreign parents were less likely to receive influenza vaccination than Japanese children only in households with high income and maternal education.</p><p><strong>Conclusions: </strong>Children with mixed and foreign parents, especially in households with high socioeconomic status, had lower influenza vaccine coverage than Japanese children.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15851"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ARC syndrome accompanied with glaucoma in one of two affected siblings.","authors":"Takashi Okuno, Motohiro Takeuchi, Sachi Shimizu, Naoko Hiragi, Yusei Ohshima","doi":"10.1111/ped.15875","DOIUrl":"10.1111/ped.15875","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15875"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}