Long-term trend of cumulative incidence of venous thromboembolism in Korean pediatric inflammatory bowel disease.

IF 0.9 4区医学 Q3 PEDIATRICS

Pediatrics International Pub Date : 2025-01-01 DOI:10.1111/ped.70158

Seongjin Choi, Seo-Hee Kim, Seong Pyo Kim, Yujin Park, Su Hwan Kim, Yeong Eun Kim, Ho Jung Choi, In Sook Jeong, Seak Hee Oh, Hyung-Jin Yoon, Kyung Mo Kim

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引用次数: 0

Abstract

Background: Research on venous thromboembolism (VTE) in pediatric inflammatory bowel disease (PIBD) is rare in Asia. This study aimed to investigate the epidemiological characteristics of VTE within the Korean PIBD population.

Methods: A cohort study was conducted on pediatric patients (<17 years) using South Korea's health claims data from 2005 to 2015. IBD and VTE were identified using ICD-10 codes. We analyzed incidence rate, cumulative incidence, and risk factors, including very early-onset (VEO, <6 years) IBD.

Results: Among 2456 newly diagnosed PIBD patients (2005-2015), 15 (0.6%) developed VTE. The overall VTE incidence was 11.08 per 10,000 patient-years, with rates of 76.72 for VEO-IBD and 9.79 for late-onset (LO, 6-16 years) PIBD. Cumulative VTE rates at 0, 1, 5, and 10 years were 0.04%, 0.08%, 0.56%, and 1.26%, respectively. Age at onset increased VTE risk, while gender and disease type did not show significant differences.

Conclusions: The incidence of VTE in PIBD steadily increased over the 10-year period, with a higher occurrence in those with VEO-IBD. This study emphasizes the importance of continuous follow-up for VTE from the early stages of the disease in pediatric IBD patients, particularly focusing on younger age groups.

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韩国儿童炎症性肠病静脉血栓栓塞累积发病率的长期趋势

背景：儿童炎症性肠病（PIBD）中静脉血栓栓塞（VTE）的研究在亚洲很少见。本研究旨在调查韩国PIBD人群中静脉血栓栓塞的流行病学特征。方法：对儿科患者进行队列研究。结果：2005-2015年2456例新诊断PIBD患者中，15例（0.6%）发生静脉血栓栓塞。静脉血栓栓塞总发生率为11.08 / 10000患者年，VEO-IBD为76.72 / 10000患者年，晚发性PIBD为9.79 / 10000患者年。0年、1年、5年和10年的累计VTE率分别为0.04%、0.08%、0.56%和1.26%。发病年龄增加静脉血栓栓塞风险，而性别和疾病类型无显著差异。结论：10年间，PIBD患者静脉血栓栓塞的发生率稳步上升，其中VEO-IBD患者的发生率更高。本研究强调了从儿童IBD患者疾病早期开始对静脉血栓栓塞进行持续随访的重要性，特别是关注年轻年龄组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics International 医学-小儿科

CiteScore

2.00

自引率

7.10%

发文量

519

审稿时长

12 months

期刊介绍： Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.