Pediatrics International最新文献

Antigenicity of proteins in cooked egg powder and skim milk powder for children with egg and milk allergies. 对鸡蛋和牛奶过敏儿童的熟蛋粉和脱脂奶粉中蛋白质的抗原性。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15861

Michihiro Naito, Teruaki Matsui, Shiro Sugiura, Komei Ito, Hidehiko Izumi

引用次数: 0

Successful pregnancy in a patient with OTCD using advanced technologies and liver transplant. 采用先进技术和肝移植治疗OTCD患者成功妊娠。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70006

Sachi Koinuma, Aiko Sasaki, Kei Murayama, Kou Sueoka, Atsuko Murashima, Mureo Kasahara

引用次数: 0

Sirolimus treatment for intractable vascular anomalies (SIVA): An open-label, single-arm, multicenter, prospective trial. 西罗莫司治疗顽固性血管异常（SIVA）：一项开放标签、单臂、多中心、前瞻性试验。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70002

Michio Ozeki, Saori Endo, Shiho Yasue, Ryuta Asada, Akiko M Saito, Hiroya Hashimoto, Shigeru Ueno, Shoji Watanabe, Motoi Kato, Kyoichi Deie, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Mototoshi Kato, Tatsuo Kuroda, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Junkichi Takemoto, Naonori Kawakubo, Akihiro Fujino

{"title":"Sirolimus treatment for intractable vascular anomalies (SIVA): An open-label, single-arm, multicenter, prospective trial.","authors":"Michio Ozeki, Saori Endo, Shiho Yasue, Ryuta Asada, Akiko M Saito, Hiroya Hashimoto, Shigeru Ueno, Shoji Watanabe, Motoi Kato, Kyoichi Deie, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Mototoshi Kato, Tatsuo Kuroda, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Junkichi Takemoto, Naonori Kawakubo, Akihiro Fujino","doi":"10.1111/ped.70002","DOIUrl":"10.1111/ped.70002","url":null,"abstract":"Background: Intractable vascular anomalies (VAs), including vascular tumors and venous, lymphatic, and mixed malformations, often have severe symptoms and a poor prognosis, highlighting the need for new treatments. We conducted a prospective trial of sirolimus (tablet and granule forms) for the treatment of VAs.Methods: In this open-label, single-arm, multicenter trial across four Japanese institutions, patients with VAs received oral sirolimus daily, targeting a trough concentration of 5-15 ng/mL. We evaluated response rates (radiological volume changes in lesions), skin lesions, performance status, respiratory function, visceral symptoms (bleeding, pain), laboratory data, quality of life, and safety at 12, 24, and 52 weeks.Results: Thirteen patients with VAs were treated with sirolimus. Seven patients (53.8%; 95% confidence interval: 25.1%-80.8%) showed a partial radiological response at 24 weeks, with no complete responses, and 61.5% had a partial response by 12 weeks, with little subsequent change in patients who had stable disease thereafter. Improvements in skin lesions, blood coagulation, and activities of daily living were noted. Common adverse events included stomatitis, dermatitis, diarrhea, and fever.Conclusions: Sirolimus may reduce VA tissue volume and potentially improve symptoms and activities of daily living in patients with VAs.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70002"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric characteristics of child survivors after the Kahramanmaraş double earthquake. kahramanmaraki双重地震后幸存儿童的精神特征。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15830

Gonca Özyurt, Gülberat Totur, Özlem Üzüm, Ezgi Karagöz Tanıgör, Cemaliye Başaran, Fatma Mutlubaş, Belde Kasap Demir, Demet Alaygut, Mehmet Zeynel Keskin, Nihal Olgaç Dündar, Aynur Akay, Secil Arslansoyu Çamlar

{"title":"Psychiatric characteristics of child survivors after the Kahramanmaraş double earthquake.","authors":"Gonca Özyurt, Gülberat Totur, Özlem Üzüm, Ezgi Karagöz Tanıgör, Cemaliye Başaran, Fatma Mutlubaş, Belde Kasap Demir, Demet Alaygut, Mehmet Zeynel Keskin, Nihal Olgaç Dündar, Aynur Akay, Secil Arslansoyu Çamlar","doi":"10.1111/ped.15830","DOIUrl":"https://doi.org/10.1111/ped.15830","url":null,"abstract":"Background: The two strongest earthquakes in Turkey for eight decades hit Kahramanmaraş province on February 6, 2023. This study aimed to determine psychiatric complaints, acute stress symptoms, anxiety, depression, and sleep characteristics in children who were treated in a tertiary inpatient pediatric unit after the earthquakes. They were evaluated in the fourth week after the earthquake.Methods: Trauma experiences and acute stress disorders were evaluated by child and adolescent psychiatrists, sleep characteristics were examined by the Child Sleep Habits Questionnaire (CSHQ), and the anxiety and depressive symptoms were investigated using the Revised Child Anxiety and Depression Scale (RCADS). Forty-two patients aged 1-17 were included.Results: Trauma experiences and acute stress disorder symptoms were similar for all age groups examined. There were no significant differences in RCADS or CSHQ scores based on age or gender groups. There were significant differences in RCADS scores when the children were grouped as having parental loss or not and, similarly, there were significant differences in sleep anxiety and resistance to bedtime in CSHQ between these children.Conclusion: This research offered baseline findings about psychological outcomes after these earthquakes in child survivors, and it may provide a further basis to assess the effect of psychological interventions after earthquakes. These results may offer a foundation for suitable psychological interventions for children in developing countries.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15830"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15887

Chia-Fen Wu, Tai-Ling Liu, Yu-Ping Chang, Huei-Fan Hu, Fan-Hao Chou, Cheng-Fang Yen

{"title":"Factors related to parenting difficulties among caregivers of adolescents with attention-deficit/hyperactivity disorder during the COVID-19 pandemic.","authors":"Chia-Fen Wu, Tai-Ling Liu, Yu-Ping Chang, Huei-Fan Hu, Fan-Hao Chou, Cheng-Fang Yen","doi":"10.1111/ped.15887","DOIUrl":"https://doi.org/10.1111/ped.15887","url":null,"abstract":"Background: Caregivers of children with attention-deficit/hyperactivity disorder (ADHD) experience more parenting stress than do caregivers of children without ADHD. Evidence suggests that ADHD severity is positively associated with parenting stress. In adolescents, ADHD increases the risks of contracting Coronavirus disease 2019 (COVID-19) and having poor outcomes. This follow-up study explored the prospective and cross-sectional factors influencing parenting difficulties experienced by the caregivers of adolescents with ADHD during the COVID-19 pandemic.Methods: The following data were collected at baseline (before the outbreak of the pandemic in Taiwan): caregivers' demographic characteristics, affiliate stigma, parenting stress, depressive and anxiety symptoms, perceived ADHD causes, and adolescents' ADHD, oppositional defiant disorder (ODD), depressive, and anxiety symptoms. The following data were collected at follow-up (after the pandemic): caregivers' parenting difficulties during the pandemic, depressive and anxiety symptoms, and adolescents' ADHD symptoms.Results: Stepwise multivariate regression analysis indicated that caregivers' parenting stress and adolescents' hyperactivity and impulsivity symptoms at baseline were positively correlated with caregivers' parenting difficulties during the pandemic. Furthermore, adolescents' hyperactivity, impulsivity, and ODD symptoms at follow-up were cross-sectionally and positively correlated with caregivers' parenting difficulties during the pandemic.Conclusion: Caregivers' parenting stress and adolescents' hyperactivity, impulsivity, and ODD symptoms should be considered when developing interventions for improving caregivers' ability to manage adolescents with ADHD, particularly in relation to self-protection, learning, life changes, daily routines, and emotional well-being.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15887"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality improvement activities in an NICU: Stop UNplanned eXtubation (SUNX). NICU质量改进活动：停止非计划拔管（SUNX）。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15889

Hidehiko Maruyama, Shoichiro Amari, Kana Yamada, Ayumi Ohshima, Kanako Sugashima, Naomi Homma, Tetsuya Isayama, Yushi Ito

{"title":"Quality improvement activities in an NICU: Stop UNplanned eXtubation (SUNX).","authors":"Hidehiko Maruyama, Shoichiro Amari, Kana Yamada, Ayumi Ohshima, Kanako Sugashima, Naomi Homma, Tetsuya Isayama, Yushi Ito","doi":"10.1111/ped.15889","DOIUrl":"https://doi.org/10.1111/ped.15889","url":null,"abstract":"Background: A target unplanned extubation (UE) rate of <1/100 ventilator days has been recommended. Our hospital has 21 NICU beds (12 beds in NICU 2 and 3 for extremely low birth weight [ELBW] infants). In 2020, we experienced an abrupt UE increase, leading to the initiation of the Stop UNplanned eXtubation (SUNX) project. At that time, UE rate was 1.30/100 ventilator days. The aim of the SUNX project was to keep the low UE rate.Methods: We collected data on UE rates from April 2019 to March 2024. The intervention was implemented through Plan-Do-Study-Act cycles. Cause analysis with the Pareto chart led to the drivers, we had to deal with: judicious use of sedations, Endotracheal tube (ETT) tape loosening, and stuff number during infant care. Additionally, we did simulation training for sudden SpO2 decrease and UE event review. We also gathered data about ELBW infant admission and their NICU stay.Results: The UE rate in total NICU was kept lower than 1/100 ventilator days after the intervention. After our intervention, we found no special cause variation. It meant that our intervention was not statistically significant. However, our intervention gradually penetrated into the NICU daily practices; judicious use of sedation, ETT tape template, body position change by two nurses, UE event review, and so on. We continued a systematic approach to preventing UE.Conclusions: Although abrupt UE increase in 2020 might be a special cause variation, SUNX activities brought us systematic approach for UE prevention.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15889"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of 6-12 years-old child sleep habits scale and investigation of its psychometric properties. 6-12岁儿童睡眠习惯量表的编制及其心理测量学性质的研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70020

Çiğdem Müge Haylı, Mehmet Zeki Avci, Dilek Demir Kösem, Neşe Ataman Bor

{"title":"Development of 6-12 years-old child sleep habits scale and investigation of its psychometric properties.","authors":"Çiğdem Müge Haylı, Mehmet Zeki Avci, Dilek Demir Kösem, Neşe Ataman Bor","doi":"10.1111/ped.70020","DOIUrl":"https://doi.org/10.1111/ped.70020","url":null,"abstract":"Background: Sleep and sleep habits in children are important in terms of bio-psycho-social aspects. The aim of this research was to develop a new scale under the name of the evaluation of sleep and sleep habits of children aged 6-12. 600 children aged 6-12 years constituted the sample of the study.Methods: The parents of the children were asked to answer the question list in the sleep habits scale of 6-12-year-old children, in which sleep and sleep habits were evaluated, which was formed by the socio-demographic information from an expert opinion by the research team. To examine the reliability of the scale based on internal consistency, Cronbach and Omega alpha coefficients were calculated, and test-retest analysis and criterion validity were performed to determine the stability of the scale and whether it could make consistent measurements over time.Results: In the correlation coefficient used as a test-retest reliability method, there were moderate and high levels of positive and significant correlations between the scores obtained from the first and second applications. According to the criterion validity findings, a moderately positive and significant relationship was found between the scores obtained from the overall sleep habits scale and the scores obtained from the overall child sleep habits questionnaire (r = 0.61; p < 0.01).Conclusion: These results showed that the 6-12 age child sleep habits scale, which is a parent-reported scale, is a valid and reliable new scale that can evaluate sleep and sleep habits of children and screen for potential sleep problems.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70020"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of pulmonary embolism occurring with cardiopulmonary arrest after catheter ablation. 导管消融后肺栓塞并发心肺骤停1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15858

Hiroki Ishii, Yu Matsumura, Tadahiro Yoshikawa

引用次数: 0

A high-throughput TREC- and KREC-based newborn screening for severe inborn errors of immunity. 基于TREC和krecs的新生儿严重先天性免疫错误的高通量筛查

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15872

Haruka Hiroki, Kunihiko Moriya, Toru Uchiyama, Fumi Hirose, Akifumi Endo, Iori Sato, Yasuhiro Tomaru, Kazumi Sawakami, Norio Shimizu, Hidenori Ohnishi, Tomohiro Morio, Kohsuke Imai

{"title":"A high-throughput TREC- and KREC-based newborn screening for severe inborn errors of immunity.","authors":"Haruka Hiroki, Kunihiko Moriya, Toru Uchiyama, Fumi Hirose, Akifumi Endo, Iori Sato, Yasuhiro Tomaru, Kazumi Sawakami, Norio Shimizu, Hidenori Ohnishi, Tomohiro Morio, Kohsuke Imai","doi":"10.1111/ped.15872","DOIUrl":"https://doi.org/10.1111/ped.15872","url":null,"abstract":"Introduction: Severe combined immunodeficiency (SCID) due to T-cell deficiency is the most severe form of inborn error of immunity (IEI). It frequently leads to severe and recurrent infections and the first infection or live vaccines can sometimes be fatal. Patients with B-cell deficiency (BCD), such as X-linked agammaglobulinaemia (XLA), also suffer from severe or recurrent infections. Thus, early diagnosis via newborn screening (NBS) is suitable for these types of diseases. We developed a lyophylized TaqMan-based quantitative polymerase chain reaction (qPCR) kit with primers and probes for the simultaneous detection of T-cell receptor excision circles (TREC) and κ-deleting recombination excision circles (KREC). We also developed a fully automated DNA extraction and purification process using Magtration technology from dried blood spots (DBS), enabling high-throughput analysis METHODS: We examined 15,258 stored DBS collected from 2014 to 2015 by this method. Newborn screening samples from children with a known SCID, XLA or ataxia-telangiectasia (AT) were also examined as positive controls.Results: RPPH1 (internal control), TREC, and KREC all had near-normal distributions. One specimen was below the cut-off for TREC (0.00657%) after exclusion of 36 specimens due to the failure of DNA extraction (0.23%). The TREC levels in the patients with AT and SCID, and KREC levels in the patients with AT and XLA were all below cut-off or absent.Conclusions: This assay would allow the establishment of qPCR-based NBS in unfamiliar laboratories leading to the early diagnosis of SCID and BCD.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15872"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk score for non-vaccination of voluntary vaccines: The Japan Environment and Children's Study. 未接种自愿疫苗的风险评分：日本环境与儿童研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15888

Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

{"title":"Risk score for non-vaccination of voluntary vaccines: The Japan Environment and Children's Study.","authors":"Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso","doi":"10.1111/ped.15888","DOIUrl":"https://doi.org/10.1111/ped.15888","url":null,"abstract":"Background: In Japan, as several important vaccines are still categorized as voluntary vaccines that require out-of-pocket payment, the vaccination coverage of voluntary vaccines is lower than that of routine vaccines. Thus, higher voluntary vaccination rates are desired. Herein, we used nationwide birth cohort data to create a voluntary vaccine risk score to identify high-risk individuals who were not vaccinated with voluntary vaccines.Methods: The data from 74,733; 73,571; and 74,360 infants were analyzed for rotavirus, mumps virus, and influenza virus vaccinations, respectively. The risk score for non-vaccination of voluntary vaccines was created from the regression coefficients of the logistic regression models.Results: The items included for the score resulted from the analysis were the mother's drug allergy history, mother's depression history, mother's educational background, father's educational background, household income, maternal smoking during pregnancy, paternal smoking during pregnancy, fertility treatment, number of siblings, maternal drinking at 1 month of age, maternal age, and maternal nationality. The mother's drug allergy history, mother's depression history, fertility treatment, maternal drinking at 1 month of age, and maternal nationality were factors not previously reported and associated with taking voluntary vaccine. The receiver operating characteristic curve of the risk score for non-vaccination of voluntary vaccines suggested that a score ≥16 predicted non-vaccinated infants for rotavirus, mumps virus, and influenza virus vaccines with 78.6%, 75.0%, and 74.5% sensitivity and 44.2%, 43.2%, and 37.1% specificity, respectively.Conclusions: We developed a risk score for non-vaccination of voluntary vaccines consisting of 10 domains with high sensitivity but low specificity.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15888"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0