{"title":"Prevalence and associated factors of lower urinary tract dysfunction in school-aged children in Zonguldak, Turkey.","authors":"Zühal Örnek, İbrahim Etem Pişkin, Sinem Abasız","doi":"10.1111/ped.70046","DOIUrl":"https://doi.org/10.1111/ped.70046","url":null,"abstract":"<p><strong>Background: </strong>Lower urinary tract dysfunction (LUTD) is a common issue in children. Data on the prevalence of LUTD in our country are limited. We aimed to investigate the prevalence and associated factors of LUTD among children in grades 1-8 in Zonguldak, located in northwestern Turkey, using a validated voiding dysfunction scoring system.</p><p><strong>Methods: </strong>The study included students in grades 1-8 from schools in central Zonguldak during the 2021-2022 academic year. Parents of children who were included in the study were sent a questionnaire via the Internet. Demographic information, the child's medical history, details about voiding habits, and voiding dysfunction symptom score (VDSS) information were obtained. The data from 654 students whose parents completed the survey were analyzed.</p><p><strong>Results: </strong>The prevalence of LUTD, daytime urinary incontinence, and nocturnal enuresis were 9.6% (n = 63), 12.4% (n = 81), and 13% (n = 85), respectively. According to the survey responses, the most common symptoms were urgency (n = 253, 39%), followed by holding maneuvers (n = 140, 21.4%). There was no significant relationship between the mother's educational level and daytime urinary incontinence (p = 0.091). Daytime urinary incontinence was more common in children of fathers with lower educational levels (p = 0.021).</p><p><strong>Conclusions: </strong>This study demonstrates a high prevalence of LUTD among school-aged children. Constipation, urinary tract infections, and family history should be integral parts of the initial evaluation. Identifying the prevalence of LUTD and related risk factors in children is considered the first step in reducing and managing the number of affected children in the community.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70046"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hen's egg allergy is a risk factor for zinc deficiency.","authors":"Hiroaki Yamane, Eishi Makita, Daisuke Sugawara, Kae Itabashi","doi":"10.1111/ped.70038","DOIUrl":"https://doi.org/10.1111/ped.70038","url":null,"abstract":"<p><strong>Background: </strong>Insufficient zinc intake causes zinc deficiency. We hypothesized that dietary restrictions due to food allergy (FA) may be a zinc deficiency risk. Thus, we evaluated the relationship between serum zinc levels and FA in children.</p><p><strong>Methods: </strong>Children aged 10 months to 6 years were prospectively enrolled; the FA group comprised 73 children with IgE-dependent allergies to hen's egg, cow's milk, or wheat; the control group comprised 49 children without FA. Clinical data and serum zinc, hemoglobin, iron, and 25-hydroxy vitamin D levels were measured and statistically analyzed. The risk factors for zinc deficiency (zinc < 70 μg/dL) were analyzed.</p><p><strong>Results: </strong>The median age was 2.3 years for both the FA and control groups (p > 0.05). Serum zinc levels were significantly lower in the FA group than in the control group (median [interquartile range]: 70 [64-76] μg/dL vs. 77 [71-85] μg/dL; p < 0.001). Regarding other blood test results, only serum iron levels were significantly lower in the FA group. In the multivariate analysis, hen's egg allergy was the only significant risk factor for zinc deficiency, other FA and atopic dermatitis history were not. In patients with hen's egg allergy, the zinc levels in those with severe dietary restrictions were significantly lower than in the others.</p><p><strong>Conclusions: </strong>Serum zinc levels were significantly low in the FA group. Notably, hen's egg allergy was a significant risk factor for zinc deficiency. For patients with severe dietary restrictions due to hen's egg allergy, zinc levels should be assessed and appropriate nutritional advice provided.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70038"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fayize Maden Bedel, Özgür Balasar, Nagehan Bilgeç, Hüseyin Çaksen
{"title":"Two cases with cutis laxa: Two novel variants in the ATP6V0A2 gene and new findings.","authors":"Fayize Maden Bedel, Özgür Balasar, Nagehan Bilgeç, Hüseyin Çaksen","doi":"10.1111/ped.70014","DOIUrl":"https://doi.org/10.1111/ped.70014","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70014"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of anaphylaxis in an infant due to inhalation of soybean hulls.","authors":"Atsuko Nakano, Erika Yano, Yuri Takaoka, Naoki Hashimoto, Yoko Iida, Ken Takagawa, Tatsuya Moriyama","doi":"10.1111/ped.70049","DOIUrl":"https://doi.org/10.1111/ped.70049","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70049"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anxiety disorders in children with non-cardiac chest pain: Is routine screening needed in pediatric clinics?","authors":"Leyla Bozatlı, Murat Deveci, Işık Görker","doi":"10.1111/ped.70084","DOIUrl":"https://doi.org/10.1111/ped.70084","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to determine anxiety disorders and other psychopathologies in children and adolescents with non-cardiac chest pain.</p><p><strong>Methods: </strong>A total of 115 patients (between 8 and 16 years of age), including 61 cases of non-cardiac chest pain referred from the Pediatric Cardiology Outpatient Clinic and 54 healthy volunteers, were included in the study.</p><p><strong>Results: </strong>The majority of patients with chest pain were girls (82%, p = 0.001). The pain was predominantly localized to the left chest (73.8%), occurred both on exertion and at rest (59%), was not radiating (80.3%), lasted 1-5 min (37.7%), and had been present for more than a year. Psychiatric disorders were found in 39.3% of the chest pain group (p < 0.001). Generalized anxiety disorder (GAD) was the most common diagnosis (19.7%), followed by Attention-deficit/hyperactivity disorder (ADHD) (8.2%). Social anxiety disorder (SAD) (5.6%) and GAD (3.7%) were more common in the control group. The prevalence of GAD was significantly different between groups (p = 0.009). Screen for child anxiety-related disorders (SCARED) (p < 0.001) and Children's Somatization Inventory-24 (CSI-24) (p < 0.001) scores were significantly higher in the chest pain group. The SCARED total score was higher in girls (p = 0.011), and the subscale scores were higher for GAD in adolescents (p = 0.019) and separation anxiety in children (p = 0.043).</p><p><strong>Conclusion: </strong>We believe that it would be beneficial to perform screenings using scales in outpatient clinics with a high number of patients presenting with chest pain and to refer them for psychiatric evaluation to prevent unnecessary medical diagnostic procedures in children who describe unexplained chest pain and to prevent the potential for mental disorder diagnoses in children.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70084"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burcu Güven, Serhat Yıldırım, Zeynep Gökçe Gayretli Aydın, Gökçe Pınar Reis İskenderoğlu, Tülay Kamaşak, Murat Çakır
{"title":"Drug-induced liver injury in pediatric age group: Single-center experience.","authors":"Burcu Güven, Serhat Yıldırım, Zeynep Gökçe Gayretli Aydın, Gökçe Pınar Reis İskenderoğlu, Tülay Kamaşak, Murat Çakır","doi":"10.1111/ped.70099","DOIUrl":"https://doi.org/10.1111/ped.70099","url":null,"abstract":"<p><strong>Background: </strong>There is no clear information regarding the frequency of drug-induced liver injury (DILI) in the pediatric age group. In this study, we aimed to investigate the incidence of DILI in pediatric patients and to determine the drug groups responsible for the etiology of DILI and the factors associated with this disease.</p><p><strong>Methods: </strong>The prospective study was conducted in patients aged 0-18 years and diagnosed with DILI. Age, gender, drugs used by the patients, indications for drug use, duration and dosage of drugs, and laboratory parameters were recorded. Liver injury pattern was classified as hepatocellular, mixed and cholestatic type.</p><p><strong>Results: </strong>The mean age was 7.8 ± 5.5 years; 187 (62.3%) were male. A total of 90 drugs were found to be responsible for hepatotoxicity, among which methotrexate (8.66%) and cephalosporin group antibiotics (8.66%) were found to be the most commonly identified drugs, followed by carbapenem group antibiotics (6.77%), steroids (6.77%) and mercaptopurine (5.04%). Hepatocellular type developed in 67% (n = 122), mixed type in 28% (n = 51) and cholestatic type in 5% (n = 8) patients.</p><p><strong>Conclusions: </strong>Hepatocellular type was found to be the most common type among the patterns of liver injury in the pediatric age group. Although antibiotics constitute the leading cause of DILI, antibiotic choices are changing due to increasing resistant infections. The frequency of carbapenem-induced DILI is increasing.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70099"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Gençeli, Özge Metin Akcan, Sümeyye Beyza Kılınç, Sinan Saylık, Mehmet Kocaoğlu, Uğur Saraç, Mehmet Burhan Oflaz
{"title":"Transient sinus bradycardia during the course of MIS-C.","authors":"Mustafa Gençeli, Özge Metin Akcan, Sümeyye Beyza Kılınç, Sinan Saylık, Mehmet Kocaoğlu, Uğur Saraç, Mehmet Burhan Oflaz","doi":"10.1111/ped.70114","DOIUrl":"https://doi.org/10.1111/ped.70114","url":null,"abstract":"<p><strong>Background: </strong>Following COVID-19 infection, multisystem inflammatory syndrome in children (MIS-C) presents as a hyperinflammatory condition affecting multiple organ systems. We observed that many of the patients have bradycardia in the course of the disease.</p><p><strong>Methods: </strong>In a retrospective analysis of medical records from June 2020 to July 2023, we investigated the clinical course of MIS-C. Clinical recovery day was defined as the point at which there was an absence of fever (≥38°C) and no further need for vasoactive inotropes or respiratory support. The relationship between clinical recovery day and bradycardia and its implications for clinical course and prognosis was examined in this study.</p><p><strong>Results: </strong>The study included 46 patients diagnosed with MIS-C with a mean age of 10.06 ± 4.06 years. The median time of clinical recovery was 4.0 (IQR = 1.0) days. Asymptomatic sinus bradycardia developed in 36 (78.3%) patients at a median duration of 4.0 (IQR = 2.0) days in the follow-up period. There was a strong positive correlation (ρ = 0.701, p < 0.001) between the onset of bradycardia and clinical improvement. There was a strong positive correlation between the onset of bradycardia and clinical improvement in patients with cardiac involvement (ρ = 0.590, p = 0.026) and a very strong positive correlation in patients with no cardiac involvement (ρ = 0.765, p < 0.001).</p><p><strong>Conclusions: </strong>Evidence suggests potential associations between the onset of bradycardia and clinical recovery in the course of MIS-C. Large-scale multicenter studies are needed to validate our findings and elucidate its clinical significance.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70114"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}