Pediatrics International最新文献_第10页

Drug-induced liver injury in pediatric age group: Single-center experience. 儿童年龄组药物性肝损伤：单中心经验。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70099

Burcu Güven, Serhat Yıldırım, Zeynep Gökçe Gayretli Aydın, Gökçe Pınar Reis İskenderoğlu, Tülay Kamaşak, Murat Çakır

{"title":"Drug-induced liver injury in pediatric age group: Single-center experience.","authors":"Burcu Güven, Serhat Yıldırım, Zeynep Gökçe Gayretli Aydın, Gökçe Pınar Reis İskenderoğlu, Tülay Kamaşak, Murat Çakır","doi":"10.1111/ped.70099","DOIUrl":"https://doi.org/10.1111/ped.70099","url":null,"abstract":"Background: There is no clear information regarding the frequency of drug-induced liver injury (DILI) in the pediatric age group. In this study, we aimed to investigate the incidence of DILI in pediatric patients and to determine the drug groups responsible for the etiology of DILI and the factors associated with this disease.Methods: The prospective study was conducted in patients aged 0-18 years and diagnosed with DILI. Age, gender, drugs used by the patients, indications for drug use, duration and dosage of drugs, and laboratory parameters were recorded. Liver injury pattern was classified as hepatocellular, mixed and cholestatic type.Results: The mean age was 7.8 ± 5.5 years; 187 (62.3%) were male. A total of 90 drugs were found to be responsible for hepatotoxicity, among which methotrexate (8.66%) and cephalosporin group antibiotics (8.66%) were found to be the most commonly identified drugs, followed by carbapenem group antibiotics (6.77%), steroids (6.77%) and mercaptopurine (5.04%). Hepatocellular type developed in 67% (n = 122), mixed type in 28% (n = 51) and cholestatic type in 5% (n = 8) patients.Conclusions: Hepatocellular type was found to be the most common type among the patterns of liver injury in the pediatric age group. Although antibiotics constitute the leading cause of DILI, antibiotic choices are changing due to increasing resistant infections. The frequency of carbapenem-induced DILI is increasing.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70099"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient sinus bradycardia during the course of MIS-C. MIS-C过程中的一过性窦性心动过缓。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70114

Mustafa Gençeli, Özge Metin Akcan, Sümeyye Beyza Kılınç, Sinan Saylık, Mehmet Kocaoğlu, Uğur Saraç, Mehmet Burhan Oflaz

{"title":"Transient sinus bradycardia during the course of MIS-C.","authors":"Mustafa Gençeli, Özge Metin Akcan, Sümeyye Beyza Kılınç, Sinan Saylık, Mehmet Kocaoğlu, Uğur Saraç, Mehmet Burhan Oflaz","doi":"10.1111/ped.70114","DOIUrl":"https://doi.org/10.1111/ped.70114","url":null,"abstract":"Background: Following COVID-19 infection, multisystem inflammatory syndrome in children (MIS-C) presents as a hyperinflammatory condition affecting multiple organ systems. We observed that many of the patients have bradycardia in the course of the disease.Methods: In a retrospective analysis of medical records from June 2020 to July 2023, we investigated the clinical course of MIS-C. Clinical recovery day was defined as the point at which there was an absence of fever (≥38°C) and no further need for vasoactive inotropes or respiratory support. The relationship between clinical recovery day and bradycardia and its implications for clinical course and prognosis was examined in this study.Results: The study included 46 patients diagnosed with MIS-C with a mean age of 10.06 ± 4.06 years. The median time of clinical recovery was 4.0 (IQR = 1.0) days. Asymptomatic sinus bradycardia developed in 36 (78.3%) patients at a median duration of 4.0 (IQR = 2.0) days in the follow-up period. There was a strong positive correlation (ρ = 0.701, p < 0.001) between the onset of bradycardia and clinical improvement. There was a strong positive correlation between the onset of bradycardia and clinical improvement in patients with cardiac involvement (ρ = 0.590, p = 0.026) and a very strong positive correlation in patients with no cardiac involvement (ρ = 0.765, p < 0.001).Conclusions: Evidence suggests potential associations between the onset of bradycardia and clinical recovery in the course of MIS-C. Large-scale multicenter studies are needed to validate our findings and elucidate its clinical significance.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70114"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast milk pasteurization for preventing cytomegalovirus infection: A preliminary study in a Japanese perinatal center. 母乳巴氏消毒预防巨细胞病毒感染：日本围产期中心的初步研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70076

Sakiko Uho, Sota Iwatani, Shohei Ohyama, Toshihiko Ikuta, Sachiko Matsui, Seiji Yoshimoto

{"title":"Breast milk pasteurization for preventing cytomegalovirus infection: A preliminary study in a Japanese perinatal center.","authors":"Sakiko Uho, Sota Iwatani, Shohei Ohyama, Toshihiko Ikuta, Sachiko Matsui, Seiji Yoshimoto","doi":"10.1111/ped.70076","DOIUrl":"10.1111/ped.70076","url":null,"abstract":"Background: Postnatal cytomegalovirus (CMV) infection, primarily transmitted through breast milk, poses significant risks for very preterm infants (VPIs), potentially leading to sepsis-like syndromes, necrotizing enterocolitis, and pneumonia. Although pasteurization of breast milk has been shown to be effective in preventing postnatal CMV infection, no studies in Japan have examined its clinical efficacy in practice. This preliminary study investigated the incidence of postnatal CMV infection in VPIs born to CMV-seropositive mothers who received pasteurized breast milk at our Japanese perinatal center.Methods: VPIs born before 32 weeks' gestational age (GA) from September 2019 to August 2023, excluding those born to CMV-seronegative or untested mothers, were retrospectively analyzed. Frozen-thawed breast milk was sterilized by Holder pasteurization at 63°C for 30 min. Urine CMV polymerase chain reaction (PCR) testing was routinely performed within the first 3 weeks of life and again at 36 weeks' corrected GA to assess CMV infection status.Results: A total of 56 VPIs born to CMV-seropositive mothers underwent urine CMV PCR at 36 weeks' corrected GA to evaluate postnatal CMV infection. Among them, three cases (5.4%) were diagnosed with postnatal CMV infection; however, it remains unclear whether these cases were attributable to breast milk transmission or blood transfusions.Conclusions: This preliminary study is the first in Japan to demonstrate that the incidence of postnatal CMV infection in VPIs born to CMV-seropositive mothers after receiving breast milk sterilized by Holder pasteurization was only 5.4%. These results support the effectiveness of our pasteurization protocol in preventing postnatal CMV infection.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70076"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and clinical predictors of hyper-direct bilirubinemia in preterm infants without underlying disease. 无基础疾病早产儿超直接胆红素血症的发病率和临床预测因素

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70026

Takuya Akimoto, Nobuhiko Nagano, Yuki Sato, Hidetoshi Go, Koichiro Hara, Takayuki Imaizumi, Ryoji Aoki, Midori Hijikata, Aya Okahashi, Ichiro Morioka

{"title":"Incidence and clinical predictors of hyper-direct bilirubinemia in preterm infants without underlying disease.","authors":"Takuya Akimoto, Nobuhiko Nagano, Yuki Sato, Hidetoshi Go, Koichiro Hara, Takayuki Imaizumi, Ryoji Aoki, Midori Hijikata, Aya Okahashi, Ichiro Morioka","doi":"10.1111/ped.70026","DOIUrl":"https://doi.org/10.1111/ped.70026","url":null,"abstract":"Backgrounds: This study aimed to identify the incidence and clinical predictors of hyper-direct bilirubinemia (hyper-DB) in preterm infants without underlying diseases.Methods: We enrolled neonates born at <34 weeks of gestational age (GA) between 2019 and 2020. The incidence of hyper-DB was calculated, and neonates were categorized into hyper-DB and nonhyper-DB groups. Hyper-DB was defined as DB ≥ 1 mg/dL when total bilirubin (TB) was <5 mg/dL or DB ≥20% of TB when TB was ≥5 mg/dL during their neonatal intensive care unit stay. Clinical data regarding maternal and neonatal factors were compared using univariate and multivariate analyses, respectively. A receiver operating characteristic curve was generated and the threshold value of the GA was determined using the Youden index.Results: Hyper-DB was diagnosed in 16 of the 131 infants (12%). Eleven clinical factors, including GA, birth weight, absence of premature rupture of membranes (PROM), and incidence of neonatal persistent pulmonary hypertension (PPHN), were significantly different between the two groups (p < 0.05). Multivariate analyses showed that a shorter GA (odds ratio [OR]: 0.48), presence of PPHN (OR: 87.2), and absence of PROM (OR: 0.01) were independent clinical predictors of the development of hyper-DB. Using the Youden index, a cutoff value of 30 weeks for GA was determined as the threshold to manifest hyper-DB.Conclusions: We observed that 12% of preterm infants at <34 weeks' GA without an underlying disease developed hyper-DB. Low GA (less than 30 weeks), presence of PPHN, and absence of PROM were associated with the development of hyper-DB.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70026"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B-cell precursor acute lymphoblastic leukemia in a girl with microphthalmia with linear skin defects syndrome. b细胞前体急性淋巴母细胞白血病伴线性皮肤缺陷综合征的小眼女孩。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70027

Tomoko Tsuge, Yasuhiro Naiki, Tomoo Osumi, Takanobu Maekawa, Keiko Matsubara, Motohiro Kato, Akira Ishiguro

引用次数: 0

Invasive pneumococcal infection after allogeneic hematopoietic cell transplantation for NEMO deficiency. 同种异体造血细胞移植治疗NEMO缺乏后的侵袭性肺炎球菌感染。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70125

Tetsuhiro Yamaguchi, Yuko Kajiho, Hiroyuki Tanaka, Akiko Kinumaki, Shoichiro Kanda, Takahiro Kamiya, Hirokazu Kanegane