Pediatrics International最新文献_第10页

Breastfeeding rate survey: Analysis by combining factors of presence of previous delivery and age in Japanese women. 母乳喂养率调查：结合日本妇女是否有过分娩和年龄因素分析。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70029

Shigeru Nishimaki, Kazuhiro Iwama, Masafumi Yamamoto, Takeshi Ikegaya, Azusa Uozumi

{"title":"Breastfeeding rate survey: Analysis by combining factors of presence of previous delivery and age in Japanese women.","authors":"Shigeru Nishimaki, Kazuhiro Iwama, Masafumi Yamamoto, Takeshi Ikegaya, Azusa Uozumi","doi":"10.1111/ped.70029","DOIUrl":"10.1111/ped.70029","url":null,"abstract":"Background: Age and presence of previous delivery are inextricably linked to breastfeeding. This study aims to examine breastfeeding during the first year after childbirth by combining four factors: primiparas and multiparas, as well as ages <35 years and ≥35 years.Methods: Four hundred thirty-six healthy mothers and their infants (vaginally delivered singleton term infants with birth weight >2500 g) were divided into four groups: (1) 134 pairs of primiparas aged <35 years and their infant (P [<35] group), (2) 72 pairs of primiparas aged ≥35 years and their infant (P [≥35] group), (3) 108 pairs of multiparas aged <35 years and their infant (M [<35] group), and (4) 122 pairs of multiparas aged ≥35 years and their infant (M [≥35] group), and the breastfeeding rate was examined at 0, 1, 2, 4, 6, 8, 10, and 12 months after childbirth.Results: The percentage of the 436 cases with only breastfeeding was 59.6% at 0 months, 69.1% at 4 months, and 56.6% at 12 months. Comparing the four groups, the percentage with only breastfeeding in decreasing order was M [<35] group (70.8%-85.8%, range of rates at each time point) > M [≥35] group (57.9%-69.4%) > P [<35] group (47.8%-61.2%) > P [≥35] group (36.1%-51.4%).Conclusions: There were difficulties with breastfeeding for primiparas, especially those aged ≥35 years. We propose that breastfeeding should be analyzed by combining maternal age and presence or absence of previous delivery together rather than as independent factors.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70029"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory failure due to unilateral bronchial stenosis caused by infant acute myeloid leukemia. 婴儿急性髓性白血病单侧支气管狭窄致呼吸衰竭。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70051

Shun Maki, Haruko Iwabuchi, Kou Matsui, Nobuhiro Kubo, Masaru Imamura, Akihiko Saitoh, Chihaya Imai

引用次数: 0

Detection of anti-neuronal cell-surface antigen antibodies in pediatric patients with acute encephalitis in Japan. 日本小儿急性脑炎患者抗神经元细胞表面抗原抗体的检测。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15865

Yoshiki Kawamura, Yasuaki Mizutani, Mao Asakura, Ryunosuke Nagao, Akihiro Ueda, Hirohisa Watanabe, Tetsushi Yoshikawa

引用次数: 0

A pediatric case of Streptococcal pyogenes empyema due to the M1_UK genotype. 由M1UK基因型引起的儿童化脓性链球菌脓胸1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15877

Keiichi Koizumi, Tomohiro Saito, Ken Takada, Toshimichi Fukao, Fuminori Numano, Noboru Oyachi, Minako Hoshiai

引用次数: 0

Enhancing long-distance medical transport with non-invasive ventilation by linking transport services: A case report. 通过连接运输服务加强无创通气的远程医疗运输：1例报告。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15867

Shinya Miura, Hideki Ohara, Mai Miyaji, Yoshihiro Igarashi, Shinano Horie, Daigo Ando

引用次数: 0

Inhibition of renal fibrosis via Nrf2 activators for unilateral ureteral obstruction in a rat model. Nrf2激活剂对单侧输尿管梗阻大鼠模型肾纤维化的抑制作用。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70000

Hiroki Miyano, Amane Endo, Akira Mizutani, Mayu Nakagawa, Koji Sakuraya, Yayoi Murano, Naoto Nishizaki, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu

{"title":"Inhibition of renal fibrosis via Nrf2 activators for unilateral ureteral obstruction in a rat model.","authors":"Hiroki Miyano, Amane Endo, Akira Mizutani, Mayu Nakagawa, Koji Sakuraya, Yayoi Murano, Naoto Nishizaki, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu","doi":"10.1111/ped.70000","DOIUrl":"https://doi.org/10.1111/ped.70000","url":null,"abstract":"Background: Reactive oxygen species aggravate renal fibrosis, prompting the activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a key mediator in the cellular response to oxygen stress. Nrf2 exerts renoprotective effects by upregulating antioxidant response element (ARE)-dependent genes that antagonize renal fibrosis. Elucidating mechanisms to attenuate renal fibrosis in children is essential for developing therapeutic interventions. This study aimed to examine the renoprotective effects of Nrf2 activators on ARE action in rats with unilateral ureteral obstruction (UUO)-induced renal injury.Methods: The time course of Nrf2 was evaluated in 8-week-old male Sprague-Dawley rats with UUO, with or without Nrf2 activators (bardoxolone methyl) for 2 weeks postoperatively. Kidney tissues were collected on Days 7 and 14 post-surgery. Renoprotective effects were examined using real-time polymerase chain reaction (RT-PCR) and histopathological analyses of kidney samples.Results: Nrf2 activators reduced the interstitial fibrotic area in UUO kidneys, causing a substantial decline in ED-1-positive cell infiltration and transforming growth factor-β expression. RT-PCR revealed that Nrf2 activators suppressed the expression of renal fibrotic factors and promoted the expression of ARE-dependent genes. Moreover, immunostaining for Nrf2 demonstrated increased nuclear translocation and activation induced by Nrf2 activators.Conclusions: Nrf2 activators induced nuclear translocation and activation of Nrf2, resulting in upregulation of ARE-dependent genes. Although the function of Nrf2 in children is often unknown, this study may lead to future progress in oxidation and antioxidant function in children.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70000"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-COVID in children and their parents: A prospective cohort study. 儿童及其父母的长期covid：一项前瞻性队列研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70042

Hiroyuki Iijima, Takanori Funaki, Mitsuru Kubota

{"title":"Long-COVID in children and their parents: A prospective cohort study.","authors":"Hiroyuki Iijima, Takanori Funaki, Mitsuru Kubota","doi":"10.1111/ped.70042","DOIUrl":"https://doi.org/10.1111/ped.70042","url":null,"abstract":"Background: Long-COVID is a significant global health concern, regardless of age. However, few reports have longitudinally evaluated the characteristics, prevalence, and risk factors of long-COVID in children.Methods: Participants were Japanese children younger than 18 years hospitalized for COVID-19 between November 2021 and October 2022, along with their COVID-19 affected parents. During hospitalization and at 1-, 3-, and 6-month follow-ups, participants completed age-appropriate questionnaires on long-COVID symptoms. The quality of life (QOL) score was assessed in children older than 2 years. The prevalence of long-COVID symptoms by age group was compared. Multivariable logistic regression analysis was conducted to investigate risk factors affecting long-COVID. Analysis of covariance adjusted for potential confounders was conducted to determine which symptoms affect QOL score.Results: Of 108 children enrolled, the prevalence of long-COVID was 44.9%, 37.8%, and 22.8% at 1, 3, and 6 months, respectively, after SARS-CoV-2 infection. There were no specific risk factors for long-COVID. Cough, fatigue, and sleep disturbance were the most common long-COVID symptoms, with sleep disturbance associated with a change in lower QOL score from admission at all three follow-ups (mean difference 9.25, 20.15, and 19.81; 95% CI, 1.58-16.91, 3.38-36.92, and 5.51-34.11). The prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms among 0-6 years was significantly lower than among 7-17 years and parents; there was no significant difference between 7 and 17 years and parents.Conclusion: Even 6 months after SARS-CoV-2 infection, 22.8% of pediatric patients still had long-COVID symptoms. Some of these symptoms were similar to those of ME/CFS, potentially affecting children's QOL.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70042"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous remission in a child with acute myeloid leukemia with invasive group G streptococcal infection. 侵袭性G群链球菌感染的急性髓性白血病患儿的自发性缓解。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70024

Taro Ikeda, Ryohei Fukunaga, Koichi Kobayashi, Yujiro Tanabe, Toshikazu Itabashi, Takahiro Ueda

引用次数: 0

Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia. 监测NUP98:: nsd1阳性急性髓性白血病中可测量的残留疾病。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15859

Ikuo Okuchi, Akira Nishimura, Takahiro Kamiya, Makiko Sasaki, Motoi Yamashita, Akihiro Hoshino, Michiko Kajiwara, Takeshi Isoda, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi

{"title":"Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia.","authors":"Ikuo Okuchi, Akira Nishimura, Takahiro Kamiya, Makiko Sasaki, Motoi Yamashita, Akihiro Hoshino, Michiko Kajiwara, Takeshi Isoda, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi","doi":"10.1111/ped.15859","DOIUrl":"10.1111/ped.15859","url":null,"abstract":"Background: NUP98 fusion genes are detected in acute myeloid leukemia (AML) subgroups that have a poor prognosis. An appropriate therapeutic approach should therefore be established. Treatment intensification according to the minimal residual disease (MRD) level can lead to a better prognosis in patients with acute lymphoblastic leukemia (ALL). However, the importance of MRD monitoring in the patient with NUP98-positive AML is unclear.Methods: This study aimed to develop a digital droplet polymerase chain reaction (ddPCR) method for monitoring NUP98::NSD1-positive leukemic cells and to report its utility compared with the results of NUP98 split fluorescence in situ hybridization (FISH).Results: The results of NUP98::NSD1 ddPCR correlated with those of NUP98 split FISH and were more sensitive than NUP98 split FISH. The sensitivity of ddPCR was 0.001%, equivalent to 1 in 1 × 105 cells. The MRD level of NUP98::NSD1, measured by ddPCR, correlated well with relapse.Conclusion: The use of ddPCR to target NUP98::NSD1 chimera mRNA for MRD monitoring would be beneficial for NUP98::NSD1 AML treatment.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15859"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beckwith-Wiedemann syndrome with Hirschsprung's disease and Meckel's diverticulum. 贝克维斯-魏德曼综合征伴先天性巨结肠病和梅克尔憩室。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70012

Atsuhisa Fukuta, Takuya Kondo, Naonori Kawakubo, Koichiro Yoshimaru, Kouji Nagata, Toshiharu Matsuura, Tatsuro Tajiri

引用次数: 0