{"title":"Early and late outcomes of congenital biliary dilatation in pediatric patients.","authors":"Yoshiaki Takahashi, Takashi Kobayashi, Yoshiaki Kinoshita, Yuhki Arai, Toshiyuki Ohyama, Naoki Yokota, Yu Sugai, Shoichi Takano","doi":"10.1111/ped.15712","DOIUrl":"10.1111/ped.15712","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to reveal the early and late postoperative complications and outcomes after surgery for congenital biliary dilatation (CBD) by reviewing cases over the past 40 years.</p><p><strong>Methods: </strong>We retrospectively evaluated 59 patients with CBD who underwent radical surgery for complications and outcomes, based on medical records. Early complications were defined as those requiring treatment within 5 years of the initial operation. Late complications were defined as those treated more than 5 years later.</p><p><strong>Results: </strong>The median age at the first surgery was 37 months. Regarding biliary reconstruction, 54 of the 59 patients (91.5%) underwent hepaticojejunostomy. Although three patients underwent cholecystoduodenostomy and one patient underwent hepaticoduodenostomy, all were converted to hepaticojejunostomy after a median of 12.5 years. One patient developed synchronous biliary carcinoma and underwent pancreaticoduodenectomy. Early complications occurred in seven patients with 10 events (surgical site infection, n = 3 bile leakage, n = 3; ileus, n = 3; bile duct obstruction, n = 1 and intussusception, n = 1). Late complications occurred in nine patients with 12 events (ileus, n = 3; anastomotic stricture, n = 3; hepatolithiasis, n = 3; asynchronous biliary carcinoma, n = 2; pancreatolithiasis, n = 1). Two of the three patients with hepatolithiasis underwent hepatectomy refractory to the endoscopic approach. Two patients developed asynchronous biliary carcinoma at 34 and 13 years after last operation; both ultimately died of the carcinoma. Only 35 patients (61.4%) underwent a follow-up examination. A total of 11 female patients (45.8%) eventually married, and all successfully gave birth.</p><p><strong>Conclusion: </strong>Although the long-term prognosis is excellent with complete cyst excision and hepaticojejunostomy, we emphasize the importance of long-term follow-up.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15712"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A novel scoring system for the prediction of disease severity in STEC-HUS.","authors":"Emi Ishibazawa, Tsunehisa Nagamori, Mio June Kurisawa, Masayuki Sato, Yoichiro Yoshida, Hironori Takahashi, Hiromi Manabe, Toru Ishioka, Yurika Miura, Hiroki Kajino, Yasuto Suzuki, Soichiro Wada, Shigetoshi Ogiwara, Yuji Tomii, Hayato Aoyagi, Kazushige Nagai, Hiroyuki Naito, Satoru Takahashi","doi":"10.1111/ped.15833","DOIUrl":"10.1111/ped.15833","url":null,"abstract":"<p><strong>Background: </strong>Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a life-threatening condition complicated by acute kidney injury, acute respiratory distress syndrome, and central nervous system disorders. The early identification of high-risk patients is required to facilitate timely and appropriate treatment.</p><p><strong>Methods: </strong>The medical records of patients with STEC-HUS treated at 11 hospitals in Hokkaido, Japan, were reviewed retrospectively. A multi-institutional retrospective analysis was performed in which patients were divided into two groups according to the presence or absence of severe complications requiring blood purification therapy or encephalopathy. We compared the laboratory values at diagnosis between the severe and mild groups. To identify patients at high risk of developing severe complications, a scoring system, referred to as the \"STEC-HUS severity (STEC-HUSS) score,\" was constructed based on the parameters showing significant differences.</p><p><strong>Results: </strong>Of the 41 patients with STEC-HUS, 11 were classified into the severe group and 30 into the mild group. Significant differences were observed between the groups in terms of white blood cell count, activated partial thromboplastin time, fibrinogen, D-dimer, total protein, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatinine, and C-reactive protein levels. The STEC-HUSS score was calculated on a scale of 0-10 by summing the number of test items that demonstrated abnormal values. The STEC-HUSS score, when the cut-off value was 4, showed a sensitivity of 100% and a specificity of 91% in the severe group.</p><p><strong>Conclusion: </strong>We developed a novel scoring system to identify patients at high risk of severe STEC-HUS.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15833"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selective coronary arteriography via transradial access in young children.","authors":"Yasuto Maeda, Tadashi Inoue, Yoshiyuki Kagiyama, Ryuta Takase, Yusuke Koteda, Kenji Suda","doi":"10.1111/ped.15841","DOIUrl":"https://doi.org/10.1111/ped.15841","url":null,"abstract":"<p><strong>Background: </strong>Transradial access (TRA) is not a common vascular access in children. We have been performing TRA actively to reduce puncture complications, and the purpose of this study was to investigate the safety and efficacy of TRA in young children.</p><p><strong>Methods: </strong>The study included 29 patients aged 5-12 years who underwent diagnostic catheterization at Kurume University Hospital. Vascular access was placed through TRA in 11 of these patients and through transfemoral access (TFA) in 18 patients with comparable ages. We compared TRA with TFA using various demographic data.</p><p><strong>Results: </strong>The median age of TRA was 10 years (5-12 years) and that of TFA was 7 years (5-11 years). They were not significantly different. Transradial access showed an acceptably high success rate (91%), which was comparable with that of TFA (100%), although we had to switch to TFA in one patient in which the radial artery diameter was too small to puncture and due to failure of appropriate sedation and local anesthesia. A comparison between the two groups showed no significant differences in weight, puncture success rate, total time to completion of both arterial and venous puncture, or fluoroscopy time. However, none of the patients with TRA required post-catheter bed rest after removal of the arterial sheath, whereas patients with TFA required 6 h of bed rest. Although there were no puncture complications in group TRA, one patient with TFA had a subcutaneous hematoma.</p><p><strong>Conclusion: </strong>Transradial access can be performed safely in young children and may be more beneficial than TFA.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15841"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of parent-child interaction therapy for children born premature.","authors":"Miyuki Matano, Koyuru Kurane, Kei Wakabayashi, Yukari Yada, Yumi Kono, Toshihiro Tajima, Hitoshi Osaka, Yukifumi Monden","doi":"10.1111/ped.15742","DOIUrl":"10.1111/ped.15742","url":null,"abstract":"<p><strong>Background: </strong>Premature children are known to be at a high risk of developing behavioral problems. This study examined the effectiveness of parent-child interaction therapy (PCIT) in reducing behavioral problems in young children born premature.</p><p><strong>Methods: </strong>The study included 18 child-parent pairs with children born at less than 35 weeks of gestation (range: 23-34 weeks, median: 31.0 weeks) and aged 27-52 months (median: 38.0 months). They were assigned to either the PCIT group (n = 7) or the non-PCIT group (n = 11) based on maternal desire for treatment. The study was designed to examine the effects of PCIT. Specifically, the Eyberg Child Behavior Inventory (ECBI) intensity score, ECBI problem score, and Parenting Stress Index Short Form (PSI-SF) scores were compared before treatment and after 6 months.</p><p><strong>Results: </strong>In the PCIT group, the mean ECBI intensity score was 135.7 (SD = 13.5; T-score = 64) at baseline and 90.1 (SD = 15.5; T-score = 46) at post-assessment, the mean ECBI problem score was 9.8 (SD = 1.9; T-score = 54) at baseline and 4.4 (SD = 3.1; T-score = 44) at post-assessment, the mean PSI-SF total score was 60.1 (SD = 4.8; 95%tile) at baseline and 49.6 (SD = 5.6; 85%tile) at post-assessment, showing a significant improvement (ECBI intensity scores: p < 0.001, d = 2.03; ECBI problem scores: p < 0.001, d = 1.94; PSI-SF total scores: p = 0.004, d = 0.86). On the other hand, none of the scores showed significant change in the non-PCIT group.</p><p><strong>Conclusions: </strong>The PCIT can be considered as a potential treatment option for behavioral problems in young children born premature.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15742"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thyroid hormone may predict treatment failure in Kawasaki disease.","authors":"Yuichiro Hashida, Yoichi Mino, Keisuke Okuno, Hitoshi Uemasu, Shinji Sakata, Masanobu Fujimoto, Noriyuki Namba","doi":"10.1111/ped.15723","DOIUrl":"10.1111/ped.15723","url":null,"abstract":"<p><strong>Background: </strong>In systemic inflammatory conditions, inflammatory cytokines can cause low thyroid hormone levels. There are no reports discussing the relation between thyroid hormone levels and response to treatment for Kawasaki disease.</p><p><strong>Methods: </strong>We investigated 67 patients who underwent treatment in the acute phase of Kawasaki disease. We divided patients into two groups based on their response to initial intravenous immunoglobulin (IVIG) treatment: the responder group (n = 40), and the non-responder group (n = 27). The serum levels of the thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were compared before and after treatment in all patients, and between responder and non-responder groups.</p><p><strong>Results: </strong>The FT3, FT4, and TSH levels were low before the initial treatment and increased significantly after treatment (p < 0.05). The FT3, FT4, and TSH levels before treatment were significantly lower in the non-responder group than in the responder group (p < 0.05). Logistic regression analysis suggested that the addition of pre-treatment FT4 values to Gunma score was useful in predicting treatment failure.</p><p><strong>Conclusions: </strong>Thyroid hormone and TSH levels were lower in the non-responder group than in the responder group in the initial IVIG treatment for Kawasaki disease. This study suggests that Kawasaki disease in the acute phase is associated with low thyroid hormone levels and TSH. It is possible that these hormone levels predict response to the initial IVIG.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15723"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two cases of pediatric splenic torsion as a possible late complication of laparoscopic fundoplication.","authors":"Takayuki Hiraba, Hiroya Ogita, Takayuki Yokota, Sonoko Kondo, Aya Tanaka, Ryuichi Shimono, Takashi Kusaka","doi":"10.1111/ped.15810","DOIUrl":"10.1111/ped.15810","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15810"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}