{"title":"Evaluation of the effect of inhaled β<sub>2</sub> agonist on lung sounds of children with acute bronchiolitis.","authors":"Yu Kuramochi, Mami Ichinose, Takashi Matsushita, Takanori Kagawa, Takashi Sakama, Kota Hirai, Hiroyuki Furuya, Fumio Niimura, Hiroyuki Mochizuki","doi":"10.1111/ped.70053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Discussions regarding the treatment of acute bronchiolitis are ongoing. In this study, we investigated the effects of bronchodilators in infants with viral bronchiolitis using a lung sound analysis.</p><p><strong>Methods: </strong>Subjects were hospitalized children diagnosed with viral acute bronchiolitis who received inhaled short-acting inhaled beta 2-agonist (SABA). Lung sounds were collected before and after SABA inhalation, and imaged and quantified using a dedicated analysis system to objectively evaluate the effects of SABA. Furthermore, we investigated the influence of the child's clinical symptoms (clinical score, SpO<sub>2</sub> value, hospitalization days, etc.), past history and family history of allergic diseases on the changes in lung sounds after SABA inhalation.</p><p><strong>Results: </strong>Twenty-six children (male: female = 16: 10, median age: 11 months) participated in the study, and wheezes on the lung sound spectrogram disappeared or decreased after inhalation of SABA in 57.7% (n = 15). However, no improvement in the low-pitched sounds of the lung spectrogram was evident, and no significant change was observed in the exhalation/inspiration power ratio. Although SpO<sub>2</sub> in the group whose wheezes improved due to SABA inhalation was significantly lower than that in the group without improvement (p = 0.008), there were no significant differences in other factors.</p><p><strong>Conclusion: </strong>The lung sound analysis confirmed that wheezes improved after SABA inhalation in half of the infants with acute viral bronchiolitis. However, since there was no improvement in clinical symptoms or low-pitched sounds, it was hypothesized that respiratory dysfunctions were caused by various mechanisms in infants with acute bronchiolitis.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70053"},"PeriodicalIF":1.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatrics International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ped.70053","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Discussions regarding the treatment of acute bronchiolitis are ongoing. In this study, we investigated the effects of bronchodilators in infants with viral bronchiolitis using a lung sound analysis.
Methods: Subjects were hospitalized children diagnosed with viral acute bronchiolitis who received inhaled short-acting inhaled beta 2-agonist (SABA). Lung sounds were collected before and after SABA inhalation, and imaged and quantified using a dedicated analysis system to objectively evaluate the effects of SABA. Furthermore, we investigated the influence of the child's clinical symptoms (clinical score, SpO2 value, hospitalization days, etc.), past history and family history of allergic diseases on the changes in lung sounds after SABA inhalation.
Results: Twenty-six children (male: female = 16: 10, median age: 11 months) participated in the study, and wheezes on the lung sound spectrogram disappeared or decreased after inhalation of SABA in 57.7% (n = 15). However, no improvement in the low-pitched sounds of the lung spectrogram was evident, and no significant change was observed in the exhalation/inspiration power ratio. Although SpO2 in the group whose wheezes improved due to SABA inhalation was significantly lower than that in the group without improvement (p = 0.008), there were no significant differences in other factors.
Conclusion: The lung sound analysis confirmed that wheezes improved after SABA inhalation in half of the infants with acute viral bronchiolitis. However, since there was no improvement in clinical symptoms or low-pitched sounds, it was hypothesized that respiratory dysfunctions were caused by various mechanisms in infants with acute bronchiolitis.
期刊介绍：
Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere.
Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
