Pediatrics International最新文献_第8页

Trough value prediction using umbilical blood cystatin C value during tobramycin administration. 妥布霉素给药期间脐血胱抑素C值的谷值预测。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70041

Kentaro Hirayama, Arisa Fukui, Tomoya Tsuchihashi, Takayuki Suzuki, Mitsuhiko Riko, Takuya Sugimoto, Takeshi Kumagai, Daisuke Tokuhara

{"title":"Trough value prediction using umbilical blood cystatin C value during tobramycin administration.","authors":"Kentaro Hirayama, Arisa Fukui, Tomoya Tsuchihashi, Takayuki Suzuki, Mitsuhiko Riko, Takuya Sugimoto, Takeshi Kumagai, Daisuke Tokuhara","doi":"10.1111/ped.70041","DOIUrl":"https://doi.org/10.1111/ped.70041","url":null,"abstract":"Background: Therapeutic monitoring is recommended for aminoglycoside drugs, which are often used in neonatal care. In this study, we examined whether it is possible to estimate the trough value after administration using serum creatinine (Cr) and serum cystatin C (CysC) values of umbilical cord artery blood in infants, which can be measured without increasing risks due to invasive tests.Methods: Subjects included infants who were hospitalized between March 2022 and March 2023 and treated with tobramycin (TOB) from 0 days old. In addition to cord blood Cr and CysC, TOB blood concentration (trough value) was measured at 3 days. The correlation coefficient (r) between serum Cr and CysC values and TOB trough value was calculated.Results: Sixteen cases were included in the study. Cord blood Cr and CysC values were divided by gestational week (GW), birth weight (BW), and body surface area (BSA), respectively, and the correlations with TOB trough values were determined. Cord blood CysC/GW/BSA showed a strong correlation with TOB trough value (r = 0.77). The receiver operating characteristic curve for the relationship between cord blood CysC/GW/BSA and TOB trough values ≥1 mg/mL revealed a cut-off value of 0.29 (area under the curve: 0.927, sensitivity: 1.00, specificity: 0.75).Conclusion: Umbilical cord blood CysC/GW/BSA values were strongly correlated with TOB trough values. Cord blood samples can be used to estimate trough values before drug administration without increasing the risk to infants associated with invasive tests, enabling determination of the dosage that will not cause nephrotoxicity.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70041"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of the clinical pathways for children hospitalized for the treatment of acute asthma exacerbation. 儿童住院治疗急性哮喘加重的临床路径的有效性。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70073

Riko Kanda, Masaru Kawamura, Masumi Kojiro, Yoshihisa Fujino, Takayuki Hoshina

{"title":"The effectiveness of the clinical pathways for children hospitalized for the treatment of acute asthma exacerbation.","authors":"Riko Kanda, Masaru Kawamura, Masumi Kojiro, Yoshihisa Fujino, Takayuki Hoshina","doi":"10.1111/ped.70073","DOIUrl":"https://doi.org/10.1111/ped.70073","url":null,"abstract":"Background: Guidelines for the treatment of bronchial asthma (BA) include several corticosteroids recommended for the treatment of children with acute asthma exacerbation. Clinical pathways (CPs) may contribute to the standardization of the treatment of acute asthma exacerbation and the reduction of treatment-related incidents. We investigated the effectiveness of CPs in children with acute asthma exacerbation.Methods: This retrospective study included children hospitalized for acute asthma exacerbation from August 2015 to June 2021. The patients were divided into two groups: before (pre-CP, n = 236) and after (post-CP, n = 198) the introduction of CPs for the treatment of acute asthma exacerbation. We compared the outcomes, including the length of hospital stay, types of corticosteroids used, and use of an antimicrobial agent, between the two groups.Results: Most patients in the post-CP group were treated with prednisolone or methylprednisolone, whereas several corticosteroids were administered during the pre-CP period. The proportion of patients treated with antimicrobial agents was lower in the post-CP group than in the pre-CP group (p < 0.001). The length of hospital stay was shorter in the post-CP group than in the pre-CP group (p < 0.001). The re-admission rates were similar between the two groups. No treatment-related incidents occurred during the investigation period.Conclusion: For the treatment of acute asthma exacerbation in children, the introduction of CP was useful for standardizing therapies, reducing inappropriate antimicrobial therapy, and shortening the length of hospital stay.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70073"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pigmentovascularis in a child with heterochromia. 异色症儿童的色素血管炎。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70022

Abdulrahman Mamoon Allaf, Ta Chen Chang

引用次数: 0

Video gaming is associated with maternal overprotective parenting style: A cross-sectional study in preschool children. 视频游戏与母亲过度保护的养育方式有关：一项针对学龄前儿童的横断面研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70056

Meryem Erat Nergiz, Nilgün Çaylan, Siddika Songül Yalçın

{"title":"Video gaming is associated with maternal overprotective parenting style: A cross-sectional study in preschool children.","authors":"Meryem Erat Nergiz, Nilgün Çaylan, Siddika Songül Yalçın","doi":"10.1111/ped.70056","DOIUrl":"https://doi.org/10.1111/ped.70056","url":null,"abstract":"Background: Parents are responsible for rules and limits regarding screen use by preschool-aged children. In this study, we aimed to investigate the association between mothers' parenting styles and preschool children's video game playing.Methods: Two hundred and sixty-four mothers who had children aged 2-5 years were included in this cross-sectional study. The mothers filled out a structured questionnaire including general questions about demographic and video gaming characteristics and a parental attitude scale (PAS). PAS consisted of four subscales: \"Authoritative,\" \"Authoritarian,\" \"Overprotective,\" and \"Permissive.\" Subscale scores were categorized into the 1st, 2nd, and 3rd tertiles. Adjusted Odds ratios (AORs) with 95% confidence intervals (CIs) were calculated. To assess the impact of PAS's subscale score tertiles on video gaming, multivariate logistic regression analysis was conducted.Results: 29.2% of children were playing video games. Video gaming was associated with older age, male sex, low paternal education, having an older sibling, and exceeding the recommended daily screen time (p < 0.05). Multivariate logistic regression analyses showed that mothers' high authoritarian [AOR: 2.47 (1.25-4.90)] and overprotective [AOR: 3.62 (1.69-7.79)] scores were associated with video gaming. When other parenting styles were included in the multivariate analysis, only the overprotective parenting style was associated with video gaming [AOR: 3.70 (1.68-8.16)].Conclusions: The findings highlight a potential association between maternal overprotective parenting style and video gaming in preschool children.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70056"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 14-year girl with thrombotic thrombocytopenic purpura and Sjögren's syndrome. 一个14岁的女孩，患有血栓性血小板减少性紫癜和Sjögren综合征。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70069

Nao Kohri, Yuka Kimura, Naoki Hirano, Souichi Suenobu, Kenji Ihara

引用次数: 0

Classic 21-hydroxylase deficiency in opposite-sex twins. 异性双胞胎典型的21-羟化酶缺乏症。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70058

Shiori Shirakawa, Haruki Yamano, Ryosei Iemura, Akito Sutani, Eriko Adachi, Kenichi Kashimada, Kei Takasawa

引用次数: 0

Long-term impact of Maternal and Child Health handbook in rural Bangladesh: A post-trial follow-up study. 孟加拉国农村妇幼保健手册的长期影响：一项试验后随访研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70123

Yorin Watabe, Syed Emdadul Haque, Benay Kumar Datta, Abul Kashem, Minato Nakazawa, Ruoyan Gai Tobe, Rintaro Mori

{"title":"Long-term impact of Maternal and Child Health handbook in rural Bangladesh: A post-trial follow-up study.","authors":"Yorin Watabe, Syed Emdadul Haque, Benay Kumar Datta, Abul Kashem, Minato Nakazawa, Ruoyan Gai Tobe, Rintaro Mori","doi":"10.1111/ped.70123","DOIUrl":"10.1111/ped.70123","url":null,"abstract":"Background: This was a five-year follow-up study of a cluster randomized controlled trial (RCT) that evaluated the effectiveness of the Maternal and Child Health (MCH) handbook in rural Bangladesh, with a specific focus on maternal parental stress and children's anthropometric measurements.Methods: We conducted a follow-up survey from September to November 2023 on the mother-child dyads who participated in the cluster RCT during 2017-2018 in Lohagora Upazila, Narail District, located in the southwestern region of Bangladesh. Of the 620 mother-child dyads recruited, 617 dyads from nine unions were analyzed in this study using structured questionnaires. We used the Parental Stress Scale (PSS) to measure the mothers' parental stress. The mothers' health-seeking behaviors and children's anthropometric measurements were also examined. Multiple regression analysis was performed to examine the effectiveness of the MCH handbook.Results: Based on the PSS, stress levels among the mothers in the MCH handbook intervention group were lower in the univariate (p = 0.053) and multiple linear regression analysis, after adjusting for confounding variables (p = 0.057). However, there were no significant differences between the groups in both primary outcome (PSS) and secondary outcomes (growth monitoring experience, number of sources of parenting information used by the mothers, and children's growth status).Conclusion: Although this study showed that the distribution of the MCH handbook generally reduced maternal parental stress, there were no significant differences between the groups. Further research is necessary to evaluate the effectiveness of the MCH handbook on parental stress as a distal outcome.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70123"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing and mode of death and impact of starting organ donation in a pediatric intensive care unit: 2016-2024 in Japan. 日本儿科重症监护病房开始器官捐赠的死亡时间和模式及其影响：2016-2024年

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70079

Takanari Ikeyama, Sho Wada, Masako Kawamura, Mihoko Kato

{"title":"Timing and mode of death and impact of starting organ donation in a pediatric intensive care unit: 2016-2024 in Japan.","authors":"Takanari Ikeyama, Sho Wada, Masako Kawamura, Mihoko Kato","doi":"10.1111/ped.70079","DOIUrl":"https://doi.org/10.1111/ped.70079","url":null,"abstract":"Background: There are very few descriptions of end-of-life (EOL) practices from pediatric intensive care units in Japan. Our objective is to describe the mode and timing of death and EOL practices in a tertiary care PICU in Japan.Methods: This is a retrospective observational study using data from February 2016 to April 2024. Organ donation started locally in 2020. The patients who died in the PICU and were younger than 18 years were included. The mode of death was determined through independent chart review by 2 reviewers. Patient demographic data, care intensity within 24 h before death, length of ICU stay, and interval between consensus on EOL care and death were recorded. Comparisons between before and after starting organ donation were performed.Results: In total, 77 pediatric deaths were included, and their modes of death were as follows: 48 (62%) cases of limitation of life-sustaining therapy, 11 (14%) of withdrawal of life-sustaining therapy, 12 (16%) of maximal support, and 6 (8%) of DNC. Mechanical ventilation was withdrawn in 82% (9/11) of the withdrawal group. The median and IQR of the interval between EOL consensus and death in our cohort were 12 (4, 23) days. The proportion of patients who died within 2 weeks after the EOL consensus was reached increased after organ donation program initiation (69% vs. 90%, p < 0.05).Conclusions: Seventy-seven percent of modes of death were either limitation or withdrawal of life-sustaining therapies. More patients died within 2 weeks after the EOL consensus increased after the organ donation program initiation.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70079"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary loss-of-response associated with intolerance to Janus kinase inhibitor in a boy with ulcerative colitis. 继发性反应丧失与溃疡性结肠炎男孩对Janus激酶抑制剂不耐受相关。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15880

Yuka Minoura, Koji Yokoyama, Yuko Okada, Shinya Fukuda, Hideki Kumagai

引用次数: 0

A case of a cervical cyst due to congenital pyriform sinus fistula in a neonate. 新生儿先天性梨状窦瘘致宫颈囊肿1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70017

Michinobu Ohno, Kyohei Isshiki, Sou Takei, Rie Irie, Fumiko Yoshida

引用次数: 0