Drug-induced liver injury in pediatric age group: Single-center experience.

IF 1 4区医学 Q3 PEDIATRICS

Pediatrics International Pub Date : 2025-01-01 DOI:10.1111/ped.70099

Burcu Güven, Serhat Yıldırım, Zeynep Gökçe Gayretli Aydın, Gökçe Pınar Reis İskenderoğlu, Tülay Kamaşak, Murat Çakır

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引用次数: 0

Abstract

Background: There is no clear information regarding the frequency of drug-induced liver injury (DILI) in the pediatric age group. In this study, we aimed to investigate the incidence of DILI in pediatric patients and to determine the drug groups responsible for the etiology of DILI and the factors associated with this disease.

Methods: The prospective study was conducted in patients aged 0-18 years and diagnosed with DILI. Age, gender, drugs used by the patients, indications for drug use, duration and dosage of drugs, and laboratory parameters were recorded. Liver injury pattern was classified as hepatocellular, mixed and cholestatic type.

Results: The mean age was 7.8 ± 5.5 years; 187 (62.3%) were male. A total of 90 drugs were found to be responsible for hepatotoxicity, among which methotrexate (8.66%) and cephalosporin group antibiotics (8.66%) were found to be the most commonly identified drugs, followed by carbapenem group antibiotics (6.77%), steroids (6.77%) and mercaptopurine (5.04%). Hepatocellular type developed in 67% (n = 122), mixed type in 28% (n = 51) and cholestatic type in 5% (n = 8) patients.

Conclusions: Hepatocellular type was found to be the most common type among the patterns of liver injury in the pediatric age group. Although antibiotics constitute the leading cause of DILI, antibiotic choices are changing due to increasing resistant infections. The frequency of carbapenem-induced DILI is increasing.

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儿童年龄组药物性肝损伤：单中心经验。

背景：关于儿童年龄组药物性肝损伤（DILI）的发生率尚无明确的信息。在本研究中，我们旨在调查DILI在儿科患者中的发病率，并确定导致DILI病因的药物组以及与该疾病相关的因素。方法：前瞻性研究纳入0 ~ 18岁诊断为DILI的患者。记录患者的年龄、性别、使用的药物、用药适应证、用药时间和剂量、实验室参数等。肝损伤类型分为肝细胞型、混合型和胆汁淤积型。结果：患者平均年龄7.8±5.5岁；男性187例（62.3%）。共发现90种引起肝毒性的药物，其中以甲氨蝶呤类抗生素（8.66%）和头孢菌素类抗生素（8.66%）最为常见，其次是碳青霉烯类抗生素（6.77%）、类固醇（6.77%）和巯基嘌呤（5.04%）。67% （n = 122）为肝细胞型，28% （n = 51）为混合型，5% （n = 8）为胆汁淤积型。结论：肝细胞型是儿童肝损伤类型中最常见的类型。虽然抗生素是DILI的主要原因，但由于耐药感染的增加，抗生素的选择正在发生变化。碳青霉烯类药物诱导DILI的频率正在增加。

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来源期刊

Pediatrics International 医学-小儿科

CiteScore

2.00

自引率

7.10%

发文量

519

审稿时长

12 months

期刊介绍： Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.