Hen's egg allergy is a risk factor for zinc deficiency.

IF 0.9 4区医学 Q3 PEDIATRICS

Pediatrics International Pub Date : 2025-01-01 DOI:10.1111/ped.70038

Hiroaki Yamane, Eishi Makita, Daisuke Sugawara, Kae Itabashi

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引用次数: 0

Abstract

Background: Insufficient zinc intake causes zinc deficiency. We hypothesized that dietary restrictions due to food allergy (FA) may be a zinc deficiency risk. Thus, we evaluated the relationship between serum zinc levels and FA in children.

Methods: Children aged 10 months to 6 years were prospectively enrolled; the FA group comprised 73 children with IgE-dependent allergies to hen's egg, cow's milk, or wheat; the control group comprised 49 children without FA. Clinical data and serum zinc, hemoglobin, iron, and 25-hydroxy vitamin D levels were measured and statistically analyzed. The risk factors for zinc deficiency (zinc < 70 μg/dL) were analyzed.

Results: The median age was 2.3 years for both the FA and control groups (p > 0.05). Serum zinc levels were significantly lower in the FA group than in the control group (median [interquartile range]: 70 [64-76] μg/dL vs. 77 [71-85] μg/dL; p < 0.001). Regarding other blood test results, only serum iron levels were significantly lower in the FA group. In the multivariate analysis, hen's egg allergy was the only significant risk factor for zinc deficiency, other FA and atopic dermatitis history were not. In patients with hen's egg allergy, the zinc levels in those with severe dietary restrictions were significantly lower than in the others.

Conclusions: Serum zinc levels were significantly low in the FA group. Notably, hen's egg allergy was a significant risk factor for zinc deficiency. For patients with severe dietary restrictions due to hen's egg allergy, zinc levels should be assessed and appropriate nutritional advice provided.

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鸡蛋过敏是锌缺乏的一个危险因素。

背景：锌摄入不足导致锌缺乏。我们假设由于食物过敏（FA）引起的饮食限制可能是锌缺乏的风险。因此，我们评估了儿童血清锌水平与FA之间的关系。方法：前瞻性纳入10个月至6岁的儿童；FA组包括73名对鸡蛋、牛奶或小麦有ige依赖性过敏的儿童；对照组为49例无FA的患儿。测定临床资料及血清锌、血红蛋白、铁、25-羟基维生素D水平，并进行统计学分析。锌缺乏的危险因素(锌结果：FA组和对照组的中位年龄均为2.3岁（p < 0.05）。FA组血清锌水平显著低于对照组(中位数[四分位数范围]:70 [64-76]μg/dL vs. 77 [71-85] μg/dL；p结论：FA组血清锌水平显著降低。值得注意的是，鸡蛋过敏是锌缺乏的重要危险因素。对于因鸡蛋过敏而有严重饮食限制的患者，应评估锌水平并提供适当的营养建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics International 医学-小儿科

CiteScore

2.00

自引率

7.10%

发文量

519

审稿时长

12 months

期刊介绍： Publishing articles of scientific excellence in pediatrics and child health delivery, Pediatrics International aims to encourage those involved in the research, practice and delivery of child health to share their experiences, ideas and achievements. Formerly Acta Paediatrica Japonica, the change in name in 1999 to Pediatrics International, reflects the Journal''s international status both in readership and contributions (approximately 45% of articles published are from non-Japanese authors). The Editors continue their strong commitment to the sharing of scientific information for the benefit of children everywhere. Pediatrics International opens the door to all authors throughout the world. Manuscripts are judged by two experts solely upon the basis of their contribution of original data, original ideas and their presentation.