Pediatrics International最新文献_第6页

Detection of anti-neuronal cell-surface antigen antibodies in pediatric patients with acute encephalitis in Japan. 日本小儿急性脑炎患者抗神经元细胞表面抗原抗体的检测。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15865

Yoshiki Kawamura, Yasuaki Mizutani, Mao Asakura, Ryunosuke Nagao, Akihiro Ueda, Hirohisa Watanabe, Tetsushi Yoshikawa

引用次数: 0

A pediatric case of Streptococcal pyogenes empyema due to the M1_UK genotype. 由M1UK基因型引起的儿童化脓性链球菌脓胸1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15877

Keiichi Koizumi, Tomohiro Saito, Ken Takada, Toshimichi Fukao, Fuminori Numano, Noboru Oyachi, Minako Hoshiai

引用次数: 0

Enhancing long-distance medical transport with non-invasive ventilation by linking transport services: A case report. 通过连接运输服务加强无创通气的远程医疗运输：1例报告。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15867

Shinya Miura, Hideki Ohara, Mai Miyaji, Yoshihiro Igarashi, Shinano Horie, Daigo Ando

引用次数: 0

Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia. 监测NUP98:: nsd1阳性急性髓性白血病中可测量的残留疾病。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15859

Ikuo Okuchi, Akira Nishimura, Takahiro Kamiya, Makiko Sasaki, Motoi Yamashita, Akihiro Hoshino, Michiko Kajiwara, Takeshi Isoda, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi

{"title":"Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia.","authors":"Ikuo Okuchi, Akira Nishimura, Takahiro Kamiya, Makiko Sasaki, Motoi Yamashita, Akihiro Hoshino, Michiko Kajiwara, Takeshi Isoda, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi","doi":"10.1111/ped.15859","DOIUrl":"https://doi.org/10.1111/ped.15859","url":null,"abstract":"Background: NUP98 fusion genes are detected in acute myeloid leukemia (AML) subgroups that have a poor prognosis. An appropriate therapeutic approach should therefore be established. Treatment intensification according to the minimal residual disease (MRD) level can lead to a better prognosis in patients with acute lymphoblastic leukemia (ALL). However, the importance of MRD monitoring in the patient with NUP98-positive AML is unclear.Methods: This study aimed to develop a digital droplet polymerase chain reaction (ddPCR) method for monitoring NUP98::NSD1-positive leukemic cells and to report its utility compared with the results of NUP98 split fluorescence in situ hybridization (FISH).Results: The results of NUP98::NSD1 ddPCR correlated with those of NUP98 split FISH and were more sensitive than NUP98 split FISH. The sensitivity of ddPCR was 0.001%, equivalent to 1 in 1 × 105 cells. The MRD level of NUP98::NSD1, measured by ddPCR, correlated well with relapse.Conclusion: The use of ddPCR to target NUP98::NSD1 chimera mRNA for MRD monitoring would be beneficial for NUP98::NSD1 AML treatment.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15859"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with early onset hypocalcemia: A retrospective cohort study. 与早发型低钙血症相关的因素：一项回顾性队列研究。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15849

Baek Sup Shin, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim

{"title":"Factors associated with early onset hypocalcemia: A retrospective cohort study.","authors":"Baek Sup Shin, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim","doi":"10.1111/ped.15849","DOIUrl":"https://doi.org/10.1111/ped.15849","url":null,"abstract":"Background: Early onset hypocalcemia, occurring within 3 days of birth, is prevalent among preterm infants. A central line is required to deliver calcium (Ca). The prediction of hypocalcemia is therefore clinically important when the requirement for initial intravascular calcium administration is anticipated.Methods: This retrospective study included preterm infants born between 2019 and 2023 with a birthweight <1500 g or a gestational age (GA) <32 weeks in a single tertiary center. Hypocalcemia was defined as serum Ca <7 mg/dL or ionized calcium (iCa) <0.8 mmol/L within 72 h after birth. Perinatal factors and laboratory test results associated with hypocalcemia were collected and analyzed.Results: Of the 348 infants, 20 died within 7 postnatal days, 22 were transferred to other hospitals, and eight were transferred from other hospitals and were thus excluded. Of 298 enrolled infants, 20 were diagnosed with hypocalcemia. In multivariate analysis, male sex, elevated day 1 phosphorus (d1P), magnesium (d1Mg) levels, and maternal premature rupture of membranes (PROM) were significant risk factors for early onset hypocalcemia. These factors, along with birthweight, a widely recognized risk factor, were used to develop predictive models for early onset hypocalcemia. Among the six suggested models, logistic regression exhibited the highest accuracy. Conversely, the random forest model outperformed others in the Youden index and area under the receiver operating characteristic curve.Conclusions: In our cohort, early onset hypocalcemia was linked to male sex, lower GA, higher d1P and d1Mg, and maternal PROM. Notably, higher d1P has not been previously reported as a risk factor.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15849"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment with teduglutide for an adolescent with cerebral palsy accompanied by short bowel syndrome. 替杜鲁肽成功治疗青少年脑瘫伴短肠综合征。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15894

Megumi Tsuji, Azusa Ikeda, Yu Tsuyusaki, Tomohide Goto, Mizue Iai

引用次数: 0

Fatal encephalopathy and congenital heart defects with MEF2C-related disorder. 致命脑病和先天性心脏缺陷伴mef2c相关疾病。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15883

Yoshitaka Asagai, Naoya Morisada, Yasunobu Miki, Hiroshi Kurosawa, Azusa Maruyama, Kandai Nozu, Kenjiro Kosaki

引用次数: 0

Glucose and lipid metabolic aberrations in preterm and low birth weight infants: Associations with lifestyle-related diseases. 早产儿和低出生体重儿的糖脂代谢异常：与生活方式相关疾病的关系

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70003

Nobuhiko Nagano, Ichiro Morioka

{"title":"Glucose and lipid metabolic aberrations in preterm and low birth weight infants: Associations with lifestyle-related diseases.","authors":"Nobuhiko Nagano, Ichiro Morioka","doi":"10.1111/ped.70003","DOIUrl":"https://doi.org/10.1111/ped.70003","url":null,"abstract":"The concept of the developmental origins of health and disease is well established. Prenatal undernutrition, resulting from a mismatch between pre- and postnatal environments, leads to permanent changes in body composition, function, and metabolism. These changes contribute to the development of lifestyle-related diseases such as type 2 diabetes mellitus and hyperlipidemia later in life. The future risk of lifestyle-related diseases in preterm and low-birth-weight infants is closely related to a thrifty phenotype. This phenotype is characterized by an advantageous ability to survive in a low-energy environment, resulting in reduced growth potential and muscle mass. Small size and low muscle mass lead to a decrease in basal metabolism, making it easier to accumulate excess energy as body fat. This differs fundamentally from the typical clinical presentation of obesity, which occurs in a state of energy excess. Our research focuses on two main areas: (1) investigating the increase in insulin resistance due to growth patterns and persistent reduction in lean body mass in preterm and low-birth-weight infants, and (2) studying the development of subcutaneous adipose tissue during the neonatal and infant periods, along with its associated metabolic and hormonal factors. In this review, we provide detailed insights into the mechanism by which sustained decrease in lean body mass and the development of lipid/fatty acid metabolism and adipose tissue during the fetal and neonatal periods may impact the onset of lifestyle-related diseases later in life.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70003"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruxolitinib for preventing relapse of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Ruxolitinib预防Epstein-Barr病毒相关性噬血细胞淋巴组织细胞病复发

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70032

Eri Okura, Kenichi Sakamoto, Yuta Maruyama, Koichi Hirabayashi, Shoji Saito, Ryu Yanagisawa, Yozo Nakazawa

引用次数: 0

Successful treatment of pediatric mature B-cell lymphoma with MYC and BCL6 rearrangements. MYC和BCL6重排成功治疗儿童成熟b细胞淋巴瘤。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70037

Ryo Hamada, Masaki Yamamoto, Yusuke Akane, Keita Igarashi, Takeshi Tsugawa

引用次数: 0