Parasitology International最新文献

{"title":"Assessing the health-related quality of life of cutaneous Leishmaniasis patients in Draa-Tafilalet, southeastern Morocco","authors":"Driss Ait Ali ,&nbsp;Abdessamad El Hamdi ,&nbsp;Nourelwiam Boumeshouli ,&nbsp;Adnane Hakem ,&nbsp;Abdelaati El Khiat ,&nbsp;Mohamed El Koutbi ,&nbsp;Brahim El Houate ,&nbsp;Nicola Luigi Bragazzi ,&nbsp;Amelia Rizzo ,&nbsp;Francesco Chirico ,&nbsp;Hicham Khabbache","doi":"10.1016/j.parint.2024.102963","DOIUrl":"10.1016/j.parint.2024.102963","url":null,"abstract":"<div><p>Cutaneous leishmaniasis is a significant public health concern globally. This study aims to evaluate the impact of cutaneous leishmaniasis on the quality of life of patients in the Draa-Tafilalet region of Morocco. In this cross-sectional study, data were collected from 87 patients between December 2022 and July 2023 using the Skindex-16 questionnaire. The results revealed that cutaneous leishmaniasis has a mild to moderate impact on health-related quality of life, with 26.4 % of participants reporting a low impact and 73.6 % reporting a moderate impact. A significant gender difference was observed in Skindex-16 scores, with moderate impact being more prevalent among females (60.90 % vs. 30.10 %, <em>p</em> = 0.002). Furthermore, facial lesions were associated with a statistically significant reduction in quality of life, particularly in the emotional (<em>p</em> &lt; 0.001) and functioning (<em>p</em> = 0.01) domains. These findings highlight the need for targeted management strategies that address the substantial impact of cutaneous leishmaniasis on patients' quality of life. Future studies with larger sample sizes and extended follow-up periods are warranted to further elucidate the effects of cutaneous leishmaniasis on patients' well-being.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102963"},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible transmission of plasmodium malariae through liver transplantation: Diagnosis with a Sysmex XN-20™ hematology analyzer","authors":"Andreu Martínez-Cerezuela ,&nbsp;Luiza Tofan ,&nbsp;José Miguel Sahuquillo-Arce ,&nbsp;Marino Blanes-Juliá ,&nbsp;María Teresa Contreras-Martínez","doi":"10.1016/j.parint.2024.102955","DOIUrl":"10.1016/j.parint.2024.102955","url":null,"abstract":"<div><p>Malaria is an infectious disease caused by several species of the genus <em>Plasmodium.</em> It is usually transmitted by female <em>Anopheles</em> mosquitoes. Other routes of transmission include mother-to-child transmission, shared use of needles, blood transfusion and solid organ transplantation. In non-endemic countries, malaria is often diagnosed on the basis of a history of journeys or migration from endemic areas. Transplant-transmitted malaria might represent a diagnostic challenge for clinicians.</p><p>Here, we report the casual diagnosis of possible transplant-transmitted malaria in a Spanish patient with no previous visits to endemic areas. He developed symptoms one month after receiving a liver transplant from a deceased donor immigrated from Ghana. After being admitted to the Emergency Room, a complete blood count revealed an abnormal cell population which activated an ‘infested red blood cells’ flag (<em>iRBC</em>). This finding led to perform a blood smear and further tests which confirmed the diagnosis of malaria.</p><p>Given that automated complete blood counts are usually performed for any patient with fever, they represent a useful tool to detect malaria in unsuspected patients. In particular, the <em>iRBC</em> flag implemented in Sysmex XN-Series™ hematology analyzers is a useful screening tool for malaria in clinical laboratories.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102955"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paronatrema davidbowiei n. sp. (Trematoda: Syncoeliidae), a new parasite of the pelagic thresher (Alopias pelagicus) and its phylogenetic relationships within the suborder Hemiurata Skrjabin & Guschanskaja, 1954","authors":"Mario Santoro ,&nbsp;Flavia Occhibove ,&nbsp;Alejandro López-Verdejo ,&nbsp;Alicia Rojas ,&nbsp;Alberto Solano-Barquero","doi":"10.1016/j.parint.2024.102953","DOIUrl":"10.1016/j.parint.2024.102953","url":null,"abstract":"<div><p>A new species of hemiurid trematode found on the gills and in the aorta of the pelagic thresher <em>Alopias pelagicus</em> from the eastern Pacific, off Costa Rica, is described based on an integrative taxonomic approach that includes the use of light and scanning electron microscopy, and 28S rDNA sequencing. Phylogenetic analysis was also performed to explore, for the first time, the relationships of a member of the subfamily Otiotrematinae within the suborder Hemiurata. <em>Paronatrema davidbowiei</em> n. sp. can be distinguished from the congeners by having tegumental spines on the dorsal surface of the forebody, papillae on the oral sucker, and different morphology or number of testicular follicles. BLAST analysis revealed that sequences of <em>Paronatrema davidbowiei</em> n. sp. had the highest degree of similarity with <em>Hirudinella</em> spp. (Hirudinellidae). Results from Maximum Likelihood and Bayesian phylogenetic analyses, returning trees with the exact same topology and strong branch support, distinguished between the two superfamilies included in the suborder Hemiurata: Azygioidea and Hemiuroidea. Our analysis placed the new species in a clade with <em>Copiatestes filiferus</em>, the only existing sequence of the family Syncoeliidae.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102953"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of parasitic diseases in Japan and request from a clinician to parasitologists","authors":"Kenji Ohnishi","doi":"10.1016/j.parint.2024.102952","DOIUrl":"10.1016/j.parint.2024.102952","url":null,"abstract":"<div><p>In Japan, parasitic diseases are rare today, with the exception of amebiasis and anisakidosis. As a result, many Japanese clinicians have limited knowledge of parasitic diseases and do not consider them important. Parasitology departments in the schools of medicine in Japan have tended to be replaced or downsized, and the amount of time spent for the teaching of parasitology to undergraduate students has been shortened. However, even in Japan, patients with parasitic diseases visit clinics or hospitals. Medical students have to learn the diagnosis and basic treatment of parasitic diseases that could cause death or serious sequelae without proper treatment, and those which are relatively frequently encountered in Japan. It is also essential for the students to know the circumstances they should suspect parasitic diseases. There is nothing restricting a parasitologist from responding to questions and requests from clinicians regarding diagnosis and treatment; rather, it is in the best interest of patients with parasitic diseases to do so based on their professional knowledge.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102952"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acanthocephaliasis by Plagiorhynchus sp. (Acanthocephala:Plagiorhynchidae) associated with necrotic enteritis in quetzals (Pharomachrus mocinno) maintained in captivity","authors":"F.D. Sanchez-Godoy ,&nbsp;J.R.E. Martinez-Guzmán ,&nbsp;R. Hernandez-Castro ,&nbsp;F. Martinez-Hernandez ,&nbsp;O. Urquiza-Bravo ,&nbsp;N. Rivas ,&nbsp;R. Alejandre-Aguilar ,&nbsp;M. Palma-Irizarry ,&nbsp;X. Hernandez-Velasco","doi":"10.1016/j.parint.2024.102954","DOIUrl":"10.1016/j.parint.2024.102954","url":null,"abstract":"<div><p>The present report describes a case of acanthocephaliasis associated with necrotic enteritis in quetzals (<em>Pharomachrus mocinno</em>). Three juvenile quetzals exhibited depression, anorexia, ruffled feathers, and sudden death. They were submitted to the laboratory for examination. The birds had hatched and lived in captivity in an aviary in Mexico. Gross lesions observed were hemorrhagic, fibrinoid necrotic enteritis, with acanthocephalans adhered to the intestinal mucosa. The specimens were identified by parasitology, electronic microscopy, and molecular biology as <em>Plagiorhynchus</em> (<em>Prosthorhynchus</em>) sp. Lesions compatible with necrotic enteritis were also confirmed by isolation and genotyping of <em>Clostridium perfringens</em> type E. This is the first report of <em>Plagiorhynchus</em> (<em>Prosthorhynchus</em>) sp. in quetzals in captivity in Mexico. The findings in this manuscript suggest that this parasite could be a predisposing factor for necrotic enteritis as well as a risk component in the breeding programs and survival of this avian species in captivity.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102954"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Seropositivity of toxoplasmosis in pregnant women living with HIV/ADIS worldwide: Systematic review and meta- analysis” [Parasitology International, Volume 102, October 2024,102922]","authors":"Eden Woldegerima ,&nbsp;Mulugeta Aemiro ,&nbsp;Mastewal Birhan ,&nbsp;Getnet Fetene ,&nbsp;Nega Birhanie","doi":"10.1016/j.parint.2024.102951","DOIUrl":"10.1016/j.parint.2024.102951","url":null,"abstract":"","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102951"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1383576924001028/pdfft?md5=09dd7fbf340144aa687661238c8f070e&pid=1-s2.0-S1383576924001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An advance in the understanding the systematics of Echinochasmus Dietz, 1909 and Stephanoprora Odhner, 1902 (Digenea: Echinochasmidae), with the description of a new species of Echinochasmus from the Neotropical region of Mexico","authors":"Alma Gabriela Islas-Ortega,&nbsp;Yeraldin Aldama-Prieto,&nbsp;Ana Lucia Sereno-Uribe,&nbsp;Martín García-Varela","doi":"10.1016/j.parint.2024.102948","DOIUrl":"10.1016/j.parint.2024.102948","url":null,"abstract":"<div><p>Echinochasmids are a group of globally distributed digeneans, and the adults are found in the intestines of birds, mammals and reptiles. In the Neotropical region of Mexico, adult specimens were obtained from seven fish-eating bird species in six localities, whereas specimens of <em>Stephanoprora aylacostoma</em> were obtained experimentally in Argentina. Morphologically, the new specimens from the Neotropical region of Mexico were identified as <em>Stephanoprora uruguayense</em> and an undescribed species of <em>Echinochasmus</em>. Sequences for two nuclear (large subunit (28S) and internal transcribed spacer from DNA ribosomal (ITS1–5.8S–ITS2)) molecular markers were generated and analysed together with other sequences downloaded from GenBank. The phylogenies obtained with each molecular marker indicated that <em>Echinochasmus</em> is paraphyletic and agreed with previous phylogenetic studies. The first cluster included the type species (<em>E. coaxatus,</em> which has 24 head-collar spines) plus three congeneric species. The second cluster contained species of <em>Echinochasmus</em> plus <em>Stephanoprora,</em> including the species analysed herein, <em>S. uruguayense</em>, <em>S. aylacostoma</em> (with 22 head-collar spines) and <em>Echinochasmus</em> sp. (with 20 head-collar spines), which formed three independent subclades, allowing us to recognize a lineage that was described morphologically as a new species. <em>Echinochasmus ostrowskiae</em> n. sp. can be distinguished from its congeners by having a head collar with 20 spines in a single row, seven spines on each edge and three angle spines, and a pharynx with an irregular edge and by the body, egg and collar spine sizes. Additionally, new host and locality records for <em>S. uruguayense</em> are presented, expanding its geographical distribution range in the Americas.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102948"},"PeriodicalIF":1.5,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1383576924000990/pdfft?md5=cb6b49ffdf7ab296940eceacb234508a&pid=1-s2.0-S1383576924000990-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen Cannabis and Oleum Hyperici: Antileishmanial activity against Leishmania tropica promastigotes and intracellular amastigotes","authors":"Ahmet Yıldırım ,&nbsp;Tülay Aksoy ,&nbsp;Hüsniye Kayalar ,&nbsp;İbrahim Cüneyt Balcıoğlu","doi":"10.1016/j.parint.2024.102950","DOIUrl":"10.1016/j.parint.2024.102950","url":null,"abstract":"<div><p>The exploration of alternative agents and novel drug candidates for the effective treatment of cutaneous leishmaniasis has garnered significant attention, driven by the high cost, toxic effects, and the emergence of drug resistance associated with current therapeutic options. Plant extracts derived from Semen Cannabis, the seeds of the <em>Cannabis sativa</em> L. (hemp) plant, and Oleum Hyperici, the oily macerate of <em>Hypericum perforatum</em> L. (St. John's Wort) plant, were prepared by using solvents of varying polarity (n-hexane, chloroform, ethanol, and 60% aqueous ethanol). The primary objective of this study was to research <em>in vitro</em> and <em>ex vivo</em> antileishmanial efficacy of Semen Cannabis and Oleum Hyperici plant extracts against <em>Leishmania tropica</em> promastigotes and intracellular amastigotes. The efficacy of plant extracts against promastigotes were assessed using the cell counting by hemocytometer and the CellTiter-Glo assay. Additionally, their impact on infected THP-1 macrophages and the quantity of intracelluler amastigotes were investigated. Cytotoxicity was evaluated in THP-1 macrophages. Among the tested plant extracts, chloroform extract of Oleum Hyperici demonstrated significant antileishmanial activity against promastigotes (SI: 12.6) and intracellular amastigotes (SI: 16.8) of <em>L. tropica</em> without inducing cytotoxic effects and hold promise for further investigation as potential antileishmanial agents.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102950"},"PeriodicalIF":1.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinococcus ortleppi infection in humans: An emerging zoonosis in Asia","authors":"Ayako Yoshida ,&nbsp;Takao Irie ,&nbsp;Lan-Anh Le ,&nbsp;Khanh-Linh Bui ,&nbsp;Yukifumi Nawa","doi":"10.1016/j.parint.2024.102949","DOIUrl":"10.1016/j.parint.2024.102949","url":null,"abstract":"<div><p><em>Echinococcus ortleppi</em> is the genotype G5 of <em>Echinococcus granulosus</em> sensu lato and is a zoonotic canine tapeworm of which larvae causes cystic diseases in domestic animals and also humans. While this species is highly endemic and widely spread in domestic animals, human infection is extremely rare and only sporadic, and thus, entire picture of human cystic echinococcosis due to infection with <em>E. ortleppi</em> is unclear. We have made an extensive literature review on the cases of <em>E. ortleppi</em> infection in humans and found a total of 19 cases from various places in the world with recent emergence in Asian countries.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102949"},"PeriodicalIF":1.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of medicinal plants and their derived biomolecules against Plasmodium falciparum","authors":"Umme Qulsum ,&nbsp;Md Thoufic Anam Azad ,&nbsp;Kentaro Kato","doi":"10.1016/j.parint.2024.102946","DOIUrl":"10.1016/j.parint.2024.102946","url":null,"abstract":"<div><p>Many apicomplexan pathogens pose significant threats to humans and domestic animals, with the lack of effective drugs and drug resistance representing major challenges in disease management. To address this, the search for new and potent antimalarial drugs is crucial. Plant-based formulations offer a promising alternative for such drug development. Here, we evaluated the <em>in vitro</em> antiplasmodial activity of nine plant extracts, traditionally used to treat fever-like symptoms in Bangladesh. We assessed the antimalarial activity of plant extracts by using the <em>Plasmodium falciparum</em> 3D7 growth inhibition assay, an invasion assay, and a cytotoxicity assay. Of the nine plants studied, ethanolic and methanolic leaf extracts of <em>Ficus hispida</em>, <em>Streblus asper</em>, and <em>Boerhavia repens</em> exhibited high antiplasmodial activity, with IC₅₀ values of 9.31, 4.13, 9.63 μg/ml (ethanolic) and 15.12, 6.63, 7.58 μg/ml (methanolic), respectively, and minimal toxicity (cell viability &gt;80%). <em>Clerodendrum viscosum</em> displayed antiplasmodial effects with IC₅₀ values of 28.90 μg/ml (ethanolic) and 30.57 μg/ml (methanolic). <em>Adhatoda vasica</em>, <em>Mussaenda corymbosa</em>, and <em>Amaranthus spinosus</em> ethanolic extracts showed antimalarial effects with IC₅₀ values of 61.78 μg/ml, 66.31 μg/ml, and 64.14 μg/ml, respectively. However, methanolic extracts of <em>A. vasica</em> and <em>A. spinosus</em> had IC₅₀ values &gt;100 μg/ml. The ethanolic and methanolic extracts of <em>A. vasica</em>, <em>A. spinosus</em>, <em>F. hispida</em>, <em>S. asper</em>, and <em>B. repens</em> significantly reduced parasitemia by inhibiting invasion into erythrocytes. This study highlights the robust antimalarial activity and low cytotoxicity of leaf extracts of <em>F. hispida</em>, <em>S. asper</em>, and <em>B. repens</em>, indicating the presence of antimalarial compounds that warrant further investigation.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102946"},"PeriodicalIF":1.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}