Parasitology International最新文献

{"title":"Pulmonary infection by Lophomonas spp. and Aspergillus spp. in a B-cell acute lymphocytic leukemia patient from Chile","authors":"Isabel Iturrieta-González ,&nbsp;Enzo Moenen-Locoz ,&nbsp;Alejandro Hidalgo ,&nbsp;Fernando Vega ,&nbsp;Johanna Cabrera ,&nbsp;Carla Concha ,&nbsp;Carolina Chahin ,&nbsp;Javier Briones ,&nbsp;Flery Fonseca-Salamanca","doi":"10.1016/j.parint.2024.102971","DOIUrl":"10.1016/j.parint.2024.102971","url":null,"abstract":"<div><div>The flagellated protozoan <em>Lophomonas</em> spp. is a commensal microorganism found in the intestinal tracts of cockroaches, termites, mites, and certain birds. It is the causative agent of a rare infection in humans called lophomoniasis, primarily affecting the lungs and mainly immunocompromised individuals. This parasitosis is transmitted to humans by air or through ingestion of the cystic forms of the parasite. We describe the case of a 50-year-old patient treated at a tertiary hospital in southern Chile with a history of B-cell acute lymphocytic leukemia. Radiological findings, along with increased levels of inflammatory parameters and galactomannan antigen in serum and Bronchoaveolar Lavage (BAL) raised the suspicion of a pulmonary infection. Microscopic study of BAL revealed oval to pyriform cells with mobile flagella at the anterior end, which were identified as <em>Lophomonas</em> spp. trophozoites, which based on EORTC/MSG criteria were associated with diagnosis of a probable pulmonary aspergillosis. Lophomoniasis was treated with metronidazole (500 mg IV every 8 h) for 14 days and pulmonary aspergillosis required a combination of fluconazole, voriconazole, anidulafungin, liposomal amphotericin B and isavuconazole. The patient responded favorably and was discharged after 95 days of hospitalization. This case highlights the importance of recognizing lophomoniasis as a parasitic infection in respiratory samples from immunocompromised patients who present pulmonary symptoms, especially those who do not respond satisfactorily to conventional antimicrobial treatments. Further research is needed to understand the various sources of <em>Lophomonas</em> spp. infection and develop infection prevention strategies particularly for high-risk patients.</div></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102971"},"PeriodicalIF":1.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel triplex-PCR assay for the identification of feline hemoplasma species and survey of hemoplasma species in cats in Türkiye","authors":"Kursat Altay ,&nbsp;Alparslan Coskun ,&nbsp;Ufuk Erol ,&nbsp;Omer Faruk Sahin ,&nbsp;Sefer Turk","doi":"10.1016/j.parint.2024.102969","DOIUrl":"10.1016/j.parint.2024.102969","url":null,"abstract":"<div><p>Three hemoplasma species, <em>Mycoplasma haemofelis, Candidatus</em> Mycoplasma haemominutum, and <em>Candidatus</em> Mycoplasma turicensis, have been identified in domestic and wild felids. <em>M. haemofelis</em> may cause severe clinical manifestations in domestic cats, whereas others can lead to mild infections. Identification of these pathogens is done using molecular diagnostic tools like conventional-PCR or real-time PCR. However, these have disadvantages, such as the failure to differentiate species or high cost. This study aimed to develop a triplex-PCR method for the diagnosis and discrimination of feline hemoplasma species. Furthermore, it is aimed at providing molecular data on the epidemiology of feline hemoplasma species in Türkiye, where there is a paucity of information on these pathogens. Triplex-PCR primers amplifying the <em>16S rRNA</em> gene regions of <em>M. haemofelis</em> (1022 bp), <em>Ca.</em> Mycoplasma haemominutum (607 bp), and <em>Ca.</em> Mycoplasma turicensis (456 bp) species were designed and optimized. Moreover, the detection limits of the method were also determined and it was found that the primers could detect 0.001 ng/μL amount of DNA for <em>M. haemofelis</em>, 0.0001 ng/μL for <em>Ca.</em> Mycoplasma haemominutum, and 0.0002 ng/μL for <em>Ca.</em> Mycoplasma turicensis in the sample. 286 cat blood samples obtained from Sivas province were researched for feline hemoplasma species. Feline hemoplasma species were detected in samples of 29 out of 286 cats (10.23 %). Five samples (1.74 %) were infected with only <em>M. haemofelis,</em> whereas 22 (7.69 %) were only infected with <em>Ca.</em> Mycoplasma haemominutum. Two samples (0.69 %) were found to be infected with both <em>M. haemofelis</em> and <em>Ca.</em> Mycoplasma haemominutum. <em>Ca.</em> Mycoplasma turicensis was not detected in this study. A triplex-PCR method that can be used for the identification and species differentiation of feline hemoplasma species in hosts was developed. Moreover, hemoplasma species were found to be circulating in cats in the study area, and it is recommended that veterinarians and animal owners take the necessary precautions to protect themselves and their cats from these pathogens.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102969"},"PeriodicalIF":1.5,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of intestinal protist detection in humans, animals, and the environment in a slum area in Mymensingh, Bangladesh","authors":"Sadiya Maxamhud ,&nbsp;Md Shahiduzzaman ,&nbsp;A.R.M. Beni Amin ,&nbsp;Md. Zawad Hossain ,&nbsp;Eleni Gentekaki ,&nbsp;Anastasios D. Tsaousis","doi":"10.1016/j.parint.2024.102967","DOIUrl":"10.1016/j.parint.2024.102967","url":null,"abstract":"<div><p>The purpose of this study was to investigate the presence and transmission of <em>Cryptosporidium</em> spp., <em>Blastocystis</em> sp.<em>, Giardia intestinalis</em> and <em>Entamoeba histolytica</em> between different hosts and their shared environment in a slum area of Bangladesh. A total of 102 samples were collected from Mymensingh, Bangladesh. This collection encompassed 16 human samples, 35 soil samples and 51 animal samples from various households within the region. The detection of <em>Cryptosporidium</em> spp., <em>Blastocystis</em> sp., <em>G. intestinalis</em>, and <em>E. histolytica</em> was carried out using nested PCR and/or quantitative PCR methodologies. Among the samples, 24 human, animal, and soil out of 102 were found positive for <em>Blastocystis</em> sp., spanning seven subtypes: ST2, ST3, ST7, ST10, ST23, ST24 and ST25. Additionally, eight samples (8/102) including human, animal and soil tested positive for <em>Cryptosporidium</em> spp., including <em>C. parvum, C. baileyi, C. bovis,</em> and <em>C. meleagridis</em>. Furthermore, one soil sample tested positive for <em>G. intestinalis</em> assemblage B, while no samples tested positive for <em>E. histolytica</em>. The detection of <em>Cryptosporidium</em> spp., <em>Blastocystis</em> sp., and <em>G. intestinalis</em> in this study has provided insights into their presence, extending beyond humans. Moreover, these findings highlight the importance of embracing a One Health perspective with an emphasis on specific parasitic microorganisms.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102967"},"PeriodicalIF":1.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1383576924001181/pdfft?md5=be3732ca356ad1ec57a14ddbe42802a8&pid=1-s2.0-S1383576924001181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and bio-efficacy of agro-waste plant extracts and their potential as bioinsecticides against Culex pipiens mosquitoes","authors":"Mohamed M. Baz ,&nbsp;Mohamed A.M. El-Tabakh ,&nbsp;Abdelfattah Selim ,&nbsp;Saeed M. Alasmari ,&nbsp;Abeer Mousa Alkhaibari ,&nbsp;Mohammed H. Alruhaili ,&nbsp;Hattan S. Gattan ,&nbsp;Heba F. Abdelkhalek","doi":"10.1016/j.parint.2024.102968","DOIUrl":"10.1016/j.parint.2024.102968","url":null,"abstract":"<div><p>Mosquitoes are considered one of the most lethal creatures on the planet and are responsible for millions of fatalities annually through the transmission of several diseases to humans. Green trash is commonly employed in agricultural fertilizer manufacturing and microbial bioprocesses for energy production. However, there is limited information available on the conversion of green waste into biocides. This study investigates the viability of utilizing green waste as a new biopesticide against <em>Culex pipiens</em> mosquito larvae. The current study found that plant extracts from <em>Punica granatum</em> (98.4 % mortality), <em>Citrus sinensis</em> (92 % mortality), <em>Brassica oleracea</em> (88 % mortality), <em>Oryza sativa</em> (81.6 % mortality), and <em>Colocasia esculenta</em> (53.6 % mortality) were very good at killing <em>Cx. pipiens</em> larvae 24 h post-treatment. The LC₅₀ values were 314.43, 370.72, 465.59, 666.67, and 1798.03 ppm for <em>P. granatum, C. sinensis, B. oleracea, O. sativa,</em> and <em>C. esculenta</em>, respectively. All plant extracts, particularly <em>P. granatum</em> extract (14.93 and 41.87 U/g), showed a significant reduction in acid and alkaline phosphate activity. Additionally, pomegranate extract showed a significant decrease (90 %) in field larval density, with a stability of up to five days post-treatment. GC–MS results showed more chemical classes, such as terpenes, esters, fatty acids, alkanes, and phenolic compounds. HPLC analysis revealed that the analyzed extracts had a high concentration of phenolic and flavonoid components. Moreover, there are many variations among these plants in the amount of each compound. The docking interaction showed a simulation of the atomic-level interaction between a protein and a small molecule through the binding site of target proteins, explaining the most critical elements influencing the enzyme's activity or inhibitions. The study's findings showed that the various phytochemicals found in agro-waste plants had high larvicidal activity and provide a safe and efficient substitute to conventional pesticides for pest management, as well as a potential future in biotechnology.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102968"},"PeriodicalIF":1.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the health-related quality of life of cutaneous Leishmaniasis patients in Draa-Tafilalet, southeastern Morocco","authors":"Driss Ait Ali ,&nbsp;Abdessamad El Hamdi ,&nbsp;Nourelwiam Boumeshouli ,&nbsp;Adnane Hakem ,&nbsp;Abdelaati El Khiat ,&nbsp;Mohamed El Koutbi ,&nbsp;Brahim El Houate ,&nbsp;Nicola Luigi Bragazzi ,&nbsp;Amelia Rizzo ,&nbsp;Francesco Chirico ,&nbsp;Hicham Khabbache","doi":"10.1016/j.parint.2024.102963","DOIUrl":"10.1016/j.parint.2024.102963","url":null,"abstract":"<div><p>Cutaneous leishmaniasis is a significant public health concern globally. This study aims to evaluate the impact of cutaneous leishmaniasis on the quality of life of patients in the Draa-Tafilalet region of Morocco. In this cross-sectional study, data were collected from 87 patients between December 2022 and July 2023 using the Skindex-16 questionnaire. The results revealed that cutaneous leishmaniasis has a mild to moderate impact on health-related quality of life, with 26.4 % of participants reporting a low impact and 73.6 % reporting a moderate impact. A significant gender difference was observed in Skindex-16 scores, with moderate impact being more prevalent among females (60.90 % vs. 30.10 %, <em>p</em> = 0.002). Furthermore, facial lesions were associated with a statistically significant reduction in quality of life, particularly in the emotional (<em>p</em> &lt; 0.001) and functioning (<em>p</em> = 0.01) domains. These findings highlight the need for targeted management strategies that address the substantial impact of cutaneous leishmaniasis on patients' quality of life. Future studies with larger sample sizes and extended follow-up periods are warranted to further elucidate the effects of cutaneous leishmaniasis on patients' well-being.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"104 ","pages":"Article 102963"},"PeriodicalIF":1.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible transmission of plasmodium malariae through liver transplantation: Diagnosis with a Sysmex XN-20™ hematology analyzer","authors":"Andreu Martínez-Cerezuela ,&nbsp;Luiza Tofan ,&nbsp;José Miguel Sahuquillo-Arce ,&nbsp;Marino Blanes-Juliá ,&nbsp;María Teresa Contreras-Martínez","doi":"10.1016/j.parint.2024.102955","DOIUrl":"10.1016/j.parint.2024.102955","url":null,"abstract":"<div><p>Malaria is an infectious disease caused by several species of the genus <em>Plasmodium.</em> It is usually transmitted by female <em>Anopheles</em> mosquitoes. Other routes of transmission include mother-to-child transmission, shared use of needles, blood transfusion and solid organ transplantation. In non-endemic countries, malaria is often diagnosed on the basis of a history of journeys or migration from endemic areas. Transplant-transmitted malaria might represent a diagnostic challenge for clinicians.</p><p>Here, we report the casual diagnosis of possible transplant-transmitted malaria in a Spanish patient with no previous visits to endemic areas. He developed symptoms one month after receiving a liver transplant from a deceased donor immigrated from Ghana. After being admitted to the Emergency Room, a complete blood count revealed an abnormal cell population which activated an ‘infested red blood cells’ flag (<em>iRBC</em>). This finding led to perform a blood smear and further tests which confirmed the diagnosis of malaria.</p><p>Given that automated complete blood counts are usually performed for any patient with fever, they represent a useful tool to detect malaria in unsuspected patients. In particular, the <em>iRBC</em> flag implemented in Sysmex XN-Series™ hematology analyzers is a useful screening tool for malaria in clinical laboratories.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102955"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paronatrema davidbowiei n. sp. (Trematoda: Syncoeliidae), a new parasite of the pelagic thresher (Alopias pelagicus) and its phylogenetic relationships within the suborder Hemiurata Skrjabin & Guschanskaja, 1954","authors":"Mario Santoro ,&nbsp;Flavia Occhibove ,&nbsp;Alejandro López-Verdejo ,&nbsp;Alicia Rojas ,&nbsp;Alberto Solano-Barquero","doi":"10.1016/j.parint.2024.102953","DOIUrl":"10.1016/j.parint.2024.102953","url":null,"abstract":"<div><p>A new species of hemiurid trematode found on the gills and in the aorta of the pelagic thresher <em>Alopias pelagicus</em> from the eastern Pacific, off Costa Rica, is described based on an integrative taxonomic approach that includes the use of light and scanning electron microscopy, and 28S rDNA sequencing. Phylogenetic analysis was also performed to explore, for the first time, the relationships of a member of the subfamily Otiotrematinae within the suborder Hemiurata. <em>Paronatrema davidbowiei</em> n. sp. can be distinguished from the congeners by having tegumental spines on the dorsal surface of the forebody, papillae on the oral sucker, and different morphology or number of testicular follicles. BLAST analysis revealed that sequences of <em>Paronatrema davidbowiei</em> n. sp. had the highest degree of similarity with <em>Hirudinella</em> spp. (Hirudinellidae). Results from Maximum Likelihood and Bayesian phylogenetic analyses, returning trees with the exact same topology and strong branch support, distinguished between the two superfamilies included in the suborder Hemiurata: Azygioidea and Hemiuroidea. Our analysis placed the new species in a clade with <em>Copiatestes filiferus</em>, the only existing sequence of the family Syncoeliidae.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102953"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of parasitic diseases in Japan and request from a clinician to parasitologists","authors":"Kenji Ohnishi","doi":"10.1016/j.parint.2024.102952","DOIUrl":"10.1016/j.parint.2024.102952","url":null,"abstract":"<div><p>In Japan, parasitic diseases are rare today, with the exception of amebiasis and anisakidosis. As a result, many Japanese clinicians have limited knowledge of parasitic diseases and do not consider them important. Parasitology departments in the schools of medicine in Japan have tended to be replaced or downsized, and the amount of time spent for the teaching of parasitology to undergraduate students has been shortened. However, even in Japan, patients with parasitic diseases visit clinics or hospitals. Medical students have to learn the diagnosis and basic treatment of parasitic diseases that could cause death or serious sequelae without proper treatment, and those which are relatively frequently encountered in Japan. It is also essential for the students to know the circumstances they should suspect parasitic diseases. There is nothing restricting a parasitologist from responding to questions and requests from clinicians regarding diagnosis and treatment; rather, it is in the best interest of patients with parasitic diseases to do so based on their professional knowledge.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102952"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acanthocephaliasis by Plagiorhynchus sp. (Acanthocephala:Plagiorhynchidae) associated with necrotic enteritis in quetzals (Pharomachrus mocinno) maintained in captivity","authors":"F.D. Sanchez-Godoy ,&nbsp;J.R.E. Martinez-Guzmán ,&nbsp;R. Hernandez-Castro ,&nbsp;F. Martinez-Hernandez ,&nbsp;O. Urquiza-Bravo ,&nbsp;N. Rivas ,&nbsp;R. Alejandre-Aguilar ,&nbsp;M. Palma-Irizarry ,&nbsp;X. Hernandez-Velasco","doi":"10.1016/j.parint.2024.102954","DOIUrl":"10.1016/j.parint.2024.102954","url":null,"abstract":"<div><p>The present report describes a case of acanthocephaliasis associated with necrotic enteritis in quetzals (<em>Pharomachrus mocinno</em>). Three juvenile quetzals exhibited depression, anorexia, ruffled feathers, and sudden death. They were submitted to the laboratory for examination. The birds had hatched and lived in captivity in an aviary in Mexico. Gross lesions observed were hemorrhagic, fibrinoid necrotic enteritis, with acanthocephalans adhered to the intestinal mucosa. The specimens were identified by parasitology, electronic microscopy, and molecular biology as <em>Plagiorhynchus</em> (<em>Prosthorhynchus</em>) sp. Lesions compatible with necrotic enteritis were also confirmed by isolation and genotyping of <em>Clostridium perfringens</em> type E. This is the first report of <em>Plagiorhynchus</em> (<em>Prosthorhynchus</em>) sp. in quetzals in captivity in Mexico. The findings in this manuscript suggest that this parasite could be a predisposing factor for necrotic enteritis as well as a risk component in the breeding programs and survival of this avian species in captivity.</p></div>","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102954"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Seropositivity of toxoplasmosis in pregnant women living with HIV/ADIS worldwide: Systematic review and meta- analysis” [Parasitology International, Volume 102, October 2024,102922]","authors":"Eden Woldegerima ,&nbsp;Mulugeta Aemiro ,&nbsp;Mastewal Birhan ,&nbsp;Getnet Fetene ,&nbsp;Nega Birhanie","doi":"10.1016/j.parint.2024.102951","DOIUrl":"10.1016/j.parint.2024.102951","url":null,"abstract":"","PeriodicalId":19983,"journal":{"name":"Parasitology International","volume":"103 ","pages":"Article 102951"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1383576924001028/pdfft?md5=09dd7fbf340144aa687661238c8f070e&pid=1-s2.0-S1383576924001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}