Prevalence of three important tick-borne pathogens in ticks and humans in Shaanxi Province, Northwest China

IF 1.5 4区医学 Q3 PARASITOLOGY

Parasitology International Pub Date : 2024-10-10 DOI:10.1016/j.parint.2024.102980

Rui Guan , Na Wei , Meng Cao , Jian-Gong Yang , Ru Wu , Hui Li

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Abstract

The investigation of important prevalent tick-borne pathogens is central to the control of tick-borne diseases. To understand the prevalence of Borrelia burgdorferi s.l., Borrelia miyamotoi, and the Alongshan virus in ticks and patients in Shaanxi Province, China, a total of 670 adult ticks and 524 patient blood samples were collected in the region between 2022 and 2023. In this study, PCR was used to estimate the prevalence of the three pathogens. The results revealed that the overall positive rates of B. burgdorferi s.l, B. miyamotoi, and ALSV infection in the collected ticks were 13.58 %, 2.46 %, and 4.17 %, respectively. Three genospecies of B. burgdorferi s.l. were detected in this study, namely, B. garinii, B. afzelii, and B. bavariensis, with positive rates of 4.63 %, 3.58 %, and 5.37 %, respectively. The prevalence rates of B. miyamotoi, ALSV and B. burgdorferi s.l. in the patients were 0.38 %, 0.95 %, and 15 %, respectively. Moreover, B. burgdorferi s.l. and ALSV coinfection was also detected in three patients. Evolutionary analysis revealed that the isolate of B. miyamotoi belongs to the Asian type (Siberian type) and that of ALSV is closely related to that of Finland. To our knowledge, this is the first report on B. miyamotoi and ALSV detection in both ticks and humans in Shaanxi Province; the prevalence indicates that the regions in this province might be endemic areas. The results also suggest that humans in these regions are at risk of infection with these three tick-borne diseases.

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中国西北地区陕西省蜱虫和人体内三种重要蜱媒病原体的流行情况。

调查重要的蜱传病原体是控制蜱传疾病的关键。为了了解中国陕西省蜱虫和患者体内布氏包柔氏菌、宫本包柔氏菌和阿龙山病毒的流行情况，研究人员于2022年至2023年期间在该地区共采集了670只成年蜱虫和524份患者血液样本。本研究采用 PCR 方法估算三种病原体的流行率。结果显示，采集到的蜱虫中感染 B. burgdorferi s.l、B. miyamotoi 和 ALSV 的总体阳性率分别为 13.58%、2.46% 和 4.17%。本研究中检测到了 B. burgdorferi s.l. 的三个基因种，即 B. garinii、B. afzelii 和 B. bavariensis，阳性率分别为 4.63 %、3.58 % 和 5.37 %。宫本氏杆菌、勃氏杆菌和 ALSV 在患者中的感染率分别为 0.38 %、0.95 % 和 1.15 %。此外，在 3 名患者中还检测到了 B. burgdorferi s.l. 和 ALSV 合并感染。进化分析表明，宫本虫的分离株属于亚洲型（西伯利亚型），而 ALSV 的分离株与芬兰的分离株关系密切。据我们所知，这是陕西省首次报告在蜱虫和人体内发现宫本虫和 ALSV；其流行情况表明该省的一些地区可能是流行区。研究结果还表明，这些地区的人类有感染这三种蜱媒疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parasitology International 医学-寄生虫学

CiteScore

4.00

自引率

10.50%

发文量

140

审稿时长

61 days

期刊介绍： Parasitology International provides a medium for rapid, carefully reviewed publications in the field of human and animal parasitology. Original papers, rapid communications, and original case reports from all geographical areas and covering all parasitological disciplines, including structure, immunology, cell biology, biochemistry, molecular biology, and systematics, may be submitted. Reviews on recent developments are invited regularly, but suggestions in this respect are welcome. Letters to the Editor commenting on any aspect of the Journal are also welcome.