Pancreatology最新文献

{"title":"\"Harnessing the power of organoids for improved outcomes in pancreatic cancer\".","authors":"Laxmi Kirola, Saurabh Kedia, Sujata Mohanty","doi":"10.1016/j.pan.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.pan.2025.02.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Risk score to predict inpatient mortality of acute pancreatitis patients admitted to the intensive care unit.","authors":"Hiba Thasleem, Saad Khan, Fatima Sohail, Maryam Adnan, Junai'd Imran","doi":"10.1016/j.pan.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.pan.2025.02.003","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albumin ratio-based indicator for predicting inpatient mortality in acute pancreatitis patients admitted to the intensive care unit.","authors":"Guangyao Yang, Qifang Shi, Ying Xu","doi":"10.1016/j.pan.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.pan.2025.02.002","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why is the rectal route for NSAIDS favorable for preventing post-ERCP pancreatitis?","authors":"Gayathri Swaminathan, Yu-Chu Lin, Jianbo Ni, Asna Khalid, Cheng-Yu Tsai, Ying Ding, Na Bo, Judy-April Murayi, Thottala Jayaraman, Ronald Poropatich, Rita Bottino, Georgios I Papachristou, Sunil G Sheth, Li Wen, Monique T Barakat, Adam R Frymoyer, Mang Yu, Sohail Z Husain","doi":"10.1016/j.pan.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.pan.2025.02.004","url":null,"abstract":"<p><strong>Objective: </strong>Acute pancreatitis is a frequent, burdensome adverse event of endoscopic retrograde cholangiography (ERCP). Rectal nonsteroidal anti-inflammatory drugs (NSAIDs) have reduced post-ERCP pancreatitis (PEP) risk by about 50 % and show greater efficacy over parenteral or oral administration, although the mechanism for its superiority remains unclear. To probe this question, we investigated in a preclinical model, the pharmacokinetics in the blood, pancreas and other tissues of the NSAID diclofenac given via the rectal, intravenous, or intragastric routes.</p><p><strong>Methods: </strong>The data on diclofenac was extracted from a larger study that examined a combination of diclofenac and tacrolimus. 20.8 mg diclofenac/kg body weight, which is the mouse equivalent dosing used in clinical practice for PEP prophylaxis, was administered to C57BL/6J mice via the rectal, intravenous and intragastric (oral) routes. Cross-collection of blood and tissues was done at various timepoints after administration for the evaluation of drug levels and pharmacokinetic parameters.</p><p><strong>Results: </strong>Rectal diclofenac demonstrated favorable blood pharmacokinetics and systemic bioavailability as well as sustained pancreas penetration. The total pancreas exposure to diclofenac over 24 h following rectal dosing was not significantly different as compared to intravenous and oral dosing.</p><p><strong>Conclusion: </strong>Our findings suggest that the efficacy of rectal diclofenac in PEP prevention relates more to its higher and consistent systemic exposure than its absolute pancreas levels. The implications are that the rectal route provides both systemic and pancreas exposure for the full duration of PEP vulnerability.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic extracellular volume fraction on routine contrast-enhanced computed tomography can predict pancreatic fibrosis and postoperative pancreatic fistula","authors":"Takahide Sasaki ,&nbsp;Yukihisa Takayama ,&nbsp;Shinji Tanaka ,&nbsp;Yoshihiro Hamada ,&nbsp;Ryo Nakashima ,&nbsp;Shigetoshi Naito ,&nbsp;Masatoshi Kajiwara ,&nbsp;Suguru Hasegawa","doi":"10.1016/j.pan.2024.12.003","DOIUrl":"10.1016/j.pan.2024.12.003","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Postoperative pancreatic fistula (POPF) is a critical complication of pancreatectomy, with a higher risk associated with the absence of pancreatic fibrosis. We investigated whether pancreatic extracellular volume fraction (ECV) calculated from preoperative contrast-enhanced computed tomography (CE-CT) images can be used to predict pancreatic fibrosis and POPF.</div></div><div><h3>Methods</h3><div>This retrospective study included patients who underwent CE-CT before pancreatectomy. ECV map was created by subtracting unenhanced from equilibrium-phase images. We assessed the relationship between pancreatic ECV, the histopathological grade of fibrosis at the pancreatic resection margin, and the occurrence of POPF.</div></div><div><h3>Results</h3><div>Among the 107 patients included, 66 underwent pancreaticoduodenectomy (PD) and 41 underwent distal pancreatectomy (DP). The median ECV at the pancreatic resection margin was 22.5 %. Pancreatic ECV significantly correlated with the histopathological grade of pancreatic fibrosis (ρ = 0.689; <em>p</em> &lt; 0.001). In PD cases, the ECV was an independent risk factor for all-grade POPF (odds ratio, 0.852; 95 % confidence interval, 0.755−0.934), with excellent predictive capability (area under the curve, 0.912; 95 % confidence interval, 0.842−0.983). In DP cases, pancreatic thickness was the only factor associated with all-grade POPF.</div></div><div><h3>Conclusions</h3><div>Pancreatic ECV obtained from routine CE-CT images accurately predicted the histopathological grade of pancreatic fibrosis and was an independent risk factor for POPF after PD.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 153-159"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequence analysis of the 5′ region of the chymotrypsin C (CTRC) gene in chronic pancreatitis","authors":"Zain A. Karamya ,&nbsp;Regina Stefanovics ,&nbsp;Máté Sándor ,&nbsp;Réka Madarász ,&nbsp;Adrienn Nagy ,&nbsp;Andrea Szentesi ,&nbsp;Péter Hegyi ,&nbsp;László Czakó ,&nbsp;Balázs Csaba Németh","doi":"10.1016/j.pan.2024.12.020","DOIUrl":"10.1016/j.pan.2024.12.020","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Loss-of-function chymotrypsin C (<em>CTRC</em>) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5’ upstream region that includes the promoter might affect <em>CTRC</em> expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.</div></div><div><h3>Methods</h3><div>We analyzed ∼1.4 kb of the 5’ region of the <em>CTRC</em> gene in 293 patients with chronic pancreatitis of alcoholic and non-alcoholic etiology and 402 controls from the Hungarian National Pancreas Registry by direct Sanger sequencing.</div></div><div><h3>Results</h3><div>We identified 14 gene variants, which included 11 novel variants and 3 previously reported variants. When allele frequencies were considered, none of the variants were significantly overrepresented in CP cases or controls. Genotype distribution of the frequently occurring variant c.-913A&gt;G showed a statistically significant enrichment of the homozygous GG genotype (versus the AA genotype) in CP cases versus controls (OR 1.67, 95 % CI 1.2–2.4, <em>P</em> 0.0053). However, the disease association was driven by the linkage disequilibrium with the known <em>CTRC</em> risk variant c.180C&gt;T.</div></div><div><h3>Conclusions</h3><div>We found no significant association between variants in the 5’ region of the <em>CTRC</em> gene and CP risk.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 65-69"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of percutaneous endoscopic versus endoscopic transmural necrosectomy for necrotizing pancreatitis: A propensity score-matched study","authors":"Ling Ding ,&nbsp;Lei Li ,&nbsp;Jingwen Rao ,&nbsp;Yong Zhu,&nbsp;Liang Xia,&nbsp;Pi Liu,&nbsp;Lingyu Luo,&nbsp;Huifang Xiong,&nbsp;Yang Hu,&nbsp;Yao Wu,&nbsp;Huajing Ke,&nbsp;Xin Huang,&nbsp;Yupeng Lei,&nbsp;Xu Shu,&nbsp;Zhijian Liu,&nbsp;Youxiang Chen,&nbsp;Nonghua Lu,&nbsp;Yin Zhu ,&nbsp;Wenhua He","doi":"10.1016/j.pan.2024.11.004","DOIUrl":"10.1016/j.pan.2024.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Few published studies exist that compare the outcomes of different endoscopic necrosectomy methods for necrotizing pancreatitis (NP). We compared the safety and efficacy of percutaneous versus transmural endoscopic necrosectomy for NP patients.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, we analyzed adult NP patients who underwent either percutaneous endoscopic necrosectomy (PEN) or endoscopic transmural necrosectomy (ETN), and compared safety and efficacy between the two groups. Propensity score-matched analysis and multivariable logistic regression analysis were conducted.</div></div><div><h3>Results</h3><div>A total of 280 patients were enrolled, among which 142 underwent PEN and 138 underwent ETN. There were differences in baseline characteristics between the two groups, including body mass index, C-reactive protein, systemic inflammatory response syndrome score. The incidences of sepsis, respiratory failure, and intensive care unit stay were higher among patients who underwent PEN than those who underwent ETN (all P &lt; 0.01). Ninety-one pairs were matched with comparable baseline characteristics and severity. The incidence of postoperative complications, open surgery, clinical success, radiological success, collection recurrence, and reintervention were not significantly different between the ETN group and PEN group (all P &gt; 0.05). Multivariate analysis also showed that the approaches (PEN vs ETN) was not associated with postoperative complications or mortality.</div></div><div><h3>Conclusions</h3><div>In real world setting, sicker patients tend to be more effectively managed through PEN compared to ETN. PEN demonstrates comparable efficacy and safety to ETN in the treatment of NP patients.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 5-11"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frozen section analysis of pancreatic resection margins during pancreaticoduodenectomy for pancreatic adenocarcinoma is not affected by neoadjuvant therapy","authors":"Patricia A. Repollet Otero,&nbsp;Elsayed Ibrahim,&nbsp;Saverio Ligato","doi":"10.1016/j.pan.2024.12.008","DOIUrl":"10.1016/j.pan.2024.12.008","url":null,"abstract":"<div><h3>Background/objectives</h3><div>The aim of our study was to evaluate if the histopathological changes occurring in the pancreas post neoadjuvant-therapy (PNAT) for pancreatic ductal adenocarcinoma (PDAC) may negatively affect the assessment of intra-operative frozen section (FS) analysis of pancreatic resection margins (PRMs).</div></div><div><h3>Methods</h3><div>The clinicopathological data of patients who underwent pancreatoduodenectomy for PDAC between 2015 and 2022 were analyzed. Comparison of the accuracy of the FS analysis in treatment naïve (TN) and PNAT patients for all pancreatic margins was performed.</div></div><div><h3>Results</h3><div>We identified 81 patients with PDAC (40 female, 41 male) of which 47 (58.0 %) were TN and 34 (42.0 %) PNAT. Including FSs performed for re-excisions of initially positive PRMs, we identified 2/103 discrepancies for the pancreatic neck margin, one in a TN patient and one in a PNAT patient; one discrepancy for the common bile duct margin (1/47) in a TN patient; and 2/14 discrepancies for the uncinate margin, both in TN patients. In summary, accuracy of FS analysis was similar in the PNAT and TN groups (98.8 % vs. 96.7 %).</div></div><div><h3>Conclusions</h3><div>The histopathological changes occurring in the pancreas PNAT for PDAC do not affect the histopathological interpretation of FS analysis of PRMs, and the accuracy of FS analysis is similar in the PNAT and TN patients.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 142-146"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring endoscopy for infected pancreatic necrosis: DEN or PEN or combined?","authors":"Soumya Jagannath Mahapatra MD ,&nbsp;Raj Shah MD","doi":"10.1016/j.pan.2025.01.005","DOIUrl":"10.1016/j.pan.2025.01.005","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 3-4"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation and management of pancreatic hydatid cyst: A comprehensive systematic review of the literature with meta-data","authors":"Berun A. Abdalla ,&nbsp;Aland S. Abdullah ,&nbsp;Deari A. Ismaeil ,&nbsp;Hemn H. Kaka Ali ,&nbsp;Omer H.G. Hawramy ,&nbsp;Dana T. Gharib ,&nbsp;Hoshmand A. Asaad ,&nbsp;Karokh F. HamaHussein ,&nbsp;Dlshad HamaSaeed Ahmed ,&nbsp;Soran H. Tahir ,&nbsp;Ali H. Hasan ,&nbsp;Muhammed Bag A. Ali ,&nbsp;Sasan M. Ahmed ,&nbsp;Fakher Abdullah ,&nbsp;Fahmi H. Kakamad","doi":"10.1016/j.pan.2024.11.019","DOIUrl":"10.1016/j.pan.2024.11.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Hydatid cysts are among many cysts that can develop in the pancreas. Both the size and location of these cysts significantly influence clinical presentation and surgical approach required for management. This study aims to review the literature concerning pancreatic hydatic cysts, their presentations, and management strategies.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted across CINAHL, Pubmed/Medline, Cochrane Library, Web of Science, and EMBASE Databases to identify English-language studies published up to January 2nd, 2024.</div></div><div><h3>Results</h3><div>The mean age of the patients was 35.4 ± 17.4years, with females comprising 92 (59.0 %) of the cohort. Abdominal pain was the most common complaint, reported by 92 (59.0 %) patients. Serological testing for the echinococcal antigen demonstrated highest sensitivity at 67.0 %, whereas computed tomography exhibited a sensitivity of 34.1 %, and ultrasonography showed a sensitivity of 27.7 %. Among surgical interventions, laparotomy was the most frequently performed approach, utilized in 42(26.9 %) of the cases.</div></div><div><h3>Conclusion</h3><div>Although pancreatic hydatid cysts are rare and can be challenging to diagnose, their prognosis is generally favorable when appropriate therapeutic measures are employed. Surgical intervention, often combined with Albendazole, remains the mainstay of treatment.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 167-188"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}