Pancreatology最新文献

{"title":"Cost-effectiveness of biodegradable pancreatic stents in post-ERCP pancreatitis prophylaxis","authors":"Abdullah Abbasi ,&nbsp;Raheel Anjum ,&nbsp;Pavit Tewatia ,&nbsp;Shyam Menon","doi":"10.1016/j.pan.2025.11.022","DOIUrl":"10.1016/j.pan.2025.11.022","url":null,"abstract":"<div><h3>Background</h3><div>Biodegradable biliopancreatic stents (BDS) are commercially available alternatives to conventional stents. While these offer potential economic benefits—such as eliminating the need for follow-up imaging or endoscopic procedures to retrieve retained stents—they have not been evaluated in a cost-effectiveness model. We aimed to develop a health economic model comparing conventional pancreatic stents (PS) with BDS for the prophylaxis of post-ERCP pancreatitis (PEP).</div></div><div><h3>Methods</h3><div>Data on pancreatic stents used for PEP and follow-up outcomes were extracted from the endoscopy database at The Royal Wolverhampton NHS Trust, United Kingdom, to develop a cost-benefit decision analysis model. Healthcare-associated quality of life data were sourced from the literature to derive utility values for the model. Complications related to retained stents were incorporated. Deterministic and probabilistic sensitivity analyses were performed. Incremental cost-effectiveness ratios (ICERs) were calculated using a willingness-to-pay (WTP) threshold of £30,000.</div></div><div><h3>Results</h3><div>Deterministic analysis demonstrated that using BDS for PEP prophylaxis was cost-effective compared to conventional PS (£656.12, 0.98 QALY for BDS vs. £377.59, 0.95 QALY for PS), yielding an ICER of £9316.70. Probabilistic sensitivity analysis similarly confirmed the cost-effectiveness of BDS over PS, with BDS being cost-effective at £666.67 for 0.98 QALY versus £373.68 for 0.95 QALY for PS. Threshold analysis identified a cost threshold of £353.37 for BDS to remain cost-effective.</div></div><div><h3>Conclusion</h3><div>BDS for PEP prophylaxis is cost effective compared to conventional PS, avoiding the need for follow-up imaging and repeat procedures for stent removal.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 355-362"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal patterns and dynamics of acute pancreatitis emergency department visits in Korea","authors":"Shinjie Choi ,&nbsp;Dong-Uk Kim ,&nbsp;Yeji Kim ,&nbsp;Lia Kim ,&nbsp;Jung Ok Shim ,&nbsp;Jin Soo Moon ,&nbsp;Jong Woo Hahn ,&nbsp;Hye Ran Yang ,&nbsp;Ju Young Chang ,&nbsp;Jae Sung Ko","doi":"10.1016/j.pan.2026.02.010","DOIUrl":"10.1016/j.pan.2026.02.010","url":null,"abstract":"<div><h3>Background/objectives</h3><div>The incidence of acute pancreatitis (AP) varies seasonally in some populations. However, evidence from Korea remains limited. This study aimed to investigate seasonal patterns of AP visits and evaluate potential infectious enteric pathogens contributing to this variation in both pediatric (≤18 years) and adult (&gt;18 years) populations.</div></div><div><h3>Methods</h3><div>Nationwide emergency department (ED) data from the National Emergency Department Information System (NEDIS) were analyzed. The age-stratified seasonal variation in AP visits was modeled using negative binomial harmonic regression (NBHR) models with harmonic terms. Pearson correlation coefficients between AP visits and case counts of enteric infections were calculated to investigate potential infectious agents. Mediation analysis was performed to assess whether specific pathogens mediated the seasonal increase in AP visits.</div></div><div><h3>Results</h3><div>A total of 48,412 ED visits (1481 pediatric and 46,931 adult visits) resulting in hospital admission were included in the analysis. NBHR models revealed significant cyclical seasonality across age groups, with AP visits peaking in the summer. Correlation analysis revealed significant positive associations between AP visits and several pathogens. The mediation analysis suggested that substantial proportions of both <em>Campylobacter</em> and <em>Salmonella</em> species were temporally associated with the changes in AP visits.</div></div><div><h3>Conclusions</h3><div>This study demonstrated a pronounced summer peak in AP visits among both pediatric and adult populations in Korea. <em>Campylobacter</em> and <em>Salmonella</em> species may be linked to this seasonal pattern, suggesting a temporal association between infections with these species and AP seasonality. Further research is needed to clarify other mechanisms underlying seasonal AP surges and inform targeted preventive strategies.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 370-379"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letters to the editor regarding the use of aspirin and mortality due to acute pancreatitis","authors":"Do Han Kim ,&nbsp;Donghyun Ko ,&nbsp;Carlos Elizondo Alatorre ,&nbsp;Frank J. Lukens ,&nbsp;Jose A. Porres ,&nbsp;Pedro Palacios Argueta ,&nbsp;Massimo Raimondo ,&nbsp;Baoan Ji ,&nbsp;Yan Bi ,&nbsp;Paul T. Kröner","doi":"10.1016/j.pan.2026.03.010","DOIUrl":"10.1016/j.pan.2026.03.010","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 511-512"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding methodological refinement and microbiome-centric endpoints","authors":"Shivam Kalia ,&nbsp;Preetam Nath ,&nbsp;Anil Chandra Anand ,&nbsp;Bipadabhanjan Mallick ,&nbsp;Dibyalochan Praharaj ,&nbsp;Sarat Chandra Panigrahi ,&nbsp;Saroj Kanta Sahu ,&nbsp;Suprabhat Giri ,&nbsp;Subrat Kumar Acharya","doi":"10.1016/j.pan.2026.04.013","DOIUrl":"10.1016/j.pan.2026.04.013","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 519-520"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare resource use for acute pancreatitis in patients with familial chylomicronemia syndrome treated with olezarsen.","authors":"Asia Sikora Kessler, Montserrat Vera-Llonch, Veronica J Alexander, Catrina Richards, Quratul Ann, Spyros Paparrodopoulos, Shuting Xia, Sotirios Tsimikas, Seth J Baum","doi":"10.1016/j.pan.2026.04.019","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.019","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oligometastatic disease in pancreatic ductal adenocarcinoma: A critical appraisal of evidence standards for emerging definitions.","authors":"Mauro Iannopollo","doi":"10.1016/j.pan.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.018","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Early progression of paediatric pancreatitis: Is early chronic pancreatitis underdiagnosed?","authors":"Ujjal Poddar, Sadhna B Lal","doi":"10.1016/j.pan.2026.04.017","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.017","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147818961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor regarding microbiome-genetic interplay in intraductal papillary mucinous neoplasms of the pancreas.","authors":"Kosuke Fukuda, Yuto Hozaka, Takao Ohtsuka","doi":"10.1016/j.pan.2026.04.016","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.016","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging population-based health checkup data for pancreatic cancer risk stratification: toward pragmatic early detection.","authors":"Koichiro Haruki, Ken-Ichi Okada, Takao Ohtsuka","doi":"10.1016/j.pan.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.014","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical utility of nutritional and immunological indices as prognostic factors in pancreatic cancer after pancreatectomy.","authors":"Yuki Adachi, Hiromitsu Hayashi, Takuya Tajiri, Kousuke Kanemitsu, Takashi Ofuchi, Daisuke Ogawa, Shinsei Yumoto, Yuki Kitano, Hirohisa Okabe, Masaaki Iwatsuki","doi":"10.1016/j.pan.2026.04.008","DOIUrl":"https://doi.org/10.1016/j.pan.2026.04.008","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer (PC) exhibits aggressive malignant behavior and is the most lethal cancer type worldwide. It is often accompanied by malnutrition, which exacerbates as the disease progresses. We investigated the clinical utility of nutritional and immunological indices as prognostic factors in patients with PC using five major nutritional indices: the Controlling Nutritional Status (CONUT) score, C-reactive protein/albumin ratio, neutrophil/lymphocyte ratio, platelet-to-lymphocyte ratio, and Prognostic Nutritional Index.</p><p><strong>Methods: </strong>We retrospectively analyzed 328 patients with PC who underwent R0 pancreatectomy at Kumamoto University Hospital between 2004 and 2023.</p><p><strong>Results: </strong>Among the evaluated indices, CONUT-High (score ≥3) was the most significant poor prognostic factor for overall survival (OS; P = 0.039) and recurrence-free survival (RFS; P = 0.013) post-pancreatectomy. Among clinicopathological factors, CONUT-High was independently associated with poorer RFS (hazard ratio [HR]: 1.35, P = 0.034) but was not significant for OS (HR: 1.30, P = 0.088). Even in patients with carbohydrate antigen 19-9 (CA19-9)-negative PC, the CONUT score remained a useful prognostic factor for OS (HR: 1.64, P = 0.0496) and RFS (HR: 1.68, P = 0.024). In the 1:1 propensity score matching analysis, CONUT-High was identified as an independent poor prognostic factor for RFS (HR: 1.50, P = 0.021), but not OS (HR: 1.43, P = 0.063).</p><p><strong>Conclusion: </strong>The CONUT score may serve as a simple, independent prognostic factor for RFS in PC, regardless of CA19-9 elevation.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}