Pancreatology最新文献_第3页

Clinical significance and therapeutic implication of CD200 in pancreatic cancer. CD200 在胰腺癌中的临床意义和治疗作用。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1016/j.pan.2024.10.007

Shoichi Kinoshita, Taichi Terai, Minako Nagai, Kota Nakamura, Yuichiro Kohara, Satoshi Yasuda, Yasuko Matsuo, Shunsuke Doi, Takeshi Sakata, Kazuhiro Migita, Noriko Ouji-Sageshima, Toshihiro Ito, Masayuki Sho

{"title":"Clinical significance and therapeutic implication of CD200 in pancreatic cancer.","authors":"Shoichi Kinoshita, Taichi Terai, Minako Nagai, Kota Nakamura, Yuichiro Kohara, Satoshi Yasuda, Yasuko Matsuo, Shunsuke Doi, Takeshi Sakata, Kazuhiro Migita, Noriko Ouji-Sageshima, Toshihiro Ito, Masayuki Sho","doi":"10.1016/j.pan.2024.10.007","DOIUrl":"10.1016/j.pan.2024.10.007","url":null,"abstract":"Background: CD200, a negative regulator of T cells as well as a marker for cancer stem cells, represents a significant prognostic factor and potential therapeutic target in certain cancers. However, its clinical significance remains unknown in pancreatic ductal adenocarcinoma (PDAC).Methods: CD200 was assessed in 220 resected PDAC patients who underwent surgery with or without neoadjuvant chemoradiotherapy (NACRT). We examined the clinicopathological outcomes associated with CD200 and further assessed its clinical implications regarding immunological and cancer stem cell properties.Results: NACRT was associated with higher CD200 expression (66.4 % vs. 32.2 %, P < 0.001) compared to upfront surgery. CD200 was identified as an independent poor prognostic factor in NACRT (hazard ratio 1.90, 95 % confidence interval 1.12-3.23, P = 0.016), but not in upfront surgery patients. Post-recurrence survival was significantly worse in CD200+ patients compared to CD200- patients in the NACRT group, but there was no significant difference observed in the upfront surgery group. CD200 expression was correlated with significantly lower levels of CD4+, CD8+, and CD45RO+ tumor-infiltrating lymphocytes. Furthermore, the correlation of CD200 with pancreatic cancer stem cell markers CD44/CD24/ESA was stronger in irradiated human pancreatic cancer cells.Conclusions: Our data underscore novel roles for CD200 in immune evasion as well as therapy resistance in pancreatic cancer. CD200 may represent a novel poor prognostic predictive factor and potential therapeutic target for PDAC with NACRT.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1280-1287"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing of pancreatic enzyme therapy for malabsorption in unresectable pancreatic cancer: Cross-sectional survey across New Zealand and Australia. 开具胰酶疗法处方以治疗不可切除胰腺癌患者的吸收不良：新西兰和澳大利亚横断面调查。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-10-13 DOI: 10.1016/j.pan.2024.10.008

Amanda Landers, Helen Brown, Kylie Russell, Niamh Fanning, Fong Fu, Clare McKenzie, Meera R Agar, Vanessa M Yenson, Kate Clarke, John Windsor

{"title":"Prescribing of pancreatic enzyme therapy for malabsorption in unresectable pancreatic cancer: Cross-sectional survey across New Zealand and Australia.","authors":"Amanda Landers, Helen Brown, Kylie Russell, Niamh Fanning, Fong Fu, Clare McKenzie, Meera R Agar, Vanessa M Yenson, Kate Clarke, John Windsor","doi":"10.1016/j.pan.2024.10.008","DOIUrl":"10.1016/j.pan.2024.10.008","url":null,"abstract":"Objective: To investigate the practices of clinicians prescribing pancreatic enzyme replacement therapy (PERT) for unresectable pancreatic cancer in Aotearoa New Zealand and Australia.Methods: A mixed media advertising campaign was used to recruit appropriate clinicians to complete a questionnaire that collected demographic data, information regarding prescribed medication, and awareness of PERT guidelines.Results: The study recruited 161 clinicians, with 93 and 68 respondents from Aotearoa New Zealand and Australia respectively. Most respondents from both countries were experienced gastrointestinal surgeons and dietitians. Aotearoa New Zealand clinicians and dietitians used faecal elastase more frequently to diagnose PEI than other groups. Clinicians had a tendency to under-prescribe PERT, and to advise incorrectly on the timing of the medication. The majority of clinicians from Aotearoa New Zealand and Australia were not aware of any best practice clinical guidelines for PERT (70 % and 77 %, respectively).Conclusion: This study suggests clinicians are over-reliant on faecal elastase to diagnose PEI and are uncertain about the correct dose and timing of PERT for optimal patient benefit in those with unresectable pancreatic cancer. Most clinicians were not aware of best practice guidelines.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1288-1293"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter to Editor regarding "Evaluation of postoperative pancreatic fistula prediction scales following pancreatoduodenectomies based on magnetic resonance imaging: A diagnostic test study". 对 "基于磁共振成像的胰十二指肠切除术后胰瘘预测量表的评估：诊断测试研究"。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-10-20 DOI: 10.1016/j.pan.2024.10.009

Fnu Venjhraj, Naren Kumar Matlani, Muzna Murtaza, Zainab Muhammad Hanif, Mukesh Kumar

引用次数: 0

Ca²⁺ signaling of pancreatic acinar cells in malignant hyperthermia susceptibility. 胰腺尖顶细胞的 Ca2+ 信号在恶性高热中的易感性

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1016/j.pan.2024.11.005

Nikolett Geyer, Gyula Diszházi, Zsuzsanna É Magyar, Beatrix Dienes, Réka Csáki, Péter Enyedi, Tamara Madácsy, József Maléth, János Almássy

{"title":"Ca2+ signaling of pancreatic acinar cells in malignant hyperthermia susceptibility.","authors":"Nikolett Geyer, Gyula Diszházi, Zsuzsanna É Magyar, Beatrix Dienes, Réka Csáki, Péter Enyedi, Tamara Madácsy, József Maléth, János Almássy","doi":"10.1016/j.pan.2024.11.005","DOIUrl":"10.1016/j.pan.2024.11.005","url":null,"abstract":"Background: Malignant hyperthermia susceptibility (MHS) and acute pancreatitis (AP) share a common cellular pathomechanism that is Ca2+-overload of the muscle fiber and the pancreatic acinar cell (PAC). In the muscle, gain-of-function mutations of the ryanodine receptor (RyR1) make the Ca2+-release mechanism hypersensitive to certain ligands, including Ca2+, volatile anaesthetics and succinylcholine, creating a medical emergency when the patient is exposed to these drugs. As RyR1 was shown to contribute to Ca2+-overload in PAC, we presumed that pancreata of MHS individuals are more prone to AP. Accordingly, a recent case study reported coincidence of MHS with recurrent AP, indicating a pathological link between the two diseases.Methods: We tested if MHS poses a risk for AP in mice carrying the Y522S MHS mutation. Fluorescent Ca2+ imaging was performed in PACs. Conventional histopathological analysis and plazma amylase measurement was performed using a cerulein-induced pancreatitis mouse model.Results: The intracellular Ca2+-signals of PACs from MHS mice were slightly bigger then in wild type when stimulated with 0.2 and 2 μM carbachol (cch) or with 1 and 5 mM bile acid (taurocholic acid). Store-operated-Ca2+-entry was also higher in PACs from MHS mice. Nevertheless, histopathological analysis and plasma amylase levels did not indicate more severe AP in MHS.Conclusions: These results suggest that the Y522S RyR1 mutation alter the Ca2+-homeostasis in PACs, but not as much as to cause or aggravate AP.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1257-1264"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and prognosis of patients with pancreatic adenocarcinoma not expressing CA19-9: Analysis of the National Cancer Database.

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-11-17 DOI: 10.1016/j.pan.2024.11.011

Toshitaka Sugawara, Salvador Rodriguez Franco, Samantha Sherman, Michael J Kirsch, Kathryn Colborn, Oskar Franklin, Jun Ishida, Samuele Grandi, Mohammed H Al-Musawi, Ana Gleisner, Richard D Schulick, Marco Del Chiaro

{"title":"Characteristics and prognosis of patients with pancreatic adenocarcinoma not expressing CA19-9: Analysis of the National Cancer Database.","authors":"Toshitaka Sugawara, Salvador Rodriguez Franco, Samantha Sherman, Michael J Kirsch, Kathryn Colborn, Oskar Franklin, Jun Ishida, Samuele Grandi, Mohammed H Al-Musawi, Ana Gleisner, Richard D Schulick, Marco Del Chiaro","doi":"10.1016/j.pan.2024.11.011","DOIUrl":"10.1016/j.pan.2024.11.011","url":null,"abstract":"Background: Around 5-10 % of pancreatic cancer patients are non-expressors of carbohydrate antigen 19-9 (CA 19-9), which has an unknown impact on the aggressiveness and prognosis of pancreatic adenocarcinoma (PDAC). This study aimed to evaluate the characteristics and the prognosis of PDAC patients who do not express CA 19-9.Methods: Patients with PDAC diagnosed between 2010 and 2018 were identified in the National Cancer Database. Clinical characteristics were compared according to CA 19-9 levels stratified in four different groups: non-expressors (≤1.0 U/mL), normal range (1.1-37.0 U/mL), mildly elevated (37.1-97.9 U/mL), and CA 19-9 ≥98.0 U/mL. The characteristics were analyzed in the whole cohort and overall survival (OS) was evaluated in a subgroup of upfront resected patients who had cT1-3 tumors without distant metastases.Results: In total, 88,749 patients were included, of which 4.5 % were CA 19-9 non-expressors. The non-expressors had a higher risk of having distant metastasis at diagnosis, compared to patients with normal-range or mildly elevated CA 19-9 levels. In resected patients (n = 4008), CA 19-9 non-expressors had shorted median OS compared to patients with normal-range CA 19-9 levels (29.3 vs 34.4 months, p = 0.024). This OS association remained in a multivariable Cox regression model (adjusted HR 1.22, 95 % CI 1.04-1.44).Conclusions: CA 19-9 non-expression is associated with distant metastatic disease at diagnosis and with death in resected non-metastatic patients compared to normal-range CA 19-9 levels. This clinically relevant subgroup requires alternative biomarkers, and may need consideration of more extensive preoperative staging and intensive perioperative systemic therapy.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1340-1347"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating necroptosis markers in chronic pancreatitis and pancreatic cancer: Associations with diagnosis and prognostic factors.

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1016/j.pan.2024.11.016

Hanna Belfrage, Krista Kuuliala, Antti Kuuliala, Harri Mustonen, Pauli Puolakkainen, Leena Kylänpää, Hanna Seppänen, Johanna Louhimo

{"title":"Circulating necroptosis markers in chronic pancreatitis and pancreatic cancer: Associations with diagnosis and prognostic factors.","authors":"Hanna Belfrage, Krista Kuuliala, Antti Kuuliala, Harri Mustonen, Pauli Puolakkainen, Leena Kylänpää, Hanna Seppänen, Johanna Louhimo","doi":"10.1016/j.pan.2024.11.016","DOIUrl":"10.1016/j.pan.2024.11.016","url":null,"abstract":"Objectives: Necroptosis, a programmed inflammatory cell death, is implicated in the pathogenesis of pancreatitis and its potential progression to pancreatic ductal adenocarcinoma (PDAC), but its role remains unclear. We compared plasma levels of necroptosis-related markers - mixed lineage kinase domain-like protein (MLKL), interleukin (IL)-33, and its soluble receptor (sST2)- in patients with chronic pancreatitis (CP), PDAC, and healthy controls (HC), to explore their diagnostic and prognostic significance.Methods: Plasma was collected from patients pre-procedurally (PDAC, n = 82; CP, n = 25) and from HC (n = 39), and studied by ELISA. Clinical and routine laboratory data were collected, and pancreas was defined as soft or non-soft based on intraoperative or imaging findings. Mann-Whitney U test, Spearman correlation coefficients, ROC analysis were used for statistical analysis.Results: Plasma MLKL was lower in patients with CP than in other groups (p < 0.001) and PDAC patients treated with upfront surgery (PDACUS, n = 65) had lower MLKL than HC (p = 0.035). MLKL differentiated CP from PDACUS (AUC 0.83, p < 0.001). sST2 levels were significantly lower in HC than in other groups (p < 0.001) and in PDAC patients with a soft pancreas compared with non-soft (p < 0.005). In Lewis antigen positive PDACUS (n = 59), sST2 had positive correlations with CA19-9 measured concurrently and after 1 month, and with CEA measured after 1 or 6 months.Conclusions: Circulating levels of MLKL are lower in patients with CP than PDAC. Elevated sST2 levels are associated with pancreatic diseases. Further studies are required to show whether MLKL and sST2 could be useful biomarkers in evaluating pancreatic diseases.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1229-1236"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A causal relationship between distinct immune features and acute or chronic pancreatitis: results from a mendelian randomization analysis. 不同免疫特征与急性或慢性胰腺炎之间的因果关系：孟德尔随机分析的结果。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.pan.2024.10.006

Rujuan Liu, Kui Wang, Xiaoyu Guo, Qiqi Wang, Xiuli Zhang, Kaixin Peng, Wanyi Lu, Zhigao Chen, Feng Cao, Zheng Wang, Li Wen

{"title":"A causal relationship between distinct immune features and acute or chronic pancreatitis: results from a mendelian randomization analysis.","authors":"Rujuan Liu, Kui Wang, Xiaoyu Guo, Qiqi Wang, Xiuli Zhang, Kaixin Peng, Wanyi Lu, Zhigao Chen, Feng Cao, Zheng Wang, Li Wen","doi":"10.1016/j.pan.2024.10.006","DOIUrl":"10.1016/j.pan.2024.10.006","url":null,"abstract":"Objectives: This study aimed to thoroughly examining the causal link between immune traits and four types of pancreatitis, using mendelian randomization.Methods: Data on 731 immune traits were collected from the genome-wide association study (GWAS) database as exposure. Information regarding acute pancreatitis (AP), alcohol-induced acute pancreatitis (AAP), chronic pancreatitis (CP), and alcohol-induced chronic pancreatitis (ACP) were acquired from the FinnGen Consortium as outcomes. Mendelian randomization (MR) using inverse variance weighting (IVW) evaluated the links between immune traits and pancreatitis. We evaluated the robustness of the IVW results through sensitivity analyses and validated them using meta-analysis with AP and CP data from the UK Biobank in the GWAS catalog.Results: A total of 36 immune traits showed significant associations with susceptibility of four types of pancreatitis, including AP (7 traits), AAP (8 traits), CP (14 traits), and ACP (7 traits). Twenty characteristics were found to be potential risk factors for pancreatitis, identified in B Cells (5 traits), conventional dendritic cells (cDCs, 2 traits), maturation stage of T cells (2 traits), monocytes (2 traits), myeloid cells (2 traits), T cells, B cells, natural killer cells (TBNK, 2 traits), and regulatory T cells (Treg cells, 5 traits). Multiple sensitivity analyses confirmed the validity of the findings. Meta-analysis confirmed a solid causal relationship between CX3CR1 on CD14- CD16-of monocyte panel and the susceptibility of CP.Conclusions: Our MR study identified immune traits causally linked to acute and chronic pancreatitis, offering new insights for early clinical intervention and immune cell-targeted therapies.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1219-1228"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An improved invagination pancreaticojejunostomy technique associated with a lower incidence of pancreatic fistula: A single-center study. 胰腺空肠吻合术技术改进后，胰瘘发生率降低：一项单中心研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-11-05 DOI: 10.1016/j.pan.2024.10.013

Jiayue Zou, Ding Sun, Weigang Zhang, Daobin Wang, Danyang Shen, Lei Qin, Xiaofeng Xue

{"title":"An improved invagination pancreaticojejunostomy technique associated with a lower incidence of pancreatic fistula: A single-center study.","authors":"Jiayue Zou, Ding Sun, Weigang Zhang, Daobin Wang, Danyang Shen, Lei Qin, Xiaofeng Xue","doi":"10.1016/j.pan.2024.10.013","DOIUrl":"10.1016/j.pan.2024.10.013","url":null,"abstract":"Purpose: This study compared the incidence of postoperative pancreatic fistula (POPF) between standard invagination pancreaticojejunostomy (PJ) and an improved PJ technique after pancreaticoduodenectomy and evaluated the clinical utility of the improved PJ procedure.Methods: Clinical and postoperative data of 363 patients who underwent pancreaticoduodenectomy at the First Affiliated Hospital of Soochow University from February 2018 to October 2021 were analyzed retrospectively. In our cohort, 155 patients underwent the improved PJ technique (group A), and 208 underwent standard invagination PJ (group B). Data on demographic characteristics, pathological nature, intraoperative factors, and postoperative complications, including POPF, were collected and analyzed.Results: There were no significant between-group differences in demographic characteristics (p > 0.05). The improved PJ technique was associated with a significantly lower incidence of clinically relevant POPF (CR-POPF) in the total cohort (11.6 % vs. 26.4 %, p < 0.001) and in the subgroup with high fistula risk scores (16.0 % vs. 38.6 %, p < 0.001).Conclusion: The improved invagination PJ technique reduces the incidence of CR-POPF and improves prognosis.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1355-1359"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a core outcome set for recurrent acute and chronic pancreatitis: Results of a Delphi poll.

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1016/j.pan.2024.11.013

Lola Rahib, William Salerno, Maisam Abu-El-Haija, Darwin L Conwell, A Jay Freeman, Phil A Hart, Stephen J Pandol, Emily R Perito, Dhiraj Yadav, Tonya M Palermo

{"title":"Development of a core outcome set for recurrent acute and chronic pancreatitis: Results of a Delphi poll.","authors":"Lola Rahib, William Salerno, Maisam Abu-El-Haija, Darwin L Conwell, A Jay Freeman, Phil A Hart, Stephen J Pandol, Emily R Perito, Dhiraj Yadav, Tonya M Palermo","doi":"10.1016/j.pan.2024.11.013","DOIUrl":"10.1016/j.pan.2024.11.013","url":null,"abstract":"Background/objective: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) lack effective therapies. There is no consensus or guidance on which endpoints or outcome measures should be used in clinical trials. This study aimed to develop a core outcome set aligned with both patient and provider priorities for RAP and CP. Utilizing the Outcomes Measures in Rheumatology (OMERACT) framework, a multi-stakeholder approach was adopted to identify and prioritize outcome domains.Methods: A two-round Delphi poll was conducted among four stakeholder groups: adult patients, parents and pediatric patients, adult health care providers and pediatric health care providers. Steering committee consensus further refined the core outcome domains, categorizing them as mandatory, important but optional, or research agenda domains, with full consensus achieved.Results: Pain severity, ability to participate in social roles and activities, pancreatitis related hospitalization/ER visits and acute pancreatitis flare-ups were recommended as mandatory outcome domains for future clinical trials in RAP/CP.Conclusions: Using the OMERACT framework, we developed a core outcome set for RAP and CP. Future research will focus on identifying validated measures for each domain, facilitating standardized assessments across clinical trials.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":"1237-1243"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor regarding 'Prevalence and risk factors of fatigue and its association with quality of life among patients with chronic pancreatitis: A cross-sectional study'. 致编辑的信慢性胰腺炎患者疲劳的发生率和风险因素及其与生活质量的关系：一项横断面研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-12-01 Epub Date: 2024-07-05 DOI: 10.1016/j.pan.2024.07.002

Hamza Yousuf Ibrahim, Shehdev Meghwar

引用次数: 0