Pancreatology最新文献

{"title":"Longitudinal clinical characteristics of misfolding-induced hereditary pancreatitis caused by PRSS1 p.L104P variant in a Hungarian family","authors":"Barbara Anna Bokor , Szilárd Váncsa , Árpád V. Patai , Péter Hegyi , Balázs Csaba Németh","doi":"10.1016/j.pan.2026.02.003","DOIUrl":"10.1016/j.pan.2026.02.003","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 489-491"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of hypertriglyceridemia-associated acute pancreatitis: a prospective multicenter Italian cohort","authors":"Giulia De Marchi , Nicolò de Pretis , Gabriele Capurso , Raffaele Pezzilli , Alberto Zambon , Clara Agnolon , Clara Benedetta Conti , Luca Gianotti , Sara Massironi , Marta Stegagnini , Andrea Galli , Tommaso Innocenti , Laura Apadula , Luca Giampaolo , Fabio Farinati , Edoardo Giovanni Giannini , Davide Checchin , Anna Giacomin , Chiara Canalis , Francesco Covotta , Luca Frulloni","doi":"10.1016/j.pan.2026.03.004","DOIUrl":"10.1016/j.pan.2026.03.004","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 501-503"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMAD3 activation in pancreatic stellate cells correlates with PTGDR2 expression and favorable stromal features in pancreatic cancer","authors":"Naohiro Hirano ,&nbsp;Koetsu Inoue ,&nbsp;Shuichi Aoki ,&nbsp;Shingo Yoshimachi ,&nbsp;Hideaki Sato ,&nbsp;Mitsuhiro Shimura ,&nbsp;Hajime Taniguchi ,&nbsp;Masahiro Iseki ,&nbsp;Daisuke Douchi ,&nbsp;Keigo Murakami ,&nbsp;Shimpei Maeda ,&nbsp;Takayuki Miura ,&nbsp;Masaharu Ishida ,&nbsp;Masamichi Mizuma ,&nbsp;Atsushi Masamune ,&nbsp;Michiaki Unno","doi":"10.1016/j.pan.2026.03.007","DOIUrl":"10.1016/j.pan.2026.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Pancreatic cancer is characterized by a dense tumor microenvironment enriched with cancer-associated fibroblasts (CAFs), which display context-dependent tumor-promoting and tumor-restraining properties. However, the molecular basis of stromal heterogeneity remains incompletely understood.</div></div><div><h3>Methods</h3><div>We examined stromal responses of pancreatic stellate cells (PSCs), a major source of CAFs, using an orthotopic mouse co-implantation model, RNA sequencing, conditioned medium–based functional assays, and immunohistochemical analysis of resected pancreatic cancer specimens.</div></div><div><h3>Results</h3><div>Co-implantation of PSCs with pancreatic cancer cells was associated with smaller primary tumor volumes and selective activation of SMAD3 in PSCs. Cancer cell–derived conditioned medium activated SMAD3 signaling in PSCs but not in cancer cells, suggesting cell type–specific pathway activation. Transcriptomic analysis identified prostaglandin D2 receptor 2 (PTGDR2) as a gene upregulated in association with SMAD3 activation, and its expression decreased following SMAD3 inhibition. Functional assays showed that SMAD3 activation was associated with modulation of PTGDR2 and inflammatory gene expression in PSCs. In clinical samples, higher p-SMAD3 expression in CAFs correlated with favorable overall survival.</div></div><div><h3>Conclusions</h3><div>SMAD3 activation in PSCs was observed in association with PTGDR2 expression, altered inflammatory profiles, and reduced tumor growth <em>in vivo</em>. These findings support the presence of distinct stromal phenotypes in pancreatic cancer and warrant further investigation into CAF modulation strategies.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 459-468"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective observational study on the impact of hepatic steatosis, hepatic fibrosis, and metabolic syndrome on the outcome of patients with acute pancreatitis","authors":"Abhirup Chatterjee ,&nbsp;Surinder Singh Rana ,&nbsp;Vaneet Jearth ,&nbsp;Ajay Duseja ,&nbsp;Jimil Shah ,&nbsp;Mandeep Kang ,&nbsp;Kamal Kishore ,&nbsp;Rajesh Gupta","doi":"10.1016/j.pan.2026.02.001","DOIUrl":"10.1016/j.pan.2026.02.001","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 486-488"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective long-term assessment of pulmonary impairment in chronic pancreatitis: A comparative study with healthy controls (RespPanc)","authors":"Amer Hadi ,&nbsp;Mikkel Parsberg Werge ,&nbsp;Lise Lotte Gluud ,&nbsp;Ejvind Frausing ,&nbsp;John Gásdal Karstensen ,&nbsp;Srdan Novovic","doi":"10.1016/j.pan.2026.02.005","DOIUrl":"10.1016/j.pan.2026.02.005","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 495-497"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic mucinous cystic neoplasms (MCN) during pregnancy grow rapidly and undergo malignant transformation: A series of 69 operated cases","authors":"Olga V. Korhonen ,&nbsp;Cristina Verdejo Gil ,&nbsp;Judith Millastre Bocos ,&nbsp;Margaret G. Keane ,&nbsp;Anne Antila ,&nbsp;Linda N. Nilsson ,&nbsp;Awad Shamali ,&nbsp;Monica Marijnissen-van Zanten ,&nbsp;Marco Del Chiaro ,&nbsp;Johanna Laukkarinen","doi":"10.1016/j.pan.2026.03.018","DOIUrl":"10.1016/j.pan.2026.03.018","url":null,"abstract":"<div><h3>Background</h3><div>The diagnosis of mucinous cystic neoplasm (MCN) during pregnancy is rare and presents unique challenges. We analyzed all reported cases of pregnancy-associated MCNs to assess malignant potential and identify predictive factors.</div></div><div><h3>Methods</h3><div>A total of 69 patients with MCN were included: 65 from systematic literature search and 4 cases from our institutional databases. Data included patient demographics, symptoms, diagnostics, surgical management, histopathology, and clinical outcomes.</div></div><div><h3>Results</h3><div>The median age was 33 years (range 20–47). 74% (49/66) presented with symptoms. Tumor-related complications occurred in 27% (16/60), including acute pancreatitis in eight and cyst rupture in four. Median MCN diameter at diagnosis was 12.0 cm (1.5–30). Median tumor growth during pregnancy was 2.5 cm (0.5–20) over a median period of 2.75 months (1–78). All patients underwent surgical resection: 29% (20/69) in second trimester and 59% (41/69) postpartum. Postoperative complications occurred in four patients, all including pancreatic fistula or fluid collection. Fetal complications were reported in eight cases, without tumor-related mortality. 20% (13/66) had invasive adenocarcinoma (IC), 14% (9/66) high-grade dysplasia (HGD), and rates were similar if resected during pregnancy or postpartum. Symptomatic presentation and high-risk imaging features significantly correlated with malignant MCN. During the median follow-up of 24 months (2–154), local recurrence occurred in three patients and one patient died.</div></div><div><h3>Conclusions</h3><div>Pregnancy-related MCNs were typically large, symptomatic, and grew rapidly. A third of tumors harbored IC or HGD. Prompt surgical resection, typically during the second trimester appears safe, with a low rate of maternal and fetal complications.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 444-450"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin use and acute pancreatitis mortality","authors":"Kuan-Fu Liao ,&nbsp;Shih-Wei Lai","doi":"10.1016/j.pan.2025.10.008","DOIUrl":"10.1016/j.pan.2025.10.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 509-510"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia in chronic pancreatitis is associated with increased mortality and morbidity. A propensity-score matched population-based study","authors":"Hussam Almasri ,&nbsp;Himsikhar Khataniar ,&nbsp;Ishita Gupta ,&nbsp;Khalid Ahmed ,&nbsp;Rahul Karna ,&nbsp;Guru Trikudanathan","doi":"10.1016/j.pan.2026.02.008","DOIUrl":"10.1016/j.pan.2026.02.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 498-500"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of past accomplishments and looking forward to the next 5 years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC)","authors":"Chris E. Forsmark ,&nbsp;Stephen Pandol","doi":"10.1016/j.pan.2025.12.023","DOIUrl":"10.1016/j.pan.2025.12.023","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 340-342"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer”","authors":"Kenichiro Okumura","doi":"10.1016/j.pan.2025.12.026","DOIUrl":"10.1016/j.pan.2025.12.026","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 515-516"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}