Pancreatology最新文献

{"title":"Estrogen receptor expression as a predictive biomarker for patient-derived xenograft engraftment in pancreatic cancer: A pilot study.","authors":"Hyun-Kyung Lim, Joon Seong Park, Joohee Jung","doi":"10.1016/j.pan.2026.10.009","DOIUrl":"https://doi.org/10.1016/j.pan.2026.10.009","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per-oral pancreatoscopy-guided pancreatic duct biopsy collection in chronic pancreatitis patients allows culture of organoids suitable for assessing CFTR function.","authors":"Dora Angyal, Erdene Baigal, Tessa A Groeneweg, Layla Moesker, Willem J Lammers, Pieter-Jan F de Jonge, Maikel P Peppelenbosch, Marco J Bruno, Marcel J C Bijvelds","doi":"10.1016/j.pan.2026.10.008","DOIUrl":"https://doi.org/10.1016/j.pan.2026.10.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioids and pain prescribing in chronic pancreatitis- time to tackle this problem head-on.","authors":"Saurabh Chawla, Fred S Gorelick","doi":"10.1016/j.pan.2026.10.004","DOIUrl":"https://doi.org/10.1016/j.pan.2026.10.004","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal body composition changes distinguish pancreatic ductal adenocarcinoma from controls in a pre-diagnostic CT cohort.","authors":"Aleksander M Bogdanski, Derk C F Klatte, Jeanin E van Hooft, Shrinath Patel, Monique E van Leerdam, Che G Ngufor, Shiba P Kuanar, Alex D Weston, Michael B Wallace, Yan Bi","doi":"10.1016/j.pan.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.008","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage, limiting curative treatment options. Although prior studies have characterized longitudinal body composition changes in PDAC, it remains unclear whether these pre-diagnostic trajectories differ from matched controls or distinguish PDAC cases from non-PDAC individuals.</p><p><strong>Methods: </strong>In this retrospective, multicenter case-control study, adults diagnosed with PDAC between 2002 and 2020 with abdominal CT imaging within 36 months before diagnosis were identified. Controls were selected from CT-imaged individuals and matched 2:1 to cases on age, sex, and diabetes status. Deep learning-based segmentation quantified skeletal muscle index (SMI), visceral fat index (VFI), and subcutaneous fat index (SFI). Cohort-level trajectories were evaluated using locally estimated scatterplot smoothing and linear mixed-effects models. For individual-level analyses, body composition rates of change were estimated and evaluated for discrimination.</p><p><strong>Results: </strong>Cohort-level analyses included 1825 cases and 3650 controls. Compared with controls, PDAC cases exhibited steeper declines in SFI (-0.53 cm²/m²/month, p < 0.001) and VFI (-0.37 cm²/m²/month, p < 0.001) over 36 months preceding diagnosis, whereas SMI differences emerged within the final 12 months (-0.28 cm²/m²/month, p = 0.01). Individual-level analyses (581 cases, 581 controls) showed longitudinal changes in SMI, SFI, and VFI moderately discriminated cases from controls (AUC 0.76; 95% CI, 0.73-0.78), with performance driven largely by changes occurring closer to diagnosis.</p><p><strong>Conclusions: </strong>In a CT-imaged cohort, PDAC is associated with measurable longitudinal body composition changes prior to diagnosis that differ from matched controls. These changes demonstrate moderate discrimination to distinguish cases from controls but appear to reflect processes occurring closer to clinical diagnosis.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of sarcopenia in chronic pancreatitis: Insights from muscle biopsy and molecular profiling.","authors":"Neelam Lohani, Sumaira Qamar, Deepika Verma, Srikanth Gopi, Nidhi Singh, Deepak Gunjan, Meher Chanda Sharma, Uma Kanga, S S Chauhan, Namrata Singh, N R Dash, Sujoy Pal, Imteyaz Ahmad Khan, Samagra Agarwal, Anoop Saraya","doi":"10.1016/j.pan.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.003","url":null,"abstract":"<p><strong>Background and aim: </strong>Sarcopenia is a significant complication of chronic pancreatitis (CP), contributing to increased morbidity and adverse outcomes. Chronic inflammation and metabolic dysregulation may promote skeletal muscle wasting through catabolic signaling activation, though underlying molecular mechanisms remain incompletely understood. This study investigated molecular pathways associated with sarcopenia in CP.</p><p><strong>Methods: </strong>260 CP patients were evaluated for sarcopenia using skeletal muscle index (SMI) at L3 via CT, applying Asian ethnicity-specific cut-offs (<36.5 cm²/m² men, <30.2 cm²/m² women). Serum inflammatory and metabolic mediators were quantified by Luminex/ELISA assay. Rectus abdominis biopsies from sarcopenic (n = 10), non-sarcopenic (n = 7), and healthy controls (n = 6) underwent qPCR, Western blotting, immunohistochemistry, and electron microscopy.</p><p><strong>Results: </strong>Of 260 patients (median illness duration 36 months), 88 (33.8%) were sarcopenic (mean age 36.2 ± 10.6 years), with idiopathic CP the leading etiology (58.5%). Sarcopenic patients had significantly lower BMI (18.73 ± 2.90 vs. 21.93 ± 3.59 kg/m², p < 0.001), elevated myostatin, activin A, and TIMP, and reduced IGF-1 (p < 0.05). Histology showed reduced myofiber cross-sectional area and increased fat infiltration; ultrastructural analysis revealed mitochondrial abnormalities with disrupted cristae and lipid accumulation. Sarcopenic muscle showed downregulated IGF-1/AKT/mTOR signaling (reduced AKT2, mTOR expression and phosphorylation of AKT, mTOR, p70S6K), activated myostatin/activin-SMAD2/3 signaling, upregulated FOXO3, increased MuRF1/MAFbx, and downregulated autophagy markers (LC3B, Beclin-1).</p><p><strong>Conclusion: </strong>Sarcopenia is common in patients of chronic pancreatitis, and it is characterized by activation of catabolic signaling, impaired anabolic pathways, mitochondrial dysfunction, and defective autophagy. These findings are hypothesis-generating and, if confirmed in larger mechanistic studies, may help identify targets to mitigate muscle loss and improve outcomes.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of timing of onset and duration of systemic inflammatory response syndrome with the severity and outcomes of acute pancreatitis.","authors":"Ariana Pereira-García, Paulina Rodríguez-García, Mariana Quintanar-Martínez, Jorge Hernández-Calleros, Luis Uscanga-Domínguez, Mario Peláez-Luna","doi":"10.1016/j.pan.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.007","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149063274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letters to the Editor regarding impact of epidural versus wound catheter analgesia for patients undergoing open pancreatoduodenectomy: A randomized controlled trial.","authors":"Piia Peltoniemi, Harri Mustonen, Pertti Pere, Hanna Seppänen","doi":"10.1016/j.pan.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.006","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broadening the applicability of analgesia trial findings in pancreatoduodenectomy: A note on the excluded ISGPS type D subgroup.","authors":"Zhiqiang Sun, Ding Li","doi":"10.1016/j.pan.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.004","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample-size justification, differential post-randomization exclusion, and multiplicity in a randomized trial of epidural versus wound catheter analgesia after pancreatoduodenectomy.","authors":"Imen Ben Ismail, Mariem Marzouki","doi":"10.1016/j.pan.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.005","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Wang X, Wang R, Lin X et al. Comparative evaluation of chemotherapy and CAR-T cell therapy in genetically engineered self-sustaining primary pancreatic cancer organoids\" [Pancreatology (2026), 26(6), 896-907].","authors":"Xu Wang, Ruijie Wang, Xuan Lin, Xuan Zou, Yusheng Chen, Mingjian Ma, Mengxing Pan, Jinxin Chen, Yu Yan, Fei Ding, Shuai Zhou, Xianjun Yu, Chen Liu, Xu Wang, He Cheng","doi":"10.1016/j.pan.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.001","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}