Pancreatology最新文献

Microbiome-genetic interplay in intraductal papillary mucinous neoplasms: A critical appraisal of emerging evidence. 导管内乳头状黏液性肿瘤中的微生物组-遗传相互作用：对新出现证据的关键评估。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-10-09 DOI: 10.1016/j.pan.2025.10.001

Zain Mazhar, Husnain Bashir

引用次数: 0

Textbook oncologic outcome in pancreatic cancer surgery: Quality metric or prognostic marker? 胰腺癌手术的肿瘤预后：质量指标还是预后指标？

IF 2.7 2区医学

Pancreatology Pub Date : 2025-10-08 DOI: 10.1016/j.pan.2025.10.002

Yosuke Inoue

引用次数: 0

Aiming for high quality of care for completed resections and improved margin status in pancreatic cancer surgery. 旨在提高胰腺癌手术中完整切除的护理质量和改善切缘状况。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-10-06 DOI: 10.1016/j.pan.2025.09.029

Ashika D Maharaj, Bronwyn Brown, Hamish Evans, Sue M Evans, Liane J Ioannou, Arul Earnest, Daniel Croagh, Charles Hc Pilgrim, Elysia Greenhill, Rachel E Neale, David Goldstein, James G Kench, Neil D Merrett, Kate White, Koroush S Haghighi, Jaswinder S Samra, John R Zalcberg

{"title":"Aiming for high quality of care for completed resections and improved margin status in pancreatic cancer surgery.","authors":"Ashika D Maharaj, Bronwyn Brown, Hamish Evans, Sue M Evans, Liane J Ioannou, Arul Earnest, Daniel Croagh, Charles Hc Pilgrim, Elysia Greenhill, Rachel E Neale, David Goldstein, James G Kench, Neil D Merrett, Kate White, Koroush S Haghighi, Jaswinder S Samra, John R Zalcberg","doi":"10.1016/j.pan.2025.09.029","DOIUrl":"https://doi.org/10.1016/j.pan.2025.09.029","url":null,"abstract":"Purpose: To assess associations between six diagnostic, staging, and coordination of care indicators in pancreatic cancer, and: (1) surgery being abandoned intraoperatively; or (2) a positive macroscopic margin (R2 resection) or a positive microscopic pathological margin (R1 resection).Methods: Data was provided by the Upper Gastrointestinal Cancer Registry operating across two Australian states. Associations were tested using multivariable logistic regression.Results: 704 patients underwent an attempted surgical resection (54 % male; median age 69 years). Of the completed resections (n = 585) with a known margin status (n = 513), 54 % (n = 278) were reported as having a negative pathological (R0) margin, 41 % (n = 211) had an R1 margin, and 5 % (n = 24) had an R2 margin. Patients who underwent surgery or neoadjuvant therapy within 60 days from referral had double the odds of a complete resection (OR=2.12, 95 % CI, 1.19 - 3.76). Imaging undertaken beyond 30 days prior to surgery had a 40 % reduction in the odds of a completed resection (OR=0.58, 95 % CI, 0.37 - 0.92). Patients with their ECOG and/or ASA documented at presentation had 90 % increased odds of a R0 margin resection (OR=1.90, 95 % CI, 1.32 - 2.73).Conclusions: Timely progression to primary treatment had the most significant association with achieving complete resection status.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of diagnosing intraductal papillary mucinous neoplasm with mural nodules by contrast-enhanced endoscopic ultrasound using time-intensity curve analysis with a new support program: A multicenter retrospective study (with video). 采用时间-强度曲线分析的对比增强内镜超声诊断导管内乳头状粘液瘤伴壁结节的疗效：一项多中心回顾性研究（带视频）。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-10-01 DOI: 10.1016/j.pan.2025.09.035

Kazuya Miyamoto, Daisuke Uchida, Kazuyuki Matsumoto, Yosuke Saragai, Tsuneyoshi Ogawa, Toru Ueki, Kei Harada, Nao Hattori, Taisuke Obata, Ryosuke Sato, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Shigeru Horiguchi, Koichiro Tsutsumi, Soichiro Uemoto, Takayoshi Tanimoto, Akimitsu Ohto, Motoyuki Otsuka

{"title":"Efficacy of diagnosing intraductal papillary mucinous neoplasm with mural nodules by contrast-enhanced endoscopic ultrasound using time-intensity curve analysis with a new support program: A multicenter retrospective study (with video).","authors":"Kazuya Miyamoto, Daisuke Uchida, Kazuyuki Matsumoto, Yosuke Saragai, Tsuneyoshi Ogawa, Toru Ueki, Kei Harada, Nao Hattori, Taisuke Obata, Ryosuke Sato, Akihiro Matsumi, Hiroyuki Terasawa, Yuki Fujii, Shigeru Horiguchi, Koichiro Tsutsumi, Soichiro Uemoto, Takayoshi Tanimoto, Akimitsu Ohto, Motoyuki Otsuka","doi":"10.1016/j.pan.2025.09.035","DOIUrl":"https://doi.org/10.1016/j.pan.2025.09.035","url":null,"abstract":"Background/objectives: Preoperative diagnosis of the pathological grade of intraductal papillary mucinous neoplasms (IPMN) is challenging. This study aimed to evaluate the accuracy of contrast-enhanced endoscopic ultrasound (CE-EUS) using time-intensity curve (TIC) analysis with a newly developed support program to differentiate between low-grade dysplasia (LGD) and high-grade dysplasia (HGD)/invasive carcinoma (IC) in IPMN.Methods: This study retrospectively analyzed 32 patients who underwent CE-EUS using the support program for TIC analysis and IPMN resection (LGD: 17, HGD/IC: 15) at two medical centers. The TIC parameters of mural nodules (MN) were compared between the LGD and HGD/IC groups, and the diagnostic accuracies of the TIC parameters were evaluated.Results: The MN/pancreatic parenchyma contrast ratio was significantly higher in the HGD/IC group than in the LGD group (1.53 vs. 0.99; P < 0.0001), and the diagnostic abilities of the contrast ratio were as follows: sensitivity, 67 %; specificity, 100 %; and accuracy, 84 %. There were no differences in the echo intensity reduction rate of the MNs between the two groups (HGD/IC, 61.6 vs. 61.2, 0.99; P = 0.421), and the diagnostic abilities of the reduction rate were as follows: sensitivity, 93 %; specificity, 41 %; and accuracy, 66 %.Conclusions: The contrast ratio calculated using TIC analysis with the support program is potentially useful for differentiating between IPMNs with LGD and those with HGD/IC.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of acute and chronic pancreatitis in patients with psoriasis: A Danish nationwide cohort study. 银屑病患者急性和慢性胰腺炎的风险：丹麦全国队列研究

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-30 DOI: 10.1016/j.pan.2025.09.030

Mathias Ellgaard Cook, Niels Henrik Bruun, Rasmus Hagn-Meincke, Line Davidsen, Asbjørn Mohr Drewes, Kasper Fjellhaugen Hjuler, Søren Schou Olesen

引用次数: 0

Modified TNM staging system for well-differentiated pancreatic neuroendocrine tumors: A comparative study with the AJCC 9th edition. 改良的TNM分期系统用于分化良好的胰腺神经内分泌肿瘤：与AJCC第9版的比较研究。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-30 DOI: 10.1016/j.pan.2025.09.034

Min Yang, Jie-Yu Wen, Gui-Zhen Qian, Ting Yang, Xu-Bao Liu, Bo-le Tian, Yi Zhang, Yi Ji

{"title":"Modified TNM staging system for well-differentiated pancreatic neuroendocrine tumors: A comparative study with the AJCC 9th edition.","authors":"Min Yang, Jie-Yu Wen, Gui-Zhen Qian, Ting Yang, Xu-Bao Liu, Bo-le Tian, Yi Zhang, Yi Ji","doi":"10.1016/j.pan.2025.09.034","DOIUrl":"https://doi.org/10.1016/j.pan.2025.09.034","url":null,"abstract":"Background: Continuing to use the 8th edition criteria, the current American Joint Committee on Cancer (AJCC) 9th staging system has been demonstrated to fail to distinguish prognosis in Stage I between Stage II for patients with G1/G2 pancreatic neuroendocrine tumors (p-NETs). A modified tumor-node-metastasis (mTNM) system with revised nodal classification was previously proposed, but hasn't been comprehensively validated by large-scale institutional studies.Methods: Data of eligible patients was retrospectively collected and distributed by the proposed mTNM staging system and the current AJCC 9th staging system. The staging characteristics for G1/G2/G3 p-NETs were respectively performed and compared by two systems.Results: Our study enrolled 310 patients with well-differentiated p-NETs, including 122 ones with G1, 132 with G2 and 56 with G3. The 5-year overall survival (OS) from AJCC Stage I to Stage IV was respectively 79.0 %, 88.8 %, 39.5 % and 15.8 %, in which survival comparison between Stage I and Stage II wasn't significant (P = 0.114). The OS at 5 years from mTNM Stage I to Stage IV was respectively 93.4 %, 75.5 %, 34.1 % and 15.8 %, in which notable survival differences were offered among each stage (P < 0.05). Moreover, consistent with the results of Akaike information criteria and Harrell's concordance index, the 95 % confidence intervals in multivariate analysis for proposed mTNM staging system were smaller than that of AJCC 9th staging system, indicating a more accurate predictive ability for the OS of G1/G2/G3 p-NETs.Conclusion: The proposed mTNM staging system was superior to the current AJCC 9th system for well-differentiated p-NETs.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter to the editor: "Refining the prognostic utility of CA19-9 in neoadjuvant therapy for pancreatic cancer: Emphasizing serial monitoring and subgroup differentiation". 对致编辑的信的回复：“改进CA19-9在胰腺癌新辅助治疗中的预后效用：强调系列监测和亚组分化”。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-30 DOI: 10.1016/j.pan.2025.09.033

Satoru Miyahara, Hidenori Takahashi, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Daisaku Yamada, Hirofumi Akita, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi

引用次数: 0

Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas. kr<s:1> ppel样因子4突变对胰腺导管内乳头状黏液瘤临床病理特征及相关蛋白表达的影响

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-30 DOI: 10.1016/j.pan.2025.09.028

Yoshitaka Nagamine, Miyo Tomita, Munekazu Yamakuchi, Yuto Hozaka, Takashi Okumura, Hideyuki Oi, Kosuke Fukuda, Tetsuya Idichi, Yoichi Yamasaki, Yuko Mataki, Yota Kawasaki, Toshiaki Akahane, Michiyo Higashi, Teruto Hashiguchi, Akihide Tanimoto, Takao Ohtsuka

{"title":"Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas.","authors":"Yoshitaka Nagamine, Miyo Tomita, Munekazu Yamakuchi, Yuto Hozaka, Takashi Okumura, Hideyuki Oi, Kosuke Fukuda, Tetsuya Idichi, Yoichi Yamasaki, Yuko Mataki, Yota Kawasaki, Toshiaki Akahane, Michiyo Higashi, Teruto Hashiguchi, Akihide Tanimoto, Takao Ohtsuka","doi":"10.1016/j.pan.2025.09.028","DOIUrl":"https://doi.org/10.1016/j.pan.2025.09.028","url":null,"abstract":"Background/objectives: Krüppel-like factor 4 (KLF4) hotspot mutations are linked to non-invasive intraductal papillary mucinous neoplasms (IPMNs); however, the molecular mechanisms driving their progression remain unclear. Therefore, in this study, we aimed to identify the signaling pathways associated with KLF4 mutations and their roles in IPMNs.Methods: Thirty-three resected specimens of IPMNs were collected. Associations between genetic alterations in KLF4 and the expression levels of KLF4 protein as well as its related signaling proteins, including p21, p27, and cyclin D, were assessed.Results: KLF4 mutations were found in eight specimens of IPMNs (24 %), all of which were non-invasive lesions and non-intestinal type; of them, seven (87.5 %) showed GNAS mutations. p21 expression was significantly elevated in KLF4-mutated IPMNs (p < 0.01), whereas p27 and cyclin D1 levels were not significantly altered compared with KLF4 wild-type IPMNs. KLF4 and p21 expression levels were significantly elevated in non-invasive lesions compared with invasive lesions (p < 0.05). Higher KLF4 expression was observed in GNAS-mutated IPMNs than in GNAS wild-type IPMNs (p < 0.05).Conclusions: KLF4 mutations might enhance p21 expression, possibly influencing the indolent characteristics of non-invasive IPMNs and providing a new biomarker strategy for risk stratification in patients with IPMNs.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic impact of serum triglycerides in acute pancreatitis: Evidence from multi-center cohort study using a common data model. 血清甘油三酯对急性胰腺炎预后的影响：来自使用通用数据模型的多中心队列研究的证据。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-28 DOI: 10.1016/j.pan.2025.09.032

Da Hee Park, Seung In Seo, Jin Gu Kang, Woon Geon Shin, Jinseob Kim, Kyong Joo Lee, Se Woo Park

{"title":"Prognostic impact of serum triglycerides in acute pancreatitis: Evidence from multi-center cohort study using a common data model.","authors":"Da Hee Park, Seung In Seo, Jin Gu Kang, Woon Geon Shin, Jinseob Kim, Kyong Joo Lee, Se Woo Park","doi":"10.1016/j.pan.2025.09.032","DOIUrl":"https://doi.org/10.1016/j.pan.2025.09.032","url":null,"abstract":"Background and aims: Hypertriglyceridemia (HTG) is a risk factor for acute pancreatitis (AP); however its association with increased AP severity remains unclear. This study aimed to investigate the association between HTG levels and severity of AP.Design: This study analyzed data from 10 Korean hospital databases converted to a common data model from 2004 to 2019. Hospitalized patients with AP were divided into two groups based on their serum triglyceride (TG) levels: a high TG (HiTG) group (serum TG: >500 mg/dL) and a low TG (LoTG) group (TG: ≤500 mg/dL). Subgroup analyses were performed based on age and sex.Results: A total of 5644 AP patients were included in the study, with 534 and 5110 patients in the HiTG and LoTG groups, respectively. An increasing trend was observed in the number of patients with pancreatitis (p < 0.001 for trend), including those with HTG-associated pancreatitis. The HiTG group showed a male predominance (74.9 %), and 34.4 % of patients were between the ages of 30 and 39 years. The HiTG group showed significantly higher C-reactive protein (CRP) elevation rates (30.8 % vs. 10.6 %, P < 0.001) requiring intensive care unit (ICU) admission (12.8 % vs. 9.3 %, P = 0.050) than the LoTG group. Age-based subgroup analysis revealed that the HiTG group had significantly higher CRP levels, ICU management, and 30-day mortality in patients aged <60 years.Conclusion: HTG is associated with a higher risk of developing severe AP. Younger patients (<60 years) with HTG may be vulnerable to a more severe disease course.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TSH as a biomarker for recurrent hypertriglyceridemia pancreatitis: Key questions on thresholds, diet, and model generalization. TSH作为复发性高甘油三酯血症性胰腺炎的生物标志物：阈值、饮食和模型推广的关键问题。

IF 2.7 2区医学

Pancreatology Pub Date : 2025-09-27 DOI: 10.1016/j.pan.2025.09.027

Zhi-Min Wang, Lian-Ping He

引用次数: 0