Pancreatology最新文献

{"title":"Corrigendum to \"Wang X, Wang R, Lin X et al. Comparative evaluation of chemotherapy and CAR-T cell therapy in genetically engineered self-sustaining primary pancreatic cancer organoids\" [Pancreatology (2026), 26(6), 896-907].","authors":"Xu Wang, Ruijie Wang, Xuan Lin, Xuan Zou, Yusheng Chen, Mingjian Ma, Mengxing Pan, Jinxin Chen, Yu Yan, Fei Ding, Shuai Zhou, Xianjun Yu, Chen Liu, Xu Wang, He Cheng","doi":"10.1016/j.pan.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.pan.2026.09.001","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for food insecurity detects patients with a severe phenotype of chronic pancreatitis.","authors":"Marco A Noriega, David Guevara-Lazo, Jorge D Machicado","doi":"10.1016/j.pan.2026.08.014","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.014","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the severity of first episode of acute pancreatitis on 5-year survival.","authors":"Justine Lozac'h, Anaïs R Briant, Thomas Chaigneau, Augustin Meria, Marie-Astrid Piquet, Jean-Jacques Parienti, Benoît Dupont","doi":"10.1016/j.pan.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.015","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A role remains for endoscopic therapy for pancreas divisum despite the SHARP trial: \"throwing the baby out with the bathwater\".","authors":"Petr Vanek, Martin L Freeman","doi":"10.1016/j.pan.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.013","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral and splanchnic venous thromboembolism in acute and infected necrotizing pancreatitis: A systematic review and meta-analysis.","authors":"Vikram Rajagopalan, Sanjana Putta, Ujwala Pamidimukkala, Azizullah Beran, Kavya Raghavendra, Samreen Jawaid, Patrick Ryan, Daryl Ramai, John J Guardiola, Eugene Nwankwo, Jun Hyuk Son, Mohammad Al-Haddad, Itegbemie Obaitan","doi":"10.1016/j.pan.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.012","url":null,"abstract":"<p><strong>Background: </strong>Venous thromboembolism (VTE) is a well-established sequela of acute necrotizing pancreatitis (ANP). No prior meta-analysis has comprehensively explored the pooled incidence of VTE in this patient population.</p><p><strong>Methods: </strong>We performed a comprehensive literature search from inception to July 2025, to identify all studies reporting the incidence of VTE after an index episode of ANP. Two independent reviewers screened articles and extracted relevant variables. The random-effects model was used to calculate the pooled incidence and 95% confidence intervals (CI) of thrombosis in each anatomical location. Risk of bias assessment was done via the Newcastle-Ottawa Scale. The Higgins I² index was used to assess heterogeneity, with I² > 50% indicating significant heterogeneity.</p><p><strong>Results: </strong>4243 patients across 24 studies were analysed. The pooled incidence of extremity DVT (eDVT) was 14% (95% CI: 4%-28%, I² = 93.8%) across 6 studies and 4% (95% CI: 2-8%, I² = 76.4%) for pulmonary embolism (PE) across 5. The pooled incidence for Splanchnic vein thrombosis (SVT) was 34% (95% CI: 26%-42%, I² = 94.5%) with a higher SVT incidence of 53% (95% CI: 34%-72%, I² = 86.1%) in the infected necrosis sub-group. The splenic vein was the commonly involved vein in the splanchnic system at 20% (95% CI: 12%-29%, I² = 94.1%).</p><p><strong>Conclusion: </strong>There is a relatively high incidence of VTE in patients with pancreatic necrosis, with the incidence in some anatomical locations being of particular clinical importance. Prospective cohort studies are needed to better delineate subgroups at higher risk for thrombosis in this patient population and assess the risk/benefit of increased anticoagulation dosing.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain prescription trends and opioid disorder risk in chronic pancreatitis: A real-world data analysis from 2015 to 2024.","authors":"Yanna Cai, Jianing Li, Niwen Kong, Walter G Park, Yan Bi, Stephen Pandol, Yi Jiang","doi":"10.1016/j.pan.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.010","url":null,"abstract":"<p><strong>Background: </strong>Pain in chronic pancreatitis (CP) negatively impacts quality of life and healthcare utilization. This study characterized longitudinal analgesic prescribing trends, demographic differences, treatment pathways, and factors associated with opioid-related outcomes among patients with CP.</p><p><strong>Methods: </strong>Using TriNetX, we identified adults with CP and assessed annual incidence and annual period prevalence of documented prescriptions from 2015 to 2024 for: NSAIDs/acetaminophen, opioids, benzodiazepines, neuropathic agents, and muscle relaxants. Treatment pathways and opioid-related outcomes were analyzed using Cox regression models adjusting for 39 covariates.</p><p><strong>Results: </strong>Among 142,650 CP patients, the annual period prevalence of pain medication prescription increased from 41.24% to 58.80%, substantially exceeding the general population. NSAIDs/acetaminophen and opioid prescription prevalence showed the highest increases. Females exhibited higher use across all medication classes. Younger patients demonstrated higher initiation rates. Initial treatments mostly involved NSAIDs/acetaminophen and opioids, with frequent polypharmacy observed. 10% of patients developed opioid-related conditions, with significantly higher hazards among those with alcohol-related CP (opioid-related disorders: HR = 1.23, 95% CI 1.18-1.29, P < 0.001; opioid dependence: HR = 1.21, 95% CI 1.14-1.27, P < 0.001; opioid abuse: HR = 1.09, 95% CI: 1.02-1.18, p = 0.018) and those undergoing pancreatic surgery (opioid-related disorders: HR = 1.81, 95% CI 1.66-1.96, P < 0.001; opioid dependence: HR = 2.07, 95% CI: 1.89-2.27, p < 0.001).</p><p><strong>Conclusions: </strong>This large-scale analysis highlights substantial and increasing analgesic use in CP, marked by increasing opioid prescription burden, polypharmacy, and higher hazards of opioid-related disorders among patients with alcohol-related etiology or pancreatic surgery. These findings emphasize the need for more guideline-concordant, multimodal, and individualized pain management with careful monitoring of high-risk groups.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of indirect imaging findings for high-grade pancreatic intraepithelial neoplasia: A multicenter study.","authors":"Yusuke Kawamoto, Goro Honda, Masataka Kikuyama, Yukiko Takayama, Satomi Saito, Taito Itoh, Toru Furukawa, Shin-Ichiro Horiguchi, Jun Nakahodo, Ryota Sagami, Hidefumi Nishikiori, Hiroshi Okabe, Tatsuki Endo, Ryosuke Yamanaka, Toru Tanahashi, Yutaro Matsunaga, Akiko Omori, Shunichi Ariizumi, Nao Otsuka, Ryunosuke Hakuta, Yousuke Nakai","doi":"10.1016/j.pan.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.011","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic intraepithelial neoplasia (PanIN), a microscopic precursor of pancreatic ductal adenocarcinoma, cannot be directly visualized by conventional imaging. Secondary parenchymal and ductal changes-focal pancreatic parenchymal atrophy (FPPA), main pancreatic duct (MPD) abnormalities, and cystic lesions-have been proposed as indirect imaging findings (IIFs), but their diagnostic relevance remains uncertain. We investigated the association between specific IIFs and histopathologically confirmed malignant lesions in patients undergoing pancreatectomy without a detectable mass.</p><p><strong>Methods: </strong>In this retrospective cohort study, 155 consecutive patients at two high-volume centers who underwent pancreatectomy for suspected high-grade PanIN between October 2018 and January 2026 were included. Preoperative imaging was reviewed to identify and map three IIF types (FPPA, MPD abnormalities, and cystic lesions) to surgical specimens, which were evaluated histopathologically.</p><p><strong>Results: </strong>Of 155 patients, 94 (60.6%) had malignant lesions, including 77 (49.7%) high-grade PanIN, 14 (9.0%) invasive PDAC, and three (1.9%) non-invasive intraductal papillary mucinous carcinoma. Among 357 anatomical sites with IIFs, 125 (35.0%) contained malignancy. The positive predictive value increased with the number of overlapping IIF types: 20.7% for one, 38.5% for two, and 77.1% for three (p for trend < 0.001). Invasive PDAC occurred only at sites with multiple overlapping IIFs, in 5.2% and 14.6% of sites with two and three IIF types, respectively (p for trend < 0.001).</p><p><strong>Conclusions: </strong>A combination of IIFs was associated with a high-risk pancreatic phenotype linked to high-grade PanIN and early pancreatic cancer. Multiple IIFs may help identify patients who warrant further diagnostic evaluation and facilitate risk stratification.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of acute pancreatitis in adult zebrafish: A reproducible and quantifiable experimental model.","authors":"Prince Allawadhi, Cheng-Yu Tsai, Wenmo Hu, Shamik Banerjee, Venkata S Akshintala, Bomi Lee, Luis Hernandez Nunez, Sohail Z Husain","doi":"10.1016/j.pan.2026.08.006","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.006","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation response index (SIRI) predicts outcomes and chemotherapy benefit in metastatic pancreatic cancer: A study by the PANTHEIA- SEOM group.","authors":"Alberto Carmona-Bayonas, Axel Mariño Méndez, María Ángeles Vicente-Conesa, Paula Jimenez-Fonseca, María de Toro Carmena, Carmen Guillen-Ponce, Angela Lamarca, Mónica Benavente, Javier Gallego, Paula Cerdà Serdà, Raquel Hernández San Gil, Kreina Sharela Vega-Cano, Ana López, Maria Luisa Soriano Tabares de Navas, Inmaculada Peirò, Wagner Parra-Paladines, Patricia Zwisler-Contreras, Elena Brozos-Vázquez, Luis Cabezon-Gutiérrez, Andrés Muñoz Martin, Vilma Pacheco-Barcia","doi":"10.1016/j.pan.2026.08.008","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.008","url":null,"abstract":"<p><strong>Background: </strong>Systemic inflammation is a key driver of progression in pancreatic ductal adenocarcinoma (PDAC). We aimed to externally validate the Systemic Inflammation Response Index (SIRI) and define its non-linear prognostic value in a large multicenter cohort.</p><p><strong>Methods: </strong>We analyzed 672 patients with metastatic PDAC receiving first-line chemotherapy across 30 centers. SIRI was assessed using a validated cut-off (>2.3) and as a log-transformed continuous variable in multivariable Weibull accelerated failure-time models with restricted cubic splines.</p><p><strong>Results: </strong>Patients with low SIRI (≤2.3) had longer median OS (14.0 vs 9.2 months; p < 0.001) and PFS (5.9 vs 3.9 months; p < 0.001) than those with high SIRI. High SIRI was associated with a lower objective response rate (25% vs 37%; p < 0.001). In multivariable analyses, higher SIRI independently predicted inferior OS and PFS (75th vs 25th percentile: HR 1.14 [95% CI 1.05-1.25], HR 1.11 [95% CI 1.03-1.21]) and poorer tumor response (OR 0.78; 95% CI 0.62-1.00). Higher SIRI correlated with greater hepatic tumor burden and cachexia.</p><p><strong>Conclusions: </strong>SIRI is a robust, independent prognostic marker in metastatic PDAC. Higher values identify a phenotype with inferior survival and poorer tumor response. An open-access web calculator is provided to illustrate and explore the nonlinear, continuous prognostic gradient of SIRI and its impact on outcome.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and follow-up of IPMNS of the pancreas - bringing the ethical issues into focus.","authors":"Alberto Balduzzi, Luca Ghirotto, Massimo Tomasi, Giovanni Marchegiani, Marc Besselink, Marco J Bruno, Paolo Arcidiacono, Kevin Conlon, Stefano Crippa, Massimo Falconi, Carlos Fernandez-Del Castillo, Helmut Friess, Brian K P Goh, Dejan Radenkovic, Alain Sauvanet, Martin Smith, John Devar, Christopher Wolfgang, Jin-Young Jang, Greg D Sacks, Anne Marie Lennon, Roberto Salvia","doi":"10.1016/j.pan.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.pan.2026.08.002","url":null,"abstract":"<p><strong>Background: </strong>Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas present a broad spectrum of biological behavior, ranging from benign to malignant. Their management poses significant ethical dilemmas, particularly concerning diagnostic uncertainty, the risk of overdiagnosis and overtreatment, and resource allocation.</p><p><strong>Methods: </strong>This qualitative study employed a constructivist approach to explore the ethical challenges faced by surgeons in managing IPMNs. Data were collected through focus group meetings (FGMs) with members of an expert working group at the Verona Evidence-Based Meeting on IPMNs (2020). Discussions were analyzed to identify key ethical concerns.</p><p><strong>Results: </strong>The analysis highlighted several major ethical concerns: (1) decision-making under diagnostic uncertainty, (2) ethical challenges in patient communication, (3) overdiagnosis and over-surveillance due to defensive medicine and patient anxiety, (4) overtreatment through unnecessary surgery, and (5) issues of distributive justice in access to care and healthcare resource utilization. Participants emphasized the difficulty of balancing transparency with the need to minimize psychological distress in patients, as well as the challenge of applying international guidelines in diverse healthcare settings.</p><p><strong>Conclusions: </strong>Ethical decision-making in IPMN management requires balancing the risks of malignancy with the potential harms of overtreatment, while also considering patient autonomy and resource limitations. Enhancing decision-support tools, improving surgeon training in communication, and refining clinical guidelines to incorporate ethical considerations may help address these challenges. Further research is needed to develop strategies for more individualized and patient-centered care.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}