Pancreatology最新文献

{"title":"TSH as a biomarker for recurrent hypertriglyceridemia pancreatitis: Key questions on thresholds, diet, and model generalization","authors":"Zhi-Min Wang, Lian-Ping He","doi":"10.1016/j.pan.2025.09.027","DOIUrl":"10.1016/j.pan.2025.09.027","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 513-514"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Location Matters in IPMN: Clinicopathological differences, malignancy risk and oncological outcomes for lesions located in head vs body and tail of the pancreas","authors":"Piotr Zelga ,&nbsp;Yasmin G. Hernandez-Barco ,&nbsp;Motaz Qadan ,&nbsp;Asif Jah ,&nbsp;Peter Fagenholz ,&nbsp;Keith D. Lillemoe ,&nbsp;Anita Balakrishnan ,&nbsp;Carlos Fernández-del Castillo","doi":"10.1016/j.pan.2026.02.007","DOIUrl":"10.1016/j.pan.2026.02.007","url":null,"abstract":"<div><h3>Background</h3><div>The clinico-pathological characteristics and accuracy of the current International Association of Pancreatology guidelines for IPMN in relation to its location within the pancreas has not been investigated.</div></div><div><h3>Methods</h3><div>751 patients who underwent pancreatic resection for IPMN in two tertiary referral centers were retrospectively categorized into subgroups according to location within the pancreas. Likelihood of worrisome features, high-risk stigmata (HRS), clinico-pathological features and presence of malignancy were compared.</div></div><div><h3>Results</h3><div>480 (64%) patients had IPMN in the ventral pancreas (i.e. head, uncinate process and neck), and 271(36%) in the dorsal gland (i.e. body/tail). Malignancy was present in 54% (n = 259) of patients with ventral IPMN and in 39% (n = 107) of those with dorsal lesions (p &lt; 0.0001). There was a significantly higher proportion of intestinal epithelium in ventral IPMNs when compared to those in the dorsal pancreas, both in the general cohort and in invasive cancer group (27% vs 15%, OR: 1.94 95%CI:1.16-3.24 p = 0.006 and 31% vs 22% OR 1.52 95%CI: 0.77-3, p = 0.24 respectively). Patients with ventral IPMN more frequently presented with HRS (49%vs 37%, p &lt; 0.001), while dorsal IPMN often showed only worrisome features (54%vs 43%, p = 0.06). ROC curve analysis identified optimal cut-off values for main pancreatic duct diameter of 9 mm in ventral IPMNs and 5 mm in dorsal IPMNs for malignancy prediction.</div></div><div><h3>Conclusions</h3><div>Ventral IPMNs are more commonly resected and show higher rates of intestinal epithelium and malignancy compared with dorsal lesions. A MPD size &gt; 5 mm in IPMNs of the dorsal pancreas is associated with a substantial risk of malignancy.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 428-435"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug induced acute pancreatitis; frequency, morbidity and mortality; an Indian perspective","authors":"K.V. Padmaprakash ,&nbsp;C. Sowmya Karantha ,&nbsp;Nishant Raman ,&nbsp;Sandeep Thareja ,&nbsp;Sharad Srivastava","doi":"10.1016/j.pan.2026.03.005","DOIUrl":"10.1016/j.pan.2026.03.005","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 504-506"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of bleeding during endoscopic necrosectomy: The critical role of device selection favoring snare monotherapy","authors":"Jingwen Rao,&nbsp;Mei Yang,&nbsp;Haonan Liu,&nbsp;Kunpeng Yang,&nbsp;Jie Wu,&nbsp;Yong Zhu,&nbsp;Liang Xia,&nbsp;Yupeng Lei,&nbsp;Xin Huang,&nbsp;Huifang Xiong,&nbsp;Lingyu Luo,&nbsp;Zhijian Liu,&nbsp;Xu Shu,&nbsp;Yin Zhu,&nbsp;Nonghua Lu,&nbsp;Wenhua He","doi":"10.1016/j.pan.2026.03.013","DOIUrl":"10.1016/j.pan.2026.03.013","url":null,"abstract":"<div><h3>Background</h3><div>Patients with acute necrotizing pancreatitis (ANP) undergoing endoscopic necrosectomy (EN) are at risk of bleeding associated with the debridement devices used. This study aimed to analyze the bleeding rates associated with different devices and identify predictors of intraprocedural bleeding.</div></div><div><h3>Methods</h3><div>In this single-center retrospective study, patients undergoing EN between 2014 and 2022 were categorized by the type of debridement device(s) used. Bleeding rates were compared, and univariate and multivariate logistic regression analyses were conducted to determine independent risk factors.</div></div><div><h3>Results</h3><div>A total of 969 EN procedures were performed in 447 patients, with intraprocedural bleeding occurring in 175 instances (18.1%). Among single-device applications, the snare demonstrated the lowest bleeding rate (9.8%), significantly lower than the basket (17.9%) and grasping forceps (23.7%) (P &lt; 0.05). The combination of all three devices yielded the highest bleeding rate (30.9%) (P = 0.005). On multivariate analysis, an increase in the number of necrosectomy sessions, the use of grasping forceps, and the combined application of all three devices were independently associated with a significantly higher intraprocedural bleeding rate (P &lt; 0.05 for all). Notably, the majority of bleeding events were successfully managed endoscopically without the need for arterial embolization or surgical intervention.</div></div><div><h3>Conclusion</h3><div>Bleeding rate was higher in patients where a combination of devices was used, and the use of snare appeared safer.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 397-403"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating rifaximin prophylaxis in severe acute pancreatitis: A call for methodological refinement and microbiome-centric endpoints","authors":"Parth Aphale,&nbsp;Himanshu Shekhar,&nbsp;Shashank Dokania","doi":"10.1016/j.pan.2025.11.012","DOIUrl":"10.1016/j.pan.2025.11.012","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 517-518"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145637489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of health-related quality of life outcomes after total pancreatectomy and islet auto-transplantation","authors":"Kurt Carabott ,&nbsp;Matta Kuzman ,&nbsp;Samuel Tingle ,&nbsp;Vivek Peddakota ,&nbsp;Maisam Abu-El-Haija ,&nbsp;Melena Bellin ,&nbsp;Steven White ,&nbsp;Sanjay Pandanaboyana","doi":"10.1016/j.pan.2026.03.015","DOIUrl":"10.1016/j.pan.2026.03.015","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review the literature on quality of life (QOL) after islet transplantation following total pancreatectomy in chronic pancreatitis (CP).</div></div><div><h3>Background</h3><div>Total pancreatectomy and islet auto-transplantation (TPIAT) aims to relieve pain while preserving β-cell function in CP patients.</div></div><div><h3>Methods</h3><div>A systematic search of Medline, PubMed, EMBASE was performed according to PRISMA framework to identify studies reporting on QOL after TPIAT for CP. Random effects meta-analyses were performed to pool results on change in physical component summary (PCS) and mental component summary (MCS) QOL scores.</div></div><div><h3>Results</h3><div>Twenty-nine studies performed between 2011 and 2025 with a total of 4075 patients were included of which 24.8% were paediatric patients. 19 studies used the RAND SF36 QOL instrument, the most used instrument. The QOL surveys were performed from 1 month to more than 10 years post-TPIAT. Response rates varied from 14% to 100%. PCS scores were significantly higher at 1-year post-TPIAT (pooled estimate 10.36, 95% CI 7.33 to 13.4, p = &lt;0.001) and at longest follow up (pooled estimate 16.07, 95% CI 5.80 to 26.34, p = 0.002). MCS scores were also significantly higher at 1-year post-TPIAT (pooled estimate 5.54, 95% CI 3.30 to 7.78, p = &lt;0.001) and at longest follow up (pooled estimate 13.26, 95% CI 3.67 to 22.85, p = 0.007). Improvements in QOL appear to persist beyond 10 years.</div></div><div><h3>Conclusion</h3><div>TPIAT offers both short-term and long-term improvements in physical and mental components of QOL. However, development of TPIAT specific QOL instrument is warranted to capture TPIAT specific outcomes which determine QOL.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 412-420"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of developing diabetes following a sentinel episode of acute pancreatitis in patients with obesity: A propensity matched population study","authors":"Gordon Hong ,&nbsp;Abbinaya Elangovan ,&nbsp;Elleson Harper ,&nbsp;Jaime A. Perez ,&nbsp;Stacey Culp ,&nbsp;Hamza Shah ,&nbsp;Erica Park ,&nbsp;Jordan Burlen ,&nbsp;Eric Swei ,&nbsp;Zachary Devore ,&nbsp;Mitchell L. Ramsey ,&nbsp;Peter J. Lee ,&nbsp;Somashekar G. Krishna ,&nbsp;Kathleen Dungan ,&nbsp;Georgios I. Papachristou ,&nbsp;Phil A. Hart ,&nbsp;Raj Shah","doi":"10.1016/j.pan.2026.02.004","DOIUrl":"10.1016/j.pan.2026.02.004","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 492-494"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of sham vs. pancreatic endotherapy for painful chronic pancreatitis: Lessons from a randomized trial","authors":"Gregory A. Coté ,&nbsp;B. Joseph Elmunzer ,&nbsp;Anh Phan ,&nbsp;Haley Nitchie ,&nbsp;Czarinna M. Posadas ,&nbsp;Robert Moran ,&nbsp;Erin Forster ,&nbsp;Kaveh Sharzehi ,&nbsp;Jessica Yu ,&nbsp;Patty Hutto ,&nbsp;April Williams ,&nbsp;Jeffrey Borckhardt ,&nbsp;Valerie Durkalski-Mauldin","doi":"10.1016/j.pan.2026.01.007","DOIUrl":"10.1016/j.pan.2026.01.007","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 482-485"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of early-onset pancreatic adenocarcinoma molecular profile compared to average-onset pancreatic adenocarcinoma (CARAPAC): A systematic review and a meta-analysis","authors":"Mathias Brugel ,&nbsp;Vivien Riviere ,&nbsp;Audrey Hubert ,&nbsp;Léonie Langanay ,&nbsp;Olivier Bouche ,&nbsp;Michaël Genin ,&nbsp;Victoria Gauthier ,&nbsp;Jean-Baptiste Oudart","doi":"10.1016/j.pan.2026.03.002","DOIUrl":"10.1016/j.pan.2026.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Early-onset pancreatic adenocarcinoma (EOPA), defined as the diagnosis of pancreatic adenocarcinoma before the age of 50, is increasingly reported and may differ molecularly from average-onset pancreatic adenocarcinoma (AOPA). Understanding these differences is essential for precision medicine in this poor-prognosis malignancy.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following PRISMA guidelines. Studies published between 2015 and 2025 reporting molecular data on EOPA and/or AOPA were identified. Comparative studies stratified by age group for molecular alterations were included in the meta-analysis. Quality assessment was performed using the JBI checklist. This study aimed at systematically review and meta-analyse existing data comparing the molecular landscape of EOPA and AOPA, and evaluate whether EOPA constitutes a distinct molecular subgroup of pancreatic adenocarcinoma.</div></div><div><h3>Results</h3><div>Thirty-nine articles were included in the systematic review, of which eight met criteria for meta-analysis. <em>KRAS</em> mutations were significantly less frequent in EOPA than in AOPA (OR = 0.61; 95%CI [0.43–0.86], p = 0.005). No significant differences were observed for <em>TP53, CDKN2A, SMAD4</em>, or <em>BRCA1/2</em> alterations. Sensitivity analyses confirmed the robustness of the <em>KRAS</em> finding. Study heterogeneity was moderate (I² = 40%). Quality assessment revealed substantial variability in design, molecular methods, and reporting standards.</div></div><div><h3>Conclusions</h3><div>EOPA is enriched in <em>KRAS</em> wild-type tumours. This profile may offer alternative therapeutic opportunities, including RNA-based fusion detection, inclusion in targeted therapy trials, and suggest alternative oncogenic pathways for a proportion of this subpopulation. Standardised definitions, consistent molecular reporting, and exploration of age-specific risk factors are critical to improve understanding and management of EOPA.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 421-427"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissolving the problem: Biodegradable stents as a value-driven strategy for post-ERCP pancreatitis prophylaxis in high-risk patients","authors":"Clement Wu ,&nbsp;Venkata Akshintala","doi":"10.1016/j.pan.2026.04.002","DOIUrl":"10.1016/j.pan.2026.04.002","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 337-339"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}