Pancreatology最新文献

Reply to Moyer MT et al. “Response to international evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas regarding EUS guided cyst chemoablation” 对 Moyer MT 等人 "基于国际循证医学证据的京都胰腺导管内乳头状粘液瘤治疗指南关于 EUS 引导下囊肿化疗的回应 "的回复

IF 3.6 2区医学

Pancreatology Pub Date : 2024-09-12 DOI: 10.1016/j.pan.2024.09.008

Takao Ohtsuka, Carlos Fernandez-del Castillo

引用次数: 0

Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer 日本胰腺癌患者肠道微生物群中产生丁酸盐的细菌减少

IF 3.6 2区医学

Pancreatology Pub Date : 2024-09-05 DOI: 10.1016/j.pan.2024.09.002

Makoto Sono, Kei Iimori, Munemasa Nagao, Satoshi Ogawa, Takahisa Maruno, Yuki Nakanishi, Takayuki Anazawa, Kazuyuki Nagai, Toshihiko Masui, Hiroshi Mori, Koji Hosomi, Jun Kunisawa, Haruka Yokota, Yoshiki Tanaka, Hiroshi Ohno, Etsuro Hatano, Akihisa Fukuda, Hiroshi Seno

{"title":"Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer","authors":"Makoto Sono, Kei Iimori, Munemasa Nagao, Satoshi Ogawa, Takahisa Maruno, Yuki Nakanishi, Takayuki Anazawa, Kazuyuki Nagai, Toshihiko Masui, Hiroshi Mori, Koji Hosomi, Jun Kunisawa, Haruka Yokota, Yoshiki Tanaka, Hiroshi Ohno, Etsuro Hatano, Akihisa Fukuda, Hiroshi Seno","doi":"10.1016/j.pan.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.pan.2024.09.002","url":null,"abstract":"The incidence of pancreatic cancer is on the rise, and its prognosis remains poor. Recent reports have established a link between the gut and oral microbiome and pancreatic cancer. However, the intricacies of this association within the Japanese population remain unclear. In this study, we investigated the gut and oral microbiomes of Japanese patients with pancreatic cancer, comparing them with those of healthy individuals. We recruited 30 patients with untreated pancreatic cancer and 18 healthy controls at Kyoto University Hospital (2018–2022). We performed a comprehensive 16S rRNA gene sequencing to analyze their gut and oral microbiomes. Analysis revealed that the diversity of the gut and oral microbiomes of patients with pancreatic cancer was reduced compared to that of the healthy controls. Specifically, we observed an increase in the genus in both the gut and oral microbiomes and a significant decrease in several butyrate-producing bacteria in fecal samples. Moreover, bacteria such as and were present in pancreatic cancer tissues, suggesting that they might influence the carcinogenesis and progression of pancreatic cancer. The gut and oral microbiome differed between patients with pancreatic cancer and healthy controls, with a notable decrease in butyrate-producing bacteria in the gut microbiome of the patients. This suggests that there may be a distinct microbial signature associated with pancreatic cancer in the Japanese population. Further studies are required to elucidate the microbiome's causal role in this cancer and help develop prognostic markers or targeted therapies.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of involvement of the circumferential resection margin/surface in patients with pancreatic head cancer: A prospective evaluation of pancreatoduodenectomy specimens using the 0 and 1 mm rules 胰头癌患者周缘切除边缘/表面受累的预后意义：使用 0 毫米和 1 毫米规则对胰十二指肠切除术标本进行前瞻性评估

IF 3.6 2区医学

Pancreatology Pub Date : 2024-09-04 DOI: 10.1016/j.pan.2024.09.003

Moonhwan Kim, Jun Suh Lee, Boram Lee, Yeongsoo Jo, Haeryoung Kim, Hee Young Na, Yangkyu Lee, Soomin Ahn, Ji-Young Choe, Ho-seoung Han, Yoo-Seok Yoon

{"title":"Prognostic significance of involvement of the circumferential resection margin/surface in patients with pancreatic head cancer: A prospective evaluation of pancreatoduodenectomy specimens using the 0 and 1 mm rules","authors":"Moonhwan Kim, Jun Suh Lee, Boram Lee, Yeongsoo Jo, Haeryoung Kim, Hee Young Na, Yangkyu Lee, Soomin Ahn, Ji-Young Choe, Ho-seoung Han, Yoo-Seok Yoon","doi":"10.1016/j.pan.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.pan.2024.09.003","url":null,"abstract":"The prognostic significance of circumferential resection margin (CRM) or circumferential surface (CS) in pancreatic head cancer is controversial. We investigated the survival outcomes according to CRM or CS involvement in pancreatoduodenectomy specimens of pancreatic ductal adenocarcinoma (PDAC). A total of 102 pancreatoduodenectomy specimens after upfront surgery for PDAC between 2014 and 2018 were prospectively collected. The superior mesenteric vein/portal vein or superior mesenteric artery margins were classified as CRM, and the anterior or posterior surfaces as CS. Survival outcomes and recurrence were compared according to the CRM/CS status, which was categorized into R1, R1, and R0 (≥1 mm) by the 0 and 1 mm rules. For CRM, R1 had significantly lower overall survival (OS) ( < 0.001) and disease-free survival ( < 0.001) rates than R1 and R0, with no difference between R1 and R0. For CS, R0 had a significantly higher OS rate ( < 0.001) than R1 and R1, with no difference between R1 and R1. In multivariable analysis, R1 CRM was an independent risk factor for OS (hazard ratio 2.410, = 0.003) and DFS (hazard ratio 5.019, < 0.001). When CRM/CS were analyzed separately, only the R1 superior mesenteric artery margin was significantly associated with local recurrence ( = 0.012). The results suggest that CRM involvement defined by the 0 mm rule is more appropriate than the 1 mm rule for predicting survival outcomes, but CS involvement defined by the 0 or 1 mm rules is not prognostically significant.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of explainable artificial intelligence in guiding the management of patients with a pancreatic cyst 可解释人工智能在指导胰腺囊肿患者治疗中的表现

IF 3.6 2区医学

Pancreatology Pub Date : 2024-09-02 DOI: 10.1016/j.pan.2024.09.001

Juan M. Lavista Ferres, Felipe Oviedo, Caleb Robinson, Linda Chu, Satomi Kawamoto, Elham Afghani, Jin He, Alison P. Klein, Mike Goggins, Christopher L. Wolfgang, Ammar A. Javed, Rahul Dodhia, Nick Papadopolous, Ken Kinzler, Ralph H. Hruban, William B. Weeks, Elliot K. Fishman, Anne Marie Lennon

{"title":"Performance of explainable artificial intelligence in guiding the management of patients with a pancreatic cyst","authors":"Juan M. Lavista Ferres, Felipe Oviedo, Caleb Robinson, Linda Chu, Satomi Kawamoto, Elham Afghani, Jin He, Alison P. Klein, Mike Goggins, Christopher L. Wolfgang, Ammar A. Javed, Rahul Dodhia, Nick Papadopolous, Ken Kinzler, Ralph H. Hruban, William B. Weeks, Elliot K. Fishman, Anne Marie Lennon","doi":"10.1016/j.pan.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.pan.2024.09.001","url":null,"abstract":"Pancreatic cyst management can be distilled into three separate pathways – discharge, monitoring or surgery– based on the risk of malignant transformation. This study compares the performance of artificial intelligence (AI) models to clinical care for this task. Two explainable boosting machine (EBM) models were developed and evaluated using clinical features only, or clinical features and cyst fluid molecular markers (CFMM) using a publicly available dataset, consisting of 850 cases (median age 64; 65 % female) with independent training (429 cases) and holdout test cohorts (421 cases). There were 137 cysts with no malignant potential, 114 malignant cysts, and 599 IPMNs and MCNs. The EBM and EBM with CFMM models had higher accuracy for identifying patients requiring monitoring (0.88 and 0.82) and surgery (0.66 and 0.82) respectively compared with current clinical care (0.62 and 0.58). For discharge, the EBM with CFMM model had a higher accuracy (0.91) than either the EBM model (0.84) or current clinical care (0.86). In the cohort of patients who underwent surgical resection, use of the EBM-CFMM model would have decreased the number of unnecessary surgeries by 59 % (n = 92), increased correct surgeries by 7.5 % (n = 11), identified patients who require monitoring by 122 % (n = 76), and increased the number of patients correctly classified for discharge by 138 % (n = 18) compared to clinical care. EBM models had greater sensitivity and specificity for identifying the correct management compared with either clinical management or previous AI models. The model predictions are demonstrated to be interpretable by clinicians.","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and efficacy of cell-free and concentrate ascites reinfusion therapy (CART) for advanced pancreatic cancer patients with massive malignant ascites 无细胞浓缩腹水再灌注疗法（CART）治疗晚期胰腺癌患者大量恶性腹水的可行性和疗效。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.013

{"title":"Feasibility and efficacy of cell-free and concentrate ascites reinfusion therapy (CART) for advanced pancreatic cancer patients with massive malignant ascites","authors":"","doi":"10.1016/j.pan.2024.07.013","DOIUrl":"10.1016/j.pan.2024.07.013","url":null,"abstract":"<div><h3>Background</h3><p>The management of malignant ascites is critical for treating patients with advanced pancreatic cancer. The purpose of this study was to assess the safety of cell-free and concentrated ascites reinfusion therapy (CART) and its impact on the prognosis of patients with advanced pancreatic cancer who have massive malignant ascites.</p></div><div><h3>Methods</h3><p>This study analyzed 47 procedures in 29 patients who underwent CART for ascites caused by pancreatic cancer between 2015 and 2022. Among them, 7 patients who received chemotherapy following CART were classified as the chemotherapy group, while 22 patients without chemotherapy after CART were classified as the palliative care group.</p></div><div><h3>Results</h3><p>Among the 47 procedures, adverse events (AEs) were observed in 9 procedures (19 %). Grade 2 adverse events were observed only in one procedure, manifested as fever. There were no grade 3 or 4 AEs, nor were there any treatment-related deaths. The median survival time was 4.0 months in the chemotherapy group and 0.7 months in the palliative care group (<em>p</em> = 0.004). The albumin level in the chemotherapy group was significantly higher than that in the palliative care group.</p></div><div><h3>Conclusion</h3><p>CART is feasible and might be the optimal option to enable prolonged use of chemotherapy to improve the prognosis for late-stage pancreatic cancer patients.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature 自发性胰腺门静脉瘘的自然史：文献系统回顾

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.016

{"title":"Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature","authors":"","doi":"10.1016/j.pan.2024.07.016","DOIUrl":"10.1016/j.pan.2024.07.016","url":null,"abstract":"<div><h3>Background</h3><p>Spontaneous pancreatic portal vein fistula (PPVF) - a rare complication of pancreatic inflammation – varies widely in presentation and means of diagnosis but has been previously associated with bleeding complications and mortality. A systematic review of published literature was performed to assess the frequency of outcomes.</p></div><div><h3>Methods</h3><p>A search of electronic databases (PubMed, Ovid MEDLINE, Scopus, EMBASE, gray literature) resulted in 1667 relevant unique manuscripts; 52 met inclusion criteria.</p></div><div><h3>Results</h3><p>A total of 74 unique (male n = 47, 63.5 %) patients were included. Mean age was 53.5 (±11.9) years. History of alcohol use was reported in 55 (74.3 %). Underlying chronic pancreatitis (CP) was present in 49 (66.2 %). In cases where presenting symptoms were reported (n = 57, 77.4 %), the most frequent were abdominal pain (63.5 %), weight loss (14.9 %), rash (12.2 %), nausea/vomiting (12.2 %), and polyarthritis (9.5 %). Computed tomography was the most common imaging modality used to confirm the diagnosis (n = 20, 27.0 %), followed by magnetic resonance cholangiopancreatography (n = 14, 18.9 %). Portal vein thrombosis was reported in 57 (77.0 %), and bleeding events (luminal, variceal, or intra-pseudocyst) were reported in 13(17.6 %) patients. Younger age was associated with higher risk of bleeding events. Mortality was reported in 12 (16.2 %) patients at any time during follow up. Older age and polyarthritis at presentation were associated with mortality.</p></div><div><h3>Conclusions</h3><p>PPVF is a rare and potentially fatal condition, though rates of bleeding complication and death were relatively low in this population. High-quality observational studies are needed to better understand the pathophysiology and natural history of this diagnosis.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1424390324006963/pdfft?md5=00a4c8f73e9de80a1511514d8d25fd19&pid=1-s2.0-S1424390324006963-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of necrosis in low-enhanced pancreatic parenchyma using contrast-enhanced computed tomography was a better predictor of clinical outcomes than pancreatic inflammation: A multicentric cohort study of severe acute pancreatitis 与胰腺炎症相比，使用造影剂增强计算机断层扫描早期发现低增强胰腺实质坏死能更好地预测临床结果：重症急性胰腺炎多中心队列研究。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.001

{"title":"Early detection of necrosis in low-enhanced pancreatic parenchyma using contrast-enhanced computed tomography was a better predictor of clinical outcomes than pancreatic inflammation: A multicentric cohort study of severe acute pancreatitis","authors":"","doi":"10.1016/j.pan.2024.07.001","DOIUrl":"10.1016/j.pan.2024.07.001","url":null,"abstract":"<div><h3>Objectives</h3><p>We aim to assess the early use of contrast-enhanced computed tomography<span> (CECT) of patients with severe acute pancreatitis (SAP) using the computed tomography severity index (CTSI) in prognosis prediction. The CTSI combines quantification of pancreatic and extrapancreatic inflammation with the extent of pancreatic necrosis.</span></p></div><div><h3>Methods</h3><p>Post-hoc retrospective analysis of a large, multicentric database (44 institutions) of SAP patients in Japan. The area under the curve (AUC) of the CTSI for predicting mortality and the odds ratio (OR) of the extent of pancreatic inflammation and necrosis were calculated using multivariable analysis.</p></div><div><h3>Results</h3><p>In total, 1097 patients were included. The AUC of the CTSI for mortality was 0.65 (95 % confidence interval [CI:] [0.59–0.70]; p < 0.001). In multivariable analysis, necrosis 30–50 % and >50 % in low-enhanced pancreatic parenchyma (LEPP) was independently associated with a significant increase in mortality, with OR 2.04 and 95 % CI 1.01–4.12 (P < 0.05) and OR 3.88 and 95 % CI 2.04–7.40 (P < 0.001), respectively. However, the extent of pancreatic inflammation was not associated with mortality, regardless of severity.</p></div><div><h3>Conclusions</h3><p>The degree of necrosis in LEPP assessed using early CECT of SAP was a better predictor of mortality than the extent of pancreatic inflammation.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: Cystic fibrosis transmembrane conductance regulator (CFTR) variants and CFTR function in patients with pancreatitis 回复：胰腺炎患者的囊性纤维化跨膜传导调节器 (CFTR) 变异和 CFTR 功能。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.015

引用次数: 0

Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique 慢性胰腺炎患者的胰腺近全头切除术--一种新型外科技术的成果。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.003

{"title":"Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique","authors":"","doi":"10.1016/j.pan.2024.07.003","DOIUrl":"10.1016/j.pan.2024.07.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Chronic pancreatitis (CP) is characterized by debilitating pain which affects patients' </span>quality of life<span>. Early surgical intervention has been shown to mitigate pain and prevent a decline in quality of life. The present study evaluated the impact of bile duct and duodenum preserving pancreatic head resection (BDPPHR), an innovative technique, on pain relief, functional outcomes, postoperative morbidity, and mortality in patients with CP.</span></p></div><div><h3>Methods</h3><p>Between March 2019 and July 2022, a total of 37 patients underwent bile duct and duodenum preserving pancreatic head resection (BDPPHR) for pain relief in patients with CP. Post-operative outcomes were assessed by Izbicki pain score, exocrine insufficiency, endocrine insufficiency, and return to work. The safety of the surgical procedure was determined by evaluation of postoperative morbidity and mortality as per Clavien-Dindo scores.</p></div><div><h3>Results</h3><p>BDPPHR showed a significant reduction in Izbicki pain scores with 30 (81 %) patients experiencing complete or partial pain relief up to 18 months of follow up. 32(86 %) patients ceased narcotic use by the end of the 18-month follow-up period. 33 (89 %) patients were able to resume regular work at the end of 18 months. There were no significant alterations in both exocrine and endocrine statuses post-surgery. The median duration of hospital stay was 4.5 days (3-11). Major complications occurred in 2 (5 %) patients. There was no post-operative mortality.</p></div><div><h3>Conclusion</h3><p>BDPPHR is a novel and safe technique of near total head resection which results in very good pain relief in 81 % of patients.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nomogram to predict the occurrence of pseudocyst in patients with acute pancreatitis 预测急性胰腺炎患者假性囊肿发生率的提名图。

IF 2.8 2区医学

Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.007

{"title":"A nomogram to predict the occurrence of pseudocyst in patients with acute pancreatitis","authors":"","doi":"10.1016/j.pan.2024.08.007","DOIUrl":"10.1016/j.pan.2024.08.007","url":null,"abstract":"<div><h3>Background</h3><p>Pseudocyst formation is common in many patients with acute pancreatitis during follow-up. Many risk factors have been proposed to be associated with the development of PP, but the predictive factors are still underexplored. The focus of this study was to investigate whether early laboratory indicators could effectively predict the occurrence of PP.</p></div><div><h3>Methods</h3><p>2811 AP patients hospitalized in the Second Affiliated Hospital of Soochow University between November 2008 and September 2020 were retrospectively studied. Univariate and multivariate analyses were used to screen the risk variables. The nomograms of those risk factors were validated and evaluated by logistic analysis.</p></div><div><h3>Results</h3><p>AP patients had a 6.1 % (172/2811) incidence of PP. In a univariate analysis, the development of PP was correlated with serum lactate dehydrogenase (LDH), albumin (ALB), calcium (Ca), hemoglobin (Hb), organ dysfunction, CT severity index (CTSI), etiology, age, etc. Further logistic regression analysis showed that the risk factors were different between hyperlipidemic pancreatitis patients (LDH, ALB and Ca) and non-hyperlipidemic pancreatitis patients (LDH, Hb, ALB and Ca). A nomogram based on the identified risk factors was developed. Our model showed good discrimination ability, with a boostrap - corrected C index of 0.905 (95 % CI = 0.875–0.935), and had well-fitted calibration curves. The area under the curve (AUC) of the nomogram were 0.905 (95 % CI = 0.875–0.935) and 0.933 (95 % CI = 0.890–0.975) in the training and validation groups, respectively. The results of DCA indicated that the nomogram may have clinic usefulness.</p></div><div><h3>Conclusions</h3><p>The nomogram that incorporates early laboratory data (LDH, Hb, ALB, and Ca) in AP patients is able to predict the incidence of PP with greater accuracy than the CTSI and AP severity.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0