Pancreatology最新文献

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Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique 慢性胰腺炎患者的胰腺近全头切除术--一种新型外科技术的成果。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.003
Biju Pottakkat, S. Harilal, R. Kalayarasan, P Sai Krishna
{"title":"Near total head resection of pancreas in patients with chronic pancreatitis - Outcome of a novel surgical technique","authors":"Biju Pottakkat,&nbsp;S. Harilal,&nbsp;R. Kalayarasan,&nbsp;P Sai Krishna","doi":"10.1016/j.pan.2024.07.003","DOIUrl":"10.1016/j.pan.2024.07.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Chronic pancreatitis (CP) is characterized by debilitating pain which affects patients' </span>quality of life<span>. Early surgical intervention has been shown to mitigate pain and prevent a decline in quality of life. The present study evaluated the impact of bile duct and duodenum preserving pancreatic head resection (BDPPHR), an innovative technique, on pain relief, functional outcomes, postoperative morbidity, and mortality in patients with CP.</span></p></div><div><h3>Methods</h3><p>Between March 2019 and July 2022, a total of 37 patients underwent bile duct and duodenum preserving pancreatic head resection (BDPPHR) for pain relief in patients with CP. Post-operative outcomes were assessed by Izbicki pain score, exocrine insufficiency, endocrine insufficiency, and return to work. The safety of the surgical procedure was determined by evaluation of postoperative morbidity and mortality as per Clavien-Dindo scores.</p></div><div><h3>Results</h3><p>BDPPHR showed a significant reduction in Izbicki pain scores with 30 (81 %) patients experiencing complete or partial pain relief up to 18 months of follow up. 32(86 %) patients ceased narcotic use by the end of the 18-month follow-up period. 33 (89 %) patients were able to resume regular work at the end of 18 months. There were no significant alterations in both exocrine and endocrine statuses post-surgery. The median duration of hospital stay was 4.5 days (3-11). Major complications occurred in 2 (5 %) patients. There was no post-operative mortality.</p></div><div><h3>Conclusion</h3><p>BDPPHR is a novel and safe technique of near total head resection which results in very good pain relief in 81 % of patients.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 954-959"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrence pattern and its risk factors in patients with resected pancreatic ductal adenocarcinoma – A retrospective analysis of 272 patients 切除胰腺导管腺癌患者的复发模式及其风险因素--对272名患者的回顾性分析。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.017
Maximilian Brunner, Marteen Flessa, Anne Jacobsen, Susanne Merkel, Christian Krautz, Georg F. Weber, Robert Grützmann
{"title":"Recurrence pattern and its risk factors in patients with resected pancreatic ductal adenocarcinoma – A retrospective analysis of 272 patients","authors":"Maximilian Brunner,&nbsp;Marteen Flessa,&nbsp;Anne Jacobsen,&nbsp;Susanne Merkel,&nbsp;Christian Krautz,&nbsp;Georg F. Weber,&nbsp;Robert Grützmann","doi":"10.1016/j.pan.2024.07.017","DOIUrl":"10.1016/j.pan.2024.07.017","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this study was to investigate the patterns of recurrence and their associated risk factors in patients who underwent resection for pancreatic carcinoma.</p></div><div><h3>Methods</h3><p>This retrospective study included 272 patients, who underwent Ro/R1-resection of PDAC from 2005 to 2020 at the University Hospital Erlangen. Risk factors for different recurrence patterns and the prognostic value of recurrence pattern on the overall survival after recurrence were evaluated.</p></div><div><h3>Results</h3><p>61 % of the patients experienced recurrence, mostly within the first 12 postoperative months (62 %) and in the form of metastases (87 %). The median overall survival from recurrence was 9.2 months. The preoperative absence of diabetes and the presence of lymph node metastasis were independent risk factors for recurrence and a preoperative CA19-9 exceeding 97 U/ml for early recurrence. Additionally, lymph node metastases were associated with a higher risk of metastatic recurrence. Early recurrence, but not the site of recurrence, was identified as an independent prognostic factor for worse overall survival from recurrence.</p></div><div><h3>Conclusion</h3><p>The occurrence of recurrence and especially of early and metastatic recurrence are associated with a worse overall survival. Patients lacking preoperative diabetes, having high preoperative CA19-9 values and lymph node metastases are particularly at risk for (early) recurrence.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 930-937"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1424390324006975/pdfft?md5=d526026721e1fbbd4e39b42d3bb11b32&pid=1-s2.0-S1424390324006975-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severity and outcome of a first episode of idiopathic acute pancreatitis is not more severe than pancreatitis of other etiologies 特发性急性胰腺炎首次发病的严重程度和结果并不比其他病因引起的胰腺炎严重。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.004
Simon Sirtl , Eric Hohmann , Mahmood Ahmad , Katharina Bretthauer , Mali Junge , Marlies Vornhülz , Elisabetta Goni , Didem Saka , Mathilda Knoblauch , Ughur Aghamaliyev , Christian Schulz , Michal Zorniak , Ujjwal M. Mahajan , Julia Mayerle , Georg Beyer
{"title":"Severity and outcome of a first episode of idiopathic acute pancreatitis is not more severe than pancreatitis of other etiologies","authors":"Simon Sirtl ,&nbsp;Eric Hohmann ,&nbsp;Mahmood Ahmad ,&nbsp;Katharina Bretthauer ,&nbsp;Mali Junge ,&nbsp;Marlies Vornhülz ,&nbsp;Elisabetta Goni ,&nbsp;Didem Saka ,&nbsp;Mathilda Knoblauch ,&nbsp;Ughur Aghamaliyev ,&nbsp;Christian Schulz ,&nbsp;Michal Zorniak ,&nbsp;Ujjwal M. Mahajan ,&nbsp;Julia Mayerle ,&nbsp;Georg Beyer","doi":"10.1016/j.pan.2024.08.004","DOIUrl":"10.1016/j.pan.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><p>With respect to severity and outcome of an index episode of idiopathic acute pancreatitis the current literature reports conflicting retrospective results. One reason might be the retrospective study design precluding in depth analysis resulting in mixed etiologies and combination of index episode versus recurrent idiopathic acute pancreatitis.</p></div><div><h3>Methods</h3><p>In this retrospective monocentric cohort study, we retrieved all patients with a first acute pancreatitis episode treated between 2005 and 2021 at the LMU University Hospital from our clinical information system based on the respective ICD-10 codes. In an initial sample of 1390 presumed idiopathic pancreatitis patients we identified 68 confirmed idiopathic acute pancreatitis patients and compared those to 75 first-time alcohol-induced acute pancreatitis patients and 390 first-time biliary-induced acute pancreatitis patients. Clinical outcome (severity, SIRS, mortality, and re-admission rate) was set as outcome measures. Multinomial logistic regression analysis was performed.</p></div><div><h3>Results</h3><p>In alcohol-induced acute pancreatitis moderate and severe courses occur significantly more often when compared to idiopathic acute pancreatitis (17.33 % vs. 10.29 %; multinomial logistic regression p = 0.0021). There were no significant differences in mortality between first-time alcoholic, idiopathic and biliary pancreatitis (p = 0.6328). Patients with idiopathic acute pancreatitis had significantly more hospital readmissions (within 30 days) compared to alcohol-induced pancreatitis patients (p = 0.0284).</p></div><div><h3>Conclusion</h3><p>In the context of a first episode of acute pancreatitis, idiopathic acute pancreatitis remains a challenging diagnosis posing an increased risk of recurrence, but not an increased risk for a more severe disease course.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 840-846"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1424390324007014/pdfft?md5=c7a7cf527e2b28ab98442d6c06c3cbf5&pid=1-s2.0-S1424390324007014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nomogram to predict the occurrence of pseudocyst in patients with acute pancreatitis 预测急性胰腺炎患者假性囊肿发生率的提名图。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.007
Fengjie Ji , Wen Tang , Wen Yan , Jiujing Huang , Yuxin Liu , Jing Zhou , Shuqi Qin , Si Dai , Yulin Ji , Guojian Yin
{"title":"A nomogram to predict the occurrence of pseudocyst in patients with acute pancreatitis","authors":"Fengjie Ji ,&nbsp;Wen Tang ,&nbsp;Wen Yan ,&nbsp;Jiujing Huang ,&nbsp;Yuxin Liu ,&nbsp;Jing Zhou ,&nbsp;Shuqi Qin ,&nbsp;Si Dai ,&nbsp;Yulin Ji ,&nbsp;Guojian Yin","doi":"10.1016/j.pan.2024.08.007","DOIUrl":"10.1016/j.pan.2024.08.007","url":null,"abstract":"<div><h3>Background</h3><p>Pseudocyst formation is common in many patients with acute pancreatitis during follow-up. Many risk factors have been proposed to be associated with the development of PP, but the predictive factors are still underexplored. The focus of this study was to investigate whether early laboratory indicators could effectively predict the occurrence of PP.</p></div><div><h3>Methods</h3><p>2811 AP patients hospitalized in the Second Affiliated Hospital of Soochow University between November 2008 and September 2020 were retrospectively studied. Univariate and multivariate analyses were used to screen the risk variables. The nomograms of those risk factors were validated and evaluated by logistic analysis.</p></div><div><h3>Results</h3><p>AP patients had a 6.1 % (172/2811) incidence of PP. In a univariate analysis, the development of PP was correlated with serum lactate dehydrogenase (LDH), albumin (ALB), calcium (Ca), hemoglobin (Hb), organ dysfunction, CT severity index (CTSI), etiology, age, etc. Further logistic regression analysis showed that the risk factors were different between hyperlipidemic pancreatitis patients (LDH, ALB and Ca) and non-hyperlipidemic pancreatitis patients (LDH, Hb, ALB and Ca). A nomogram based on the identified risk factors was developed. Our model showed good discrimination ability, with a boostrap - corrected C index of 0.905 (95 % CI = 0.875–0.935), and had well-fitted calibration curves. The area under the curve (AUC) of the nomogram were 0.905 (95 % CI = 0.875–0.935) and 0.933 (95 % CI = 0.890–0.975) in the training and validation groups, respectively. The results of DCA indicated that the nomogram may have clinic usefulness.</p></div><div><h3>Conclusions</h3><p>The nomogram that incorporates early laboratory data (LDH, Hb, ALB, and Ca) in AP patients is able to predict the incidence of PP with greater accuracy than the CTSI and AP severity.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 863-869"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Quality of life is impaired in children with chronic pancreatitis: A multicenter study” "慢性胰腺炎患儿的生活质量受损:一项多中心研究"。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.06.009
{"title":"“Quality of life is impaired in children with chronic pancreatitis: A multicenter study”","authors":"","doi":"10.1016/j.pan.2024.06.009","DOIUrl":"10.1016/j.pan.2024.06.009","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The impact of chronic pancreatitis<span> (CP) on quality of life (QOL) of children is not well established. Our objective was to evaluate the QOL, identify contributing factors, and determine the prevalence of anxiety and depression in children with CP in India.</span></p></div><div><h3>Methods</h3><p><span>Children (8-18y old) with CP were prospectively enrolled across three pediatric gastroenterology centres in India. QOL was assessed using the </span>pediatric QOL inventory<span> (PedsQL 4.0) scale, administered to both children and their parents. Anxiety and depression was studied using the Revised Children's Anxiety and Depression Scale (RCADS 25). Contributing factors were identified using binary logistic regression analysis. The data was compared against published QOL data in healthy Indian children.</span></p></div><div><h3>Results</h3><p>121 children with CP (boys-57.9 %, age at QOL-14 ± 3.2years) were enrolled. A majority (82.7 %) had pain and advanced disease (Cambridge grade IV- 63.6 %). Children with CP had poorer QOL compared to controls (total score 74.6 ± 16 vs. 87.5 ± 11.1, p &lt; 0.0001). QOL scores were similar across centres. Older children were similar to younger ones, except for a poorer emotional QOL. Taking QOL &lt; -2 standard deviation (SD) of controls, ∼35 % had poor physical (50.9 ± 11.9) and 20 % had poor psychosocial (PS) QOL score (52.1 ± 7.2). On analysis, presence of pain and lower socio-economic status (SES) adversely affected both physical and PS-QOL. Additionally, girls had poorer PS-QOL than boys (Odds ratio 3.1, 95%CI:1.23–7.31). Anxiety and depression were uncommon (2,1.6 %).</p></div><div><h3>Conclusions</h3><p>Patients with CP had impaired physical and psycho-social QOL. Presence of pain and lower SES adversely affected QOL. Psychiatric comorbidities were uncommon.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 817-826"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered centriolar cohesion by CEP250 and appendages impact outcome of patients with pancreatic cancer CEP250 和附属物改变的中心粒内聚力会影响胰腺癌患者的预后。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.06.010
{"title":"Altered centriolar cohesion by CEP250 and appendages impact outcome of patients with pancreatic cancer","authors":"","doi":"10.1016/j.pan.2024.06.010","DOIUrl":"10.1016/j.pan.2024.06.010","url":null,"abstract":"<div><h3>Background</h3><p>Pancreatic ductal adenocarcinoma<span><span> (PDAC) is one of the leading cause of cancer death worldwide. PDACs are characterized by </span>centrosome aberrations, but whether centrosome-related genes influence patient outcomes has not been tested.</span></p></div><div><h3>Methods</h3><p><span>Publicly available RNA-sequencing data of patients diagnosed with PDAC were interrogated with unsupervised approaches to identify centrosome protein-encoding genes with prognostic relevance. Candidate genes were validated by </span>immunohistochemistry<span> and multiplex immunofluorescence in a set of clinical PDAC and normal pancreatic tissues.</span></p></div><div><h3>Results</h3><p>Results showed that two genes <em>CEP250</em> and <em>CEP170,</em> involved in centrosome linker and centriolar subdistal appendages, were expressed at high levels in PDAC tissues and were correlated with prognosis of PDAC patients in independent databases.</p><p>Large clustered γ-tubulin-labelled centrosomes were linked together by aberrant circular and planar-shaped CEP250 arrangements in CEP250-high expressing PDACs. Furthermore, PDACs displayed prominent centrosome separation and reduced CEP164-centrosomal labelling associated with acetylated-tubulin staining compared to normal pancreatic tissues. Interestingly, in a small validation cohort, CEP250-high expressing patients had shorter disease free- and overall-survival and almost none of those who received gemcitabine plus nab-paclitaxel first-line therapy achieved a clinical response. In contrast, weak CEP250 expression was associated with long-term survivors or responses to medical treatments.</p></div><div><h3>Conclusions</h3><p>Alteration of the centriolar cohesion and appendages has effect on the survival of patients with PDAC.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 899-908"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic pancreatico-pleural fistula: Diverting a diversion 有症状的胰胸膜瘘:转流。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.08.002
Hemanta Kumar Nayak, Shubham Gupta, Subhabrata Biswal, Saswati Kar, Kamlesh Ahari, Taraprasad Tripathy, Ranjan Kumar Patel, Bramhadatta Pattnaik, Manas Kumar Panigrahi, Subash Chandra Samal
{"title":"Symptomatic pancreatico-pleural fistula: Diverting a diversion","authors":"Hemanta Kumar Nayak,&nbsp;Shubham Gupta,&nbsp;Subhabrata Biswal,&nbsp;Saswati Kar,&nbsp;Kamlesh Ahari,&nbsp;Taraprasad Tripathy,&nbsp;Ranjan Kumar Patel,&nbsp;Bramhadatta Pattnaik,&nbsp;Manas Kumar Panigrahi,&nbsp;Subash Chandra Samal","doi":"10.1016/j.pan.2024.08.002","DOIUrl":"10.1016/j.pan.2024.08.002","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 976-979"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative level of serum transthyretin as a novel biomarker predicting survival in resected pancreatic ductal adenocarcinoma with neoadjuvant therapy 血清转甲状腺素的术前水平是预测接受新辅助治疗的切除胰腺导管腺癌生存率的新型生物标记物。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.012
Yoshihide Nanno, Hirochika Toyama, Takuya Mizumoto, Jun Ishida, Takeshi Urade, Kenji Fukushima, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto
{"title":"Preoperative level of serum transthyretin as a novel biomarker predicting survival in resected pancreatic ductal adenocarcinoma with neoadjuvant therapy","authors":"Yoshihide Nanno,&nbsp;Hirochika Toyama,&nbsp;Takuya Mizumoto,&nbsp;Jun Ishida,&nbsp;Takeshi Urade,&nbsp;Kenji Fukushima,&nbsp;Hidetoshi Gon,&nbsp;Daisuke Tsugawa,&nbsp;Shohei Komatsu,&nbsp;Sadaki Asari,&nbsp;Hiroaki Yanagimoto,&nbsp;Masahiro Kido,&nbsp;Takumi Fukumoto","doi":"10.1016/j.pan.2024.07.012","DOIUrl":"10.1016/j.pan.2024.07.012","url":null,"abstract":"<div><h3>Background</h3><p>Systemic inflammation and altered metabolism are essential hallmarks of cancer. We hypothesized that the rapid turnover protein transthyretin (TTR) (half-life: 2–3 days), compared with the conventional marker albumin (21 days), better reflects the inflammatory/metabolic dynamics of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy (NAT) and is a useful prognostic marker.</p></div><div><h3>Methods</h3><p>Serum TTR and albumin levels were measured in 104 consecutive post-NAT PDAC patients before curative resection. The associations of preoperative TTR and albumin levels with overall survival (OS) after pancreatectomy were retrospectively analyzed.</p></div><div><h3>Results</h3><p>The mean (SD) TTR and albumin levels were 21.6 (6.4) mg/dL (normal range: ≥22.0 mg/dL) and 3.9 (0.55) g/dL. A low (&lt;22.0 mg/dL) post-NAT TTR level was associated with an advanced tumor stage and higher CEA and CRP levels. Patients with low TTR levels showed significantly worse OS compared with normal levels (3-year OS 39 % vs. 54 %, <em>P</em> = 0.037), although albumin levels did not. We modified prognostic biomarkers of systemic inflammation/metabolism, such as GPS, PNI, and CONUT scores, using the serum TTR instead of albumin level and successfully showed that modified scores were better associated with OS compared with original scores using serum albumin level.</p></div><div><h3>Conclusions</h3><p>Our data suggest that the TTR level is a promising prognostic biomarker for PDAC patients after NAT.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 917-924"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venous thromboembolism in patients with pancreatic adenocarcinoma: Disease burden and initiation of ambulatory thromboprophylaxis 胰腺腺癌患者的静脉血栓栓塞:疾病负担和流动血栓预防措施的启动。
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.06.008
{"title":"Venous thromboembolism in patients with pancreatic adenocarcinoma: Disease burden and initiation of ambulatory thromboprophylaxis","authors":"","doi":"10.1016/j.pan.2024.06.008","DOIUrl":"10.1016/j.pan.2024.06.008","url":null,"abstract":"<div><h3>Background/Objectives</h3><p>Ambulatory thromboprophylaxis (AT) in patients with pancreatic adenocarcinoma (PAC) reduces venous thromboembolism (VTE) risk and is recommended for patients receiving systemic chemotherapy. We evaluated VTE rates, severity, timing, and risk factors in PAC patients as well as AT rates and initiation times.</p></div><div><h3>Methods</h3><p>Patients diagnosed with PAC were included. Data collected included patient demographics, medical history, PAC diagnosis, development of VTE, AT, and bleeding episodes. VTE was defined as a DVT or a PE. Patients were classified as receiving AT for VTE prevention if they received a prescription for outpatient anticoagulation.</p></div><div><h3>Results</h3><p>The cohort included 243 PAC patients. VTE occurred in 24 %. Overall, 52 % developing VTE were hospitalized and 5 % died as a result of the VTE. Of those who developed VTE 50 % were diagnosed within the first 2 months of PAC diagnosis. Univariate predictors of elevated VTE risk included an elevated Onkotev score, metastasis at diagnosis, male gender and not receiving AT. Multivariate predictors of elevated VTE risk included male gender (P = 0.014) and not receiving AT (P = 0.001). Overall, 30 % of patients received AT. The median time from diagnosis to initiation of AT was 43 days. Major bleeding occurred in 5.8 %. Patients receiving AT were not at a significantly increased risk of major bleeding (p = 0.5). Patients with intestinal tumor invasion were at significantly increased risk of major bleeding (P = 0.021).</p></div><div><h3>Conclusion</h3><p>VTE risk is significant and morbid in PAC patients. AT rates are low, and initiation is often delayed. Therapeutic endoscopists diagnosing PAC may be helpful in AT initiation.</p></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"24 6","pages":"Pages 894-898"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S142439032400663X/pdfft?md5=aef3b517da7a11a22f1e74088b5380ed&pid=1-s2.0-S142439032400663X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two cases of hemoptysis in pancreatitis and their rescue endovascular embolization 两例胰腺炎咯血病例及其抢救性血管内栓塞术
IF 2.8 2区 医学
Pancreatology Pub Date : 2024-09-01 DOI: 10.1016/j.pan.2024.07.011
Ranjan Kumar Patel, Subarna Acharya, Taraprasad Tripathy, Karthikeyan, Anupama Behera, Manoj Kumar Panigrahi, Hemanta Kumar Nayak, Bramhadatta Pattnaik, Nerbadyswari Deep (Bag)
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