Pancreatology最新文献

{"title":"Pancreatic mucinous cystic neoplasms (MCN) during pregnancy grow rapidly and undergo malignant transformation: A series of 69 operated cases","authors":"Olga V. Korhonen ,&nbsp;Cristina Verdejo Gil ,&nbsp;Judith Millastre Bocos ,&nbsp;Margaret G. Keane ,&nbsp;Anne Antila ,&nbsp;Linda N. Nilsson ,&nbsp;Awad Shamali ,&nbsp;Monica Marijnissen-van Zanten ,&nbsp;Marco Del Chiaro ,&nbsp;Johanna Laukkarinen","doi":"10.1016/j.pan.2026.03.018","DOIUrl":"10.1016/j.pan.2026.03.018","url":null,"abstract":"<div><h3>Background</h3><div>The diagnosis of mucinous cystic neoplasm (MCN) during pregnancy is rare and presents unique challenges. We analyzed all reported cases of pregnancy-associated MCNs to assess malignant potential and identify predictive factors.</div></div><div><h3>Methods</h3><div>A total of 69 patients with MCN were included: 65 from systematic literature search and 4 cases from our institutional databases. Data included patient demographics, symptoms, diagnostics, surgical management, histopathology, and clinical outcomes.</div></div><div><h3>Results</h3><div>The median age was 33 years (range 20–47). 74% (49/66) presented with symptoms. Tumor-related complications occurred in 27% (16/60), including acute pancreatitis in eight and cyst rupture in four. Median MCN diameter at diagnosis was 12.0 cm (1.5–30). Median tumor growth during pregnancy was 2.5 cm (0.5–20) over a median period of 2.75 months (1–78). All patients underwent surgical resection: 29% (20/69) in second trimester and 59% (41/69) postpartum. Postoperative complications occurred in four patients, all including pancreatic fistula or fluid collection. Fetal complications were reported in eight cases, without tumor-related mortality. 20% (13/66) had invasive adenocarcinoma (IC), 14% (9/66) high-grade dysplasia (HGD), and rates were similar if resected during pregnancy or postpartum. Symptomatic presentation and high-risk imaging features significantly correlated with malignant MCN. During the median follow-up of 24 months (2–154), local recurrence occurred in three patients and one patient died.</div></div><div><h3>Conclusions</h3><div>Pregnancy-related MCNs were typically large, symptomatic, and grew rapidly. A third of tumors harbored IC or HGD. Prompt surgical resection, typically during the second trimester appears safe, with a low rate of maternal and fetal complications.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 444-450"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin use and acute pancreatitis mortality","authors":"Kuan-Fu Liao ,&nbsp;Shih-Wei Lai","doi":"10.1016/j.pan.2025.10.008","DOIUrl":"10.1016/j.pan.2025.10.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 509-510"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia in chronic pancreatitis is associated with increased mortality and morbidity. A propensity-score matched population-based study","authors":"Hussam Almasri ,&nbsp;Himsikhar Khataniar ,&nbsp;Ishita Gupta ,&nbsp;Khalid Ahmed ,&nbsp;Rahul Karna ,&nbsp;Guru Trikudanathan","doi":"10.1016/j.pan.2026.02.008","DOIUrl":"10.1016/j.pan.2026.02.008","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 498-500"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of past accomplishments and looking forward to the next 5 years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC)","authors":"Chris E. Forsmark ,&nbsp;Stephen Pandol","doi":"10.1016/j.pan.2025.12.023","DOIUrl":"10.1016/j.pan.2025.12.023","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 340-342"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Focal pancreatic parenchymal atrophy could be a precursor of pancreatic cancer”","authors":"Kenichiro Okumura","doi":"10.1016/j.pan.2025.12.026","DOIUrl":"10.1016/j.pan.2025.12.026","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 515-516"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of biodegradable pancreatic stents in post-ERCP pancreatitis prophylaxis","authors":"Abdullah Abbasi ,&nbsp;Raheel Anjum ,&nbsp;Pavit Tewatia ,&nbsp;Shyam Menon","doi":"10.1016/j.pan.2025.11.022","DOIUrl":"10.1016/j.pan.2025.11.022","url":null,"abstract":"<div><h3>Background</h3><div>Biodegradable biliopancreatic stents (BDS) are commercially available alternatives to conventional stents. While these offer potential economic benefits—such as eliminating the need for follow-up imaging or endoscopic procedures to retrieve retained stents—they have not been evaluated in a cost-effectiveness model. We aimed to develop a health economic model comparing conventional pancreatic stents (PS) with BDS for the prophylaxis of post-ERCP pancreatitis (PEP).</div></div><div><h3>Methods</h3><div>Data on pancreatic stents used for PEP and follow-up outcomes were extracted from the endoscopy database at The Royal Wolverhampton NHS Trust, United Kingdom, to develop a cost-benefit decision analysis model. Healthcare-associated quality of life data were sourced from the literature to derive utility values for the model. Complications related to retained stents were incorporated. Deterministic and probabilistic sensitivity analyses were performed. Incremental cost-effectiveness ratios (ICERs) were calculated using a willingness-to-pay (WTP) threshold of £30,000.</div></div><div><h3>Results</h3><div>Deterministic analysis demonstrated that using BDS for PEP prophylaxis was cost-effective compared to conventional PS (£656.12, 0.98 QALY for BDS vs. £377.59, 0.95 QALY for PS), yielding an ICER of £9316.70. Probabilistic sensitivity analysis similarly confirmed the cost-effectiveness of BDS over PS, with BDS being cost-effective at £666.67 for 0.98 QALY versus £373.68 for 0.95 QALY for PS. Threshold analysis identified a cost threshold of £353.37 for BDS to remain cost-effective.</div></div><div><h3>Conclusion</h3><div>BDS for PEP prophylaxis is cost effective compared to conventional PS, avoiding the need for follow-up imaging and repeat procedures for stent removal.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 355-362"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal patterns and dynamics of acute pancreatitis emergency department visits in Korea","authors":"Shinjie Choi ,&nbsp;Dong-Uk Kim ,&nbsp;Yeji Kim ,&nbsp;Lia Kim ,&nbsp;Jung Ok Shim ,&nbsp;Jin Soo Moon ,&nbsp;Jong Woo Hahn ,&nbsp;Hye Ran Yang ,&nbsp;Ju Young Chang ,&nbsp;Jae Sung Ko","doi":"10.1016/j.pan.2026.02.010","DOIUrl":"10.1016/j.pan.2026.02.010","url":null,"abstract":"<div><h3>Background/objectives</h3><div>The incidence of acute pancreatitis (AP) varies seasonally in some populations. However, evidence from Korea remains limited. This study aimed to investigate seasonal patterns of AP visits and evaluate potential infectious enteric pathogens contributing to this variation in both pediatric (≤18 years) and adult (&gt;18 years) populations.</div></div><div><h3>Methods</h3><div>Nationwide emergency department (ED) data from the National Emergency Department Information System (NEDIS) were analyzed. The age-stratified seasonal variation in AP visits was modeled using negative binomial harmonic regression (NBHR) models with harmonic terms. Pearson correlation coefficients between AP visits and case counts of enteric infections were calculated to investigate potential infectious agents. Mediation analysis was performed to assess whether specific pathogens mediated the seasonal increase in AP visits.</div></div><div><h3>Results</h3><div>A total of 48,412 ED visits (1481 pediatric and 46,931 adult visits) resulting in hospital admission were included in the analysis. NBHR models revealed significant cyclical seasonality across age groups, with AP visits peaking in the summer. Correlation analysis revealed significant positive associations between AP visits and several pathogens. The mediation analysis suggested that substantial proportions of both <em>Campylobacter</em> and <em>Salmonella</em> species were temporally associated with the changes in AP visits.</div></div><div><h3>Conclusions</h3><div>This study demonstrated a pronounced summer peak in AP visits among both pediatric and adult populations in Korea. <em>Campylobacter</em> and <em>Salmonella</em> species may be linked to this seasonal pattern, suggesting a temporal association between infections with these species and AP seasonality. Further research is needed to clarify other mechanisms underlying seasonal AP surges and inform targeted preventive strategies.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 370-379"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letters to the editor regarding the use of aspirin and mortality due to acute pancreatitis","authors":"Do Han Kim ,&nbsp;Donghyun Ko ,&nbsp;Carlos Elizondo Alatorre ,&nbsp;Frank J. Lukens ,&nbsp;Jose A. Porres ,&nbsp;Pedro Palacios Argueta ,&nbsp;Massimo Raimondo ,&nbsp;Baoan Ji ,&nbsp;Yan Bi ,&nbsp;Paul T. Kröner","doi":"10.1016/j.pan.2026.03.010","DOIUrl":"10.1016/j.pan.2026.03.010","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 511-512"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding methodological refinement and microbiome-centric endpoints","authors":"Shivam Kalia ,&nbsp;Preetam Nath ,&nbsp;Anil Chandra Anand ,&nbsp;Bipadabhanjan Mallick ,&nbsp;Dibyalochan Praharaj ,&nbsp;Sarat Chandra Panigrahi ,&nbsp;Saroj Kanta Sahu ,&nbsp;Suprabhat Giri ,&nbsp;Subrat Kumar Acharya","doi":"10.1016/j.pan.2026.04.013","DOIUrl":"10.1016/j.pan.2026.04.013","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 3","pages":"Pages 519-520"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal Liquid Biopsy (TLB): A promising diagnostic tool for the differential diagnosis of pancreatic cystic lesions (PCLS) and the early detection of their malignant transformation","authors":"J. Millastre Bocos ,&nbsp;S. Hermoso Durán ,&nbsp;M. Ortiz de Solórzano ,&nbsp;F.J. Falcó Martí ,&nbsp;E. Ceamanos Ibarra ,&nbsp;G. García Rayado ,&nbsp;R. Velamazán Sandalinas ,&nbsp;M. Galochino Ballano ,&nbsp;P.F. Garrido ,&nbsp;O. Abian Franco","doi":"10.1016/j.pan.2026.01.070","DOIUrl":"10.1016/j.pan.2026.01.070","url":null,"abstract":"","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"26 2","pages":"Page 334"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147394930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}