Shauntelle Quammie, Colin John Crooks, Abdulsalam Aliyu, Guruprasad P Aithal, Aloysious D Aravinthan
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PROSPERO registration: CRD42024543050.</p><p><strong>Results: </strong>Sixteen (16) studies consisting of 117,163 CP patients met the eligibility criteria. 4015 (3.4%) patients developed 4019 EP cancers. The overall annual prevalence and incidence of EP cancers were 7962 (95% CI 5044-10880) per 100,000 CP patients and 1039 (95% CI 649-1663) per 100,000 person years. Lung cancer had the highest annual prevalence - (1540 (95% CI 667-2413) per 100,000 CP patients) and incidence (260 (95% CI 120-390) per 100,000 person years). The pooled HR were 1.31 (95% CI 1.03-1.66) and 1.58 (95% CI 1.27-1.98) for adjusted lung cancer and crude liver cancer in patients with CP compared to patients without CP, respectively.</p><p><strong>Conclusion: </strong>Patients with CP have an increased risk of developing EP cancers compared to patients without CP, in particular lung and liver cancer which had the highest relative risk. Shared risk factor modifications, such as smoking cessation and alcohol reduction, could lower the risk of common EP cancers. Further, implementing non-invasive screening measures may aid in early diagnosis in this high-risk group.</p>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis.\",\"authors\":\"Shauntelle Quammie, Colin John Crooks, Abdulsalam Aliyu, Guruprasad P Aithal, Aloysious D Aravinthan\",\"doi\":\"10.1016/j.pan.2025.05.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Chronic pancreatitis (CP) is a known risk factor for pancreatic cancer; however its association to extra pancreatic (EP) cancers remains inadequately explored. 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引用次数: 0
摘要
慢性胰腺炎（CP）是胰腺癌的已知危险因素；然而，其与外胰癌（EP）的关系仍未得到充分探讨。本系统综述的目的是调查CP作为发生EP癌的危险因素的证据。方法：在Ovid Medline、EMBASE和Scopus上检索自成立之日至2024年1月27日的CP合并EP癌患者。每种癌症的患病率和发病率是根据报告的数字尽可能计算出来的。随机效应荟萃分析用于汇总每种EP癌症的患病率、发病率和风险比（HR）。采用I2评估异质性。普洛斯彼罗注册：CRD42024543050。结果：包含117,163例CP患者的16项研究符合入选标准。4015例（3.4%）患者发生了4019例EP癌。EP癌的总体年患病率和发病率为每10万CP患者7962例（95% CI 5044-10880），每10万人年1039例（95% CI 649-1663）。肺癌的年患病率最高（每10万CP患者中有1540例（95% CI 667-2413）），发病率最高（每10万人中有260例（95% CI 120-390））。与非CP患者相比，CP患者的校正肺癌和粗肝癌的总风险比分别为1.31 （95% CI 1.03-1.66）和1.58 （95% CI 1.27-1.98）。结论：与非CP患者相比，CP患者发生EP癌的风险增加，尤其是肺癌和肝癌的相对风险最高。共同的风险因素改变，如戒烟和减少饮酒，可以降低患常见EP癌的风险。此外，实施非侵入性筛查措施可能有助于这一高危人群的早期诊断。
Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis.
Introduction: Chronic pancreatitis (CP) is a known risk factor for pancreatic cancer; however its association to extra pancreatic (EP) cancers remains inadequately explored. The aim of this systematic review is to investigate the evidence for CP as a risk factor for developing EP cancers.
Method: Electronic search was conducted on Ovid Medline, EMBASE and Scopus from inception to January 27, 2024 to identify patients with CP who developed EP cancers. Prevalence and incidence of each cancer were calculated where possible from the reported numbers. A random effects meta-analysis was used to pool prevalence, incidence and hazard ratios (HR) of each EP cancer. Heterogeneity was assessed using I2. PROSPERO registration: CRD42024543050.
Results: Sixteen (16) studies consisting of 117,163 CP patients met the eligibility criteria. 4015 (3.4%) patients developed 4019 EP cancers. The overall annual prevalence and incidence of EP cancers were 7962 (95% CI 5044-10880) per 100,000 CP patients and 1039 (95% CI 649-1663) per 100,000 person years. Lung cancer had the highest annual prevalence - (1540 (95% CI 667-2413) per 100,000 CP patients) and incidence (260 (95% CI 120-390) per 100,000 person years). The pooled HR were 1.31 (95% CI 1.03-1.66) and 1.58 (95% CI 1.27-1.98) for adjusted lung cancer and crude liver cancer in patients with CP compared to patients without CP, respectively.
Conclusion: Patients with CP have an increased risk of developing EP cancers compared to patients without CP, in particular lung and liver cancer which had the highest relative risk. Shared risk factor modifications, such as smoking cessation and alcohol reduction, could lower the risk of common EP cancers. Further, implementing non-invasive screening measures may aid in early diagnosis in this high-risk group.
期刊介绍：
Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.
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