Parkinsonism & related disorders最新文献

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Subthalamic deep brain stimulation alleviates the gait sequence effect and freezing of gait in Parkinson's disease. 丘脑下深部脑刺激可缓解帕金森病的步态序列效应和步态冻结。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-21 DOI: 10.1016/j.parkreldis.2025.108062
Chuyi Cui, Goun Je, Kevin B Wilkins, Tilman Schulte, Helen M Bronte-Stewart
{"title":"Subthalamic deep brain stimulation alleviates the gait sequence effect and freezing of gait in Parkinson's disease.","authors":"Chuyi Cui, Goun Je, Kevin B Wilkins, Tilman Schulte, Helen M Bronte-Stewart","doi":"10.1016/j.parkreldis.2025.108062","DOIUrl":"10.1016/j.parkreldis.2025.108062","url":null,"abstract":"<p><strong>Background: </strong>The sequence effect in gait-progressive shortening of strides-contributes to freezing of gait (FOG), a debilitating symptom of Parkinson's disease (PD). The sequence effect is refractory to dopaminergic medications and attentional strategies, with improvement observed only through external cueing. While subthalamic nucleus (STN) deep brain stimulation (DBS) is a standard treatment for PD, its efficacy for gait and FOG remains debated.</p><p><strong>Objective: </strong>To characterize the sequence effect in spatiotemporal gait parameters in PD and to investigate the effects of STN-DBS.</p><p><strong>Methods: </strong>Eighteen individuals with PD with bilateral STN-DBS and fourteen age-matched healthy controls performed a harnessed Stepping-In-Place task, validated to elicit FOG. PD participants were assessed OFF and ON DBS in the off-medication state. Gait kinematics were measured using shank IMU sensors. The sequence effect was quantified by fitting an exponential decay function to each spatiotemporal gait parameter prior to freezing.</p><p><strong>Results: </strong>The sequence effect was evident in PD participants but not in healthy controls. It manifested as a progressive reduction in swing angular velocity and angular range over time, with variable trends in swing time. The severity of the sequence effect significantly correlated with percent time spent freezing off therapy (p < 0.001). STN-DBS significantly alleviated the sequence effect (p = 0.002) and reduced percent time freezing (p = 0.01).</p><p><strong>Conclusions: </strong>The Stepping-In-Place task elicited the sequence effect in PD, revealing progressive deterioration in both spatial and velocity aspects of gait, which contributed to the severity of FOG. STN-DBS effectively reduced the sequence effect, thereby improving FOG.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108062"},"PeriodicalIF":3.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-onset asymmetric pallido-pyramidal syndrome due to hereditary diffuse leukoencephalopathy with spheroids 遗传性弥漫性球状脑白质病引起的成人发病不对称苍白球锥体综合征
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-18 DOI: 10.1016/j.parkreldis.2025.108054
Arunmozhimaran Elavarasi , Jerry A. George , Hemlata Jangir , Mehar Chand Sharma , Charli Roy , Ajay Garg , Manjari Tripathi , Rajesh Kumar Singh , Deepti Vibha , Jasmine Parihar
{"title":"Adult-onset asymmetric pallido-pyramidal syndrome due to hereditary diffuse leukoencephalopathy with spheroids","authors":"Arunmozhimaran Elavarasi ,&nbsp;Jerry A. George ,&nbsp;Hemlata Jangir ,&nbsp;Mehar Chand Sharma ,&nbsp;Charli Roy ,&nbsp;Ajay Garg ,&nbsp;Manjari Tripathi ,&nbsp;Rajesh Kumar Singh ,&nbsp;Deepti Vibha ,&nbsp;Jasmine Parihar","doi":"10.1016/j.parkreldis.2025.108054","DOIUrl":"10.1016/j.parkreldis.2025.108054","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108054"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of subthalamic nucleus deep brain stimulation on speech metrics in Parkinson's disease 丘脑底核深部脑刺激对帕金森病患者言语指标的影响
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-17 DOI: 10.1016/j.parkreldis.2025.108053
Goun Je , Pranav Akella , Kevin B. Wilkins , Helen M. Bronte-Stewart
{"title":"The effect of subthalamic nucleus deep brain stimulation on speech metrics in Parkinson's disease","authors":"Goun Je ,&nbsp;Pranav Akella ,&nbsp;Kevin B. Wilkins ,&nbsp;Helen M. Bronte-Stewart","doi":"10.1016/j.parkreldis.2025.108053","DOIUrl":"10.1016/j.parkreldis.2025.108053","url":null,"abstract":"<div><h3>Background</h3><div>Speech impairment frequently occurs in Parkinson's disease (PD). The sequence effect, progressive deterioration in speed or amplitude of ongoing movement, is unique to PD and does not respond well to dopaminergic therapy. While subthalamic nucleus deep brain stimulation (STN DBS) can improve various motor symptoms in PD, its impact on speech and the speech sequence effect remains unclear. Here, we investigated the effects of STN DBS on speech metrics including the sequence effect in people with PD.</div></div><div><h3>Methods</h3><div>Fifteen individuals with PD who underwent bilateral STN DBS surgery participated in this study. We utilized the sustained phonation (SP) test and the diadochokinetic (DDK) test, which were performed under both OFF and ON stimulation conditions. Primary outcome measures included total SP duration, mean intensity, DDK rates, and the speech sequence effect.</div></div><div><h3>Results</h3><div>STN DBS significantly improved the duration of SP without altering mean intensity. It also improved the rate of DDK syllable production for /pa/. However, it did not significantly change the speech sequence effect.</div></div><div><h3>Conclusions</h3><div>These findings indicate that while STN DBS can enhance certain speech parameters, it does not significantly mitigate the speech sequence effect. Further studies incorporating more comprehensive and functional speech assessment are needed to better understand the broader impact of DBS on speech and guide personalized treatment strategies for speech impairment in PD.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108053"},"PeriodicalIF":3.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Misleading EEG in CACNA1A mutation: A case of late-onset episodic ataxia type 2. CACNA1A突变引起的脑电异常:迟发性发作性2型共济失调1例。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-16 DOI: 10.1016/j.parkreldis.2025.108051
Yoon Seob Kim, Tae-Joon Kim, Jung Han Yoon, Don Gueu Park
{"title":"Misleading EEG in CACNA1A mutation: A case of late-onset episodic ataxia type 2.","authors":"Yoon Seob Kim, Tae-Joon Kim, Jung Han Yoon, Don Gueu Park","doi":"10.1016/j.parkreldis.2025.108051","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.108051","url":null,"abstract":"<p><strong>Background: </strong>Episodic ataxia type 2 (EA2) is a rare, autosomal dominant paroxysmal neurological disorder caused by mutations in the CACNA1A gene. Its hallmark features include transient episodes of ataxia and dysarthria, often responsive to acetazolamide. However, misdiagnosis as epilepsy may occur due to overlapping electroencephalographic findings.</p><p><strong>Case presentation: </strong>We report a 64-year-old woman with no prior history nor family history of neurological illness, who developed daily episodes of dysarthria and ataxic gait. Brain MRI did not show definite signs of cerebellar atrophy. Interictal EEG demonstrated sharp waves in the left temporal region, initially leading to a diagnosis of focal epilepsy. Despite trials of multiple antiseizure medications, symptoms worsened. Subsequent ictal EEG and SPECT showed no definitive seizure activity or clinical correlation. Genetic testing identified a heterozygous CACNA1A splice site variant (NM_001127222.2: c.2280-2A > T), confirming EA2. Tapering of antiseizure therapy and initiation of acetazolamide resulted in sustained symptom resolution.</p><p><strong>Discussion: </strong>This case underscores the diagnostic challenge posed by interictal EEG abnormalities in CACNA1A-related disorders. While such findings may suggest epilepsy, they can be misleading in the absence of clinical epileptic seizures. Recognition of EA2 and judicious use of genetic testing facilitated accurate diagnosis and effective treatment. Clinicians should be cautious in interpreting EEG in patients with paroxysmal neurologic symptoms and prioritize clinical correlation to avoid inappropriate therapy.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108051"},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lingual-masticatory myorhythmia and palatal tremor as a presentation of anti-IgLON5 disease 抗iglon5疾病表现为舌咀嚼律动和腭颤
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-15 DOI: 10.1016/j.parkreldis.2025.108039
Ren-Ying Wu , Tsung-Lin Lee , Cheng-Chi Hsieh , Chung-Yao Chien , Yuan-Ting Sun
{"title":"Lingual-masticatory myorhythmia and palatal tremor as a presentation of anti-IgLON5 disease","authors":"Ren-Ying Wu ,&nbsp;Tsung-Lin Lee ,&nbsp;Cheng-Chi Hsieh ,&nbsp;Chung-Yao Chien ,&nbsp;Yuan-Ting Sun","doi":"10.1016/j.parkreldis.2025.108039","DOIUrl":"10.1016/j.parkreldis.2025.108039","url":null,"abstract":"<div><div>Anti-IgLON5 disease is a progressive neurological disorder at the intersection of autoimmunity and neurodegeneration, with an increasingly recognized and heterogeneous clinical spectrum. While movement disorders such as chorea and parkinsonism have been reported, myorhythmia remains a rare manifestation. We describe a case of anti-IgLON5 disease presenting with characteristic lingual-masticatory myorhythmia and palatal tremor, which responded favorably to immunotherapy. This case underscores the diagnostic value of these uncommon movement phenomena and highlights their potential reversibility with timely immunosuppressive treatment.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108039"},"PeriodicalIF":3.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased cerebral ATP in pre-motor manifest Huntington's disease: A pilot study 运动前显性亨廷顿病的脑ATP减少:一项初步研究
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-15 DOI: 10.1016/j.parkreldis.2025.108040
Lindsay E. Golden , Jia Xu , Vincent A. Magnotta , Peg C. Nopoulos , Jordan L. Schultz
{"title":"Decreased cerebral ATP in pre-motor manifest Huntington's disease: A pilot study","authors":"Lindsay E. Golden ,&nbsp;Jia Xu ,&nbsp;Vincent A. Magnotta ,&nbsp;Peg C. Nopoulos ,&nbsp;Jordan L. Schultz","doi":"10.1016/j.parkreldis.2025.108040","DOIUrl":"10.1016/j.parkreldis.2025.108040","url":null,"abstract":"<div><h3>Background</h3><div>Huntington's Disease (HD) is characterized by brain metabolic dysfunction, but no studies to date have directly measured cerebral ATP levels in patients with HD.</div></div><div><h3>Objective</h3><div>To compare cerebral ATP between individuals with pre-motor-manifest HD (preHD) and healthy controls (HC).</div></div><div><h3>Methods</h3><div>Cerebral ATP was quantified using <sup>31</sup>Phosphorous Magnetic Resonance Spectroscopy (<sup>31</sup>P-MRS) at 7T in nine preHD subjects and nine HC subjects. Analysis of Covariance models were constructed to compare mean ATP signal (corrected by whole brain volume) between groups after adjusting for age and BMI.</div></div><div><h3>Results</h3><div>PreHD participants exhibited significantly lower total ATP compared to HCs; furthermore, preHD subjects with higher clinical burden of disease had lower ATP levels. Amongst the preHD subjects, lower ATP levels were associated with worsening composite Unified Huntington's Disease Rating Scale scores.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the potential of <sup>31</sup>P-MRS to serve as a direct assay for metabolic dysfunction in HD.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108040"},"PeriodicalIF":3.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of hospitalized patients with restless legs syndrome in Hawaiʻi by race/ethnicity 夏威夷不宁腿综合征住院患者的种族/民族特征
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-15 DOI: 10.1016/j.parkreldis.2025.108038
Lauren A. Terpak , Brooke Yasuda , Masako Matsunaga , Emma Krening , Michiko Kimura Bruno
{"title":"Characteristics of hospitalized patients with restless legs syndrome in Hawaiʻi by race/ethnicity","authors":"Lauren A. Terpak ,&nbsp;Brooke Yasuda ,&nbsp;Masako Matsunaga ,&nbsp;Emma Krening ,&nbsp;Michiko Kimura Bruno","doi":"10.1016/j.parkreldis.2025.108038","DOIUrl":"10.1016/j.parkreldis.2025.108038","url":null,"abstract":"<div><h3>Introduction</h3><div>Restless legs syndrome (RLS) patient characteristics have not been adequately studied across racial/ethnic groups, including Native Hawaiians and Pacific Islanders (NHPI) and Asian Americans (AA). The goal of this study was to determine if differences exist among NHPI and AA subgroups, and Whites who were hospitalized with RLS in the state of Hawaiʻi.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study using hospital discharge records (2016–2023) from the state of Hawaiʻi statewide registry was conducted. Patients with RLS were identified by the ICD 10 code G25.98. Patient's characteristics across racial/ethnic groups were examined by bivariate analysis with Kruskal-Wallis rank sum tests, Pearson's chi-square tests, and Fisher's exact tests.</div></div><div><h3>Results</h3><div>We identified 1624 inpatients with RLS. White (48 %) was the largest group, followed by Japanese (15 %), NHPI (15 %), Other (14 %), and Filipino (8 %). Bivariate analysis found differences in age groups, where NHPI were younger (<em>p</em> &lt; 0.001), and with higher proportion of admission with diabetes (<em>p</em> &lt; 0.001) and pregnancy (<em>p</em> = 0.02). Filipino had a significantly higher proportion of patients with a non-English primary language (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Genetic predisposition, comorbidities, and socioeconomic factors may contribute to differences in RLS characteristics among NHPI, AA, and White patients.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108038"},"PeriodicalIF":3.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and functional analysis of KIF5A related spastic paraplegia type 10 KIF5A相关痉挛性截瘫10型临床及功能分析
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-08 DOI: 10.1016/j.parkreldis.2025.108026
Wotu Tian , Li Yao , Yuwen Cao , Yang He , Chenyuan Yan , Li Cao
{"title":"Clinical and functional analysis of KIF5A related spastic paraplegia type 10","authors":"Wotu Tian ,&nbsp;Li Yao ,&nbsp;Yuwen Cao ,&nbsp;Yang He ,&nbsp;Chenyuan Yan ,&nbsp;Li Cao","doi":"10.1016/j.parkreldis.2025.108026","DOIUrl":"10.1016/j.parkreldis.2025.108026","url":null,"abstract":"<div><h3>Purpose</h3><div>We aim to summarize the clinical and genetic features of five patients with <em>KIF5A</em> variants and explore genotype-phenotype correlations alongside a functional analysis of these mutations.</div></div><div><h3>Methods</h3><div>Detailed clinical data of five unrelated SPG10 patients were collected, including clinical symptoms, family history, physical examinations, brain and spinal MRI, electrophysiological examinations, etc. <em>KIF5A</em> variants were identified by whole exome sequencing, followed by Sanger sequencing, family co-segregation, and phenotypic reevaluation. Moreover, we also performed functional studies of each identified variant.</div></div><div><h3>Results</h3><div>All five probands were male, among whom one presented with pure form, and the other four with complicated form, including sensory ataxia, cognitive impairment, and peripheral neuropathy. Five heterozygous <em>KIF5A</em> mutations were identified, including c.446-2A &gt; G, c.593T &gt; C (p.Met198Thr), c.611G &gt; A (p.Arg204Gln), c.614G &gt; A (p.Ser205Asn), and c.838C &gt; T (p.Arg280Cys). Among these, c.446-2A &gt; G and c.614G &gt; A (p.Ser205Asn) were newly reported. In vitro, c.446-2A &gt; G destroyed the original donor site, leading to either 8bp deletion upstream of Exon6 (c.446_453del, p.V149Dfs∗20<u>)</u> or Exon 6 skipping (c.446_501del, p.V149Gfs∗4), thus generating two various truncated mutant forms with 167 and 151 amino acids, respectively. The two mutants had less molecular weight and reduced protein expression level, which also lost colocalization with α‐tubulin. Another four missense mutations, with normal mRNA and protein expression levels, lost colocalization with α‐tubulin in subcellular location.</div></div><div><h3>Conclusion</h3><div>We identified five <em>KIF5A</em> mutations with different phenotypes: the classic SPG symptoms with foot deformity, and complicated phenotype with sensory ataxia or peripheral neuropathy. Furthermore, we proved that KIF5A haploinsufficiency and abnormal subcellular location are associated with SPG10.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108026"},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies 伏多巴替尼在伴路易体痴呆患者中的安全性、耐受性和潜在生物标志物
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-07 DOI: 10.1016/j.parkreldis.2025.108020
Fernando L. Pagan , Yasar Torres-Yaghi , Michaeline L. Hebron , Barbara Wilmarth , Xiaoguang Liu , Jaeil Ahn , Charbel Moussa
{"title":"Safety, tolerability and potential biomarkers of vodobatinib in patients with dementia with Lewy bodies","authors":"Fernando L. Pagan ,&nbsp;Yasar Torres-Yaghi ,&nbsp;Michaeline L. Hebron ,&nbsp;Barbara Wilmarth ,&nbsp;Xiaoguang Liu ,&nbsp;Jaeil Ahn ,&nbsp;Charbel Moussa","doi":"10.1016/j.parkreldis.2025.108020","DOIUrl":"10.1016/j.parkreldis.2025.108020","url":null,"abstract":"<div><h3>Introduction</h3><div>Activation of the tyrosine kinase Abelson (Abl) was suggested in the pathogenesis of neurodegenerative diseases. We investigated the effects of a potent and highly specific Abl kinase inhibitor vodobatinib (K0706) in patients diagnosed with dementia with Lewy bodies (DLB). We determined safety, tolerability and potential biomarkers following oral administration of vodobatinib versus placebo in DLB patients.</div></div><div><h3>Methods</h3><div>Participants were randomized 1:1:1 into vodobatinib 192 mg, or 384 mg or matching placebo in a single-center, double-blind study. Study drug was taken orally once daily for 3 months followed by one-month wash-out.</div></div><div><h3>Results</h3><div>Twenty-nine individuals were enrolled, 3 were women (10.3 %), age 76.3 ± 6 years (mean ± SD). Vodobatinib was safe and well-tolerated and more adverse events were noted in the placebo (56) vs vodobatinib 192 mg (19) or 384 mg (6) groups. The number of falls were reduced in the vodobatinib 192 mg (6) and 384 mg (0) compared to placebo (28) groups. The only potential significant change in cerebrospinal fluid (CSF) biomarkers was Aβ42/Aβ40 in 192 mg vodobatinib (p = 0.0002) and 384 mg (0.0121) compared to placebo. There was no change in homovanillic acid, a biomarker of dopamine level, or other potential CSF and plasma biomarkers of DLB. Exploratory clinical outcomes were not different between baseline and 3 months in vodobatinib compared to placebo.</div></div><div><h3>Conclusions</h3><div>Vodobatinib appears to be safe and tolerated, but larger trials and longer treatment periods are needed to determine its effects on biomarkers and clinical outcomes.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"140 ","pages":"Article 108020"},"PeriodicalIF":3.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A whiff and a dream: Hyposmia and REM sleep behavior disorder manifestations map Parkinson's disease subtypes. 一种气味和一个梦:低睡眠和快速眼动睡眠行为障碍的表现映射帕金森病亚型。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2025-09-06 DOI: 10.1016/j.parkreldis.2025.108016
Daniel Teixeira-Dos-Santos, Artur Francisco Schumacher Schuh, Hubert H Fernandez
{"title":"A whiff and a dream: Hyposmia and REM sleep behavior disorder manifestations map Parkinson's disease subtypes.","authors":"Daniel Teixeira-Dos-Santos, Artur Francisco Schumacher Schuh, Hubert H Fernandez","doi":"10.1016/j.parkreldis.2025.108016","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.108016","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108016"},"PeriodicalIF":3.4,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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