发布求助
文献互助 智能选刊 最新文献

Parkinsonism & related disorders最新文献

筛选
英文 中文
A diagnostic blind spot in late-onset ataxia: missed FGF14 repeat expansion after negative genome sequencing and the risk of forced diagnostic unification. 迟发性共济失调的诊断盲点：阴性基因组测序后遗漏FGF14重复扩增和强制诊断统一的风险
IF 4.3 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-10 DOI: 10.1016/j.parkreldis.2026.108379
Jacob Mistry, Mihaela Boca
{"title":"A diagnostic blind spot in late-onset ataxia: missed FGF14 repeat expansion after negative genome sequencing and the risk of forced diagnostic unification.","authors":"Jacob Mistry, Mihaela Boca","doi":"10.1016/j.parkreldis.2026.108379","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2026.108379","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108379"},"PeriodicalIF":4.3,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of deprescribing anticholinergics in Parkinson's disease care 抗胆碱能药物在帕金森病治疗中的重要性
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.parkreldis.2026.108224
Benjamin K.P. Woo , Jamie O.P. Chung
{"title":"The importance of deprescribing anticholinergics in Parkinson's disease care","authors":"Benjamin K.P. Woo , Jamie O.P. Chung","doi":"10.1016/j.parkreldis.2026.108224","DOIUrl":"10.1016/j.parkreldis.2026.108224","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108224"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia 血浆细胞外小泡的转录组学分析确定了帕金森病痴呆的潜在诊断生物标志物。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-01-30 DOI: 10.1016/j.parkreldis.2026.108225
Miyuki Imazawa
{"title":"Reply to: Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia","authors":"Miyuki Imazawa","doi":"10.1016/j.parkreldis.2026.108225","DOIUrl":"10.1016/j.parkreldis.2026.108225","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108225"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding microlesion and cognitive interactions in STN-DBS: A clinical perspective 从临床角度理解STN-DBS的微损伤和认知相互作用。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-03-02 DOI: 10.1016/j.parkreldis.2026.108257
Halil Onder, Seyma Tazegul, Ismet Melek
{"title":"Understanding microlesion and cognitive interactions in STN-DBS: A clinical perspective","authors":"Halil Onder, Seyma Tazegul, Ismet Melek","doi":"10.1016/j.parkreldis.2026.108257","DOIUrl":"10.1016/j.parkreldis.2026.108257","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108257"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert commentary on “A novel homozygous SQSTM1 frameshift variant in a Filipino adolescent with childhood-onset ataxia and gaze palsy” 专家评论“一种新的纯合子SQSTM1移码变异在菲律宾青少年儿童期发病共济失调和凝视性麻痹”。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-04-16 DOI: 10.1016/j.parkreldis.2026.108328
Shekeeb S. Mohammad , Hugo Morales-Briceno
{"title":"Expert commentary on “A novel homozygous SQSTM1 frameshift variant in a Filipino adolescent with childhood-onset ataxia and gaze palsy”","authors":"Shekeeb S. Mohammad , Hugo Morales-Briceno","doi":"10.1016/j.parkreldis.2026.108328","DOIUrl":"10.1016/j.parkreldis.2026.108328","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108328"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert comment for “Myoclonus-dystonia due to novel mutation in the guanine nucleotide-binding protein (GNB1) gene” 专家点评“鸟嘌呤核苷酸结合蛋白（GNB1）基因突变引起的肌收缩-肌张力障碍”。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-04-27 DOI: 10.1016/j.parkreldis.2026.108338
Patricia de Carvalho Aguiar
{"title":"Expert comment for “Myoclonus-dystonia due to novel mutation in the guanine nucleotide-binding protein (GNB1) gene”","authors":"Patricia de Carvalho Aguiar","doi":"10.1016/j.parkreldis.2026.108338","DOIUrl":"10.1016/j.parkreldis.2026.108338","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108338"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myoclonus-dystonia due to novel mutation in the guanine nucleotide-binding protein (GNB1) gene 鸟嘌呤核苷酸结合蛋白（GNB1）基因突变引起的肌阵挛-肌张力障碍。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2025-04-07 DOI: 10.1016/j.parkreldis.2025.107822
Duncan Street , Lara Teare , Tanya Georgieva , Jenna Ridley , Suzanne Broadgate , Penny Clouston , Mary O'Driscoll
{"title":"Myoclonus-dystonia due to novel mutation in the guanine nucleotide-binding protein (GNB1) gene","authors":"Duncan Street , Lara Teare , Tanya Georgieva , Jenna Ridley , Suzanne Broadgate , Penny Clouston , Mary O'Driscoll","doi":"10.1016/j.parkreldis.2025.107822","DOIUrl":"10.1016/j.parkreldis.2025.107822","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 107822"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of beta-amyloid and tau proteins on cognitive changes in Parkinson's disease β -淀粉样蛋白和tau蛋白对帕金森病认知变化的影响。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-04-24 DOI: 10.1016/j.parkreldis.2026.108332
Berit Abraham , Sophia Carl , Lan Ye , Florian Wegner , Matthias Höllerhage , Martin Schulze Westhoff , Felix Konen , Ishana V. Schneidereit , Thomas Skripuletz , Martin Klietz
{"title":"The influence of beta-amyloid and tau proteins on cognitive changes in Parkinson's disease","authors":"Berit Abraham ,&nbsp;Sophia Carl ,&nbsp;Lan Ye ,&nbsp;Florian Wegner ,&nbsp;Matthias Höllerhage ,&nbsp;Martin Schulze Westhoff ,&nbsp;Felix Konen ,&nbsp;Ishana V. Schneidereit ,&nbsp;Thomas Skripuletz ,&nbsp;Martin Klietz","doi":"10.1016/j.parkreldis.2026.108332","DOIUrl":"10.1016/j.parkreldis.2026.108332","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's dementia (AD), characterized by both motor and non-motor symptoms. Cognitive impairment is frequent and can progress to dementia. Early detection of cognitive dysfunction and timely intervention are crucial for maintaining quality of life. Identifying prognostic biomarkers for cognitive impairment therefore remains a key subject in PD research.</div></div><div><h3>Objective</h3><div>This literature review examines the prognostic value of AD-associated cerebrospinal fluid (CSF) biomarkers (beta-amyloid 1-42, beta-amyloid 1-40, total tau, and phosphorylated tau) in relation to cognitive impairment in patients with PD.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed. Inclusion criteria required a formal diagnosis of PD, CSF analysis as well as cognitive testing. Studies without longitudinal data were excluded.</div></div><div><h3>Results</h3><div>18 studies met the inclusion criteria, 11 of which utilized data from the Parkinson's Progression Markers Initiative (PPMI). Several studies demonstrated that lower CSF beta-amyloid 1-42 (Aβ42) levels and lower Aβ42:40 ratios were associated with faster cognitive decline. Findings for total tau and phosphorylated tau were inconsistent.</div></div><div><h3>Conclusion</h3><div>Aβ and tau proteins show potential as biomarkers for cognitive decline in PD, but current evidence is insufficient to support their clinical use. Inconsistencies across studies, methodological variability and short follow-up periods limit their predictive value. Future research should include larger cohorts, standardized cognitive testing and extended follow-up periods to clarify their role.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108332"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential gait disturbances in patients with Parkinson's disease and normal pressure hydrocephalus 帕金森病和常压性脑积水患者的不同步态障碍
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2025-10-10 DOI: 10.1016/j.parkreldis.2025.108081
Carolin Semmler , Veronika Wunderle , Taylan D. Kuzu , Oezguer A. Onur , Christian Grefkes , Gereon R. Fink , Michael T. Barbe , Peter H. Weiss
{"title":"Differential gait disturbances in patients with Parkinson's disease and normal pressure hydrocephalus","authors":"Carolin Semmler ,&nbsp;Veronika Wunderle ,&nbsp;Taylan D. Kuzu ,&nbsp;Oezguer A. Onur ,&nbsp;Christian Grefkes ,&nbsp;Gereon R. Fink ,&nbsp;Michael T. Barbe ,&nbsp;Peter H. Weiss","doi":"10.1016/j.parkreldis.2025.108081","DOIUrl":"10.1016/j.parkreldis.2025.108081","url":null,"abstract":"<div><h3>Introduction</h3><div>Gait disturbances are a key symptom in normal pressure hydrocephalus (NPH) and Parkinson's disease (PD). We employed instrument-supported gait analysis to characterize commonalities and differences in gait patterns among PD and NPH patients, as well as gait changes following disease-specific interventions (i.e., spinal tap and dopaminergic medication).</div></div><div><h3>Methods</h3><div>Gait and balance analyses were conducted i) before and after NPH patients (n = 19) received a spinal tap, and ii) before and after PD patients (n = 19) received soluble dopaminergic medication. Change scores were calculated relative to each patient's baseline performance. Group differences were analyzed using independent sample t-tests or Mann-Whitney U tests and within-group changes using paired sample t-tests or Wilcoxon signed-rank tests.</div></div><div><h3>Results</h3><div>Static postural control (i.e., balance) did not differ between patient groups, but dynamic postural control did, with PD patients showing significantly reduced mediolateral sway and gait width compared to NPH patients. These parameters did not change after disease-specific interventions. For gait dynamics, PD patients demonstrated significantly higher values in pace and force parameters, which improved significantly in both groups following intervention. Finally, gait regularity showed lower variability and better rhythm-related parameters in PD patients compared to NPH patients, along with differential changes after interventions.</div></div><div><h3>Conclusion</h3><div>Except for static postural control (i.e., balance), instrument-supported gait analysis revealed several characteristic gait differences between PD and NPH patients. Variability and rhythm, reflecting gait regularity, were best suited to differentiate gait disturbances in patients with PD and NPH.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108081"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the heterogeneity of infection-related movement disorders: A call for a mechanism-based classification 揭示感染相关运动障碍的异质性：呼吁基于机制的分类。
IF 3.4 3区 医学
Parkinsonism & related disorders Pub Date : 2026-06-01 Epub Date: 2026-01-05 DOI: 10.1016/j.parkreldis.2026.108180
Yusa Pan , Tiantian Zhang , Chao Zhang
{"title":"Unraveling the heterogeneity of infection-related movement disorders: A call for a mechanism-based classification","authors":"Yusa Pan ,&nbsp;Tiantian Zhang ,&nbsp;Chao Zhang","doi":"10.1016/j.parkreldis.2026.108180","DOIUrl":"10.1016/j.parkreldis.2026.108180","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"147 ","pages":"Article 108180"},"PeriodicalIF":3.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书