Parkinsonism & related disorders最新文献

{"title":"Regional gray matter volumes are not predictive of axial symptom response to subthalamic deep brain stimulation in Parkinsonian patients","authors":"Annika Peter ,&nbsp;Marvin Petersen ,&nbsp;Pawel Wrobel ,&nbsp;Frederik Schott ,&nbsp;Alessandro Gulberti ,&nbsp;Tim Magnus ,&nbsp;Goetz Thomalla ,&nbsp;Bastian Cheng ,&nbsp;Monika Pötter-Nerger","doi":"10.1016/j.parkreldis.2024.107193","DOIUrl":"10.1016/j.parkreldis.2024.107193","url":null,"abstract":"<div><h3>Introduction</h3><div>In Parkinson's disease (PD), axial symptom response to deep brain stimulation of the subthalamic nucleus (STN-DBS) is heterogeneous. This single-center, retrospective study aimed to assess imaging biomarkers of routine magnetic resonance imaging (MRI) to predict axial symptom response to STN-DBS, specifically by using an index of volumes of mesencephalon, pons, middle, and superior peduncle (“MR PIGD index”).</div></div><div><h3>Methods</h3><div>We investigated 94 PD patients pre- and three to six months postoperatively by using MDS-UPDRS III, Berg Balance Scale, Freezing of Gait Questionnaire (FOG-Q) and Ziegler Course, which were related to regional brain volumetry information using regression analysis and partial least squares correlation analysis.</div></div><div><h3>Results</h3><div>STN-DBS led to significant, but heterogeneous improvement of axial PD symptoms. Neither the MR PIGD index nor other cortical brain volumes predicted the extent of the postoperative, axial symptom improvement.</div></div><div><h3>Conclusions</h3><div>Response to STN-DBS in PD cannot be predicted by MRI regional gray matter volumes.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107193"},"PeriodicalIF":3.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical progression of Parkinson's disease in the early 21st century: Insights from the accelerating medicine partnership (AMP-PD) data","authors":"Mechelle M. Lewis ,&nbsp;Richard B. Mailman ,&nbsp;Xinyi Vivian Cheng ,&nbsp;Guangwei Du ,&nbsp;Lijun Zhang ,&nbsp;Changcheng Li ,&nbsp;Sol De Jesus ,&nbsp;Samer D. Tabbal ,&nbsp;Runze Li ,&nbsp;Xuemei Huang","doi":"10.1016/j.parkreldis.2024.107186","DOIUrl":"10.1016/j.parkreldis.2024.107186","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) therapeutic strategies have evolved since levodopa introduction in mid 1900s. To understand their impact and research gaps, this study delineated the clinical progression of PD in recent years.</div></div><div><h3>Methods</h3><div>Using Accelerating Medicine Partnership-PD (AMP-PD) data harmonized from seven biomarker discovery studies (2010–2020), we extracted: overall [Schwab and England (S&amp;E), PD Questionnaire (PDQ-39)]; motor [Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS)-II and -III and Hoehn &amp; Yahr (HY)]; and non-motor [MDS-UPDRS-I, University of Pennsylvania Smell Identification Test (UPSIT), Montreal Cognitive Assessment (MoCA), and Epworth Sleepiness Scale (ESS)] scores. Age at diagnosis was set as 0 years, and data were tracked for 15 subsequent years.</div></div><div><h3>Results</h3><div>Among 3001 PD cases identified to be suitable for this study, 2838 are white, 1843 are males, with a mean age at diagnosis was 60.2 ± 10.3 years. At baseline evaluation, the disease duration was 9.9 ± 6.0 years overall, 1915 within 0–5, 541 with 6–10, 254 within 11–15, and 163 greater than 15 years. Participants largely reported independence (S&amp;E, 5y: 86.6 ± 12.3; 10y: 78.9 ± 19.3; 15y: 78.5 ± 17.0) and good quality of life (PDQ-39, 5y: 15.5 ± 12.3; 10y: 22.1 ± 15.8; 15y: 24.3 ± 14.4). Motor scores displayed a linear progression, whereas non-motor scores plateaued ∼10–15 years. Younger onset age and female correlated with slower progression.</div></div><div><h3>Conclusions</h3><div>Twenty-first century PD patients remain largely independent in the first decade of disease at tertiary subspecialty care and research centers. There are data gaps for those who are non-whites or longer PD duration, and sensible metrics that can gauge non-motor progression when PD is beyond 10 years.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107186"},"PeriodicalIF":3.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No trend to rising rates: A review of Parkinson's prevalence studies in the United Kingdom","authors":"","doi":"10.1016/j.parkreldis.2024.107015","DOIUrl":"10.1016/j.parkreldis.2024.107015","url":null,"abstract":"<div><h3>Background</h3><div>Of the neurodegenerative diseases, Parkinson's disease is recognised to have the fastest growing prevalence. It is unclear whether this is due to the ageing global population alone, with several environmental factors increasingly implicated in changing prevalence rates. Large data sets have been used nationally and globally to help predict future disease burden. However, the reliability of such sources is yet unknown for Parkinson's disease.</div></div><div><h3>Summary</h3><div>This review discusses the methods used in all published UK prevalence studies conducted to date. Direct comparison between prevalence figures obtained from the 10 to discussed prevalence studies is precluded due to differences in methodology for case ascertainment and diagnosis. Age adjusted estimates vary from 105/100,000 to 168/100,000.</div></div><div><h3>Key messages</h3><div>These studies demonstrate no overall trend in changing prevalence figures between 1961 and 2007. No difference in prevalence trends were seen for those living in rural or urban areas. Differences between ethnic groups, for example, remains an under explored area.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107015"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmortem evaluation of the striatum in an NTCELL trial participant five years after transplantation","authors":"Thulani H. Palpagama ,&nbsp;Clinton P. Turner ,&nbsp;Victoria F. Low ,&nbsp;Richard LM. Faull ,&nbsp;Maurice A. Curtis ,&nbsp;Barry Snow","doi":"10.1016/j.parkreldis.2024.107192","DOIUrl":"10.1016/j.parkreldis.2024.107192","url":null,"abstract":"<div><div>In 2017 a novel growth factor administration therapy (termed NTCELL®) was trialled for safety and efficacy for Parkinson's disease treatment. NTCELL® administration is the transplantation of encapsulated porcine choroid plexus cells into the putamen. A clinical study demonstrated safety but failed to meet its primary clinical end-point. Here we describe the clinical and neuropathological characteristics of a case who died five years after receiving NTCELL® treatment. Using histochemical and immunohistochemical labelling, we demonstrate that the NTCELL® capsules remain in the striatum but are mainly devoid of cellular contents. A similar pattern of astrogliosis and microgliosis surrounds the capsule placement area to those surrounding the needle track for implanting the capsules. This study is important as it is the first exploration of the long-term clinical and anatomical outcomes of the NTCELL® clinical trial. The results of this study will help inform future studies aimed at regenerating neurons through the implantation of capsules.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107192"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential tremor as a prodromal feature of Parkinson's disease","authors":"Abdullah Yasir Yilmaz,&nbsp;Joseph Jankovic","doi":"10.1016/j.parkreldis.2024.107128","DOIUrl":"10.1016/j.parkreldis.2024.107128","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107128"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric parkinsonism: In-depth clinical definition and semeiology","authors":"Vincenzo Leuzzi,&nbsp;Maria Novelli,&nbsp;Ivana Paparella,&nbsp;Serena Galosi","doi":"10.1016/j.parkreldis.2024.107148","DOIUrl":"10.1016/j.parkreldis.2024.107148","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107148"},"PeriodicalIF":3.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population","authors":"Kajsa Atterling Brolin ,&nbsp;David Bäckström ,&nbsp;Joel Wallenius ,&nbsp;Ziv Gan-Or ,&nbsp;Andreas Puschmann ,&nbsp;Oskar Hansson ,&nbsp;Maria Swanberg","doi":"10.1016/j.parkreldis.2024.107191","DOIUrl":"10.1016/j.parkreldis.2024.107191","url":null,"abstract":"<div><div>Variants in <em>GBA1</em> are important genetic risk factors in Parkinson's disease (PD). <em>GBA1</em> T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of <em>GBA1</em> variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107191"},"PeriodicalIF":3.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Differences in progressive supranuclear palsy in patients of Asian ancestry? PARKRELDIS-D-24-01057.","authors":"Blas Couto, Maria Carmela Tartaglia, Gabor G Kovacs, Anthony E Lang","doi":"10.1016/j.parkreldis.2024.107179","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107179","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107179"},"PeriodicalIF":3.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a machine learning-based diagnostic model for Parkinson's disease in community-dwelling populations: Evidence from the China health and retirement longitudinal study (CHARLS)","authors":"Hongyang Fan ,&nbsp;Sai Li ,&nbsp;Xin Guo ,&nbsp;Min Chen ,&nbsp;Honggao Zhang ,&nbsp;Yingzhu Chen","doi":"10.1016/j.parkreldis.2024.107182","DOIUrl":"10.1016/j.parkreldis.2024.107182","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is a major neurodegenerative disorder in Middle-aged and elderly people.There is a pressing need for effective predictive models, particularly in chinese population. Objective:This study aims to develop and validate a machine learning-based diagnostic model to identify individuals with PD in community-dwelling populations using data from the China Health and Retirement Longitudinal Study (CHARLS).</div></div><div><h3>Methods</h3><div>We utilized data from 19,134 individuals aged 45 and above from the CHARLS dataset, with 265 adults reported to have PD. The external validation cohort included 1500 individuals, with 21 (1.4 %) having PD.The random forest (RF) algorithm was used to develop an interpretable PD prediction model, which was internally validated using 10-fold cross-validation and externally validated with a dataset from Northern Jiangsu People's Hospital. SHapley Additive exPlanation (SHAP) values were employed to elucidate the model's predictions.</div></div><div><h3>Results</h3><div>The RF model demonstrated robust performance with an Area Under the Curve (AUC) of 0.884 and high sensitivity, specificity, and F1 scores. The model's performance in external validation cohort, highlighting an AUC of 0.82 and an accuracy of 0.99. The model's performance remained consistent across internal and external validation cohorts. SHAP analysis provided insights into the importance and interaction of various predictors, enhancing model interpretability.</div></div><div><h3>Conclusion</h3><div>The study presents a highly accurate and interpretable machine learning-based diagnostic model to identify individuals with PD in middle-aged and older Chinese adults. By combined with predictive risk factors and chronic disease information, the model offers valuable insights for early identification and intervention, potentially mitigating PD progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107182"},"PeriodicalIF":3.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinocerebellar ataxia type 49 presenting with ataxia, early onset dystonia, and bradykinesia in an Indian female patient","authors":"Divyani Garg,&nbsp;Pooja Sharma,&nbsp;Mohammed Faruq,&nbsp;Ayush Agarwal,&nbsp;Ajay Garg,&nbsp;S.B. Punith,&nbsp;S. Sidharth,&nbsp;Achal Kumar Srivastava","doi":"10.1016/j.parkreldis.2024.107188","DOIUrl":"10.1016/j.parkreldis.2024.107188","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107188"},"PeriodicalIF":3.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}