Parkinsonism & related disorders最新文献

{"title":"Speech-in-noise hearing impairment is associated with increased risk of Parkinson's: A UK biobank analysis","authors":"Megan Rose Readman ,&nbsp;Yang Wang ,&nbsp;Fang Wan ,&nbsp;Ian Fairman ,&nbsp;Sally A. Linkenauger ,&nbsp;Trevor J. Crawford ,&nbsp;Christopher J. Plack","doi":"10.1016/j.parkreldis.2024.107219","DOIUrl":"10.1016/j.parkreldis.2024.107219","url":null,"abstract":"<div><h3>Background</h3><div>Hearing impairment is implicated as a risk factor for Parkinson's disease (Parkinson's) incidence, with evidence suggesting that clinically diagnosed hearing loss increases Parkinson's risk 1.5–1.6 fold over 2–5 years follow up. However, the evidence is not unanimous with additional studies observing that self-reported hearing capabilities do not significantly influence Parkinson's incidence. Thus, additional cohort analyses that draw on alternative auditory measures are required to further corroborate the link between Parkinson's and hearing impairment.</div></div><div><h3>Objectives</h3><div>To determine whether hearing impairment, estimated using a speech-in-noise test (the Digit Triplet Test, DTT), is a risk factor for Parkinson's incidence.</div></div><div><h3>Methods</h3><div>This was a pre-registered prospective cohort study using data from the UK Biobank. Data pertaining to 159,395 individuals, who underwent DTT testing and were free from Parkinson's at the point of assessment, were analysed. A Cox Proportional Hazard model, controlling for age, sex and educational attainment was conducted.</div></div><div><h3>Results</h3><div>During a median follow up of 14.24 years, 810 cases of probable Parkinson's were observed. The risk of incident Parkinson's increased with baseline hearing impairment [hazard ratio: 1.57 (95%CI: 1.018, 2.435; <em>P</em> = .041)], indicating 57 % increase in risk for every 10 dB increase in speech-reception threshold (SRT). However, when hearing impairment was categorised in accordance with UK Biobank SRT norms neither ‘Insufficient’ nor ‘Poor’ hearing significantly influenced Parkinson's risk compared to ‘Normal’ hearing.</div></div><div><h3>Conclusions</h3><div>The congruence of these findings with prior research further supports the existence of a relationship between hearing impairment and Parkinson's incidence.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"131 ","pages":"Article 107219"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression-based thresholds to detect clinical changes in verbal fluency after STN-DBS in Parkinson's disease","authors":"Francesca Mameli ,&nbsp;Edoardo Nicolò Aiello ,&nbsp;Fabiana Ruggiero ,&nbsp;Eleonora Zirone ,&nbsp;Linda Borellini ,&nbsp;Filippo Cogiamanian ,&nbsp;Angelica Marfoli ,&nbsp;Federica Solca ,&nbsp;Barbara Poletti ,&nbsp;Nicola Ticozzi ,&nbsp;Sergio Barbieri ,&nbsp;Alberto Priori ,&nbsp;Roberta Ferrucci","doi":"10.1016/j.parkreldis.2025.107300","DOIUrl":"10.1016/j.parkreldis.2025.107300","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor functions in patients with Parkinson's disease (PD) but may cause a decline in specific cognitive domains including executive processes and language.</div><div>The aim of this study was to derive standardized regression-based (SRB) reliable change indices (RCIs) in an Italian cohort of Parkinson's patients undergoing STN-DBS to detect clinically meaningful variations in verbal fluency (VF) one year after surgery define.</div></div><div><h3>Methods</h3><div>Before (T0) and 12 months after (T1) surgery, 36 PD patients who underwent bilateral STN-DBS were evaluated with the Alternate Verbal Fluency Battery (AVFB), including phonemic (PVF), semantic (SVF) and alternate VF tests (AVF) and a composite shifting index (CSI). At T0, motor status was assessed using the Unified Parkinson's Disease Rating Scale-III (UPDRS-III) and L-dopa equivalent daily dose was recorded.</div></div><div><h3>Results</h3><div>Group-level declines were limited to PVF and SVF scores. Applications of these RCIs revealed idiosyncratic patterns of longitudinal trends that differed from those at the group level. Indeed, when looking at individual performances, no clustered pattern of decline or improvement could be visibly detected. The UPDRS-III predicted T1 AVF and CSI scores.</div></div><div><h3>Conclusion</h3><div>Our study provides Italian practitioners and researchers with SRB-RCIs to detect meaningful differences in the VF performance of PD patients undergoing STN-DBS one year after surgery. Variables associated with postoperative cognitive changes can be used in future studies to develop multivariable predictive models to support clinical decision making and patient counselling.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107300"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between functional alterations and specific transcriptional expression patterns in craniocervical dystonia","authors":"Gang Liu ,&nbsp;Jiana Zhang ,&nbsp;Haoran Zhang ,&nbsp;Qinxiu Cheng ,&nbsp;Xiaodong Zhang ,&nbsp;Jun Liu ,&nbsp;Yuhan Luo ,&nbsp;Linchang Zhong ,&nbsp;Zhengkun Yang ,&nbsp;Yue Zhang ,&nbsp;Zilin Ou ,&nbsp;Zhicong Yan ,&nbsp;Weixi Zhang ,&nbsp;Kangqiang Peng ,&nbsp;Huiming Liu ,&nbsp;Jinping Xu","doi":"10.1016/j.parkreldis.2025.107315","DOIUrl":"10.1016/j.parkreldis.2025.107315","url":null,"abstract":"<div><h3>Purpose</h3><div>Craniocervical dystonia (CCD) is a large-scale network disorder that involves functional changes in multiple brain regions. However, the association between these functional changes and the underlying molecular mechanisms has not been explored.</div></div><div><h3>Objective</h3><div>We aimed to characterize the molecular changes associated with the imaging-defined functional architecture of the brain in CCD.</div></div><div><h3>Methods</h3><div>Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained from 146 patients with CCD and 137 healthy controls (HCs). Differences in the amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared between groups. Transcriptomic data were obtained from the Allen Human Brain Atlas to identify the gene expression patterns underlying the affected functional architecture in CCD using partial least squares regression.</div></div><div><h3>Results</h3><div>Compared to HCs, patients with CCD showed common functional alterations, mainly in the left middle occipital gyrus, right middle occipital gyrus, right calcarine, right precentral gyrus, and left postcentral gyrus. These functional alteration patterns were positively associated with 1763 genes (including five risk genes for dystonia) enriched for synaptic signaling, regulation of trans-synaptic signaling, and neuronal systems, while they were negatively associated with 2318 genes (including eight risk genes for dystonia), which were enriched for monoatomic cation transport, DNA damage response and neurodevelopment.</div></div><div><h3>Conclusions</h3><div>Our study reveals a genetic pathological mechanism explaining CCD-related brain functional changes.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"133 ","pages":"Article 107315"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance exercise interventions in Parkinson's disease: A systematic mapping review of components, progression, and intensity","authors":"Andreas Wallin ,&nbsp;Erika Franzén ,&nbsp;Jakob Studsgaard ,&nbsp;Mikkel Baltzer Hansen ,&nbsp;Sverker Johansson ,&nbsp;John Kodal Brincks","doi":"10.1016/j.parkreldis.2025.107310","DOIUrl":"10.1016/j.parkreldis.2025.107310","url":null,"abstract":"<div><h3>Background</h3><div>Rehabilitation in individuals with Parkinson's disease (PD) often includes balance training, but knowledge about optimal training content remains limited.</div></div><div><h3>Objectives</h3><div>To describe the design, content, delivery, and reporting of balance training for individuals with PD, and furthermore, to map the systematic use and reporting of methods monitoring intensity in balance training interventions for individuals with PD.</div></div><div><h3>Methods</h3><div>Six databases were searched. Interventions with at least 50 % of exercises challenging balance control were included. Balance training types (exergaming, multi-modal, sensory-motor integrated, and task-oriented) were categorized based on specific balance exercise components: motor (limits of stability, anticipatory motor strategies, reactive motor strategies, and control of dynamics), sensory (vestibular, visual, and somatosensory systems), and cognitive (dual-tasking in motor or cognitive activities). Training Frequency, Intensity, Time, Type, Volume, and Progression (FITT-VP principles) were extracted.</div></div><div><h3>Results</h3><div>In total, 114 studies (interventions n = 126) with 5335 participants (mean age: 67.5 years; mean PD duration: 6.8 years) were included. The highest mean number of balance components was found in the multi-modal (5.8), followed by sensory-motor (5.6), task-oriented (4.2), and exergaming (4.0). Intensity strategies were reported in 93 % of the exergaming interventions, which was superior to the other training types (multi-modal (18 %), sensory-motor (17 %), and task-oriented (6 %)).</div></div><div><h3>Conclusions</h3><div>Multi-modal and sensory-motor interventions had a greater focus on challenging balance components compared to other types of training, while exergaming interventions demonstrated superior reporting of intensity strategies. Future research is encouraged to prioritize implementing intensity strategies and aim to incorporate a broader range of balance components within balance training exercises.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"133 ","pages":"Article 107310"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal relationships between lipid traits and dementia with lewy bodies: A mendelian randomization study.","authors":"Canwen Zhang, Xiaoshuang Liu, Juan Wang, Guoqing Zhou, Biao Geng, Ming Hu, Qin Tang","doi":"10.1016/j.parkreldis.2025.107312","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107312","url":null,"abstract":"<p><strong>Background: </strong>Disruptions in lipid metabolism have been implicated in various neurodegenerative diseases. However, the specific role of lipid species in the pathogenesis of dementia with Lewy bodies (DLB) remains poorly understood. This study aims to investigate potential causal relationships between lipid traits and DLB risk using Mendelian randomization (MR).</p><p><strong>Methods: </strong>We employed MR analysis to assess causal associations between 179 lipid traits and DLB, utilizing data from comprehensive genome-wide association studies (GWAS). The lipid-related GWAS included 7174 participants, and the DLB-related GWAS included 2981 DLB cases and 4391 healthy controls.</p><p><strong>Results: </strong>Genetic predispositions to increased levels of phosphatidylinositol (PI) (18:1_20:4) were associated with an elevated risk of DLB. Conversely, genetic predispositions to increased levels of specific phosphatidylcholine (PC) species, including PC (O-18:1_20:4), PC (O-16:0_20:4) and PC (O-18:0_20:4), were found to be protective against DLB. Sensitivity analyses revealed no evidence of heterogeneity or horizontal pleiotropy among the selected instrumental variables.</p><p><strong>Conclusions: </strong>Our MR study identifies specific lipid species potentially causally linked to DLB risk. Elevated levels of PI (18:1_20:4) were associated with increased DLB risk, while higher levels of certain PC species were found to be protective. These findings offer new insights into the lipid-related mechanisms underlying DLB pathogenesis and highlight potential therapeutic targets.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107312"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECHS 1 mutation: Expanding the genotype of adulthood onset cervico-brachial dystonia with sensorineural hearing loss","authors":"Saranya B. Gomathy DM ,&nbsp;Animesh Das DM ,&nbsp;Jasmine Parihar DM ,&nbsp;Rajesh Kumar Singh DM ,&nbsp;Deepti Vibha DM ,&nbsp;Manjari Tripathi DM","doi":"10.1016/j.parkreldis.2025.107303","DOIUrl":"10.1016/j.parkreldis.2025.107303","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107303"},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum neurotoxin and immunomodulation for treatment of hemimasticatory spasms associated with hemifacial atrophy and morphea","authors":"Farsana Mustafa ,&nbsp;Kanukuntla Sai Krishna ,&nbsp;Divya M. Radhakrishnan ,&nbsp;Binod K. Khaitan ,&nbsp;Sudheer Arava ,&nbsp;Sumanta Das ,&nbsp;Divyani Garg ,&nbsp;Ayush Agarwal ,&nbsp;Awadh Kishor Pandit ,&nbsp;Achal Kumar Srivastava","doi":"10.1016/j.parkreldis.2025.107304","DOIUrl":"10.1016/j.parkreldis.2025.107304","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107304"},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-shunt prognosis in patients with idiopathic normal-pressure hydrocephalus and comorbid progressive supranuclear palsy: A retrospective, single-center study in Japan.","authors":"Hirokazu Uchigami, Naoyuki Samejima, Akira Watanabe, Nobumasa Kuwana, Takeyuki Tsuchida, Masaaki Saito","doi":"10.1016/j.parkreldis.2025.107308","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107308","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107308"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-genetic analysis of patients with LRRK2-related Parkinson's disease from a referral centre in India","authors":"Shivani Rath ,&nbsp;Vikram V. Holla ,&nbsp;Prashant Phulpagar ,&nbsp;Sneha D. Kamath ,&nbsp;Nitish Kamble ,&nbsp;Babylakshmi Muthusamy ,&nbsp;Ravi Yadav ,&nbsp;Pramod K. Pal","doi":"10.1016/j.parkreldis.2025.107299","DOIUrl":"10.1016/j.parkreldis.2025.107299","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107299"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic prosodic parameters associated with Parkinson's disease cognitive impairment","authors":"Ye Liu ,&nbsp;Xi-Xi Wang ,&nbsp;Xu-Jun Wang ,&nbsp;Min-Min Yin ,&nbsp;Mo-Yao Tan ,&nbsp;Chang-Peng Wang ,&nbsp;Tie-Nan Feng ,&nbsp;Jie Liu ,&nbsp;Yu Wang ,&nbsp;Xuan Li ,&nbsp;Si-Jia Peng ,&nbsp;Xiao-Jin Zhang ,&nbsp;Xiao-Ying Zhu ,&nbsp;Ya Feng ,&nbsp;Eng-King Tan ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.parkreldis.2025.107306","DOIUrl":"10.1016/j.parkreldis.2025.107306","url":null,"abstract":"<div><h3>Background</h3><div>Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in Alzheimer's disease (AD). We hypothesize that acoustic analysis can also differentiate cognitive impairment in Parkinson's disease (PD).</div></div><div><h3>Methods</h3><div>We investigated acoustic parameters in 90 subjects including 30 PD with normal cognition (PD-NC), 30 PD with mild cognitive impairment (PD-MCI) and 30 PD with dementia (PDD). The reading task “Supermarket Passage” and the picture description task “Cookie Theft” were used. Feature selection and modelling were then performed to systematically evaluate the importance and clinical implications of the acoustic parameters in identifying PD with cognitive impairment.</div></div><div><h3>Results</h3><div>Analysis of covariance (ANCOVA) and mediation analysis revealed that acoustic parameters were independently associated with cognitive impairment including PDD and PD-MCI. These Acoustic parameters enabled the detection of PD with cognitive impairment with an area under the receiver operating characteristic curve (AUC) of 0.826. Compared with PD-NC, speech rate, pre-verb pause (≥1s), between-utterance pause (≥2s) in the “Cookie Theft” task were the two key cognitive impairment detection factors, which were frequently identified by LASSO model in both PDD and PD-MCI. F₀SD of interrogative sentence was often selected in PDD. In feature selection, AUC was 0.944 in discriminating PDD from PD-NC and AUC was 0.753 in discriminating PD-MCI from PD-NC.</div></div><div><h3>Conclusion</h3><div>We demonstrated that acoustic parameters are useful in differentiating PD patients with cognitive impairment from patients with normal cognition after adjusting variables such as age, which was also a significant contributor to cognitive decline. Acoustic parameters may be valuable for automated screening the risk of cognitive decline in PD patients. It deserves further investigation.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107306"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}