Parkinsonism & related disorders最新文献_第10页

The association between cigarette smoking and dementia with Lewy bodies 吸烟与路易体痴呆症之间的关系

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-03 DOI: 10.1016/j.parkreldis.2024.107133

Anna E. Goodheart , Stephen N. Gomperts

{"title":"The association between cigarette smoking and dementia with Lewy bodies","authors":"Anna E. Goodheart , Stephen N. Gomperts","doi":"10.1016/j.parkreldis.2024.107133","DOIUrl":"10.1016/j.parkreldis.2024.107133","url":null,"abstract":"<div><h3>Introduction</h3><p>Cigarette smoking is associated with a reduced risk of Parkinson's disease (PD). As dementia with Lewy bodies (DLB) and PD share core neuropathologic features, we set out to examine the relationship between smoking and DLB.</p></div><div><h3>Methods</h3><p>Diagnosis at baseline visit and smoking history of participants ≥50 years old in the National Alzheimer's Coordinating Center (NACC) cohort were evaluated in this cross-sectional study. Odds of diagnosis of cognitive impairment due to DLB, PD, vascular dementia (VD), or Alzheimer's disease (AD) compared to normal cognition based on smoking status and duration were determined using logistic regression.</p></div><div><h3>Results</h3><p>37,478 participants were included (mean age 72 years (SD 9), 57 % female). The odds of DLB were reduced in all smoking status groups compared to never smokers (OR (95 % CI)): ever smokers 0.850 (0.745–0.971), former smokers 0.871 (0.761–0.997), current smokers 0.640 (0.419–0.947)) and in all smoking duration groups. As expected, the odds of PD were reduced in all smoking groups and fell with longer smoking duration. The odds of VD were increased in the current smoking group and rose with greater smoking duration. The odds of AD were unchanged in current smokers, decreased in ever and former smokers, and increased with longer cumulative smoking duration.</p></div><div><h3>Conclusions</h3><p>Cigarette smoking is associated with lower odds of diagnosis of DLB at baseline visit in the NACC cohort. In the context of the well-established reduced risk of PD among smokers, this preliminary evidence of a potential protective effect of smoking on DLB warrants further study.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107133"},"PeriodicalIF":3.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total physical activity, plant-based diet and neurodegenerative diseases: A prospective cohort study of the UK biobank 总运动量、植物性饮食与神经退行性疾病：英国生物库前瞻性队列研究。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-02 DOI: 10.1016/j.parkreldis.2024.107125

Xiaoting Zheng, Jiyong Liu, Shichan Wang, Yi Xiao, Qirui Jiang, Chunyu Li, Huifang Shang

{"title":"Total physical activity, plant-based diet and neurodegenerative diseases: A prospective cohort study of the UK biobank","authors":"Xiaoting Zheng, Jiyong Liu, Shichan Wang, Yi Xiao, Qirui Jiang, Chunyu Li, Huifang Shang","doi":"10.1016/j.parkreldis.2024.107125","DOIUrl":"10.1016/j.parkreldis.2024.107125","url":null,"abstract":"<div><h3>Introduction</h3><p>Neurodegenerative diseases (NDDs) result from a complex interplay of genetic, environmental and aging factors. A balanced diet and adequate physical activity (PA) are recognized as pivotal components among modifiable environmental factors. The independent impact on NDD incidence has been previously debated. This investigation seeks to delineate the association between PA and NDDs across various levels of adherence to a plant-based diet.</p></div><div><h3>Methods</h3><p>In this study, a cohort of 368,934 participants from the UK Biobank was analyzed. Total physical activity (TPA) levels and healthful plant-based diet index (hPDI) were calculated and categorized. A multiple adjusted Cox model was utilized to evaluate the influence of TPA and hPDI on common NDDs, respectively.</p></div><div><h3>Results</h3><p>Finally, 4602 identified cases diagnosed as Alzheimer's disease (AD), Parkinson's disease (PD) or amyotrophic lateral sclerosis (ALS). We found that higher TPA was significantly associated with a reduced risk of developing AD (Q3: HR 0.87; Q4: HR 0.78) and PD (Q3: HR 0.86; Q4: HR 0.81). The protective effect was further accentuated with adherence to a plant-based diet. However, these connections were not observed in the analysis of ALS regardless of dietary patterns.</p></div><div><h3>Conclusion</h3><p>Our findings underscore a significant association between higher TPA and reduced risks of AD and PD, with an enhanced effect observed in conjunction with a plant-based diet. This study contributes to addressing the knowledge gap regarding the combined impact of TPA and a plant-based diet on NDDs occurrence, providing insights into potential underlying mechanisms.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107125"},"PeriodicalIF":3.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024011374/pdfft?md5=7c263b9f3ebe8a99e970c29366c3bebe&pid=1-s2.0-S1353802024011374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living with Parkinson's disease in Portugal: Findings from PRISM study 葡萄牙帕金森病患者的生活：PRISM 研究结果

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-02 DOI: 10.1016/j.parkreldis.2024.107124

Helena C. Brigas , Ana Margarida Rodrigues , Ana Morgadinho , Miguel F. Gago , Rita M. Simões

{"title":"Living with Parkinson's disease in Portugal: Findings from PRISM study","authors":"Helena C. Brigas , Ana Margarida Rodrigues , Ana Morgadinho , Miguel F. Gago , Rita M. Simões","doi":"10.1016/j.parkreldis.2024.107124","DOIUrl":"10.1016/j.parkreldis.2024.107124","url":null,"abstract":"<div><h3>Background</h3><p>Parkinson's disease (PD) ranks second in global neurodegenerative disorders. The “Parkinson's Real-world Impact assesSMent (PRISM)” study addressed the disease burden and treatment of European PD patients. Yet, the burden on Portuguese PD patients remains unexplored. Here, we outline the demographics, clinical features, and impact of PD in the Portuguese PRISM cohort.</p></div><div><h3>Methods</h3><p>Descriptive analysis of the PRISM Portuguese cohort (80 patients) was performed, emphasizing socio-demographic data, anti-PD medication usage, PD impact on patients' lives and healthcare resources utilization.</p></div><div><h3>Results</h3><p>The predominant comorbidities in the Portuguese PD cohort (55 % male; mean age 66.2 years; mean disease duration 8.8 years) included depression (26.3 %) and anxiety (26.3 %). Levodopa was the initial prescribed anti-PD medication for 88 % of patients. Among Portuguese PDP, dopamine agonists (DA), monoamine oxidase-B (MAO-B) inhibitors, and catechol-O-methyltransferase (COMT) inhibitors were used by 50 %, 44.4 %, and 18.3 %, respectively. Portuguese PDP experienced impaired quality of life (PDQ-39 score: 31.3 ± 16.8), various non-motor symptoms, namely sadness/blues (65.4 %), urinary urgency (63.5 %), high/low sex interest (57.7 %), while 56 % reported at least one impulse control behavior. Additionally, 30.8 % retired early due to PD and 31.8 % reduced hours in daily activities. Mental health appointments were attended by 31 %, primarily in psychiatry (19 %) and psychology (6 %), and psychotherapy.</p></div><div><h3>Conclusion</h3><p>This study uncovers the burden of PD among Portuguese patients, revealing current treatment methods, impact on daily life and healthcare resources employed in Portugal. It emphasizes the need for personalized clinical strategies at national and international levels to improve long-term health outcomes and quality of life of PD patients.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107124"},"PeriodicalIF":3.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142135862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurovascular conflict in primary hemifacial spasm: A radiological topographic and severity assessment of contact 原发性半面痉挛的神经血管冲突：对接触的放射地形和严重程度进行评估。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-02 DOI: 10.1016/j.parkreldis.2024.107130

D.D.S. Anudeep, K. Karthik, Vikram V. Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Rohan R. Mahale

引用次数: 0

Hope vs. Hype III: Rescue/on-demand therapies are preferable to device-assisted therapies in Parkinson disease 希望与炒作 III：帕金森病的抢救/按需疗法优于设备辅助疗法

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106079

引用次数: 0

Thyroid disease and cervical dystonia 甲状腺疾病与颈肌张力障碍

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106082

引用次数: 0

Hope vs. Hype II: It is time to offer pre-symptomatic genetic testing for GBA and LRRK2 variants 希望与炒作之二：现在是提供 GBA 和 LRRK2 变异症状前基因检测的时候了。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107041

引用次数: 0

Importance of physical exercise for combatting sarcopenia in patients with Parkinson's disease: What is the next step? 体育锻炼对防治帕金森病患者肌肉疏松症的重要性：下一步该怎么做？

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107068

Ryul Kim, Kyeongho Byun, Beomseok Jeon

引用次数: 0

Insight into the early pathogenesis and therapeutic strategies of spinocerebellar ataxia type 3/machado–joseph disease from mouse models 从小鼠模型中洞察脊髓小脑共济失调 3 型/马加多-约瑟夫病的早期发病机制和治疗策略。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106991

引用次数: 0

Convention vs. Innovation II: Skin biopsy for synuclein inclusions will replace dopamine transporter imaging for Parkinson disease diagnosis 传统与创新之二：皮肤活检检测突触核蛋白内含物将取代多巴胺转运体成像用于帕金森病诊断。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107083

Liana S. Rosenthal , Oliver Phillips , Zoltan Mari

引用次数: 0