Parkinsonism & related disorders最新文献

{"title":"Short-term neuropsychiatric outcomes following deep brain stimulation for Parkinson's disease","authors":"Audrey E. De Paepe ,&nbsp;Linda Wang ,&nbsp;David Zhang ,&nbsp;Andrés Pascual-Leone ,&nbsp;Kimberly Kwei ,&nbsp;Sarah A. O'Shea ,&nbsp;Guy M. McKhann ,&nbsp;Gordon H. Baltuch ,&nbsp;Marla Hamberger ,&nbsp;Jeffrey Cole ,&nbsp;Brett E. Youngerman","doi":"10.1016/j.parkreldis.2025.108163","DOIUrl":"10.1016/j.parkreldis.2025.108163","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is effective for Parkinson's disease (PD) motor symptoms; however, effects on neuropsychiatric symptoms remain uncertain.</div></div><div><h3>Methods</h3><div>Baseline and post-operative neuropsychiatric outcomes were retrospectively reviewed among a cohort of patients with PD undergoing bilateral STN- or GPi-DBS, using the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Starkstein Apathy Scale (SAS). Absolute changes in psychiatric scores, rate of clinical meaningful score reduction (≥½ standard deviation below baseline scores), and number needed to treat (NNT) were calculated.</div></div><div><h3>Results</h3><div>Fifty-nine PD patients received either STN-DBS (<em>n</em> = 40) or GPi-DBS (<em>n</em> = 19). Clinically significant baseline anxiety (BAI ≥16) was present in 35.6 % of patients (STN-DBS = 13.50 ± 7.18; GPi-DBS = 17.47 ± 13.78). STN-DBS patients demonstrated a statistically significant reduction in anxiety (<em>d</em> = −4.75, <em>P</em> = 0.002) at 10.0 ± 7.4 months follow-up. Clinically meaningful anxiety improvement was observed in 52.5 % of STN-DBS patients (NNT = 1.9) compared to 26.3 % of GPi-DBS patients (NNT = 3.8). Longitudinal depression and apathy scores were stable for both groups.</div></div><div><h3>Conclusions</h3><div>STN-DBS was associated with a statistically and clinically significant reduction in anxiety, while GPi-DBS did not reach statistical significance but still yielded clinically meaningful improvement in one-quarter of patients. These findings highlight the potential anxiolytic benefits of STN-DBS and suggest that GPi-DBS may also offer benefit for some individuals, warranting further investigation.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"143 ","pages":"Article 108163"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia.","authors":"Miyuki Imazawa","doi":"10.1016/j.parkreldis.2026.108225","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2026.108225","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108225"},"PeriodicalIF":3.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of deprescribing anticholinergics in Parkinson's disease care.","authors":"Benjamin K P Woo, Jamie O P Chung","doi":"10.1016/j.parkreldis.2026.108224","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2026.108224","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108224"},"PeriodicalIF":3.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the heterogeneity of infection-related movement disorders: A call for a mechanism-based classification.","authors":"Yusa Pan, Tiantian Zhang, Chao Zhang","doi":"10.1016/j.parkreldis.2026.108180","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2026.108180","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"108180"},"PeriodicalIF":3.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal structural changes in Parkinson's disease: differences in pRNFL thickness between GBA1-associated and idiopathic cases","authors":"Giacomo Portaro ,&nbsp;Michelangelo Giacomelli ,&nbsp;Sara Grisanti ,&nbsp;Lisa Taruffi ,&nbsp;Giulia Di Rauso ,&nbsp;Valentina Fioravanti ,&nbsp;Gaetano Salomone ,&nbsp;Giacomo Argenziano ,&nbsp;Rossella Sabadini ,&nbsp;Giulia Toschi ,&nbsp;Ottavia Iotti ,&nbsp;Isabella Campanini ,&nbsp;Andrea Merlo ,&nbsp;Lorenzo Cavazzuti ,&nbsp;Benedetta Damiano ,&nbsp;Sara Scaltriti ,&nbsp;Augusto Scaglioni ,&nbsp;Jefri J. Paul ,&nbsp;Peter Bauer ,&nbsp;Giuseppe Biagini ,&nbsp;Francesco Cavallieri","doi":"10.1016/j.parkreldis.2025.108134","DOIUrl":"10.1016/j.parkreldis.2025.108134","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent years, retinal structural changes have attracted considerable attention as a potential biomarker of neurodegeneration in Parkinson's disease (PD). Several studies have reported a reduced Retinal Nerve Fiber Layer (pRNFL) thickness in patients with PD compared with age-matched controls. However, potential retinal differences between “idiopathic” PD and GBA1-associated PD (GBA-PD) remain largely unexplored.</div></div><div><h3>Methods</h3><div>In this single-center observational study, we enrolled 59 PD patients: 32 GBA-PD and 27 non-mutated (NM-PD). A comprehensive clinical assessment included MoCA, MDS-UPDRS and Hoehn-Yahr. Spectral-domain OCT measured pRNFL thickness at 3.5, 4.1 and 4.7 mm diameters across six sectors. Statistical analysis assessed intergroup differences and associations with clinical variables.</div></div><div><h3>Results</h3><div>NM-PD exhibited significantly thinner temporal sectors compared to GBA-PD (p &lt; .05, Mann-Whitney <em>U</em> test). In NM-PD, positive correlations emerged between temporal-superior pRNFL and MoCA scores, in line with previous studies, and, more surprisingly, between nasal-inferior sector and MDS-UPDRS part-IV. No robust associations with clinical variables were found in GBA-PD.</div></div><div><h3>Conclusions</h3><div>This study demonstrates differences in retinal thickness between GBA-PD and NM-PD. In particular, a lower pRNFL in NM-PD may be the product of a different pathophysiological mechanism. Moreover, sector-specific retinal thickness showed correlations to cognitive impairment and motor complications in NM-PD. These observations provide novel insights into genotype-specific mechanisms of neurodegeneration in PD and suggest that retinal imaging may offer a window into both cognitive and motor complications. Further longitudinal studies, including healthy controls and expanded retinal layer analyses, are needed to confirm and expand these findings.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 108134"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145621004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye blinking abnormalities in Tourette syndrome: Blink more or blink differently?","authors":"Julius Verrel ,&nbsp;Ronja Schappert ,&nbsp;Nele Brügge ,&nbsp;Tina Rawish ,&nbsp;Tobias Bäumer ,&nbsp;Yifan Hao ,&nbsp;Roland Stenger ,&nbsp;Christian Beste ,&nbsp;Sebastian Fudickar ,&nbsp;Veit Roessner ,&nbsp;Alexander Münchau","doi":"10.1016/j.parkreldis.2025.108121","DOIUrl":"10.1016/j.parkreldis.2025.108121","url":null,"abstract":"<div><h3>Introduction</h3><div>Blinking abnormalities are among the earliest and most common symptoms in Gilles de la Tourette syndrome (GTS) but have not been studied using precise quantitative methods. Here, we use automated video-based analyses to assess blinking abnormalities in GTS in terms of blink rates as well as alterations in spatiotemporal blink features.</div></div><div><h3>Methods</h3><div>We analyzed 2.5-minute video recordings from age- and sex-matched adult GTS and healthy control (HC) samples (56 participants with 136 videos per group; 18–59 years). Eye aperture time series were used to detect blink events and extract blink features (amplitude, amplitude asymmetry, duration, inter-blink intervals). Individual blinks were categorized as “typical” or “atypical” relative to feature distributions from an independent HC sample.</div></div><div><h3>Results</h3><div>Overall blink rates were twice as high in GTS compared to HC (34.1 vs. 17.3 blinks/minute). This difference was most pronounced for atypical blinks (10.8 vs. 1.9 atypical blinks/minute), even allowing high-accuracy classification of GTS vs. HC videos (83.1 %) using cross-validated logistic regression. Classification based on the rate of typical blinks, average blink features, or single feature deviation rates yielded considerably lower accuracies. On average, 58.7 % of atypical blinks of a given participant shared the same feature deviation, but the feature deviation patterns significantly varied between participants, as confirmed using permutation statistics.</div></div><div><h3>Conclusion</h3><div>Blinking abnormalities in GTS are best characterized by the frequency of atypical blinks, which appear to drive the overall increase in blink rate. Blinking abnormalities were consistent within but heterogeneous across individuals.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 108121"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expanding spectrum of eye movement disorders in genetic dystonia syndromes","authors":"Wei-Sheng Lin","doi":"10.1016/j.parkreldis.2025.107907","DOIUrl":"10.1016/j.parkreldis.2025.107907","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 107907"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zolpidem in Parkinson's disease: An unexpected friend?","authors":"Shivam Om Mittal,&nbsp;Khushal B. Girigosavi","doi":"10.1016/j.parkreldis.2025.108113","DOIUrl":"10.1016/j.parkreldis.2025.108113","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 108113"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dipeptidyl peptidase 4 inhibitor use on mortality in diabetic Parkinson's disease patients: A nationwide cohort study","authors":"Mincheol Park ,&nbsp;Ho Kyung Lee ,&nbsp;Yeonju Jin ,&nbsp;Sanghee Yoo ,&nbsp;Sung-Woo Kim ,&nbsp;Sojeong Park ,&nbsp;Jiwon Hong ,&nbsp;Jin Yong Hong ,&nbsp;Ickpyo Hong ,&nbsp;Min Seok Baek","doi":"10.1016/j.parkreldis.2025.108111","DOIUrl":"10.1016/j.parkreldis.2025.108111","url":null,"abstract":"<div><h3>Background</h3><div>Dipeptidyl peptidase-4 inhibitors (DPP4i) are commonly used oral hypoglycemic agents that enhance the bioavailability of active glucagon-like peptide-1 by inhibiting its degradation. Recent studies suggest possible neuroprotective effects of DPP4i in Parkinson's disease (PD); however, their association with mortality in PD is unclear.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed the Korean National Health Insurance Service database. The cohort included 1093 adults diagnosed with both PD and type 2 diabetes (DM) between 2009 and 2019. We divided the participants into two groups: those not receiving DPP4i (PD-DPP4i⁺, n = 557) and those treated with DPP4i (PD-DPP4i⁻, n = 536). We used Kaplan–Meier survival analyses and Cox proportional hazard models to evaluate survival rates. Cox regression models included age, sex, number of comorbidities, and end-organ complication of DM including diabetic neuropathy and retinopathy as covariates.</div></div><div><h3>Results</h3><div>The average age of the study participants was 73.40 (±7.67) years, and the majority were female (n = 674, 61.67 %). Kaplan-Meier analysis revealed the lower risk of mortality in the PD-DPP4i⁺ group (<em>p</em> &lt; 0.0001). The Cox proportional hazards regression model indicated that PD-DPP4i⁺ group had a lower risk of death compared to PD-DPP4i⁻ group (hazard ratio, 0.762; 95 % confidence interval, 0.611–0.949; <em>p</em> = 0.0153). Factors including male sex, older age at PD diagnosis, and the presence of more than two comorbidities were associated with an increased risk of death.</div></div><div><h3>Conclusions</h3><div>These findings suggest that the use of DPP4i in PD patients with co-existing DM is associated with lower risk of mortality.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 108111"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study” recently published by C. Hall and colleagues","authors":"Polona Rus Prelog ,&nbsp;Matija Zupan ,&nbsp;Senta Frol","doi":"10.1016/j.parkreldis.2025.107952","DOIUrl":"10.1016/j.parkreldis.2025.107952","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"142 ","pages":"Article 107952"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}