Parkinsonism & related disorders最新文献

{"title":"Idiopathic normal pressure hydrocephalus concomitant with progressive supranuclear palsy","authors":"Tomoyo Shimada ,&nbsp;Anri Sakurai ,&nbsp;Shunichi Niiyama ,&nbsp;Kaito Kawamura ,&nbsp;Madoka Nakajima ,&nbsp;Ayami Okuzumi ,&nbsp;Taku Hatano ,&nbsp;Masakazu Miyajima ,&nbsp;Nobutaka Hattori ,&nbsp;Taiji Tsunemi","doi":"10.1016/j.parkreldis.2025.107273","DOIUrl":"10.1016/j.parkreldis.2025.107273","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent studies by us and others have unveiled a frequent coexistence of idiopathic normal pressure hydrocephalus (iNPH) with neurodegenerative movement disorders, including progressive supranuclear palsy (PSP). This study aims to explore the clinical and radiological characteristics of patients with iNPH who also had comorbid with PSP, referred to as iNPHc + PSP.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with iNPH admitted to our department between 2009 and 2024. We adhered to the established clinical criteria for iNPH and the Movement Disorder Society (MDS)-PSP criteria for probable or possible PSP with minor modifications.</div></div><div><h3>Results</h3><div>Among 85 iNPH patients, 18 were categorized as having iNPHc + PSP (21.2 %). Clinically, comorbid PSP led to impaired vertical eye movement, axial-dominant parkinsonism, and a propensity to fall backward in iNPH (p = 0.022, p = 0.002, and p &lt; 0.005, respectively). Radiologically, comorbid PSP demonstrated a shortened mesencephalic tegmentum length in the magnetic resonance imaging and an asymmetrical deficit of dopamine transporter activities in the DaTscan (p = 0.0005, p = 0.0129, respectively). Lumboperitoneal shunt (LPS) surgery improved the modified Rankin scale (p = 0.038) and the iNPH grading scale (total score, p = 0.003; gait disturbance, p = 0.020; urinary incontinence, p = 0.026) one-year after surgery.</div></div><div><h3>Conclusions</h3><div>PSP can coexist with iNPH, and detailed clinical and radiological assessment can aid in detecting this comorbidity. Importantly, LPS surgery can improve outcomes of patients with iNPHc + PSP.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107273"},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert commentary for: A challenging case of cerebellar ataxia associated with orofacial dominant chorea","authors":"Maria C. Garcia ,&nbsp;Hugo Morales-Briceño","doi":"10.1016/j.parkreldis.2025.107270","DOIUrl":"10.1016/j.parkreldis.2025.107270","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107270"},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence regarding “Letter to the editor: TMS-evoked potentials provide novel neurophysiological features of Tourette syndrome”","authors":"Saar Anis","doi":"10.1016/j.parkreldis.2025.107269","DOIUrl":"10.1016/j.parkreldis.2025.107269","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107269"},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing a MoCA cut-off point for cognitive impairment detection in Mexican people living with Parkinson's disease: A comprehensive assessment (level II) approach","authors":"Ana Jimena Hernández-Medrano ,&nbsp;Amin Cervantes-Arriaga ,&nbsp;Erick I. Correa-Medina ,&nbsp;Gerardo Sánchez-Dinorín ,&nbsp;Mayela Rodríguez-Violante ,&nbsp;Rodolfo Solís-Vivanco","doi":"10.1016/j.parkreldis.2025.107265","DOIUrl":"10.1016/j.parkreldis.2025.107265","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairment (CI) is a prevalent and debilitating non-motor symptom of Parkinson's disease (PD), affecting around 25–30 % of the people living with PD (PwP). The Montreal Cognitive Assessment (MoCA) is a widely used tool for detecting CI. Yet, its optimal cut-off score for PwP, particularly within specific populations such as the Mexican demographic, remains inadequately defined.</div></div><div><h3>Objective</h3><div>This study aimed to identify the optimal MoCA cut-off score for detecting CI in Mexican PwP based on a comprehensive assessment (level II), according to the Movement Disorders Society Task Force recommendations.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study including PwP of Mexican nationality and proficiency in Spanish. Participants underwent global cognitive evaluation using the Mexican version of the MoCA (version 8.1) and a comprehensive neuropsychological assessment (NPA) with at least 2 tests for each of 5 cognitive domains (attention, executive function, language, memory, and visuospatial abilities). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy through the Receiver Operating Characteristic (ROC) curve and Youden index were calculated.</div></div><div><h3>Results</h3><div>A total of 91 PwP were included. CI prevalence was 26.4 %. A cut-off of ≤24 points yielded a sensitivity of 41.7 %, specificity of 76.1 %, PPV of 38.5 %, NPV of 78.5 %, and diagnostic accuracy of 67.0 %. The ROC analysis indicated an AUC of 0.59 (p &lt; 0.001), with a Youden index of 0.18.</div></div><div><h3>Conclusion</h3><div>These findings underscore the MoCA's utility in the nuanced detection of CI among Mexican PwP, highlighting the need for tailored NPA strategies in this clinical population.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107265"},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of apolipoprotein A and B in Parkinson's disease: A prospective study from UK Biobank","authors":"Shuqi Cao ,&nbsp;Xia Fu ,&nbsp;Wenjing Li ,&nbsp;Peixi Wang ,&nbsp;Chunyu Li ,&nbsp;Huifang Shang","doi":"10.1016/j.parkreldis.2025.107266","DOIUrl":"10.1016/j.parkreldis.2025.107266","url":null,"abstract":"<div><h3>Introduction</h3><div>Evidence have indicated relation between apolipoproteins and neurodegenerative disorders (NDDs). However, previous studies have produced inconsistent results, and a comprehensive analysis of apolipoproteins in NDDs is currently lacking.</div></div><div><h3>Methods</h3><div>Using Cox proportional hazards regression analysis based on data from UK Biobank, we examined the association between baseline serum levels of apolipoprotein A (ApoA) and apolipoprotein B (ApoB) and risk of Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and multiple sclerosis.</div></div><div><h3>Results</h3><div>Elevated baseline levels of serum ApoA (HR = 0.84, 95 % CI: 0.71–0.99, P = 0.047) and ApoB (HR = 0.67, 95 % CI: 0.57–0.78, P = 3.18E-07) were associated with a reduced risk of incident PD. Subgroup analyses suggested the protective effect of serum ApoA was more significant for older participants and those with lower alcohol consumption, while higher serum ApoB was a more significant protective factor in males and those without stroke. No significant associations were found between apolipoproteins and other NDDs.</div></div><div><h3>Conclusion</h3><div>Increased baseline levels of serum ApoA and ApoB are linked to a lower risk of PD. These findings enhance understanding of the role of apolipoproteins in PD, and have implications for the development of therapeutic strategies in clinical trials.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107266"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of Cerebrotendinous Xanthomatosis: Progressive gait difficulties and juvenile cataracts in a 33-year-old male.","authors":"Villa-Lopez Marta, Sugumar Tripthi, Suchowersky Oksana","doi":"10.1016/j.parkreldis.2024.107259","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107259","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107259"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar ataxia - Tremor syndrome from inhalation of solvents containing toluene: A case series from Eastern India","authors":"Jacky Ganguly ,&nbsp;Shantanu Subham Jha ,&nbsp;Purba Basu ,&nbsp;Neha Pandita ,&nbsp;Banashree Mondal ,&nbsp;Soumava Mukherjee ,&nbsp;Nilam Singh ,&nbsp;Hrishikesh Kumar","doi":"10.1016/j.parkreldis.2025.107264","DOIUrl":"10.1016/j.parkreldis.2025.107264","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107264"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild behavioral impairment and its relation to amyloid load in isolated REM sleep behavior disorder","authors":"Eun Jin Yoon ,&nbsp;Jee-Young Lee ,&nbsp;Kyung Ah Woo ,&nbsp;Seoyeon Kim ,&nbsp;Heejung Kim ,&nbsp;Hyunwoong Park ,&nbsp;Ryul Kim ,&nbsp;Bora Jin ,&nbsp;Seungmin Lee ,&nbsp;Hyunwoo Nam ,&nbsp;Yu Kyeong Kim","doi":"10.1016/j.parkreldis.2025.107267","DOIUrl":"10.1016/j.parkreldis.2025.107267","url":null,"abstract":"<div><h3>Introduction</h3><div>In isolated REM sleep behavior disorder (iRBD), the evidence of cognitive impairment and co-existing amyloid pathology suggests that mild behavioral impairment (MBI) may be associated with disease progression. In this study, we investigated MBI and its association with cognitive function, brain amyloid load and glucose metabolism in iRBD patients to evaluate the utility of MBI as a predictive marker of disease progression.</div></div><div><h3>Methods</h3><div>Patients with iRBD underwent a neuropsychological evaluation, ¹⁸F-florbetaben (FBB) PET, and ¹⁸F-fluorodeoxyglucose (FDG) PET. MBI was evaluated using the MBI-checklist (MBI-C). Comparisons between MBI-positive and MBI-negative groups and correlations with MBI-C total scores were examined on neuropsychological performances and PET regional standardized uptake value ratios (SUVRs). Additionally, associations between regional amyloid burden and glucose metabolism and mediating role of MBI status on these associations were evaluated in all iRBD patients.</div></div><div><h3>Results</h3><div>Of 36 iRBD patients, about one-third were classified as MBI-positive. Although we did not find the differences between the MBI groups and correlations with MBI-C total scores in neuropsychological performances and brain glucose metabolism, the MBI-positive group revealed higher FBB SUVRs in the anterior cingulate cortex, prefrontal cortex, caudate nucleus, and putamen than the MBI-negative group. The FBB SUVR of caudate nucleus was negatively correlated with glucose metabolism in the precuneus, which was not directly mediated by the MBI.</div></div><div><h3>Conclusion</h3><div>Characteristic amyloid accumulation in prefrontal and subcortical structures in MBI-positive iRBD patients suggests that MBI may be associated with early amyloid pathology that can be an integral role in disease progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107267"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmental brainstem myoclonus in ADCK3-Related ataxia: A novel phenomenon?","authors":"Vito Luigi Colona, Giacomo Garone, Francesco Nicita, Lorena Travaglini, Stefano Pro, Maria Camilla Rossi-Espagnet, Anna Piluso, Eleonora Bisozzi, Donatella Lettori, Enrico Bertini, Gessica Vasco","doi":"10.1016/j.parkreldis.2025.107262","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107262","url":null,"abstract":"<p><p>Segmental Brainstem Myoclonus (SBM) is a rare movement disorder characterized by rhythmic contractions of muscles innervated by brainstem segments. We report a 20-year-old patient with ADCK3-related spinocerebellar ataxia type 9 (SCAR9) presenting with sudden-onset myoclonic movements of the throat, tongue, and soft palate. Brain MRI showed stable findings, including dentate nucleus hyperintensities. This case suggests a possible association between SBM and SCAR9, warranting further investigation.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107262"},"PeriodicalIF":3.1,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical neurophysiology for tremor: Common questions in clinical practice","authors":"Petra Schwingenschuh ,&nbsp;Madelein Van der Stouwe ,&nbsp;Sanjay Pandey ,&nbsp;Stephanie Hirschbichler ,&nbsp;Pattamon Panyakaew ,&nbsp;Maja Kojovic ,&nbsp;Adreesh Mukherjee ,&nbsp;Marina AJ. Tijssen ,&nbsp;Shabbir Hussain I. Merchant ,&nbsp;Felipe Vial ,&nbsp;the MDS Clinical neurophysiology Study group","doi":"10.1016/j.parkreldis.2024.107196","DOIUrl":"10.1016/j.parkreldis.2024.107196","url":null,"abstract":"<div><h3>Background</h3><div>A thorough history and physical examination may be insufficient for comprehensively studying patients with tremor. In such instances, neurophysiology serves as an adjunct to the physical examination.</div></div><div><h3>Objectives</h3><div>Our aim is to present compelling evidence supporting the utilization of neurophysiological studies in various tremor conditions.</div></div><div><h3>Methods</h3><div>A panel of global experts, convened by the Study Group on Clinical Neurophysiology for Movement Disorders, examined the application and utility of neurophysiology across diverse movement disorders.</div></div><div><h3>Results</h3><div>This manuscript provides a detailed methodology for electrophysiological studies in tremors helping to differentiate them from myoclonus, comparing tremor in parkinson vs atypical parkinsonisms, describing dystonic tremor, describing the differences between Parkinson and essential tremor and the characteristics of functional tremor.</div></div><div><h3>Conclusions</h3><div>Neurophysiological studies play a crucial role in characterizing tremor syndromes and aiding in their differentiation from other hyperkinetic movement disorders.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107196"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}