Parkinsonism & related disorders最新文献_第9页

Early discontinuation and titration strategies in foslevodopa/foscarbidopa therapy for Parkinson's disease. foslevodopa/foscarbidopa治疗帕金森病的早期停药和滴定策略。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-08-07 DOI: 10.1016/j.parkreldis.2025.107985

Paolo Solla, Tommaso Ercoli

引用次数: 0

Non-motor symptom subtypes in early Parkinson's disease. 早期帕金森病的非运动症状亚型。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-08-06 DOI: 10.1016/j.parkreldis.2025.107982

Vittorio Velucci, Giovanni Iliceto, Barbara Vitucci, Sarah Idrissi, Giammarco Milella, Marcello Mario Mascia, Antonella Muroni, Giovanni Defazio

{"title":"Non-motor symptom subtypes in early Parkinson's disease.","authors":"Vittorio Velucci, Giovanni Iliceto, Barbara Vitucci, Sarah Idrissi, Giammarco Milella, Marcello Mario Mascia, Antonella Muroni, Giovanni Defazio","doi":"10.1016/j.parkreldis.2025.107982","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107982","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a clinically heterogeneous disorder characterized by a broad spectrum of non-motor symptoms. Defining non-motor subtypes may help clarify early pathophysiological mechanisms, predict disease progression, and guide personalized care.</p><p><strong>Objective: </strong>To identify non-motor PD subtypes through an unsupervised approach, evaluate their consistency with proposed models of PD pathology, and assess their prognostic value.</p><p><strong>Methods: </strong>Data from 824 newly diagnosed, drug-naïve PD patients enrolled in the Parkinson's Progression Markers Initiative were analyzed. Five core non-motor features at baseline-REM sleep behavior disorder (RBD), hyposmia, dysautonomia, anxiety, and cognitive impairment-were used for two-step cluster analysis. Cluster-wise progression to Hoehn and Yahr stage 3, motor complications, and dementia was assessed using Kaplan-Meier and Cox regression analyses.</p><p><strong>Results: </strong>Three non-motor clusters emerged. Cluster 1 (RBD-/hyposmia+, n = 474) included patients with mild anxiety and selective cognitive deficits. Cluster 2 (RBD+, n = 219) exhibited the greatest non-motor burden, including dysautonomia, psychiatric symptoms, and global cognitive impairment. These patients were older at diagnosis and showed more symmetric and axial motor signs, faster progression to Hoehn and Yahr stage 3, and a higher risk of dementia. Cluster 3 (RBD-/hyposmia-, n = 131) displayed minimal non-motor involvement. No differences were found in time to motor complications across clusters.</p><p><strong>Conclusions: </strong>This is the first study to identify PD subtypes based exclusively on early non-motor symptoms in a large, untreated cohort. The resulting data-driven clusters aligned with some proposed models of PD pathology and demonstrated clear, independent prognostic value for progression to Hoehn and Yahr stage 3 and dementia risk.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107982"},"PeriodicalIF":3.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending the use of MANAGE-PD: A case for post-device therapy reassessment in Parkinson's disease. 扩展MANAGE-PD的使用：帕金森病器械治疗后再评估一例。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-08-06 DOI: 10.1016/j.parkreldis.2025.107984

Halil Onder, Selcuk Comoglu

引用次数: 0

Hope vs. Hype I: It is time to redefine and rename Parkinson disease based on alpha-synuclein 希望vs炒作1：是时候根据α -突触核蛋白重新定义和重命名帕金森病了（PSG辩论2024）。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-08-06 DOI: 10.1016/j.parkreldis.2025.107983

Kathleen L. Poston , Camila C. Piccinin , Tiago A. Mestre

引用次数: 0

Optimal cut-off scores for the Mini Mental State Examination and Montreal Cognitive Assessment to detect MCI and dementia in Multiple System Atrophy 迷你精神状态检查和蒙特利尔认知评估检测MCI和多系统萎缩痴呆的最佳截止分数。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-30 DOI: 10.1016/j.parkreldis.2025.107974

Sofia Cuoco , Immacolata Carotenuto , Maria Claudia Russillo , Valentina Andreozzi , Marina Picillo , Marianna Amboni , Roberto Erro , Andrea Soricelli , Paolo Barone , Maria Teresa Pellecchia

{"title":"Optimal cut-off scores for the Mini Mental State Examination and Montreal Cognitive Assessment to detect MCI and dementia in Multiple System Atrophy","authors":"Sofia Cuoco , Immacolata Carotenuto , Maria Claudia Russillo , Valentina Andreozzi , Marina Picillo , Marianna Amboni , Roberto Erro , Andrea Soricelli , Paolo Barone , Maria Teresa Pellecchia","doi":"10.1016/j.parkreldis.2025.107974","DOIUrl":"10.1016/j.parkreldis.2025.107974","url":null,"abstract":"<div><h3>Background</h3><div>Mild cognitive impairment (MCI) and dementia are reported in up to 44 % and 7 % of patients with Multiple system atrophy (MSA), respectively. The sensitivity and discriminative power of brief cognitive screening tools such as the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) for detecting MCI and dementia in MSA has not yet been evaluated.</div></div><div><h3>Objective</h3><div>The aim of this study was to determine the optimal cut-off scores of the MMSE and MoCA for accurately differentiating MSA patients with MCI and dementia from those with normal cognition. The fluency item of MoCA was also assessed separately for the same purpose.</div></div><div><h3>Methods</h3><div>Sixty-two MSA patients underwent a comprehensive II level neuropsychological evaluation, in order to diagnose dementia or MCI.</div><div>ROC analyses were used to establish the optimal cut-off scores for MCI and dementia, respectively.</div></div><div><h3>Results</h3><div>According to the II level neuropsychological evaluation, 4.8 % of MSA patients met criteria for dementia and 53,2 % for MCI. The optimal MMSE cut-off scores were 20.5 for dementia (AUC = 0.915) and 26.5 for MCI (AUC = 0.698). For MoCA, the most accurate cut-offs were 14.0 to detect dementia (AUC = 0.919) and 19.5 to detect MCI (AUC = 0.702).ROC analysis suggested that both tests were more accurate to identify MCI than dementia. The optimal cut-off for MoCA fluency item to identify MCI was 8.5 words (AUC = 0.717).</div></div><div><h3>Conclusion</h3><div>Our findings support MMSE and MoCA as effective and accessible tools to detect MCI and dementia in MSA. MoCA fluency item emerged as a reliable tool to detect MCI.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"138 ","pages":"Article 107974"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long term follow-up of MSA patients on 24 hour continuous LCIG infusion: a case series MSA患者连续24小时LCIG输注的长期随访：一个病例系列

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-30 DOI: 10.1016/j.parkreldis.2025.107978

Massimo Marano , Stefano Toro , Vincenzo Di Lazzaro

引用次数: 0

Relationships between neuronal loss, age of death, disease duration and MRI brain volumes in progressive supranuclear palsy 进行性核上性麻痹的神经元丧失、死亡年龄、病程与MRI脑容量的关系

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-30 DOI: 10.1016/j.parkreldis.2025.107980

Mahesh Kumar , Shanu F. Roemer , Nirubol Tosakulwong , Stephen D. Weigand , Farwa Ali , Heather M. Clark , Julie Stierwalt , Rodolfo Savica , Dennis W. Dickson , Jennifer L. Whitwell , Keith A. Josephs

{"title":"Relationships between neuronal loss, age of death, disease duration and MRI brain volumes in progressive supranuclear palsy","authors":"Mahesh Kumar , Shanu F. Roemer , Nirubol Tosakulwong , Stephen D. Weigand , Farwa Ali , Heather M. Clark , Julie Stierwalt , Rodolfo Savica , Dennis W. Dickson , Jennifer L. Whitwell , Keith A. Josephs","doi":"10.1016/j.parkreldis.2025.107980","DOIUrl":"10.1016/j.parkreldis.2025.107980","url":null,"abstract":"<div><h3>Background</h3><div>Neuronal loss and the presence of tau lesions in specific brain regions is required for a definitive diagnosis of progressive supranuclear palsy (PSP). We previously found tau burden in basal ganglia and red nucleus to be associated with disease duration and age at death. It is currently unknown whether neuronal loss is also associated with disease duration and age at death, or with antemortem brain volume loss in PSP.</div></div><div><h3>Objective</h3><div>To investigate whether neuronal loss is associated with tau burden, age at death, disease duration, or brain volume loss in PSP.</div></div><div><h3>Methods</h3><div>Forty-one pathologically confirmed PSP participants prospectively recruited and followed by the Neurodegenerative Research Group (NRG), Mayo Clinic, MN, between 2009 and 2023, of which 40 completed antemortem MRI, were analyzed. Neuronal loss in the subthalamic and red nuclei was determined on hematoxylin and eosin. Multinomial logistic regressions with age at death, disease duration, and brain volume as independent variables, and regional neuronal loss as outcome, were performed.</div></div><div><h3>Results</h3><div>Fourteen participants (34 %) were female, median age at death was 74 years [68, 79], and median disease duration was 8.2 years [5.7, 9.9]. Greater neuronal loss was associated with greater burden of glial, but not neuronal, tau lesions in both nuclei. Greater neuronal loss was associated with shorter disease duration in both nuclei, particularly in the subthalamic nucleus, and smaller volume on MRI of the red nucleus.</div></div><div><h3>Conclusions</h3><div>Neuronal loss in subthalamic and red nuclei, cardinal PSP regions, appear to be playing a role in disease duration and brain volume loss in PSP.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"139 ","pages":"Article 107980"},"PeriodicalIF":3.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory network reorganization in Parkinson's disease 帕金森病的嗅觉网络重组

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-29 DOI: 10.1016/j.parkreldis.2025.107964

Mohammed Saqib , Laura Pesantez Pacheco , Debra J. Ehrlich , Silvina G. Horovitz

引用次数: 0

Rapid-onset dystonia-parkinsonism: First African case of ATP1A3 mutation 快速发作的肌张力障碍-帕金森病：非洲首例ATP1A3突变病例。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-28 DOI: 10.1016/j.parkreldis.2025.107972

Hicham El Otmani , Asmae Sikkal , Aya Harrati , Ghita Hjiej , Hajar Khattab , Kamal Haddouali , Salma Bellakhdar , Bouchra El Moutawakil , Mohammed Abdoh Rafai

引用次数: 0

Reply to the commentary on Defining 'OFF' time in device-aided therapy criteria for Parkinson's disease: Gaps and opportunities. 回复关于在帕金森病的设备辅助治疗标准中定义“关闭”时间的评论：差距和机会。

IF 3.4 3区医学

Parkinsonism & related disorders Pub Date : 2025-07-28 DOI: 10.1016/j.parkreldis.2025.107979

Roongroj Bhidayasiri, Phooi Leng Lean, K Ray Chaudhuri

引用次数: 0