发布求助
文献互助 智能选刊 最新文献

Parkinsonism & related disorders最新文献

筛选
英文 中文
Hope vs. Hype II: It is time to offer pre-symptomatic genetic testing for GBA and LRRK2 variants 希望与炒作之二：现在是提供 GBA 和 LRRK2 变异症状前基因检测的时候了。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107041
{"title":"Hope vs. Hype II: It is time to offer pre-symptomatic genetic testing for GBA and LRRK2 variants","authors":"","doi":"10.1016/j.parkreldis.2024.107041","DOIUrl":"10.1016/j.parkreldis.2024.107041","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 107041"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024010538/pdfft?md5=4c85e98142b16901e90be0ba7438a621&pid=1-s2.0-S1353802024010538-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of physical exercise for combatting sarcopenia in patients with Parkinson's disease: What is the next step? 体育锻炼对防治帕金森病患者肌肉疏松症的重要性：下一步该怎么做？
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107068
Ryul Kim, Kyeongho Byun, Beomseok Jeon
{"title":"Importance of physical exercise for combatting sarcopenia in patients with Parkinson's disease: What is the next step?","authors":"Ryul Kim, Kyeongho Byun, Beomseok Jeon","doi":"10.1016/j.parkreldis.2024.107068","DOIUrl":"10.1016/j.parkreldis.2024.107068","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 107068"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into the early pathogenesis and therapeutic strategies of spinocerebellar ataxia type 3/machado–joseph disease from mouse models 从小鼠模型中洞察脊髓小脑共济失调 3 型/马加多-约瑟夫病的早期发病机制和治疗策略。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106991
{"title":"Insight into the early pathogenesis and therapeutic strategies of spinocerebellar ataxia type 3/machado–joseph disease from mouse models","authors":"","doi":"10.1016/j.parkreldis.2024.106991","DOIUrl":"10.1016/j.parkreldis.2024.106991","url":null,"abstract":"<div><p><span>Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is the most common subtype of </span>hereditary ataxia<span> (HA), which is characterized by motor deficits and a lack of effective treatments, and imposes a huge physical, mental, and financial burden on patients and their families. Therefore, it is important to study the early pathogenesis of spinal cerebellar ataxia type 3 based on a mouse model for subsequent preventive treatment and seeking new therapeutic targets.</span></p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106991"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convention vs. Innovation II: Skin biopsy for synuclein inclusions will replace dopamine transporter imaging for Parkinson disease diagnosis 传统与创新之二：皮肤活检检测突触核蛋白内含物将取代多巴胺转运体成像用于帕金森病诊断。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107083
Liana S. Rosenthal , Oliver Phillips , Zoltan Mari
{"title":"Convention vs. Innovation II: Skin biopsy for synuclein inclusions will replace dopamine transporter imaging for Parkinson disease diagnosis","authors":"Liana S. Rosenthal ,&nbsp;Oliver Phillips ,&nbsp;Zoltan Mari","doi":"10.1016/j.parkreldis.2024.107083","DOIUrl":"10.1016/j.parkreldis.2024.107083","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 107083"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024010952/pdfft?md5=a95a176f1635fb34dd5b9fb0772db9d1&pid=1-s2.0-S1353802024010952-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of cerebrospinal fluid monoamine metabolites with striatal dopamine transporter binding and 123I-meta-iodobenzylguanidine cardiac scintigraphy in Parkinson's disease: Multivariate analyses 帕金森病患者脑脊液单胺代谢物与纹状体多巴胺转运体结合力和 123I-eta-iodobenzylguanidine 心脏闪烁扫描的关系：多变量分析。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.107129
Ryosuke Shimasaki , Masanori Kurihara , Keiko Hatano , Ryoji Goto , Kenichiro Taira , Ryoko Ihara , Mana Higashihara , Yasushi Nishina , Masashi Kameyama , Atsushi Iwata
{"title":"Associations of cerebrospinal fluid monoamine metabolites with striatal dopamine transporter binding and 123I-meta-iodobenzylguanidine cardiac scintigraphy in Parkinson's disease: Multivariate analyses","authors":"Ryosuke Shimasaki ,&nbsp;Masanori Kurihara ,&nbsp;Keiko Hatano ,&nbsp;Ryoji Goto ,&nbsp;Kenichiro Taira ,&nbsp;Ryoko Ihara ,&nbsp;Mana Higashihara ,&nbsp;Yasushi Nishina ,&nbsp;Masashi Kameyama ,&nbsp;Atsushi Iwata","doi":"10.1016/j.parkreldis.2024.107129","DOIUrl":"10.1016/j.parkreldis.2024.107129","url":null,"abstract":"<div><p>Cerebrospinal fluid (CSF) homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), dopamine and serotonin metabolites, are decreased in Parkinson's disease (PD). Although some reported associations between HVA and striatal dopamine transporter (DAT) or 5-HIAA and cardiac <sup>123</sup>I-meta-iodobenzylguanidine (MIBG) findings, respectively, whether these are direct associations remained unknown. We retrospectively reviewed 57 drug-naïve patients with PD who underwent CSF analyses and DAT and cardiac MIBG imaging. Z-score of striatal DAT specific binding ratio (Z-SBR) was measured, and the positivity of MIBG abnormalities were judged by an expert. The mean age was 75.5 ± 8.7 years. Thirty-three were MIBG-positive and 24 were MIBG-negative. 5-HIAA levels were significantly lower in the MIBG-positive group. Logistic regression analysis showed that MIBG positivity was associated with 5-HIAA level (odds ratio = 0.751, p = 0.006) but not with age, sex, and HVA. DAT Z-SBR correlated with both HVA and 5-HIAA. Multiple regression analysis showed that HVA was the only significant variable associated with Z-SBR (t = 3.510, p &lt; 0.001). We confirmed direct associations between 5-HIAA and cardiac MIBG, and between HVA and striatal DAT binding.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107129"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024011416/pdfft?md5=9331f70f575b23a271c7b388cfb7d8af&pid=1-s2.0-S1353802024011416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of AI and machine learning in the diagnosis of Parkinson's disease and atypical parkinsonisms 人工智能和机器学习在帕金森病和非典型帕金森病诊断中的作用。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106986
{"title":"The role of AI and machine learning in the diagnosis of Parkinson's disease and atypical parkinsonisms","authors":"","doi":"10.1016/j.parkreldis.2024.106986","DOIUrl":"10.1016/j.parkreldis.2024.106986","url":null,"abstract":"<div><p>Parkinson's disease is a neurodegenerative movement disorder associated with motor and non-motor symptoms causing severe disability as the disease progresses. The development of biomarkers for Parkinson's disease to diagnose patients earlier and predict disease progression is imperative. As artificial intelligence and machine learning techniques efficiently process data and can handle multiple data types, we reviewed the literature to determine the extent to which these techniques have been applied to biomarkers for Parkinson's disease and movement disorders. We determined that the most applicable machine learning techniques are support vector machines and neural networks, depending on the size and type of the data being analyzed. Additionally, more complex machine learning techniques showed increased accuracy when compared to less complex techniques, especially when multiple machine learning models were combined. We can conclude that artificial intelligence and machine learning techniques may have the capacity to significantly boost diagnostic capacity in movement disorders and Parkinson's disease.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106986"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024009982/pdfft?md5=06f763ebfdd818081c210078287b7d5c&pid=1-s2.0-S1353802024009982-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hope vs. Hype I: Spreading alpha-synuclein explains cognitive deficits in Parkinson disease 希望与炒作 I：扩散的α-突触核蛋白可解释帕金森病的认知障碍。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106042
{"title":"Hope vs. Hype I: Spreading alpha-synuclein explains cognitive deficits in Parkinson disease","authors":"","doi":"10.1016/j.parkreldis.2024.106042","DOIUrl":"10.1016/j.parkreldis.2024.106042","url":null,"abstract":"<div><p>The Parkinson Study Group (PSG) gathered North American experts in Parkinson disease during the 9<sup>th</sup> Annual Symposium on “Shaping the Management of Parkinson Disease: Debating Current Controversies”. Debaters were tasked with agree or disagree positions to a particular prompt. This is the first in three-part series of “Hype vs. Hope” debates involving current trends and advances in Parkinson disease. With the prompt of “Spreading alpha-synuclein explains cognitive deficits in Parkinson disease,” Dr. Kelly Mills, MD, MHS was tasked with the “agree” stance and Dr. Abhimanyu Mahajan, MD, MHS was tasked with the “disagree” stance. The following point-of-view article is an adaptation of this debate</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106042"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024000543/pdfft?md5=caa8f0fd6a5efd3d128df9e79dd3f861&pid=1-s2.0-S1353802024000543-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid disease in cervical dystonia- is the coexistence of thyroid diseases and cervical dystonia a coincidence? 颈肌张力障碍中的甲状腺疾病--甲状腺疾病和颈肌张力障碍同时存在是巧合吗？
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106044
{"title":"Thyroid disease in cervical dystonia- is the coexistence of thyroid diseases and cervical dystonia a coincidence?","authors":"","doi":"10.1016/j.parkreldis.2024.106044","DOIUrl":"10.1016/j.parkreldis.2024.106044","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106044"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pursuing ear-wise stimulations for Parkinson's Disease: Pathways and parameters matters 追求帕金森病的耳部刺激：路径和参数问题。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106083
{"title":"Pursuing ear-wise stimulations for Parkinson's Disease: Pathways and parameters matters","authors":"","doi":"10.1016/j.parkreldis.2024.106083","DOIUrl":"10.1016/j.parkreldis.2024.106083","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106083"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statin therapy in Parkinson's disease cuts mortality 他汀类药物治疗帕金森病可降低死亡率
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-09-01 DOI: 10.1016/j.parkreldis.2024.106043
{"title":"Statin therapy in Parkinson's disease cuts mortality","authors":"","doi":"10.1016/j.parkreldis.2024.106043","DOIUrl":"10.1016/j.parkreldis.2024.106043","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"126 ","pages":"Article 106043"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信