Parkinsonism & related disorders最新文献

{"title":"Atypical Presentation of Autosomal Recessive Cerebellar Ataxia Type I Mimicking Amyotrophic Lateral Sclerosis","authors":"T. Saltoğlu , Ö.K. Koçak , Y.S. Karadağ","doi":"10.1016/j.parkreldis.2025.107858","DOIUrl":"10.1016/j.parkreldis.2025.107858","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107858"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Case of Ataxia and Hyperkinetic Movements","authors":"S. Gunawardena , U. Shuaib","doi":"10.1016/j.parkreldis.2025.107863","DOIUrl":"10.1016/j.parkreldis.2025.107863","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107863"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ataxia with Oculomotor Apraxia Type 2: A Case Series of Four Family Members","authors":"T. Saltoğlu, B. Şahin, Z.S. Tuğlu, A. Hareket, H. Yüksel, Y.S. Karadağ","doi":"10.1016/j.parkreldis.2025.107860","DOIUrl":"10.1016/j.parkreldis.2025.107860","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107860"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Complex Case of Stiff Person Syndrome and Corticobasal Syndrome: Diagnostic Challenges","authors":"X.P. Pizarro , P.A. Salles","doi":"10.1016/j.parkreldis.2025.107861","DOIUrl":"10.1016/j.parkreldis.2025.107861","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107861"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetric Parkinsonism and Ataxia with autonomic dysfunction and RBD","authors":"A. Elavarasi, M. Jog","doi":"10.1016/j.parkreldis.2025.107859","DOIUrl":"10.1016/j.parkreldis.2025.107859","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107859"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(IN)VISIBLE ZEBRAS IN PLAIN SIGHT","authors":"F. Trpcheski , A. Angelova , G. Novotni","doi":"10.1016/j.parkreldis.2025.107864","DOIUrl":"10.1016/j.parkreldis.2025.107864","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107864"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POLG-Associated Mitochondrial Disorder Manifesting as Severe Hemidystonia","authors":"S. Anis","doi":"10.1016/j.parkreldis.2025.107862","DOIUrl":"10.1016/j.parkreldis.2025.107862","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107862"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of discontinuation in foslevodopa/foscarbidopa therapy for Parkinson's disease","authors":"Noriko Nishikawa , Taku Hatano , Daiki Kamiyama , Hikaru Kamo , Yutaka Oji , Chihiro Abe , Junko Shinada , Genko Oyama , Nobutaka Hattori","doi":"10.1016/j.parkreldis.2025.107896","DOIUrl":"10.1016/j.parkreldis.2025.107896","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107896"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of screening tools for depression and anxiety in cervical dystonia","authors":"Davide Martino ,&nbsp;Mehrafarin Ramezani ,&nbsp;Steven Bellows ,&nbsp;Brian D. Berman ,&nbsp;Florence Ching-Fen Chang ,&nbsp;Jeanne Feuerstein ,&nbsp;Victor Fung ,&nbsp;Gamze Kilic Berkmen ,&nbsp;Irene A. Malaty ,&nbsp;Claire MacIver ,&nbsp;Scott A. Norris ,&nbsp;Kathryn J. Peall ,&nbsp;Joel S. Perlmutter ,&nbsp;Sarah Pirio Richardson ,&nbsp;Laura J. Wright ,&nbsp;Zahra Goodarzi ,&nbsp;Hyder A. Jinnah","doi":"10.1016/j.parkreldis.2025.107891","DOIUrl":"10.1016/j.parkreldis.2025.107891","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite their high prevalence and impact, depression and anxiety are not routinely screened for, and accuracy of screening procedures is unknown in adult-onset dystonia. We evaluated accuracy parameters of selected self-rated scales for depression and anxiety in patients with idiopathic cervical dystonia (CD).</div></div><div><h3>Methods</h3><div>Two-hundred-and-ten patients with idiopathic CD were recruited from 10 movement disorders centers from the US, Canada, Australia, and UK. At the end of each botulinum toxin cycle, participants were administered the Adult Standard Mini-International Neuropsychiatric Interview (MINI) as reference standard for depression and anxiety. Participants completed 8 self-administered index instruments (2 for depression, 2 for anxiety, and 4 combining screening for both). Sensitivity, specificity, positive and negative predictive values, covariate-adjusted area under the receiver operating characteristic curve (AUC), and likelihood ratios were calculated for all instruments.</div></div><div><h3>Results</h3><div>On the MINI, 8.6 % (100 % female) fulfilled criteria for current major depressive disorder and 10.5 % (91 % female) fulfilled criteria for any current disorder amongst panic, social anxiety or generalized anxiety disorders. For depression screening, all tools had an AUC higher than 0.80, with the two most accurate being the BDI-II (AUC 0.91, sensitivity 87.5 %) and the HADS-Depression (AUC 0.88, sensitivity 93.7 %). For anxiety screening, the only instrument showing clinical usefulness was the HADS-Anxiety (AUC 0.82, sensitivity 86.3 %).</div></div><div><h3>Conclusion</h3><div>Current major depression can be screened in CD with high degree of accuracy using different self-administered scales, whereas existing screening tools for anxiety perform worse. Dystonia-specific instruments are less accurate than scales developed for the general population.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107891"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive association between total bilirubin and early-stage Parkinson's disease","authors":"Wen Zhou,&nbsp;Qingqing Xia,&nbsp;Duan Liu,&nbsp;Jun-ying Li,&nbsp;Liang Gong","doi":"10.1016/j.parkreldis.2025.107888","DOIUrl":"10.1016/j.parkreldis.2025.107888","url":null,"abstract":"<div><h3>Background</h3><div>The correlation between total bilirubin and Parkinson's disease (PD) remains unclear currently. This study aimed to assess the association between total bilirubin and early-stage PD.</div></div><div><h3>Objective</h3><div>The ultimate goal is to gain a deeper understanding of the implications of this relationship between total bilirubin and early-stage PD.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cross-sectional study involving 1631 participants which collected from 2010 to 11 December 2024 in PPMI cohort. Logistic regression, smooth curve fitting, subgroup analysis, and sensitivity analyses were employed to validate the research objectives.</div></div><div><h3>Results</h3><div>The overall prevalence of PD was 81.5 % (1329/1631). Specifically, the prevalence was 78.0 % (294/377) for total bilirubin tertile 1 (T1, 3–7 μmol/L), 80.8 % (498/616) for tertile 2 (T2, 7–10 μmol/L), and 84.2 % (537/638) for tertile 3 (T3, 10–48 μmol/L), respectively (P = 0.043). Multivariate odds ratio regression adjusted for risk factors demonstrates a 5-unit increment in the total bilirubin raises the risk of early-stage PD by 1.16 times, respectively. Smooth splines analysis suggested a linear association between levels of total bilirubin and risk of early-stage PD (P nonlinearity = 0.968). Further exploratory subgroup analysis within the age, sex, BMI, and MCI groups showed that there were no significant interactions between the subgroups (all P values for interaction were &gt;0.05). Additional sensitivity analyses supported the primary findings and indicated the conclusions are robust.</div></div><div><h3>Conclusions</h3><div>The observed association between elevated total bilirubin levels and early-stage PD risk suggests that bilirubin may serve as a potential biomarker for early diagnosis and disease monitoring.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107888"},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}