Parkinsonism & related disorders最新文献

{"title":"Moderators of aerobic exercise effects on motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis.","authors":"Ryul Kim, Nyeonju Kang, Joon Ho Lee, Hanall Lee, Tae Lee Lee, Do Kyung Ko, Hajun Lee, Kyeongho Byun, Kiwon Park, Jee-Young Lee, Beomseok Jeon","doi":"10.1016/j.parkreldis.2025.107779","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107779","url":null,"abstract":"<p><strong>Introduction: </strong>Although growing evidence suggests that aerobic exercise has beneficial effects on motor symptoms in patients with Parkinson's disease (PD), it remains unclear which specific aerobic exercise regimen optimizes improvement in these symptoms. This study aimed to investigate the difference in the effects of aerobic exercise on motor function in patients with PD according to exercise intervention protocols.</p><p><strong>Methods: </strong>Through 28 qualified studies with randomized controlled trials, we assessed motor function using either the Unified PD Rating Scale (UPDRS) III or Movement Disorder Society-UPDRS III as an outcome measure. We employed random effects meta-analysis models to obtain standardized mean differences and 95 % confidence intervals (CIs). Moderator variable analyses were conducted based on exercise type (aerobic exercise vs. aerobic-based combined exercise), duration (<60 min vs. ≥60 min per session), frequency (<four vs. ≥four sessions per week), period (<12 weeks vs. ≥12 weeks), and intensity (low-to-moderate vs. moderate-to-high).</p><p><strong>Results: </strong>Aerobic exercise interventions demonstrated significant improvements in overall motor function. Although all categories were significantly effective in improving motor function, aerobic-based combined exercise had a greater effect size on motor symptoms compared to aerobic exercise alone. Additionally, ≥60 min per session showed a significantly increased effect size compared to <60 min per session. The impact of aerobic exercise did not differ based on exercise frequency, period, or intensity.</p><p><strong>Conclusions: </strong>Our observations suggest that aerobic-based combined exercise and exercise sessions lasting 60 min or longer may be associated with greater improvements in motor symptoms in patients with PD.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107779"},"PeriodicalIF":3.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pure autonomic failure, phenoconversion phenomenon and autonomic non-motor subtype of Parkinson disease: The chicken or the egg?","authors":"Daniel Rebolledo-Garcia","doi":"10.1016/j.parkreldis.2025.107773","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107773","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107773"},"PeriodicalIF":3.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Chaparro-Solano et al.: \"Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review.\" Parkinsonism Relat Disord. 2025 Jan;130:107206.","authors":"Anton J M Loonen","doi":"10.1016/j.parkreldis.2025.107774","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107774","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107774"},"PeriodicalIF":3.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholinergic basal forebrain atrophy and cortical alterations in Parkinson's disease with apathy.","authors":"Qianqian Si, Caiting Gan, Aidi Shan, Huimin Sun, Xingyue Cao, Shiyi Ye, Jiaxin Shi, Chenhui Wan, Xufeng Wang, Yongsheng Yuan, Kezhong Zhang","doi":"10.1016/j.parkreldis.2025.107793","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107793","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging evidences support the contribution of cholinergic deficiency to apathy in Parkinson's disease (PD). We aimed to ascertain the role of structural alterations of cholinergic basal forebrain (BF) and its innervated cortical regions in the pathogenesis of apathy in PD.</p><p><strong>Methods: </strong>Twenty-one PD patients with apathy (PD-A), 28 without apathy (PD-NA), and 20 healthy controls (HCs) were recruited in this study. Changes in subregional volumes of the BF were compared. Cortical thickness and local gyrification index (LGI) analysis were adopted to reveal the concomitant cortical alterations. The correlation with the severity of apathy and the diagnostic capacity were also assessed.</p><p><strong>Results: </strong>Compared to PD-NA and HCs groups, PD-A group showed excessively nucleus basalis of Meynert (NBM/Ch4) atrophy (p < 0.05 after Bonferroni correction), accompanied by cortical thinning and hypergyrification of the right entorhinal cortex (p < 0.001 after Bonferroni correction). Furthermore, regression analysis showing that the Ch4 volume was negatively associated with the severity of apathy in PD-A group (β = -23.198, T = -1.063, p = 0.039). All the above significant neuroimaging alterations showed good performance in identifying apathetic patients (p < 0.001).</p><p><strong>Conclusion: </strong>Our findings highlighted that BF cholinergic degeneration driven by Ch4 atrophy may be involved in the pathogenesis of apathy in PD patients without dementia or depression.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"107793"},"PeriodicalIF":3.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Queasy to Rigid - An amendment on the administration of contraindicated antiemetics in hospitalized people with Parkinson's disease","authors":"Camila C. Piccinin ,&nbsp;Jeryl Ritzi T. Yu ,&nbsp;Claire Sonneborn ,&nbsp;Olivia Hogue ,&nbsp;Roman Popov ,&nbsp;Debolina Ghosh ,&nbsp;Anne Brooks ,&nbsp;James Liao ,&nbsp;Shannon Shaffer ,&nbsp;Scott A. Sperling ,&nbsp;Benjamin L. Walter","doi":"10.1016/j.parkreldis.2025.107782","DOIUrl":"10.1016/j.parkreldis.2025.107782","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107782"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No causal link between smoking and dementia with Lewy bodies.","authors":"Yu-Liang Gao, Qiu-Han Xu","doi":"10.1016/j.parkreldis.2025.107775","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107775","url":null,"abstract":"<p><p>This letter addresses the findings of Goodheart and Gomperts (2024), which observed an association between smoking and reduced odds of dementia with Lewy bodies (DLB). In contrast, our Mendelian randomization analysis found no causal link, suggesting that further research using genetically informed methods is needed to clarify these results.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107775"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of SLC17A5 variants in large European cohorts reveals no association with Parkinson's disease risk","authors":"Marya S. Sabir ,&nbsp;Mary B. Makarious ,&nbsp;Marjan Huizing ,&nbsp;William A. Gahl ,&nbsp;Frances M. Platt ,&nbsp;May Christine V. Malicdan","doi":"10.1016/j.parkreldis.2025.107790","DOIUrl":"10.1016/j.parkreldis.2025.107790","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein aggregation. Aging is the primary risk factor, with both rare and common genetic variants playing a role. Previous studies have implicated lysosomal storage disorder (LSD)-related genes, including <em>SLC17A5,</em> in PD susceptibility.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the association of <em>SLC17A5</em> variants, including rare and common variants and the FSASD-associated p.Arg39Cys missense variant, with PD risk in large European ancestry cohorts.</div></div><div><h3>Methods</h3><div>Rare variant burden analyses were performed at minor allele frequency (MAF) thresholds of ≤1 % and ≤0.1 % in 7,184 PD cases and 51,650 controls using whole-genome and whole-exome sequencing data. Association testing of the p.Arg39Cys variant was conducted across five cohorts, encompassing both Finnish and non-Finnish Europeans. Common variant associations were examined using summary statistics from the largest European GWAS of PD.</div></div><div><h3>Results</h3><div>No significant association was observed between rare <em>SLC17A5</em> variants and PD at either MAF threshold. The p.Arg39Cys variant, though enriched in Finnish Europeans, showed no significant association with PD across several cohorts. Similarly, common <em>SLC17A5</em> variants (MAF ≥1%) were not associated with PD risk.</div></div><div><h3>Conclusion</h3><div>Our findings do not support a role for <em>SLC17A5</em> variants in PD susceptibility. While lysosomal dysfunction is central to PD pathogenesis, its contribution appears pathway-specific, with <em>SLC17A5</em> unlikely to influence risk. Larger, multiethnic studies and functional analyses are needed to further investigate sialic acid metabolism in PD and related disorders.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107790"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOR1AIP2 as a candidate gene for dystonia-hemichorea/hemiballism","authors":"Efthymia Kafantari ,&nbsp;Victoria J. Hernandez ,&nbsp;Ján Necpál ,&nbsp;Marina Leonidou ,&nbsp;Regina Baureder ,&nbsp;Carola Hedberg-Oldfors ,&nbsp;Robert Jech ,&nbsp;Michael Zech ,&nbsp;Thomas U. Schwartz ,&nbsp;Andreas Puschmann","doi":"10.1016/j.parkreldis.2025.107781","DOIUrl":"10.1016/j.parkreldis.2025.107781","url":null,"abstract":"<div><div>Dystonia is a movement disorder characterized by genetic and clinical heterogeneity. A recurring p.(Glu303del)-deletion in <em>TOR1A</em> is a well-established cause for DYT-<em>TOR1A</em> (DYT1), an autosomal dominant early-onset isolated dystonia. <em>TOR1A</em> encodes TorsinA, an AAA + ATPase located in the nuclear envelope. By whole exome analyses of a family with a novel dystonia-hemichorea-/hemiballism phenotype, we identified a <em>TOR1AIP2</em> NM_001199260.2 c.1234A &gt; G p.(Arg412Gly) variant. The variant is very rare in databases and was absent from whole exome data from &gt;1000 dystonia patients. <em>TOR1AIP2</em> encodes LULL1, a transmembrane protein that activates TorsinA, and correct interaction between TorsinA and LULL1 is essential for proper nuclear envelope architecture. The p.(Arg412Gly) variant disrupts the binding interface between TorsinA and LULL1 around p.Arg412; this same interface is also impaired in DYT1. Functional analyses via a co-purification assay revealed that interaction between TorsinA-LULL1^Arg412Gly is weaker than the wild-type interaction, and that it resembles the situation in DYT1 (TorsinA^ΔE303-LULL1). A second family with milder dystonia, hemichorea, and stereotypic leg flexion during gait and a <em>TOR1AIP2</em> p.(Gln338His) variant was identified. The clinical phenotype of both families shared proximal arm movements, and flutter in facial musculature. Expressivity of the movement disorder symptoms was variable. Several proteins in the nuclear envelope have been implicated in various forms of neurodevelopmental disorders with dystonia. Taken together, our findings suggest <em>TOR1AIP2</em> as a new candidate gene implicated in a complex hereditary movement disorder with dystonia and hemichorea/hemiballism.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107781"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of bright light therapy on Parkinson's disease: A pilot study using vestibular-evoked myogenic potentials","authors":"Wei-ye Xie ,&nbsp;Wen-xiang Duan ,&nbsp;Ying Chen ,&nbsp;Meng-xing Tao ,&nbsp;Han-xing Li ,&nbsp;Fan Gao ,&nbsp;Jie-yun Yin ,&nbsp;Jia-hui Yan ,&nbsp;Fen Wang ,&nbsp;Cheng-jie Mao ,&nbsp;Yun Shen ,&nbsp;Chun-feng Liu","doi":"10.1016/j.parkreldis.2025.107776","DOIUrl":"10.1016/j.parkreldis.2025.107776","url":null,"abstract":"<div><h3>Introduction</h3><div>Bright light therapy (BLT) has been proved to have beneficial effects on Parkinson's disease (PD). Brainstem pathways improvements might be crucial to BLT, but the mechanisms remained unclear. The aim of this study is to validate whether BLT improves clinical symptoms in PD and thus explore the possible mechanisms of brainstem pathways evaluated by vestibular-evoked myogenic potentials (VEMPs).</div></div><div><h3>Methods</h3><div>A total of 22 PD patients participated were enrolled in this crossover randomized placebo-controlled study. Participants received either one month of BLT or dim light therapy (DLT), separated by a 1-month wash-out period, and underwent clinical scales and VEMPs evaluations before and after each intervention. Mixed-effects regression models were used to determine the effect between BLT and DLT on PD patients by the differentials of clinical scales (Δscales) and VEMPs (ΔVEMPs). Correlations between the improvement of clinical symptoms and VEMPs parameters improvements were analyzed in PD patients receiving BLT.</div></div><div><h3>Results</h3><div>Excessive daytime sleepiness, anxiety, life quality and autonomic function were improved after BLT. Compared to DLT, the difference was not significant. There were significant differences of cervical VEMPs (cVEMP) and ocular VEMPs (oVEMP) peak latencies after BLT. Compared with DLT, there was significant difference in ΔLp13, ΔRp13 and ΔLp11 peak latencies after BLT.</div></div><div><h3>Conclusions</h3><div>BLT may be a valuable non-pharmacological intervention for improving brainstem function, thereby enhancing quality of life and overall health in PD patients.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107776"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an adapted physical activity program in Parkinson's disease: A randomized controlled study (APA-Park)","authors":"Carole Zanchet ,&nbsp;Céline Lambert ,&nbsp;Thibaut Boyer ,&nbsp;Bruno Pereira ,&nbsp;Philippe Derost ,&nbsp;Bérengère Debilly ,&nbsp;Martine Duclos ,&nbsp;Nathalie Boisseau ,&nbsp;Ana Marques","doi":"10.1016/j.parkreldis.2025.107777","DOIUrl":"10.1016/j.parkreldis.2025.107777","url":null,"abstract":"<div><h3>Context</h3><div>Previous studies assessing adapted physical activity (APA) in Parkinson's disease (PD) have been very heterogeneous regarding methodology and intervention, and have generally not addressed the question of combining various types of physical activity with a long-term evaluation.</div></div><div><h3>Objectives</h3><div>To evaluate the immediate and long-term effect of a 3-month APA program, combining endurance, resistance training and stretching on motor symptoms, body composition, cardiorespiratory function and metabolic profile in PD patients.</div></div><div><h3>Methods</h3><div>In this controlled trial, we randomly assigned forty-four PD patients in a 1:1 ratio to receive a 3-month APA program (APA + group, n = 22), or freely practice physical activity (APA− group, n = 22). The patients were evaluated for parkinsonian symptoms (UPDRS-III), body composition, cardiorespiratory function and metabolic profile at baseline, immediately after the end of the program (M3) and six months later (M9).</div></div><div><h3>Results</h3><div>Between baseline and M3, the mean UPDRS-III score decreased in PD patients from the APA + group whereas it increased in the APA− group (−1.2 ± 6.6 vs. +1.9 ± 8.9; p = 0.04), regardless of age, sex, disease duration, dopaminergic treatment, UPDRS-III and axial score at baseline, but these between group differences waned at M9. No between group difference was observed regarding the evolution of body composition, metabolic profile or cardiorespiratory function between baseline, M3 and M9.</div></div><div><h3>Conclusion</h3><div>A 3-month APA program combining endurance and resistance training plus stretching is more efficient for improving motor symptoms in PD compared to an unstructured engagement in non-specific physical activities. However, the benefits fade away six months after discontinuation of the program.</div></div><div><h3>Statistical analysis conducted by</h3><div>LAMBERT Céline, CHU Clermont-Ferrand, DRCI, Biostatistics Unit, Clermont-Ferrand, FRANCE.</div></div><div><h3>Registration number</h3><div>clinicaltrials.gov number NCT02816619.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107777"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}