Parkinsonism & related disorders最新文献

{"title":"Amygdala neurodegeneration differentiates brain-first and body-first Parkinson's disease: An MRI study","authors":"Nils Schröter ,&nbsp;Laura Matinpalo ,&nbsp;Jonas A. Hosp ,&nbsp;Marco Reisert ,&nbsp;Lea Philpsen ,&nbsp;Wolfgang H. Jost ,&nbsp;Heinz Wiendl ,&nbsp;Horst Urbach ,&nbsp;Michel Rijntjes ,&nbsp;Alexander Rau","doi":"10.1016/j.parkreldis.2025.107827","DOIUrl":"10.1016/j.parkreldis.2025.107827","url":null,"abstract":"<div><h3>Background</h3><div>Two distinct patterns of alpha-synuclein spread in Parkinson's disease were proposed with a body-first and a brain-first subtype. The body-first subtype originates in the periphery, while the brain-first subtype initiates in the central nervous system, notably affecting the amygdala.</div></div><div><h3>Objectives</h3><div>This retrospective cross-sectional study compared the integrity of the substantia nigra and amygdala between body-first and brain-first Parkinson's disease subtypes.</div></div><div><h3>Methods</h3><div>We analyzed data from 30 Parkinson's disease patients, classified into body-first (n = 21) and brain-first (n = 9) subtypes based on REM sleep behavior disorder history. Microstructural integrity was assessed using diffusion microstructure MRI.</div></div><div><h3>Results</h3><div>No significant differences were found in the substantia nigra between subtypes. However, amygdala degeneration was significantly pronounced in the “brain-first” compared to the “body-first” group reflected by increased free interstitial fluid (p = 0.02, Cohen's d = −1.22).</div></div><div><h3>Conclusions</h3><div>The degeneration of amygdala is distinctively pronounced in “brain-first” Parkinson's disease, supporting differential disease progression patterns between subtypes.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107827"},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cognitive impairment and Alzheimer's disease neuropathological changes on gait, freezing and falls in Parkinson's disease","authors":"Jacy Bezerra Parmera ,&nbsp;Sarah Wrigley ,&nbsp;Patrick W. Cullinane ,&nbsp;Tamas Revesz ,&nbsp;Zane Jaunmuktane ,&nbsp;Thomas T. Warner ,&nbsp;Eduardo de Pablo-Fernández","doi":"10.1016/j.parkreldis.2025.107826","DOIUrl":"10.1016/j.parkreldis.2025.107826","url":null,"abstract":"<div><h3>Background</h3><div>The longitudinal impact of cognitive impairment and Alzheimer's disease neuropathological changes (ADNC) on gait dysfunction in Parkinson's disease (PD) requires further evaluation. This study aimed to investigate the association between cognitive impairment and ADNC on gait disturbances in PD.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of pathology-confirmed PD patients with brain donation to the Queen Square Brain Bank between 2010 and 2022. Cognitive parameters (latency to dementia, hallucinations, and cholinesterase inhibitors prescription) and gait outcomes (falls, freezing (FoG), wheelchair use, postural instability and gait difficulty subtype (PIGD)) were collected from medical records. Lewy pathology and ADNC were assessed using standard staging systems. Cox proportional and logistic regression analyses estimated the associated risk of cognitive parameters and pathological changes with gait outcomes.</div></div><div><h3>Results</h3><div>A total of 140 PD patients (mean onset 60.7 years) were included. Dementia increased risk of future falls (Hazard Ratio (HR) 0.88; 95 %CI 0.84–0.92), wheelchair dependence (HR 0.84; 95 %CI 0.78–0.89), FoG severity (Odds Ratio(OR) 0.88; 95 %CI 0.77–0.98) and the PIGD subtype (OR 0.80; 95 %CI 0.69–0.92). Hallucinations increased FoG risk (HR 0.95; 95 %CI 0.92–0.99) and the PIGD subtype (OR 0.86; 95 %CI 0.75–0.97). Global ADNC and amyloid-β deposition were associated with earlier (HR 5.17; 95 %CI 1.50–17.78) and more severe gait freezing (OR 2.13; 95 %CI 1.25–3.62).</div></div><div><h3>Conclusion</h3><div>Cognitive impairment and hallucinations are risk factors for future gait disturbances and FoG in PD. Global ADNC (particularly amyloid-β deposition) likely contribute to the pathophysiology of FoG, with potential therapeutic implications.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107826"},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating sex-specific associations of Parkinson's disease with sex hormones and sex hormones-related phenotypes using Mendelian randomization","authors":"Shulin Liu ,&nbsp;Yuxuan Hu ,&nbsp;Jiabin Liu ,&nbsp;Yang Luo ,&nbsp;Taole Li ,&nbsp;Zhenhua Liu ,&nbsp;Qian Xu ,&nbsp;Qiying Sun ,&nbsp;Xinxiang Yan ,&nbsp;Jinchen Li ,&nbsp;Beisha Tang ,&nbsp;Zhihui Tan ,&nbsp;Jifeng Guo","doi":"10.1016/j.parkreldis.2025.107831","DOIUrl":"10.1016/j.parkreldis.2025.107831","url":null,"abstract":"<div><h3>Background</h3><div>It has been reported that the incidence of Parkinson's disease (PD) in men is 1.5 times that of women, which is easily associated with the protective effect of estrogens on the dopaminergic system. However, the exact direction and magnitude of the effect of sex hormones on PD risk have not been clarified. This study aimed to evaluate the sex-specific association between PD and sex hormones and their related phenotypes using Mendelian randomization (MR).</div></div><div><h3>Method</h3><div>We utilized summary statistics from seven sex-specific genome-wide association studies (GWAS), including the UK Biobank, FinnGen, the INTERVAL Study, and the International Parkinson's Disease Genomics Consortium. Using univariable MR (UVMR) and multivariable MR (MVMR), we investigated causal relationships between genetically predicted sex hormone levels and PD, as well as sex hormone-related traits.</div></div><div><h3>Result</h3><div>We found a negative genetic correlation between PD and total testosterone levels (rg = −0.019, <em>p</em> = 0.046) and bioavailable testosterone levels (rg = −0.028, <em>p</em> = 0.019) among the entire population. UVMR results suggested that genetically predicted elevated bioavailable and total testosterone levels were associated with a reduced risk of PD in the entire population. When evaluating reverse causation, we found that genetically predicted female PD was associated with lower levels of sex hormone-binding globulin. Using MVMR, we further identified a suggestive association between genetically predicted total testosterone levels and a lower risk of PD.</div></div><div><h3>Conclusion</h3><div>Based on our findings, we believe that there may be a potential association between genetically determined testosterone levels and the risk of PD.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107831"},"PeriodicalIF":3.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Moderators of aerobic exercise effects on motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis” [Parkinsonism & related disorders, Advance online publication/107779]","authors":"Ryul Kim ,&nbsp;Nyeonju Kang ,&nbsp;Joon Ho Lee ,&nbsp;Hanall Lee ,&nbsp;Tae Lee Lee ,&nbsp;Do Kyung Ko ,&nbsp;Hajun Lee ,&nbsp;Kyeongho Byun ,&nbsp;Kiwon Park ,&nbsp;Jee-Young Lee ,&nbsp;Beomseok Jeon","doi":"10.1016/j.parkreldis.2025.107814","DOIUrl":"10.1016/j.parkreldis.2025.107814","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107814"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A validation study of the Clinician's Tardive Inventory (CTI)","authors":"Richard M. Trosch ,&nbsp;Alicia C. Shillington ,&nbsp;Cynthia L. Comella ,&nbsp;Stanley N. Caroff ,&nbsp;William G. Ondo ,&nbsp;Brandon J. LaChappelle ,&nbsp;Qing Harshaw ,&nbsp;Robert A. Hauser ,&nbsp;Christoph U. Correll ,&nbsp;Joseph H. Friedman","doi":"10.1016/j.parkreldis.2025.107812","DOIUrl":"10.1016/j.parkreldis.2025.107812","url":null,"abstract":"<div><div>Current clinician-rated tardive dyskinesia (TD) symptom scales do not address expanding clinical signs and functional impacts. The Clinician's Tardive Inventory (CTI) is a newly developed instrument documenting designed by movement disorder specialists and psychiatrists. It is comprised of 6 anatomic domains generating a combined movement amplitude/frequency severity score (CSS), and a functional sore. This study tested the validity of the CTI.</div></div><div><h3>Methods</h3><div>Videotaped patient assessments and vignettes were rated with the CTI and Abnormal Involuntary Movement Scale (AIMS) administered on the same patient. Construct validity was determined by agreement between the CTI CSS and AIMS dyskinesia score via a Spearman rho. Exploratory analyses examined correlations between the CTI Functional Score, AIMS functional questions 9 and 10, and the CTI CSS. We examined the AIMS dyskinesia score versus AIMS questions 9 and 10.</div></div><div><h3>Results</h3><div>Seventy patients were assessed. Mean (SD) age: 59 (12) years; 51 % (73 %) were female. CSS and AIMS dyskinesia scores were highly correlated: .770 (95 % CI .653, .851). CTI Functional Score was also highly correlated with the AIMS functional questions 9: .626 (95 % CI .458, .750) and question 10: .771 (95 % CI .655, .852). CSS was not well correlated with the CTI Functional score: .285 (95 % CI .0536, .487). AIMS dyskinesia score was also weakly correlated with questions 9: .299 (95 % CI .069, .499), and 10: .395 (95 % CI .176, .576.).</div></div><div><h3>Conclusions</h3><div>CTI incorporates updated understanding of phenomenology and demonstrates validity in assessing TD movement severity. Consistent with clinical experience, movement severity does not correlate with functional impacts.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107812"},"PeriodicalIF":3.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The third wheel or the game changer? How AI could team up with neurologists in Parkinson's care","authors":"Maria Chiara Malaguti ,&nbsp;Lorenzo Gios ,&nbsp;Giuseppe Jurman","doi":"10.1016/j.parkreldis.2025.107797","DOIUrl":"10.1016/j.parkreldis.2025.107797","url":null,"abstract":"<div><h3>Introduction</h3><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by diverse motor and non-motor symptoms. AI appears to be the elephant in the neurologist's room, albeit offering transformative potential in early diagnosis, personalized care, and treatment optimization, addressing the complexities of PD management.</div></div><div><h3>Methods</h3><div>A PubMed review analyzed AI's role in PD care, focusing on multimodal data, clinician-in-the-loop models, and validation strategies to enhance clinical applicability while addressing ethical concerns.</div></div><div><h3>Results</h3><div>Thirty-nine studies met inclusion criteria. While progress is evident, challenges include limited independent validation, small sample sizes, and inconsistent clinician involvement. Key trends show growing interest in multimodal data and predictive modelling, though gaps in transparency persist.</div></div><div><h3>Conclusions</h3><div>AI holds promise for improving PD management, yet robust validation, interdisciplinary collaboration, and clearer clinician roles are essential for advancing patient-centered care and fostering trust in AI-driven innovations.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107797"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the role of amyloid in isolated REM sleep behavior disorder","authors":"Qiu-Han Xu,&nbsp;Cheng Wang","doi":"10.1016/j.parkreldis.2025.107809","DOIUrl":"10.1016/j.parkreldis.2025.107809","url":null,"abstract":"<div><div>We investigated the causal relationship between cortical amyloid-β (Aβ) deposition, isolated REM sleep behavior disorder (iRBD), and Lewy body dementia (LBD) using Mendelian randomization (MR) analysis. Our findings revealed no causal link between Aβ deposition and iRBD/LBD, suggesting amyloid accumulation in iRBD is likely a coexisting phenomenon rather than a primary driver of disease progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107809"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoclonic manifestations and skin inclusions as diagnostic clues in ATP13A2-related disorders","authors":"Chiara Benzoni ,&nbsp;Gianluca Marucci ,&nbsp;Chiara Pisciotta ,&nbsp;Andrea Stabile ,&nbsp;Emanuela Maderna ,&nbsp;Daniela Di Bella ,&nbsp;Federica Invernizzi ,&nbsp;Virginia Iacobelli ,&nbsp;Elisa Sarto ,&nbsp;Davide Rossi Sebastiano ,&nbsp;Davide Pareyson ,&nbsp;Laura Canafoglia ,&nbsp;Ettore Salsano","doi":"10.1016/j.parkreldis.2025.107813","DOIUrl":"10.1016/j.parkreldis.2025.107813","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107813"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convention vs. innovation II: Genetic profiles should be a standard consideration in the assessment for deep brain stimulation candidacy for people with Parkinson's disease (PSG debate 2024).","authors":"Thomas F Tropea, Saar Anis, Ramirez-Zamora Adolfo","doi":"10.1016/j.parkreldis.2025.107810","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107810","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107810"},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hope vs Hype III: Should physicians be more open in endorsing cannabis for Parkinson's disease? (PSG Debate 2024).","authors":"Eric Farbman, Saar Anis, Diego Torres-Russotto","doi":"10.1016/j.parkreldis.2025.107811","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107811","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107811"},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}