Apraxia of eyelid opening and the variable motor phenomenology of blepharospasm

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-04-19 DOI:10.1016/j.parkreldis.2025.107843

Antonella Muroni , Gina Ferrazzano , Vittorio Velucci , Daniele Belvisi , Angelo Fabio Gigante , Antonella Conte , Alfredo Berardelli , Giovanni Defazio

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引用次数: 0

Abstract

Apraxia of eyelid opening (AEO) is characterized by a transient inability to initiate eyelid elevation following voluntary or involuntary closure, in the absence of visible contraction of the orbicularis oculi muscle. This condition is frequently associated with blepharospasm (BSP); however, the relationship between AEO and the variable motor presentations of BSP remains unknown.

In this study, we analyzed 104 patients with isolated, idiopathic, adult-onset BSP for the presence of AEO, the type of orbicularis oculi muscle spasms, and other relevant demographic and clinical characteristics. Comparison of patients with and without AEO revealed significant associations between AEO and the presence, frequency, and duration of prolonged (>3 s) orbicularis oculi spasms leading to complete eyelid closure. This finding was specific, as no association was observed between AEO and brief (<3 s) orbicularis oculi spasms. Additionally, no other demographic or clinical parameters were significantly associated with AEO in BSP patients.

We propose that AEO and BSP with prolonged spasms may share common pathophysiological mechanisms. This observation could have important therapeutic implications for the management of patients with AEO.

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开眼睑失用症与眼睑痉挛的可变运动现象

开眼睑失用症（AEO）的特征是在没有可见的眼轮匝肌收缩的情况下，在自愿或非自愿闭上眼睑后，暂时无法启动眼睑提升。这种情况通常与眼睑痉挛（BSP）有关；然而，AEO与BSP的可变运动表现之间的关系尚不清楚。在这项研究中，我们分析了104例孤立的特发性成人发病BSP患者是否存在AEO、眼轮匝肌痉挛类型以及其他相关的人口统计学和临床特征。对有和没有AEO的患者进行比较，发现AEO与长时间（3 s）眼轮匝肌痉挛的存在、频率和持续时间之间存在显著关联，从而导致眼睑完全闭合。这一发现是特异性的，因为AEO与短暂（3 s）眼轮匝肌痉挛之间没有关联。此外，没有其他人口统计学或临床参数与BSP患者的AEO显著相关。我们认为，AEO和BSP伴长时间痉挛可能具有共同的病理生理机制。这一观察结果可能对AEO患者的治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.