Parkinsonism & related disorders最新文献

{"title":"Post-shunt prognosis in patients with idiopathic normal-pressure hydrocephalus and comorbid progressive supranuclear palsy: A retrospective, single-center study in Japan.","authors":"Hirokazu Uchigami, Naoyuki Samejima, Akira Watanabe, Nobumasa Kuwana, Takeyuki Tsuchida, Masaaki Saito","doi":"10.1016/j.parkreldis.2025.107308","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107308","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107308"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-genetic analysis of patients with LRRK2-related Parkinson's disease from a referral centre in India","authors":"Shivani Rath , Vikram V. Holla , Prashant Phulpagar , Sneha D. Kamath , Nitish Kamble , Babylakshmi Muthusamy , Ravi Yadav , Pramod K. Pal","doi":"10.1016/j.parkreldis.2025.107299","DOIUrl":"10.1016/j.parkreldis.2025.107299","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107299"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic prosodic parameters associated with Parkinson's disease cognitive impairment","authors":"Ye Liu ,&nbsp;Xi-Xi Wang ,&nbsp;Xu-Jun Wang ,&nbsp;Min-Min Yin ,&nbsp;Mo-Yao Tan ,&nbsp;Chang-Peng Wang ,&nbsp;Tie-Nan Feng ,&nbsp;Jie Liu ,&nbsp;Yu Wang ,&nbsp;Xuan Li ,&nbsp;Si-Jia Peng ,&nbsp;Xiao-Jin Zhang ,&nbsp;Xiao-Ying Zhu ,&nbsp;Ya Feng ,&nbsp;Eng-King Tan ,&nbsp;Yun-Cheng Wu","doi":"10.1016/j.parkreldis.2025.107306","DOIUrl":"10.1016/j.parkreldis.2025.107306","url":null,"abstract":"<div><h3>Background</h3><div>Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in Alzheimer's disease (AD). We hypothesize that acoustic analysis can also differentiate cognitive impairment in Parkinson's disease (PD).</div></div><div><h3>Methods</h3><div>We investigated acoustic parameters in 90 subjects including 30 PD with normal cognition (PD-NC), 30 PD with mild cognitive impairment (PD-MCI) and 30 PD with dementia (PDD). The reading task “Supermarket Passage” and the picture description task “Cookie Theft” were used. Feature selection and modelling were then performed to systematically evaluate the importance and clinical implications of the acoustic parameters in identifying PD with cognitive impairment.</div></div><div><h3>Results</h3><div>Analysis of covariance (ANCOVA) and mediation analysis revealed that acoustic parameters were independently associated with cognitive impairment including PDD and PD-MCI. These Acoustic parameters enabled the detection of PD with cognitive impairment with an area under the receiver operating characteristic curve (AUC) of 0.826. Compared with PD-NC, speech rate, pre-verb pause (≥1s), between-utterance pause (≥2s) in the “Cookie Theft” task were the two key cognitive impairment detection factors, which were frequently identified by LASSO model in both PDD and PD-MCI. F₀SD of interrogative sentence was often selected in PDD. In feature selection, AUC was 0.944 in discriminating PDD from PD-NC and AUC was 0.753 in discriminating PD-MCI from PD-NC.</div></div><div><h3>Conclusion</h3><div>We demonstrated that acoustic parameters are useful in differentiating PD patients with cognitive impairment from patients with normal cognition after adjusting variables such as age, which was also a significant contributor to cognitive decline. Acoustic parameters may be valuable for automated screening the risk of cognitive decline in PD patients. It deserves further investigation.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107306"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine transporter imaging to predict the risk of aspiration in patients with Parkinson's disease","authors":"Jun Tanimura ,&nbsp;Toshiyuki Yamamoto ,&nbsp;Yoko Shigemoto ,&nbsp;Noriko Sato ,&nbsp;Yuji Takahashi","doi":"10.1016/j.parkreldis.2025.107307","DOIUrl":"10.1016/j.parkreldis.2025.107307","url":null,"abstract":"<div><h3>Introduction</h3><div>Aspiration is a critical complication of dysphagia in Parkinson's disease (PD). Current methods for predicting aspiration are unsuitable for routine implementation owing to time constraints, cost, or insufficient predictive accuracy. We assessed the predictive performance of clinical measures, including dopamine transporter (DaT) imaging, for aspiration risk in patients with PD.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from patients with PD who underwent videofluoroscopic swallowing examinations (VF) and DaT imaging within 12 months. Patients were divided into aspiration and non-aspiration groups based on VF findings. Logistic regression and receiver operating characteristic (ROC) analyses evaluated the predictive performance of DaT imaging parameters including striatal specific binding ratio (SBR) and subregional SBRs, calculated using DaT View and DaTQUANT software.</div></div><div><h3>Results</h3><div>Among 87 patients (38 females; mean age: 64 years; disease duration: 8.3 years [range: 1–20 years]; modified Hoehn and Yahr stages: 2 [range: 1–4]), 14.9 % experienced aspiration. DaT View striatal SBRs consistently showed significantly lower values in the aspiration group and negative associations with aspiration in logistic regression models, whereas DaTQUANT exhibited limited significance in intergroup differences and associations. ROC analysis showed DaT View striatal SBR of the better side (SBR<em>better</em>) as the optimal predictor (sensitivity 0.62, specificity 0.93 at cutoff: 2.03). DaTQUANT subregional analysis identified the anterior putamen as key in aspiration risk.</div></div><div><h3>Conclusion</h3><div>Reduced SBR in DaT imaging shows potential as an indicator of aspiration risk in patients with PD. These findings can help clinicians identify patients at risk of aspiration, allowing for proactive referral for detailed evaluation.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107307"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot screening for prodromal Parkinson's disease in post-9/11 Veterans with probable rapid eye movement sleep behavior disorder","authors":"Melissa B. Jones ,&nbsp;Dakota Broadway ,&nbsp;Taryn White ,&nbsp;George R. Jackson ,&nbsp;Supriya Singh ,&nbsp;Ruosha Li ,&nbsp;Erik K. St Louis ,&nbsp;Laura E. Marsh ,&nbsp;Ricardo E. Jorge","doi":"10.1016/j.parkreldis.2025.107309","DOIUrl":"10.1016/j.parkreldis.2025.107309","url":null,"abstract":"<div><div>This pilot examined prodromal markers in post-9/11 Veterans with TBI and probable REM sleep behavior disorder (N = 12). RBD was confirmed in 5 of 10 (50 %) participants with polysomnography. Veterans with subthreshold parkinsonism had lower olfactory scores. Future studies should quantify REM sleep without atonia and include broader markers.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107309"},"PeriodicalIF":3.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regardless of the genotype, Leigh syndrome requires comprehensive work-up for clinical or subclinical multisystem involvement","authors":"Josef Finsterer","doi":"10.1016/j.parkreldis.2025.107302","DOIUrl":"10.1016/j.parkreldis.2025.107302","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107302"},"PeriodicalIF":3.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of elastic net for clinical outcome prediction and classification in progressive supranuclear palsy: A multicenter cohort study","authors":"Seungmin Lee ,&nbsp;Heejung Kim ,&nbsp;Ryul Kim ,&nbsp;Bora Jin ,&nbsp;Seoyeon Kim ,&nbsp;Kyung-Ah Woo ,&nbsp;Jung Hwan Shin ,&nbsp;Beomseok Jeon ,&nbsp;Han-Joon Kim ,&nbsp;Jee-Young Lee","doi":"10.1016/j.parkreldis.2025.107301","DOIUrl":"10.1016/j.parkreldis.2025.107301","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have used machine learning to identify clinically relevant atrophic regions in progressive supranuclear palsy (PSP). This study applied Elastic Net (EN) in PSP to uncover key atrophic patterns, offering a novel approach to understanding its pathology.</div></div><div><h3>Methods</h3><div>This study included baseline data from 74 patients with PSP enrolled in the Study of Comprehensive ANd multimodal marker-based cohort of PSP (SCAN-PSP, NCT05579301) in Seoul between January 2022 and August 2023. Participants were evaluated with PSP-rating scale (PSPRS) and Schwab &amp; England Activity of daily living (SEADL). EN regression was used to identify regions with high explanatory power for clinical outcomes, which were combined with clinical parameters to build prediction models. Features selected from EN classification were applied to discriminate between the two groups.</div></div><div><h3>Results</h3><div>EN identified the third ventricle, right anterior cingulate cortex, and left lateral orbitofrontal cortex as significant features, and multivariate linear regression models incorporating these regions with clinical variables showed high explainability for PSPRS (adjusted R² = 0.62) and SEADL (adjusted R² = 0.74). The EN-predicted values demonstrated strong correlation with actual scores of PSPRS (<em>r</em> = 0.75, <em>p</em> = 2·10⁻¹⁴) and SEADL (<em>r</em> = 0.82, <em>p</em> = 2·10⁻¹⁹). The combined EN-selected features and clinical parameters model robustly distinguished PSP-Richardson from the subcortical types (AUC = 0.94) and those with severe downgaze palsy from without (AUC = 0.90).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that EN effectively identified significant regional atrophies in PSP, with a modest sample size. Future studies could incorporate multimodal analysis to identify markers for monitoring disease progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107301"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurohistological findings in deep brain stimulation: Current knowledge and gaps.","authors":"Drew S Kern, Daniel R Kramer","doi":"10.1016/j.parkreldis.2025.107297","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107297","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107297"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just a fat joke? Time will tell","authors":"Alfonso Fasano MD, PhD, FAAN ,&nbsp;Michela Matteoli PhD","doi":"10.1016/j.parkreldis.2025.107298","DOIUrl":"10.1016/j.parkreldis.2025.107298","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107298"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoclonus classification revisited: Introducing the biaxial model","authors":"Abhimanyu Mahajan MD, MHS,&nbsp;Alberto J. Espay MD, MSc","doi":"10.1016/j.parkreldis.2025.107296","DOIUrl":"10.1016/j.parkreldis.2025.107296","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"132 ","pages":"Article 107296"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}