Parkinsonism & related disorders最新文献_第3页

Tau positron emission tomography in the Parkinson and Richardson subtypes of progressive supranuclear palsy 进行性核上性麻痹帕金森和理查德森亚型的Tau正电子发射断层扫描。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-24 DOI: 10.1016/j.parkreldis.2025.107939

Piotr Alster , Thilo van Eimeren , Natalia Madetko-Alster

{"title":"Tau positron emission tomography in the Parkinson and Richardson subtypes of progressive supranuclear palsy","authors":"Piotr Alster , Thilo van Eimeren , Natalia Madetko-Alster","doi":"10.1016/j.parkreldis.2025.107939","DOIUrl":"10.1016/j.parkreldis.2025.107939","url":null,"abstract":"<div><div>Progressive supranuclear palsy (PSP) is an atypical form of parkinsonism affected by deficiencies regarding efficient methods of examination, thereby hindering the establishment of an early and certain diagnosis prior to post-mortem examination. Most studies are based on magnetic resonance imaging analyses; however, there is growing interest in the evaluation of radiotracers in positron emission tomography (PET). In this narrative review, we attempt to elaborate on the significance of tau radiotracers and other PET biomarkers in the context of examination of two major subtypes of PSP: Richardson's syndrome (PSP-RS) and parkinsonism predominant (PSP-P). Although the subtypes show clinical boundaries and overlaps, they may be additionally evaluated using <em>in vivo</em> tau imaging. The feasibility of these methods may vary depending on cell-specific accumulation. The assessment of discrepancies in cellular tau deposition, as well as the combined analysis of these features with the pathogenesis of PSP-RS and PSP-P, may provide further insights enabling the redefinition of the diagnosis and monitoring of these conditions and the formulation of efficient therapeutic strategies.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"137 ","pages":"Article 107939"},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and incidence of Deep Brain Stimulation and Focused Ultrasound in a cohort of elders with Essential Tremor 深部脑刺激和聚焦超声在老年特发性震颤患者中的患病率和发病率

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-24 DOI: 10.1016/j.parkreldis.2025.107938

Diane S. Berry , Tomer O. Guy , Vibhash D. Sharma , Elan D. Louis

{"title":"Prevalence and incidence of Deep Brain Stimulation and Focused Ultrasound in a cohort of elders with Essential Tremor","authors":"Diane S. Berry , Tomer O. Guy , Vibhash D. Sharma , Elan D. Louis","doi":"10.1016/j.parkreldis.2025.107938","DOIUrl":"10.1016/j.parkreldis.2025.107938","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep Brain Stimulation (DBS) and Focused Ultrasound Thalamotomy (FUS) are important surgical alternatives for managing essential tremor (ET). Studies of the prevalence (i.e., the proportion of cases reporting a surgical procedure at a given observation), the incidence (i.e., the proportion of cases reporting new occurrences of a surgical procedure at a given observation), and the surgical rate (i.e., the proportion of cases with no history of surgery who underwent a surgical procedure during a given time interval) of DBS and FUS in ET cases are few and have limitations.</div></div><div><h3>Methods</h3><div>We obtained surgical histories from 346 ET participants in a longitudinal research study that ascertained cases outside of treatment centers. 283 cases participated in follow-up evaluations at 18, 36, 54, 72 and 90 months (mean length of observation = 4.4 ± 2.5 years).</div></div><div><h3>Results</h3><div>The cumulative prevalence of DBS and FUS were 0.046 % (Confidence Interval [CI] = 0.024 to 0.068) and 0.035 % (CI = 0.016 to 0.054), respectively. The cumulative incidence (9.44 per 1000 person-years, and 9.43 per 1000 person-years, respectively) and annual surgical rates (0.009, and 0.009, respectively) observed for DBS and FUS were similar. Reported rates for DBS were lower than reported from clinic-based studies.</div></div><div><h3>Conclusion</h3><div>To date, no other studies have documented the proportion of individuals with ET who have undergone FUS, and only three studies report the proportion who underwent DBS. All of the latter ascertained cases from treatment centers, biasing estimates upwards. Our data add to the understanding of surgical rates for ET.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"137 ","pages":"Article 107938"},"PeriodicalIF":3.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual hallucinations in Parkinson's disease: The critical role of intermediate nucleus basalis of Meynert 帕金森病的视幻觉：Meynert中间基底核的关键作用

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-23 DOI: 10.1016/j.parkreldis.2025.107935

Hiroyuki Hatsuta , Masashi Mizutani , Kaoru Yagita , Terunori Sano , Masaki Takao

{"title":"Visual hallucinations in Parkinson's disease: The critical role of intermediate nucleus basalis of Meynert","authors":"Hiroyuki Hatsuta , Masashi Mizutani , Kaoru Yagita , Terunori Sano , Masaki Takao","doi":"10.1016/j.parkreldis.2025.107935","DOIUrl":"10.1016/j.parkreldis.2025.107935","url":null,"abstract":"<div><h3>Background and objective</h3><div>Patients with Parkinson's disease (PD) often experience visual hallucinations (VH) and delusions. PD patients with VH reportedly have a higher incidence of dementia than PD patients without VH. The nucleus basalis of Meynert (nbM) comprises acetylcholine-releasing neurons that are critical for memory, attention, and arousal. Notably, the nbM also exhibits pathological α-synuclein accumulation, which is a hallmark of Lewy body diseases, including PD. In the present study, we investigated the distribution of abnormal α-synuclein accumulation in the nbM.</div></div><div><h3>Methods</h3><div>nbM sections of PD 28 autopsy patients were prepared and analyzed via immunohistochemistry using antibodies against phosphorylated α-synuclein and Choline acetyltransferase. The analysis included quantitative assessments of Choline acetyltransferase or α-synuclein positive neurons.</div></div><div><h3>Results</h3><div>Immunohistochemical analyses of the nbM sections revealed significant cholinergic neuron loss in the intermediate nbM of patients with VH compared with those without VH (137 vs. 191, <em>p</em> = 0.04). Moreover, the ratio of α-synuclein-positive cells to choline acetyltransferase-positive cells was significantly higher in patients with VH than in those without VH (<em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>Pathological changes in nbM—particularly cholinergic deficits in the intermediate part—were therefore identified as potential contributors to VH in PD. These findings add to our understanding of the neuropathological basis of VH in PD and may inform future therapeutic strategies.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"137 ","pages":"Article 107935"},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Prevalence and clinical impact of alpha-synuclein pathology in idiopathic normal pressure hydrocephalus: Insights from RT-QuIC assay". 对“特发性常压脑积水中α -突触核蛋白病理的患病率和临床影响：来自RT-QuIC试验的见解”的评论。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-19 DOI: 10.1016/j.parkreldis.2025.107926

Digvijay Singh Rajawat, Saketh Sainag Mandiga, Keerthi Sanapala

引用次数: 0

SLC18A2 associated infantile-onset- parkinsonism-dystonia 2: A novel genotype SLC18A2相关的婴儿期帕金森病-肌张力障碍2：一种新的基因型

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-18 DOI: 10.1016/j.parkreldis.2025.107930

Akshaya Janardhanan , Rohan Mahale , R. Mahima , Shilpi Goyal , Bhavana Chanda , Gautham Udupi , M. Pooja , Mathuranath Pavagada , Hansashree Padmanabha

引用次数: 0

Spotlight on timely diagnosis and treatment in subtle ataxia and spastic gait: Expert commentary 重点关注细微性共济失调和痉挛性步态的及时诊断和治疗：专家评论。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-17 DOI: 10.1016/j.parkreldis.2025.107925

Malco Rossi

引用次数: 0

Time to retire the term “atypical Parkinsonism” 是时候让“非典型帕金森症”这个词退休了。

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-17 DOI: 10.1016/j.parkreldis.2025.107927

Junaid H. Siddiqui , Lawrence I. Golbe

引用次数: 0

Dystonia: The ability to forget 肌张力障碍：遗忘的能力

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-16 DOI: 10.1016/j.parkreldis.2025.107929

Mark Hallett

引用次数: 0

Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: an explorative study 非典型帕金森病和帕金森病的光谱域和血管成像光学相干断层扫描：一项探索性研究

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-16 DOI: 10.1016/j.parkreldis.2025.107932

Gilda Cennamo, Laura Giovanna Di Maio, Gabriele Riccio, Rosa Coppola, Luigi Baratto, Augusta Giglio, Fiore Manganelli, Giuseppe De Michele, Ciro Costagliola, Anna De Rosa

{"title":"Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: an explorative study","authors":"Gilda Cennamo, Laura Giovanna Di Maio, Gabriele Riccio, Rosa Coppola, Luigi Baratto, Augusta Giglio, Fiore Manganelli, Giuseppe De Michele, Ciro Costagliola, Anna De Rosa","doi":"10.1016/j.parkreldis.2025.107932","DOIUrl":"10.1016/j.parkreldis.2025.107932","url":null,"abstract":"<div><h3>Background</h3><div>Research recently focused on identifying early and accurate biomarkers to differentiate Parkinson Disease (PD) from other degenerative parkinsonism, such as Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Multiple System Atrophy (MSA).</div></div><div><h3>Objective</h3><div>We aimed to investigate changes in the retinal structure and choroidal vascular network (CVN) in PSP-RS and MSA patients compared to PD and controls (Ctrl).</div></div><div><h3>Methods</h3><div>Spectral Domain-Optical Coherence Tomography (SD-OCT) was used to examine the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and subfoveal choroidal thickness, and OCT Angiography (OCTA) for the vessel area density (VAD) of retinal and CVN assessment.</div></div><div><h3>Results</h3><div>We analyzed 22 eyes from 11 PSP-RS, 14 from 7 MSA, 48 from 24 PD patients, and 50 from 25 Ctrl. In comparison to Ctrl, we observed decreased GCC thickness in PSP-RS (p = 0.001) and PD patients (p = 0.003), and reduced RNFL thickness in all three groups of patients (PD p = 0.043; PSP-RS p < 0.001; MSA p < 0.001). PD subjects showed lower values in VAD of superficial capillary plexus (p = 0.013) and radial peripapillary capillary plexus (RPCP) (p = 0.014) in comparison to Ctrl, whereas MSA and PSP-RS patients did not differ from them. Both groups presented significantly decreased RNFL thickness and higher VAD of RPCP in comparison to the PD group (p < 0.001).</div></div><div><h3>Conclusions</h3><div>Compared to PD, the retina structural damage in PSP-RS and MSA appears to be similar but more severe, whereas the CVN appears to be preserved. Our preliminary results should be confirmed in a larger series of patients to test whether OCTA can be used to differentiate degenerative parkinsonisms.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"137 ","pages":"Article 107932"},"PeriodicalIF":3.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jerky tremor with dystonia in PHARC syndrome: An uncommon neurological presentation PHARC综合征中的痉挛性震颤伴肌张力障碍：一种罕见的神经学表现

IF 3.1 3区医学

Parkinsonism & related disorders Pub Date : 2025-06-16 DOI: 10.1016/j.parkreldis.2025.107931

Sahil Mehta , Saurabh Mishra , Jagdeep Singh , Basavaraj Tigari , Vivek Lal

引用次数: 0