Parkinsonism & related disorders最新文献

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Unraveling the neural signatures: Distinct pallidal patterns in dystonia subtypes.
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-28 DOI: 10.1016/j.parkreldis.2024.107207
Alexey Sedov, Indiko Dzhalagoniya, Ulia Semenova, Anna Gamaleya, Alexey Tomskiy, Hyder A Jinnah, Aasef G Shaikh
{"title":"Unraveling the neural signatures: Distinct pallidal patterns in dystonia subtypes.","authors":"Alexey Sedov, Indiko Dzhalagoniya, Ulia Semenova, Anna Gamaleya, Alexey Tomskiy, Hyder A Jinnah, Aasef G Shaikh","doi":"10.1016/j.parkreldis.2024.107207","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107207","url":null,"abstract":"<p><strong>Introduction: </strong>Dystonia manifests as slow twisting movements (pure dystonia) or repetitive, jerky motions (jerky dystonia). Dystonia can coexist with myoclonus (myoclonus dystonia) or tremor (tremor dystonia). Each of these presentations can have distinct etiology, can involve discrete sensorimotor networks, and may have characteristic neurophysiological signature. This study reports distinct neurophysiological signatures corresponding to the phenomenological subcategories and associations of dystonia.</p><p><strong>Methods: </strong>We studied 17 dystonia patients undergoing deep brain stimulation surgery. Video-based movement tracking classified them into four phenomenological subcategories: myoclonus dystonia, pure dystonia, jerky dystonia, and tremor dystonia. Microelectrode recordings from the globus pallidus interna (GPi) and externa (GPe) were analyzed to characterize single-neuron activity reflecting underlying physiology.</p><p><strong>Results: </strong>Analysis of 1038 neurons revealed distinct patterns of burst, pause, and tonic activity across subtypes. Myoclonus dystonia had the highest prevalence of burst neurons in the GPi, while tremor dystonia showed a balanced distribution of burst and pause neurons. Myoclonus and pure dystonia had higher firing rates compared to tremor and jerky dystonia. Tremor dystonia showed the most irregular and bursty firing patterns. Overall, myoclonus and tremor dystonia had higher burst rates and lower interburst intervals than pure and jerky dystonia, highlighting distinct neuronal activity patterns across the different dystonia types.</p><p><strong>Discussion: </strong>The differences in pallidal neuron activity across the phenoemenological subtypes and associations of dystonia depict distinct neural mechanisms. These findings offer crucial physiological insights into the diverse phenomenology of different dystonia types.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"107207"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical neurophysiology for tremor: Common questions in clinical practice.
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-23 DOI: 10.1016/j.parkreldis.2024.107196
Petra Schwingenschuh, Madelein Van der Stouwe, Sanjay Pandey, Stephanie Hirschbichler, Pattamon Panyakaew, Maja Kojovic, Adreesh Mukherjee, Marina Aj Tijssen, Shabbir Hussain I Merchant, Felipe Vial
{"title":"Clinical neurophysiology for tremor: Common questions in clinical practice.","authors":"Petra Schwingenschuh, Madelein Van der Stouwe, Sanjay Pandey, Stephanie Hirschbichler, Pattamon Panyakaew, Maja Kojovic, Adreesh Mukherjee, Marina Aj Tijssen, Shabbir Hussain I Merchant, Felipe Vial","doi":"10.1016/j.parkreldis.2024.107196","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107196","url":null,"abstract":"<p><strong>Background: </strong>A thorough history and physical examination may be insufficient for comprehensively studying patients with tremor. In such instances, neurophysiology serves as an adjunct to the physical examination.</p><p><strong>Objectives: </strong>Our aim is to present compelling evidence supporting the utilization of neurophysiological studies in various tremor conditions.</p><p><strong>Methods: </strong>A panel of global experts, convened by the Study Group on Clinical Neurophysiology for Movement Disorders, examined the application and utility of neurophysiology across diverse movement disorders.</p><p><strong>Results: </strong>This manuscript provides a detailed methodology for electrophysiological studies in tremors helping to differentiate them from myoclonus, comparing tremor in parkinson vs atypical parkinsonisms, describing dystonic tremor, describing the differences between Parkinson and essential tremor and the characteristics of functional tremor.</p><p><strong>Conclusions: </strong>Neurophysiological studies play a crucial role in characterizing tremor syndromes and aiding in their differentiation from other hyperkinetic movement disorders.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107196"},"PeriodicalIF":3.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gerstmann-Straussler-Scheinker disease: Lessons from two new Indian kindreds 格斯特曼-斯特劳斯勒-申克病:从两个新的印度血统中汲取的教训
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-22 DOI: 10.1016/j.parkreldis.2024.107218
Farsana Mustafa, Ayush Agarwal, Divyani Garg, Jacky Ganguly, Ajay Garg, Hrishikesh Kumar, Mohammed Faruq, Kriti Kashyap, Achal Kumar Srivastava
{"title":"Gerstmann-Straussler-Scheinker disease: Lessons from two new Indian kindreds","authors":"Farsana Mustafa,&nbsp;Ayush Agarwal,&nbsp;Divyani Garg,&nbsp;Jacky Ganguly,&nbsp;Ajay Garg,&nbsp;Hrishikesh Kumar,&nbsp;Mohammed Faruq,&nbsp;Kriti Kashyap,&nbsp;Achal Kumar Srivastava","doi":"10.1016/j.parkreldis.2024.107218","DOIUrl":"10.1016/j.parkreldis.2024.107218","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107218"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multidisciplinary telemedicine approach for managing frailty in Parkinson's disease. A longitudinal, case-control study 管理帕金森病虚弱的多学科远程医疗方法。病例对照纵向研究
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-22 DOI: 10.1016/j.parkreldis.2024.107215
Álvaro García-Bustillo , José Miguel Ramírez-Sanz , José Luis Garrido-Labrador , Alicia Olivares-Gil , Florita Valiñas-Sieiro , Marta Allende-Río , Josefa González-Santos , Jerónimo Javier González-Bernal , Maha Jahouh , Sara Calvo-Simal , Lucía Simón-Vicente , Natividad Mariscal , José Francisco Díez-Pastor , David García-García , Álvar Arnaiz-González , José Trejo-Gabriel-Galán , Esther Cubo
{"title":"A multidisciplinary telemedicine approach for managing frailty in Parkinson's disease. A longitudinal, case-control study","authors":"Álvaro García-Bustillo ,&nbsp;José Miguel Ramírez-Sanz ,&nbsp;José Luis Garrido-Labrador ,&nbsp;Alicia Olivares-Gil ,&nbsp;Florita Valiñas-Sieiro ,&nbsp;Marta Allende-Río ,&nbsp;Josefa González-Santos ,&nbsp;Jerónimo Javier González-Bernal ,&nbsp;Maha Jahouh ,&nbsp;Sara Calvo-Simal ,&nbsp;Lucía Simón-Vicente ,&nbsp;Natividad Mariscal ,&nbsp;José Francisco Díez-Pastor ,&nbsp;David García-García ,&nbsp;Álvar Arnaiz-González ,&nbsp;José Trejo-Gabriel-Galán ,&nbsp;Esther Cubo","doi":"10.1016/j.parkreldis.2024.107215","DOIUrl":"10.1016/j.parkreldis.2024.107215","url":null,"abstract":"<div><h3>Introduction</h3><div>The interaction between frailty and Parkinson's disease (PD) is still unknown. This study aimed to study the effectiveness of a multidisciplinary telemedicine program in reducing frailty in Parkinson's disease.</div></div><div><h3>Methods</h3><div>Longitudinal, randomized, case-control study. All participants in the office were evaluated at baseline, four, and eight months (V0, V1, and V2). Patients included in the telemedicine program received additional multidisciplinary care with nurse, neurologist, and occupational therapist interventions from V0 to V1. PD motor, non-motor symptoms, frailty and health-related quality of life (HR-QoL) were assessed using recommended PD rating scales.</div></div><div><h3>Results</h3><div>Fifty patients were included, 25 patients in the telemedicine group, and 25 patients in the control group. Frailty was highly correlated with performance in activities of daily living, and freezing of gait, balance, gait speed, and motor impairment, moderately correlated with hand grip strength, number of daily steps, and HR-QoL, and slightly correlated with age and level of physical fatigue. Frailty was reduced in the telemedicine group, compared to the control group, from V0 to V1 (p = .0001) and from V0 to V2 (p = .007). In addition, gait freezing, balance, gait speed, fatigue, non-motor symptoms, and HR-QoL were also improved in the telemedicine group (p values &lt; .05).</div></div><div><h3>Conclusion</h3><div>By leveraging multidisciplinary telemedicine interventions in addition to in-office visits, healthcare providers can deliver patient-centric care, improving frailty, non-motor symptoms, gait impairment, and quality of life in Parkinson's disease. These hybrid interventions could solve current barriers to health systems with limited capacity.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107215"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TMS-evoked potentials provide novel neurophysiological features of Tourette syndrome
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-22 DOI: 10.1016/j.parkreldis.2024.107217
Simon Lassman , Noa Zifman , Hilla Fogel , Sharon Hassin-Baer , Saar Anis
{"title":"TMS-evoked potentials provide novel neurophysiological features of Tourette syndrome","authors":"Simon Lassman ,&nbsp;Noa Zifman ,&nbsp;Hilla Fogel ,&nbsp;Sharon Hassin-Baer ,&nbsp;Saar Anis","doi":"10.1016/j.parkreldis.2024.107217","DOIUrl":"10.1016/j.parkreldis.2024.107217","url":null,"abstract":"<div><h3>Introduction</h3><div>Gilles de la Tourette syndrome (TS) is a neuropsychiatric disorder associated with abnormal activation of the cortico-striatal-thalamo-cortical circuits and dopaminergic system. We sought to examine changes in neurotransmission relating to cortical excitation/inhibition of TS by measuring TMS-evoked potentials (TEPs) of selected networks.</div></div><div><h3>Methods</h3><div>Thirty-three adult TS patients and 18 healthy controls underwent evaluation of symptom severity using the YGTSS (tics), PUTS (premonitory urge), Y-BOCS (OCD), CAARS (ADHD), BDI (depression), and BAI (anxiety). TMS-EEG was performed to measure TEPs obtained from the primary motor cortex (M1), dorsolateral prefrontal cortex (DLPFC), and primary visual cortex (V1).</div></div><div><h3>Results</h3><div>TEP analysis revealed a delayed P180 latency in M1 for TS patients compared to controls (p = 0.006). Lower early amplitude of TEP in response to stimulation of DLPFC (50–70 ms), and delayed DLPFC P180 latency were associated with higher tic severity (p = 0.001 and p = 0.003, respectively). M1 early amplitude (50–70 ms) also effectively differentiated TS with mild-moderate from severe tics (p = 0.003). Significant correlation was found between TEP V1 early amplitude (15–45 ms) and severity of TS anxiety.</div></div><div><h3>Conclusion</h3><div>Distinct TEP patterns registered in response to DLPFC, M1, and V1 stimulation may shed light on the underlying pathophysiology of TS and are associated with tic severity and comorbidities.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107217"},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure factors and clinical characteristics associated with Parkinson's disease in GBA1 variant carriers: A Chinese GBA1-PD intrafamilial survey 与GBA1变异携带者帕金森病相关的暴露因素和临床特征:中国GBA1-PD家族内调查
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-19 DOI: 10.1016/j.parkreldis.2024.107212
Xuxiang Zhang , Yuwen Zhao , Li Jiang , Yuxuan Hu , Zhenhua Liu , Qian Xu , Chunyu Wang , Lifang Lei , Peishan Li , Zhihui Tan , Heng Wu , Lu Shen , Hong Jiang , Xinxiang Yan , Beisha Tang , Jifeng Guo
{"title":"Exposure factors and clinical characteristics associated with Parkinson's disease in GBA1 variant carriers: A Chinese GBA1-PD intrafamilial survey","authors":"Xuxiang Zhang ,&nbsp;Yuwen Zhao ,&nbsp;Li Jiang ,&nbsp;Yuxuan Hu ,&nbsp;Zhenhua Liu ,&nbsp;Qian Xu ,&nbsp;Chunyu Wang ,&nbsp;Lifang Lei ,&nbsp;Peishan Li ,&nbsp;Zhihui Tan ,&nbsp;Heng Wu ,&nbsp;Lu Shen ,&nbsp;Hong Jiang ,&nbsp;Xinxiang Yan ,&nbsp;Beisha Tang ,&nbsp;Jifeng Guo","doi":"10.1016/j.parkreldis.2024.107212","DOIUrl":"10.1016/j.parkreldis.2024.107212","url":null,"abstract":"<div><h3>Introduction</h3><div>Glucosylceramidase beta 1 (<em>GBA1</em>) mutations are a genetic risk factor for Parkinson's disease (PD), though most carriers do not develop the disease. This study aimed to identify exposure factors linked to PD in <em>GBA1</em> carriers and assess clinical features and the probability of prodromal PD in non-manifesting carriers.</div></div><div><h3>Methods</h3><div>Data from the Parkinson's Disease &amp; Movement Disorders Multicenter Database and Collaborative Network in China was used, including 59 <em>GBA1</em> non-manifesting carriers, 62 controls, and 107 <em>GBA1</em>-associated PD, of whom 81 were in the early stage. Exposure factors included pesticide/solvent exposure, smoking, alcohol, and tea consumption. Logistic regression assessed the association between exposure factors and PD. Clinical characteristics were evaluated using multiple scales, relevant markers were collected based on the Movement Disorders Society criteria. A naive Bayesian classifier method determined the probability of prodromal PD in <em>GBA1</em> non-manifesting carriers and controls.</div></div><div><h3>Results</h3><div>After adjusting for sociodemographic variables, pesticide/solvent exposure was positively associated with PD in <em>GBA1</em> carriers (OR 8.40; 95 % CI 2.50–28.20), while smoking was inversely associated with PD (OR 0.18; 95 % CI 0.05–0.62). Rapid eye movement sleep behavior disorder, constipation, hyposmia, and cognitive deficits were more severe in early-stage <em>GBA1</em>-associated PD than in carriers and controls. Clinical symptoms and the probability of prodromal PD were similar between carriers and controls.</div></div><div><h3>Conclusions</h3><div>PD in <em>GBA1</em> carriers is closely linked to exposure factors. Early-stage <em>GBA1</em>-associated PD shows significant prodromal symptoms, which are not evident in carriers. The probability of prodromal PD in carriers is similar to that in controls.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107212"},"PeriodicalIF":3.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsupervised definition of two clinical subtypes of Essential tremor and the underlying brain topology 无监督定义本质性震颤的两种临床亚型及其潜在的大脑拓扑。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-17 DOI: 10.1016/j.parkreldis.2024.107213
Weijin Yuan , Qianshi Zheng , Tao Guo , Jiaqi Wen , Xiaojie Duanmu , Sijia Tan , Chenqing Wu , Haoting Wu , Cheng Zhou , Qingze Zeng , Jianmei Qin , Jingjing Wu , Jingwen Chen , Yuelin Fang , Bingting Zhu , Yaping Yan , Jun Tian , Baorong Zhang , Guohua Zhao , Minming Zhang , Xiaojun Xu
{"title":"Unsupervised definition of two clinical subtypes of Essential tremor and the underlying brain topology","authors":"Weijin Yuan ,&nbsp;Qianshi Zheng ,&nbsp;Tao Guo ,&nbsp;Jiaqi Wen ,&nbsp;Xiaojie Duanmu ,&nbsp;Sijia Tan ,&nbsp;Chenqing Wu ,&nbsp;Haoting Wu ,&nbsp;Cheng Zhou ,&nbsp;Qingze Zeng ,&nbsp;Jianmei Qin ,&nbsp;Jingjing Wu ,&nbsp;Jingwen Chen ,&nbsp;Yuelin Fang ,&nbsp;Bingting Zhu ,&nbsp;Yaping Yan ,&nbsp;Jun Tian ,&nbsp;Baorong Zhang ,&nbsp;Guohua Zhao ,&nbsp;Minming Zhang ,&nbsp;Xiaojun Xu","doi":"10.1016/j.parkreldis.2024.107213","DOIUrl":"10.1016/j.parkreldis.2024.107213","url":null,"abstract":"<div><h3>Background</h3><div>Essential tremor (ET) is one of the most prevalent neurological diseases varying considerably in clinical manifestations and prognosis, which indicates the existence of subtypes. Identifying ET subtypes is crucial for explaining clinical heterogeneity. This study aimed to identify ET subtypes using unsupervised clustering analysis based on clinical manifestations and explore underlying brain topology within both functional and structural networks.</div></div><div><h3>Methods</h3><div>We recruited 103 ET patients and 43 healthy control subjects. K-means clustering analysis was performed to identify ET subtypes based on age of onset, motor and non-motor symptoms. Functional MRI and diffusion tensor imaging data were used to construct functional and structural networks. Global attributes (clustering coefficient, characteristic path length, global efficiency, and local efficiency) and nodal attributes (nodal clustering coefficient, nodal efficiency, and nodal degree centrality) were calculated for topological analysis.</div></div><div><h3>Results</h3><div>We identified two subtypes: Subtype 1 (earlier age of onset – without nonmotor symptoms subtype) and Subtype 2 (later age of onset – with nonmotor symptoms subtype). Decreased clustering coefficient and global efficiency, increased characteristic path length were observed in Subtype 2 compared to NC, while only decreased global efficiency was observed in Subtype 1. More widespread brain regions with decreased nodal clustering coefficient were specifically observed in Subtype 2.</div></div><div><h3>Conclusion</h3><div>We identified two ET subtypes based on comprehensive clinical information and revealed that Subtype 2 may be a more malignant subtype. Our study firstly unsupervisedly identifies the clinical heterogeneity of ET and provides neuroimaging evidence for better understanding the underlying disease biology.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107213"},"PeriodicalIF":3.1,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context-dependency of the REM sleep behavior disorder screening questionnaire - Clinical utility under scrutiny 快速眼动睡眠行为障碍筛查问卷的情境依赖性--临床实用性受到质疑
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-17 DOI: 10.1016/j.parkreldis.2024.107211
Sinah Röttgen , Christopher E.J. Doppler , Aline Seger , Elke Kalbe , Gereon R. Fink , Michael Sommerauer , Anja Ophey
{"title":"Context-dependency of the REM sleep behavior disorder screening questionnaire - Clinical utility under scrutiny","authors":"Sinah Röttgen ,&nbsp;Christopher E.J. Doppler ,&nbsp;Aline Seger ,&nbsp;Elke Kalbe ,&nbsp;Gereon R. Fink ,&nbsp;Michael Sommerauer ,&nbsp;Anja Ophey","doi":"10.1016/j.parkreldis.2024.107211","DOIUrl":"10.1016/j.parkreldis.2024.107211","url":null,"abstract":"<div><h3>Introduction</h3><div>The REM Sleep Behavior Disorder (RBD) Screening Questionnaire (RBDSQ) is a widely established screening tool for detecting isolated RBD (iRBD). However, its accuracy may depend on its application context, e.g., the individuals’ awareness of their RBD status. The present work aims to describe the context-dependency and retest reliability of the RBDSQ in an iRBD cohort setting.</div></div><div><h3>Methods</h3><div>Ninety-four individuals with video-polysomnography confirmed iRBD answered the RBDSQ during pre-polysomnography screening (V0) and post-diagnosis (V1).</div></div><div><h3>Results</h3><div>The RBDSQ total score significantly differed between V0 and V1 (<em>F</em>(1,92) = 8.02, <em>p</em> = .006, η<sub>p</sub><sup>2</sup> = 0.019). The intraclass correlation coefficient (ICC<sub>2,1</sub>) of the RBDSQ showed moderate reliability between consecutive timepoints (<sup>V0-V1</sup>ICC<sub>2,1</sub> = 0.544). The highest Cohen's κ was reached for items 5, 6.3, 6.4, 8, and 9 across timepoint comparisons (0.409 ≤ Cohen's κ ≤ 0.660).</div></div><div><h3>Conclusion</h3><div>Our findings underscore the context-dependency of the RBDSQ and fluctuations in self-awareness of sleep-related behaviors, necessitating a critical appraisal of questionnaire-based RBD screening tools. Future studies should explore strategies to improve the reliability and accuracy of RBD screening tools, considering the dynamic nature of sleep-related behavior.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"130 ","pages":"Article 107211"},"PeriodicalIF":3.1,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of hypoglycemic drugs in Parkinson's disease: An updated meta-analysis of randomized controlled trials. 帕金森病患者使用降糖药:随机对照试验的最新荟萃分析。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-16 DOI: 10.1016/j.parkreldis.2024.107210
Milene Vitória Sampaio Sobral, Victor Gonçalves Soares, João Lucas de Magalhães Leal Moreira, Livia Kneipp Rodrigues, Paula Rocha, Lucas Cael Azevedo Ramos Bendaham, Ocílio Ribeiro Gonçalves, Rafaela da Cunha Pirolla, Lucas Veronezi Vilela, Victoria Städler de Abreu, Kelson James Almeida
{"title":"The use of hypoglycemic drugs in Parkinson's disease: An updated meta-analysis of randomized controlled trials.","authors":"Milene Vitória Sampaio Sobral, Victor Gonçalves Soares, João Lucas de Magalhães Leal Moreira, Livia Kneipp Rodrigues, Paula Rocha, Lucas Cael Azevedo Ramos Bendaham, Ocílio Ribeiro Gonçalves, Rafaela da Cunha Pirolla, Lucas Veronezi Vilela, Victoria Städler de Abreu, Kelson James Almeida","doi":"10.1016/j.parkreldis.2024.107210","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107210","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have demonstrated an association between hypoglycemic medications and neuroprotective action in neurodegenerative diseases, such as Parkinson's disease (PD). Therefore, in this meta-analysis, our objective was to evaluate the efficacy of these medications, compared to placebo, as disease-modifying therapy in patients with PD.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and Cochrane for studies comparing the use of hypoglycemic drugs and placebo in patients with PD. Statistical analyses were performed using R Studio 4.3.2. Mean difference (MD) with 95 % confidence intervals (CI) were pooled across trials. Outcomes of interest were change in Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts I, II, III, IV, and Parkinson's Disease Questionnaire 39 (PDQ-39).</p><p><strong>Results: </strong>This meta-analysis included six randomized controlled trials (RCT) reporting data on 787 patients. Among them, 480 (61 %) received hypoglycemic drugs. Follow-up ranged from 36 to 61 weeks. At the end of follow-up, improvement in MDS-UPDRS part III score during OFF state occurred when subjects received any hypoglycemic agents at their lowest dose (MD -1.36; 95 % IC -2.78 to -0.47; I2 = 38 %), as well as highest doses (MD -1.58; 95 % IC -3.07 to -0.09; I2 = 50 %). Changes in MDS-UPDRS part III score in patients examined in the ON state who received any dose of any hypoglycemic agents (MD -3.32; 95 % IC -5.28 to -1.36; I2 = 0 %) were significant. There was no significant difference between groups MDS-UPDRS parts I, II, IV, and PDQ-39.</p><p><strong>Conclusion: </strong>In patients with PD, the use of hypoglycemic agents showed efficacy on symptomatic PD treatment with an improvement in MDS-UPDRS part III.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107210"},"PeriodicalIF":3.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A challenging case of cerebellar ataxia associated with oro facial dominant chorea. 小脑共济失调伴口面部显性舞蹈症的疑难病例。
IF 3.1 3区 医学
Parkinsonism & related disorders Pub Date : 2024-11-16 DOI: 10.1016/j.parkreldis.2024.107189
Alexane Larget, Marie Rafiq, Raquel Barbosa, Fabrice Bonneville, Chloé Bost, Margherita Fabbri, Clémence Leung, Hélène Mirabel, Emilie Rigal Milongo, Jérémie Pariente, Fabienne Ory-Magne
{"title":"A challenging case of cerebellar ataxia associated with oro facial dominant chorea.","authors":"Alexane Larget, Marie Rafiq, Raquel Barbosa, Fabrice Bonneville, Chloé Bost, Margherita Fabbri, Clémence Leung, Hélène Mirabel, Emilie Rigal Milongo, Jérémie Pariente, Fabienne Ory-Magne","doi":"10.1016/j.parkreldis.2024.107189","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2024.107189","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107189"},"PeriodicalIF":3.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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