Parkinsonism & related disorders最新文献

{"title":"Shedding light on the dark: Night blindness in autosomal recessive spastic ataxia of Charlevoix-Saguenay","authors":"Jayaram Saibaba , Priyanka Ramanathan , Ramkumar Sugumaran , Karthikeyan Mahalingam , Sunil K. Narayan , Saranya B. Gomathy","doi":"10.1016/j.parkreldis.2025.107845","DOIUrl":"10.1016/j.parkreldis.2025.107845","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107845"},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and neuropathological contributions to gait dysfunction in Parkinson's disease.","authors":"Asad Iqbal, Bilal Ahmad, Aftab Ahmad, Taimur Iqbal, Taharam Fazal","doi":"10.1016/j.parkreldis.2025.107868","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107868","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107868"},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of EEG microstates in Parkinson's disease.","authors":"Zhen Li, Xiaodong Zhu","doi":"10.1016/j.parkreldis.2025.107869","DOIUrl":"https://doi.org/10.1016/j.parkreldis.2025.107869","url":null,"abstract":"<p><p>Electroencephalography (EEG) microstate analysis is a promising technique for detecting transient brain dynamics and identifying disease-specific biomarkers in Parkinson's disease (PD). By capturing subsecond fluctuations in brain activity with intrinsic high temporal resolution and robust test-retest reliability, this method has potential applications in early diagnosis, disease severity assessment, and therapeutic monitoring in PD. Integrating microstate analysis with artificial intelligence (AI) further enhances the accuracy of recognizing PD-specific brain activity patterns. However, challenges such as methodological variability, lack of standardization, and AI-related limitations, remain substantial barriers to clinical translation. This review systematically explores the application of EEG microstate analysis in PD, broadening insights into disease mechanisms and personalized therapeutic options. Furthermore, we discuss existing challenges, underscore the need for methodological standardization, and highlight future directions, including large-scale validation studies and the integration of explainable AI (XAI) approaches to enhance clinical applicability.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107869"},"PeriodicalIF":3.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness in Parkinson's disease: Subjective experience overshadows objective motor impairment","authors":"David Andrés González ,&nbsp;Michelle H.S. Tosin ,&nbsp;Tila Warner-Rosen ,&nbsp;Mitra Afshari ,&nbsp;Brandon Barton ,&nbsp;Jori E. Fleisher ,&nbsp;Deborah A. Hall ,&nbsp;Alana E. Kirby ,&nbsp;Katie Kompoliti ,&nbsp;Abhimanyu Mahajan ,&nbsp;Neepa Patel ,&nbsp;Christina Swan ,&nbsp;Christopher G. Goetz","doi":"10.1016/j.parkreldis.2025.107867","DOIUrl":"10.1016/j.parkreldis.2025.107867","url":null,"abstract":"<div><h3>Introduction</h3><div>Loneliness is linked to poor life quality and health, but its relevance in Parkinson's disease (PD) is incompletely understood. The current study aimed to understand rates of loneliness and its determinants in PD.</div></div><div><h3>Methods</h3><div>Consecutive cross-sectional sampling resulted in 178 PD subjects (60 % men) across disease stages (86 % early-stage) with gold-standard diagnoses. Loneliness was characterized with two scales, PD was characterized by objective measures, motor ratings, and perceived functional impact, and social-emotional assessment included social connection, depression, and life space. Nonparametric bivariate and robust multivariate regression determined predictors of loneliness in PD, and social-emotional predictors of PD functional impact.</div></div><div><h3>Results</h3><div>Most participants had concern, with 64.6 % endorsing high levels of loneliness. PD stage, but not motor impairment or other objective measures, predicted loneliness. In contrast, subjective measures of PD functional impact, social network size, social support, depression, and life space had a significant relationship with loneliness. In multivariate models, depression, PD functional impact, and social network size specifically emerged as the most important predictors of loneliness. Although social loneliness was generally more impacted by PD, men had more emotional loneliness. Similarly, loneliness was a potent, independent predictor of PD functional impact.</div></div><div><h3>Conclusions</h3><div>We show that loneliness is a critical issue in PD which relates more to individual response to disease than objective motor severity. Although PD most impacts general relationships’ quality, men may have additional loss of intimate confidantes. Interventions targeting depression and social networks may not only improve loneliness but also improve PD functional impact.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107867"},"PeriodicalIF":3.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical impact of alpha-synuclein pathology in idiopathic normal pressure hydrocephalus: Insights from RT-QuIC assay","authors":"Je kook Yu ,&nbsp;Hye Joung Choi ,&nbsp;Dongwoo Kim ,&nbsp;Pham Hong Ngoc ,&nbsp;In Hee Kwak ,&nbsp;Huu Dat Nguyen ,&nbsp;Trung Nguyen Thanh ,&nbsp;Suk Jun Song ,&nbsp;Jeongjae Lee ,&nbsp;Hyeo-il Ma ,&nbsp;Young Eun Kim","doi":"10.1016/j.parkreldis.2025.107857","DOIUrl":"10.1016/j.parkreldis.2025.107857","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between idiopathic normal pressure hydrocephalus (iNPH) and synucleinopathy remains unclear. This study aimed to explore the prevalence of α-synuclein pathology in iNPH patients and its impact on clinical outcomes.</div></div><div><h3>Methods</h3><div>We enrolled 33 iNPH patients without evidence of nigrostriatal degeneration. Cerebrospinal fluid (CSF) was analyzed using the real-time quaking-induced conversion (RT-QuIC) assay to detect α-synuclein aggregates. Clinical assessments included the Timed Up and Go (TUG) test and Mini-Mental State Examination (MMSE), performed before and after a CSF tap test.</div></div><div><h3>Results</h3><div>Among the 33 patients, 11 (33.3 %) tested positive for α-synuclein pathology. Baseline demographic and clinical characteristics were similar between α-synuclein positive and negative groups (p &gt; 0.05). The MMSE and TUG tests showed no significant differences between the groups before or after the tap test. However, the RT-QuIC negative group showed significant improvement in TUG times and steps post-tap test (p &lt; 0.05), while the positive group showed a non-significant trend towards improvement (p = 0.06). Clinical global impression improved in 26 patients after CSF drainage, with similar rates in both groups (p = 0.88). Eleven patients (5 α-synuclein RT-QuIC positive and 6 negative) underwent shunt surgery, all of whom reported improvement over a median follow-up of 1.29 years.</div></div><div><h3>Conclusion</h3><div>α-synuclein pathology is present in a significant proportion of iNPH patients. Although gait improvement during the tap test was evident in α-synuclein negative group, both groups showed improvement. These findings underscore the need for further longitudinal studies to elucidate the long-term clinical impact of α-synuclein pathology in iNPH.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"136 ","pages":"Article 107857"},"PeriodicalIF":3.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Quick MSA-QoL: A validated, abbreviated health-related quality of life questionnaire for use in Multiple System Atrophy” [Park. Relat. Disord. (2024) 128 107143. doi: 10.1016/j.parkreldis.2024.107143]","authors":"D. Jugnarain,&nbsp;A. Schrag","doi":"10.1016/j.parkreldis.2025.107856","DOIUrl":"10.1016/j.parkreldis.2025.107856","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107856"},"PeriodicalIF":3.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Chaparro-Solano et al.: \"Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review.\" Parkinsonism Relat Disord. 2025 Jan;130:107206.","authors":"Anton J M Loonen","doi":"10.1016/j.parkreldis.2025.107774","DOIUrl":"10.1016/j.parkreldis.2025.107774","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107774"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response -- letter to the editor: Unraveling the neural signatures: Distinct pallidal patterns in dystonia subtypes.","authors":"Aasef G Shaikh, H A Jinnah, Alexey Sedov","doi":"10.1016/j.parkreldis.2025.107350","DOIUrl":"10.1016/j.parkreldis.2025.107350","url":null,"abstract":"<p><p>We recognize the need for longitudinal measures and mechanistic understanding of the basis for phenotype to single-neuron correlations. We clarify that pallidal neuron differs across dystonia subtypes. We highlight animal studies showing how cerebellar activity can influence pallidal neuron behavior, supporting the idea of cerebellar activity transmission to the pallidum.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107350"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderators of aerobic exercise effects on motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis.","authors":"Ryul Kim, Nyeonju Kang, Joon Ho Lee, Hanall Lee, Tae Lee Lee, Do Kyung Ko, Hajun Lee, Kyeongho Byun, Kiwon Park, Jee-Young Lee, Beomseok Jeon","doi":"10.1016/j.parkreldis.2025.107779","DOIUrl":"10.1016/j.parkreldis.2025.107779","url":null,"abstract":"<p><strong>Introduction: </strong>Although growing evidence suggests that aerobic exercise has beneficial effects on motor symptoms in patients with Parkinson's disease (PD), it remains unclear which specific aerobic exercise regimen optimizes improvement in these symptoms. This study aimed to investigate the difference in the effects of aerobic exercise on motor function in patients with PD according to exercise intervention protocols.</p><p><strong>Methods: </strong>Through 28 qualified studies with randomized controlled trials, we assessed motor function using either the Unified PD Rating Scale (UPDRS) III or Movement Disorder Society-UPDRS III as an outcome measure. We employed random effects meta-analysis models to obtain standardized mean differences and 95 % confidence intervals (CIs). Moderator variable analyses were conducted based on exercise type (aerobic exercise vs. aerobic-based combined exercise), duration (<60 min vs. ≥60 min per session), frequency (<four vs. ≥four sessions per week), period (<12 weeks vs. ≥12 weeks), and intensity (low-to-moderate vs. moderate-to-high).</p><p><strong>Results: </strong>Aerobic exercise interventions demonstrated significant improvements in overall motor function. Although all categories were significantly effective in improving motor function, aerobic-based combined exercise had a greater effect size on motor symptoms compared to aerobic exercise alone. Additionally, ≥60 min per session showed a significantly increased effect size compared to <60 min per session. The impact of aerobic exercise did not differ based on exercise frequency, period, or intensity.</p><p><strong>Conclusions: </strong>Our observations suggest that aerobic-based combined exercise and exercise sessions lasting 60 min or longer may be associated with greater improvements in motor symptoms in patients with PD.</p>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107779"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply to \"Comment on Chaparro-Solano et al.: 'Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review'\".","authors":"Henry Mauricio Chaparro-Solano, Ignacio F Mata","doi":"10.1016/j.parkreldis.2025.107804","DOIUrl":"10.1016/j.parkreldis.2025.107804","url":null,"abstract":"","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":" ","pages":"107804"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}