非典型帕金森病和帕金森病的光谱域和血管成像光学相干断层扫描：一项探索性研究

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-06-16 DOI:10.1016/j.parkreldis.2025.107932

Gilda Cennamo, Laura Giovanna Di Maio, Gabriele Riccio, Rosa Coppola, Luigi Baratto, Augusta Giglio, Fiore Manganelli, Giuseppe De Michele, Ciro Costagliola, Anna De Rosa

{"title":"非典型帕金森病和帕金森病的光谱域和血管成像光学相干断层扫描：一项探索性研究","authors":"Gilda Cennamo, Laura Giovanna Di Maio, Gabriele Riccio, Rosa Coppola, Luigi Baratto, Augusta Giglio, Fiore Manganelli, Giuseppe De Michele, Ciro Costagliola, Anna De Rosa","doi":"10.1016/j.parkreldis.2025.107932","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Research recently focused on identifying early and accurate biomarkers to differentiate Parkinson Disease (PD) from other degenerative parkinsonism, such as Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Multiple System Atrophy (MSA).</div></div><div><h3>Objective</h3><div>We aimed to investigate changes in the retinal structure and choroidal vascular network (CVN) in PSP-RS and MSA patients compared to PD and controls (Ctrl).</div></div><div><h3>Methods</h3><div>Spectral Domain-Optical Coherence Tomography (SD-OCT) was used to examine the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and subfoveal choroidal thickness, and OCT Angiography (OCTA) for the vessel area density (VAD) of retinal and CVN assessment.</div></div><div><h3>Results</h3><div>We analyzed 22 eyes from 11 PSP-RS, 14 from 7 MSA, 48 from 24 PD patients, and 50 from 25 Ctrl. In comparison to Ctrl, we observed decreased GCC thickness in PSP-RS (p = 0.001) and PD patients (p = 0.003), and reduced RNFL thickness in all three groups of patients (PD p = 0.043; PSP-RS p < 0.001; MSA p < 0.001). PD subjects showed lower values in VAD of superficial capillary plexus (p = 0.013) and radial peripapillary capillary plexus (RPCP) (p = 0.014) in comparison to Ctrl, whereas MSA and PSP-RS patients did not differ from them. Both groups presented significantly decreased RNFL thickness and higher VAD of RPCP in comparison to the PD group (p < 0.001).</div></div><div><h3>Conclusions</h3><div>Compared to PD, the retina structural damage in PSP-RS and MSA appears to be similar but more severe, whereas the CVN appears to be preserved. Our preliminary results should be confirmed in a larger series of patients to test whether OCTA can be used to differentiate degenerative parkinsonisms.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"137 ","pages":"Article 107932"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: an explorative study\",\"authors\":\"Gilda Cennamo, Laura Giovanna Di Maio, Gabriele Riccio, Rosa Coppola, Luigi Baratto, Augusta Giglio, Fiore Manganelli, Giuseppe De Michele, Ciro Costagliola, Anna De Rosa\",\"doi\":\"10.1016/j.parkreldis.2025.107932\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Research recently focused on identifying early and accurate biomarkers to differentiate Parkinson Disease (PD) from other degenerative parkinsonism, such as Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Multiple System Atrophy (MSA).</div></div><div><h3>Objective</h3><div>We aimed to investigate changes in the retinal structure and choroidal vascular network (CVN) in PSP-RS and MSA patients compared to PD and controls (Ctrl).</div></div><div><h3>Methods</h3><div>Spectral Domain-Optical Coherence Tomography (SD-OCT) was used to examine the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and subfoveal choroidal thickness, and OCT Angiography (OCTA) for the vessel area density (VAD) of retinal and CVN assessment.</div></div><div><h3>Results</h3><div>We analyzed 22 eyes from 11 PSP-RS, 14 from 7 MSA, 48 from 24 PD patients, and 50 from 25 Ctrl. In comparison to Ctrl, we observed decreased GCC thickness in PSP-RS (p = 0.001) and PD patients (p = 0.003), and reduced RNFL thickness in all three groups of patients (PD p = 0.043; PSP-RS p < 0.001; MSA p < 0.001). PD subjects showed lower values in VAD of superficial capillary plexus (p = 0.013) and radial peripapillary capillary plexus (RPCP) (p = 0.014) in comparison to Ctrl, whereas MSA and PSP-RS patients did not differ from them. Both groups presented significantly decreased RNFL thickness and higher VAD of RPCP in comparison to the PD group (p < 0.001).</div></div><div><h3>Conclusions</h3><div>Compared to PD, the retina structural damage in PSP-RS and MSA appears to be similar but more severe, whereas the CVN appears to be preserved. Our preliminary results should be confirmed in a larger series of patients to test whether OCTA can be used to differentiate degenerative parkinsonisms.</div></div>\",\"PeriodicalId\":19970,\"journal\":{\"name\":\"Parkinsonism & related disorders\",\"volume\":\"137 \",\"pages\":\"Article 107932\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parkinsonism & related disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S135380202500673X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinsonism & related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S135380202500673X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

研究背景目前的研究重点是寻找早期和准确的生物标志物来区分帕金森病（PD）与其他退行性帕金森病，如进行性核上性麻痹-理查森综合征（PSP-RS）和多系统萎缩（MSA）。目的探讨PSP-RS和MSA患者视网膜结构和脉络膜血管网络（CVN）与PD和对照组（Ctrl）的变化。方法采用光谱域光学相干断层扫描（SD-OCT）检查神经节细胞复合体（GCC）、视网膜神经纤维层（RNFL）和中央凹下脉络膜厚度，并用OCT血管造影（OCTA）评估视网膜血管面积密度（VAD）和CVN。结果我们分析了11例PSP-RS患者的22只眼睛，7例MSA患者的14只眼睛，24例PD患者的48只眼睛，25例Ctrl组患者的50只眼睛。与对照组相比，我们观察到PSP-RS患者的GCC厚度降低（p = 0.001）和PD患者（p = 0.003），三组患者的RNFL厚度均降低(PD p = 0.043；ps - rs p <；0.001;MSA p <；0.001)。PD组的浅毛细血管丛VAD值（p = 0.013）和桡动脉乳头周围毛细血管丛VAD值（p = 0.014）均低于对照组，而MSA和PSP-RS组与对照组无显著差异。与PD组相比，两组RNFL厚度均显著降低，RPCP VAD显著升高(p <；0.001)。结论与PD相比，PSP-RS和MSA的视网膜结构损伤相似，但更严重，而CVN似乎得到了保留。我们的初步结果应该在更大的患者系列中得到证实，以测试OCTA是否可以用于区分退行性帕金森病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: an explorative study

Background

Research recently focused on identifying early and accurate biomarkers to differentiate Parkinson Disease (PD) from other degenerative parkinsonism, such as Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Multiple System Atrophy (MSA).

Objective

We aimed to investigate changes in the retinal structure and choroidal vascular network (CVN) in PSP-RS and MSA patients compared to PD and controls (Ctrl).

Methods

Spectral Domain-Optical Coherence Tomography (SD-OCT) was used to examine the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and subfoveal choroidal thickness, and OCT Angiography (OCTA) for the vessel area density (VAD) of retinal and CVN assessment.

Results

We analyzed 22 eyes from 11 PSP-RS, 14 from 7 MSA, 48 from 24 PD patients, and 50 from 25 Ctrl. In comparison to Ctrl, we observed decreased GCC thickness in PSP-RS (p = 0.001) and PD patients (p = 0.003), and reduced RNFL thickness in all three groups of patients (PD p = 0.043; PSP-RS p < 0.001; MSA p < 0.001). PD subjects showed lower values in VAD of superficial capillary plexus (p = 0.013) and radial peripapillary capillary plexus (RPCP) (p = 0.014) in comparison to Ctrl, whereas MSA and PSP-RS patients did not differ from them. Both groups presented significantly decreased RNFL thickness and higher VAD of RPCP in comparison to the PD group (p < 0.001).

Conclusions

Compared to PD, the retina structural damage in PSP-RS and MSA appears to be similar but more severe, whereas the CVN appears to be preserved. Our preliminary results should be confirmed in a larger series of patients to test whether OCTA can be used to differentiate degenerative parkinsonisms.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.