Pakistan Journal of Medical Sciences最新文献

{"title":"Clinical efficacy and safety of targeted therapy, immunotherapy combined with chemotherapy for treating patients with advanced gastric cancer.","authors":"Dongyan Yang, Zhilong Gao, Xuezhu Yang, Liguo Gao","doi":"10.12669/pjms.40.9.9049","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9049","url":null,"abstract":"<p><strong>Objective: </strong>Exploring the clinical efficacy and safety of targeted therapy, immunotherapy combined with chemotherapy in the treatment of advanced gastric cancer.</p><p><strong>Methods: </strong>A retrospective analysis was performed on the medical records of 134 patients with advanced gastric cancer who visited Renmin Hospital, Hubei University of Medicine from January 2019 to December 2022. According to therapeutic regimens, enrolled patients were divided into the control group and the study group. Patients in the control group received chemotherapy intervention, while those in the study group were provided with a combined intervention of apatinib, PD-1 inhibitor and chemotherapy. We analyze the tumor control effect and incidence of adverse reactions in two groups of patients.</p><p><strong>Results: </strong>The disease control rate (DCR) of patients in the study group and the control group was 72.06% and 42.42%, with an overall response rate (ORR) of 8.82% and 4.55%, The differences are statistically significant(P<0.05). By the end of follow-up, the median progression-free survival (mPFS) and the median overall survival (mOS) of the control group patients were 3.0±0.266 and 5.0±0.224 months respectively; while the mPFS and mOS of the study group were 5.0±0.261 and 7.0±0.172 months respectively, the differences are statistically significant (P<0.05). However, there was no significant difference in adverse reactions between the two groups (P>0.05).</p><p><strong>Conclusion: </strong>The therapeutic regimen of apatinib, a PD-1 inhibitor combined with chemotherapy exhibits relatively high clinical efficacy and safety for the treatment of patients with advanced gastric cancer. It can be considered as an interventional option for this type of patient.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron overload and liver function in patients with beta thalassemia major: A cross sectional study.","authors":"Amna Faruqi, Tooba Zafar, Sikander Subuctageen, Irfan Afzal Mughal","doi":"10.12669/pjms.40.9.8961","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8961","url":null,"abstract":"<p><strong>Objective: </strong>In thalassemia major, repeated blood transfusions result in iron overload causing organ damage. The objective of this study was assessment of liver enzymes in patients with Thalassemia major and to observe their association with ferritin.</p><p><strong>Method: </strong>A cross-sectional study was performed, at Islamabad Medical and Dental College and its affiliated Akbar Niazi Teaching Hospital from November 2021 till August 2022. Serum ferritin, AST, ALT, and total bilirubin levels were determined, in 135 patients of beta thalassemia major receiving transfusions. Data analysis was performed using SPSS Version 20. For categorical variables, calculation of frequencies and percentages was performed. Mean (± standard deviation) was determined for quantitative variables. ANOVA with post hoc Tukey's test was used for determining association between liver enzymes and serum ferritin. A p-value of <0.05 was considered significant. The correlation between ferritin and LFTs was determined by Pearson's correlation coefficient.</p><p><strong>Results: </strong>Patients had an age range of 7-30 years, and males constituted 51% of sample. Mean level of ferritin was 6062.61 + 3641.79 ng/ml, with an insignificant difference between the genders (<i>p</i> =0.366). The levels of AST, ALT and bilirubin were perceived to show a significant increase in patients with ferritin levels >5000ng/ml, when compared with patients having ferritin levels < 2,500 ng/ml. A significant positive correlation of increasing serum ferritin levels was observed with ALT (r= 0.682), to a lesser extent with AST (r = 0.532), and only a weak correlation with serum bilirubin (r = 0.350).</p><p><strong>Conclusion: </strong>Liver damage was caused by increased iron deposition. LFTs should be performed regularly to detect and reduce liver damage by increasing chelation therapy, thereby reducing morbidity and mortality due to thalassemia.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of mobile health applications (mHealth apps) in reshaping the body weight for better healthcare: A cross-sectional study.","authors":"Moath Mohammed Albarrak, Nasriah Zakaria, Sultan Ayoub Meo","doi":"10.12669/pjms.40.9.9064","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9064","url":null,"abstract":"<p><strong>Objectives: </strong>Obesity is a chronic, multifaceted, leading health problem causing numerous non-communicable diseases with a huge burden on the global healthcare system and economies. Worldwide, multiple interventions have been familiarized for weight reduction strategies, however, in recent years, mobile health applications (mHealth apps) for reshaping weight reduction have been introduced. Therefore, this study aimed to investigate the role of mobile health applications in reducing weight among users in Riyadh, Saudi Arabia.</p><p><strong>Methods: </strong>This questionnaire-based cross-sectional study was conducted in the Department of Family and Community Medicine, and Medical Education, College of Medicine, King Saud University, Riyadh from May 2019 to December 2022. A total of 502 participants, 332 (66.1%) females and 170 (33.9%) males aged 18-50 years, using smartphones, residing in Riyadh, Saudi Arabia were recruited. The questionnaire was distributed via social media platforms including WhatsApp, and emails and information were recorded.</p><p><strong>Results: </strong>Among 502 participants, 221 (44.02%) were using mobile health applications and 281 (55.98%) did not use mobile health applications. The results revealed that the participants who have been using mHealth apps for the last six months had significantly decreased body weight compared to those who did not use the mHealth apps (p=0.001).</p><p><strong>Conclusions: </strong>The study participants using mobile health applications (mHealth apps) had significantly reduced their body weight and felt healthier. The mHealth apps provide health-related information regularly to individuals to track their weight, monitor diet, and physical activity, and information about their overall health.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative observation between Roxithromycin and Azithromycin sequential therapy in the treatment of Mycoplasma pneumoniae Pneumonia in Children.","authors":"Dan Liu, Yi-Fei Zhang","doi":"10.12669/pjms.40.9.8942","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8942","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of roxithromycin combined with azithromycin sequential therapy in the treatment of mycoplasma pneumoniae pneumonia in children.</p><p><strong>Methods: </strong>A retrospective study was conducted on 100 patients with mycoplasma pneumoniae pneumonia admitted to The First Affiliated Hospital of Yangtze University from January 2020 to December 2022. All patients were divided into the observation group (roxithromycin combined with azithromycin sequential therapy) and the control group (azithromycin sequential therapy), with 50 cases in each group. The clinical efficacy, improvement time of clinical symptoms/signs, inflammation indexes, oxidative stress indexes and immune function levels of the two groups were compared. Moreover, the improvement of lung function indexes and the adverse reactions were observed.</p><p><strong>Results: </strong>The overall response rate of the observation group was 96.00%, which was higher than the control group (84.00%) (<i>p<</i>0.05). The time of clinical symptoms/signs in the observation group were significantly lower than those in the control group(<i>p<</i>0.05). After treatment, significant improvements were seen in the levels of CRP, TNF-ɑ, IL-6, GSH-Px, SOD, MDA, CD3⁺, CD4⁺, CD4⁺/CD8⁺, IgM, IgG , IgA, FEV₁, FEV₁%, FVC and FEV₁/FVC of the two groups compared with those before treatment (<i>p<</i>0.05), and the improvement in the observation group was more obvious than that in the control group(<i>p<</i>0.05). The overall incidence of adverse reactions in the observation group was 6.00%, which was slightly lower than that in the control group (8.00%) (c²=0.154, <i>P</i>=0.695).</p><p><strong>Conclusion: </strong>Roxithromycin combined with azithromycin sequential therapy is a safe regimen for the treatment of mycoplasma pneumoniae pneumonia in children.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia.","authors":"Haoliang Cai, Xiaohui Wu, Xi Chen, Jun Guo, Wenting Chen","doi":"10.12669/pjms.40.9.10087","DOIUrl":"https://doi.org/10.12669/pjms.40.9.10087","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia and to construct a nomogram predictive model.</p><p><strong>Methods: </strong>This retrospective study included 292 patients who underwent gastrointestinal endoscopy under acupuncture anesthesia at the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2020 to May 2023. Logistic regression analysis was used to identify risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia. A nomogram prediction model was constructed using the RMS package of R4.1.2 software based on the independent risk factors identified. The predictive performance of the model was assessed using consistency index (C-index), calibration curve, and receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>Seventy-five patients (25.68%) had complications. Body mass index (BMI), history of cardiovascular diseases, fasting time, history of respiratory diseases, and Sedation-Agitation Scale (SAS) score were identified as risk factors for complications. Based on this risk, a nomogram predictive model was constructed. The C-index of the nomogram model was 0.927. Calibration curve showed a good consistency between actual observations and nomogram predictions. The ROC curve area under curve (AUC) was 0.927 (95% CI: 0.895-0.959), indicating a certain predictive value for the occurrence of complications. When the optimal cut-off value was selected, the sensitivity and specificity of the model were 77.0% and 92.0%, respectively, indicating that the predictive model was effective.</p><p><strong>Conclusions: </strong>BMI, history of cardiovascular disease, fasting time, history of respiratory disease, and SAS score are independent risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia. The constructed nomogram predictive model has a good performance in predicting the occurrence of complications in patients undergoing gastrointestinal endoscopy with under acupuncture anesthesia.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of different tirofiban administration times in patients with no-reflow myocardial infarction during percutaneous coronary intervention.","authors":"Chaosheng Mei, Huiping Yu","doi":"10.12669/pjms.40.9.10101","DOIUrl":"https://doi.org/10.12669/pjms.40.9.10101","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of different tirofiban administration time windows in patients with no-reflow myocardial infarction (MI) during percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This single centre retrospective observational study included patients with no-reflow MI, undergoing PCI at the Hanyang Hospital affiliated to Wuhan University of Science and Technology from March 2020 to May 2023. All patients were administered tirofiban. Patients who received tirofiban with postinterventional thrombolysis in myocardial infarction (TIMI) flow ≥ 1 were grouped as Group-I, and patients who were directly given tirofiban through the guiding catheter without forward blood flow were grouped as Group-II. TIMI blood flow classification, levels of cardiac troponin T (cTnT) and creatine kinase isoenzyme MB (CK-MB), incidence of complications and major adverse cardiovascular events (MACE) in the two groups before and after the treatment were statistically analyzed.</p><p><strong>Results: </strong>A total of 156 patients were included in this study, including 79 patients in Group-I and 77 patients in Group-II. There was no significant difference in the baseline data between the two groups (P>0.05). After treatment, TIMI blood flow classification of the two groups improved and was significantly better in Group-I compared to Group-II (<i>P</i><0.05). After treatment, levels of Serum cTnT and CK-MB in the two groups decreased, and were significantly lower in Group-I than in Group-II (<i>P</i><0.05). There was no significant difference in the incidence of complications between Group-I (3.80%) and Group-II (6.49%) (<i>P</i>>0.05). The incidence of MACE in Group-I (3.80%) was lower than that in Group-II (12.99%) (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Compared with the direct application of tirofiban, tirofiban given when TIMI Grade≥ 1 for patients with no-reflow MI during PCI can more effectively regulate the blood flow status of target vessels, reduce myocardial injury, and reduce the risk of MACE.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of argon-helium cryoablation combined with chemotherapy in the treatment of advanced NSCLC.","authors":"Yongfei Guo, Jing Yan, Mao Yang, Tongguo Si","doi":"10.12669/pjms.40.9.9882","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9882","url":null,"abstract":"<p><strong>Objective: </strong>To explore the efficacy of argon-helium cryoablation (AHC) combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A retrospective study was carried out between February 2020 to June 2022 of 85 patients with advanced NSCLC admitted to Tianjin Cancer Hospital Airport Hospital. Patients were categorized into two groups based on whether they had received AHC: patients received chemotherapy treatment alone (chemotherapy group, n=41); patients received chemotherapy combined with AHC (combined group, n=44). Tumor control rate, serum tumor marker levels, quality of life, and median survival time between the two groups were compared.</p><p><strong>Results: </strong>Tumor control rate in the combined group (86.36%) was significantly higher than that in the chemotherapy group (68.29%) (P<0.05). After treatment, the levels of serum cytokeratin 19 fragment (CYFRA21-1), carcinoembryonic antigen (CEA) and glycoprotein antigen 125 (CA125) in the two groups were significantly lower than those before the treatment, and significantly lower in the combined group compared to the chemotherapy group (P<0.05). After the treatment, the quality of life of patients in both groups was significantly higher than before the treatment. Quality of life in the combined group was significantly higher than in the chemotherapy group (P<0.05). One year after treatment, the median survival time of the combined group (10.5 months; 95% CI: 9.775-11.225) was significantly higher than that of the chemotherapy group (9.4 months; 95% CI: 8.55-10.323) (P=0.045).</p><p><strong>Conclusions: </strong>Compared with chemotherapy alone, conventional chemotherapy combined with AHC in the treatment of advanced NSCLC can significantly reduce the levels of serum tumor markers and improve overall treatment efficacy, quality of life and 1-year overall survival rate.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing demand for Bilateral Total Knee Arthroplasty: How to balance patient outcome with healthcare system challenges.","authors":"Shaukat Ali Jawaid","doi":"10.12669/pjms.40.9.10790","DOIUrl":"https://doi.org/10.12669/pjms.40.9.10790","url":null,"abstract":"","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic evaluation of myocardial dysfunction in term neonates with perinatal asphyxia.","authors":"Javaria Rasheed, Muhammad Khalid, Iram Nawaz, Barera Maryam","doi":"10.12669/pjms.40.9.9501","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9501","url":null,"abstract":"<p><strong>Background & objective: </strong>One third of the neonatal deaths worldwide are attributed to perinatal asphyxia. We aimed to determine the prevalence and determinants of cardiac dysfunction, through echocardiographic evaluation, in term neonates with perinatal asphyxia.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at a tertiary care setting over a period of six months from 1^st January 2021 to 30^th June 2021. Term neonates, weighing ≥ 2500 grams, born with Apgar score < 7 and admitted within 48-hours of life were consecutively enrolled. Using Levene classification neonates were grouped into moderate and severe perinatal asphyxia. All neonates underwent transthoracic echocardiographic evaluation after 24-hours of stabilization and within 72-hours of life. Descriptive statistics are calculated, and logistic regression analysis is done to determine the risk factors of myocardial dysfunction.</p><p><strong>Results: </strong>Among 166 neonates, 53% (n=88) were males, mean gestational age was 38.1 ± 0.89 weeks. Moderate asphyxia was present in 121 (72.9%). Most common echocardiographic finding was pulmonary hypertension in 50% followed by patent ductus arteriosus (PDA) in 37.2% and mitral regurgitation in 6.6%. Myocardial dysfunction was detected in 28.9% of the neonates. Three independent determinants of myocardial dysfunction were severe asphyxia [adjusted odds ratio (aOR) 5.01, 95% CI 2.2-11.4; p-value <0.001], having patent ductus arteriosus (aOR 5.11, 95% CI 2.2-11.8; p-value < 0.001) and delivery through cesarean section (aOR 2.65, 95% CI 1.2-5.9; p-value 0.02).</p><p><strong>Conclusions: </strong>Myocardial dysfunction among neonates with perinatal asphyxia is common and severity of asphyxia, mode of delivery and presence of patent ductus arteriosus are important determinants.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pain nursing intervention on patients with craniocerebral trauma combined with ocular trauma after decompressive craniectomy.","authors":"Dongjing Xu, Jing Li, Zhenling Jia, Jia Li, Yuchao Shan","doi":"10.12669/pjms.40.9.9107","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9107","url":null,"abstract":"<p><strong>Objective: </strong>To determine the impacts of pain nursing intervention of patients with craniocerebral trauma combined with ocular trauma after decompressive craniotomy.</p><p><strong>Method: </strong>This was retrospective study. Eighty patients with craniocerebral trauma combined with ocular trauma who underwent unilateral decompressive craniectomy in Baoding No.1 Central Hospital from January 2023 to November 2023 were included and divided into the observation group(n=40) and the control group(n=40) according to different nursing methods. Patients in the control group received conventional nursing intervention, while those in the observation group received pain nursing intervention. The differences in sleep quality, self-care ability, quality of life, psychological state and nursing satisfaction were compared between the two groups.</p><p><strong>Results: </strong>After intervention, the pain degree of both groups was significantly reduced compared with that before intervention, and the reduction degree of the observation group was more than that of the control group, with a statistically significant difference (<i>p<</i>0.05). The SS-QOL scores of both groups were significantly improved compared with before intervention, and the improvement degree of the observation group was significantly better than that of the control group, with a statistically significant difference (<i>p<</i>0.05). The nursing satisfaction score of the observation group was (93.35±3.83) points, which was higher than (83.38±3.59) points of the control group, with a statistically significant difference (<i>t</i>=12.019, <i>P</i>=0.000).</p><p><strong>Conclusion: </strong>Pain nursing intervention shows a variety of benefits in the treatment of patients with craniocerebral trauma combined with ocular trauma after decompressive craniectomy, improving their quality of life, self-care ability and nursing satisfaction.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}