Khushal Nadir Hadi, Niktash Khan Hadi, Ayesha Bangash, Fawad Rahim
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引用次数: 0
Abstract
Objective: To determine the association between hypomagnesemia and chronic use of proton pump inhibitors (PPIs) among patients visiting a tertiary care hospital.
Method: This cross-sectional study was conducted in the Department of Medicine at Hayatabad Medical Complex, Peshawar, Pakistan from July 2024 to December 2024. A total of 303 patients aged 18 years and above, who had used a PPI for at least one month, were enrolled. Age, gender, body mass index, patient setting, duration and type of PPI used, and the presence of hypertension and diabetes mellitus were documented. Serum magnesium levels were measured for all participants. The data were analyzed using SPSS.
Results: Hypomagnesemia was observed in 51.5% (n=156) patients. Patients with hypomagnesemia had a significantly higher mean age compared to those without (48.9±12.3 vs 38.2±11.4 years, p <0.001). On multivariate analysis, PPI use for more than six months (AOR: 58.1, 95% CI: 22.2-152.5, p<0.001), diabetes mellitus (AOR: 23.1, 95% CI: 6.4-82.6, p<0.001), and hypertension (AOR: 3.2, 95% CI: 1.4 - 7.1, p<0.001) were identified as independent predictors of hypomagnesemia. No significant differences in serum magnesium levels were found among patients using different types of PPIs (p=0.131).
Conclusion: Hypomagnesemia was found in 51.5% of patients, irrespective of PPI type. Significant risk factors included advanced age, prolonged PPI use, diabetes mellitus, and hypertension. Raising awareness among healthcare professionals about PPI's potential adverse effects and advocating for prudent prescription practices is essential.
期刊介绍:
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.