Association of hypomagnesemia with chronic use of proton-pump inhibitors in patients visiting a tertiary care hospital in Peshawar, Pakistan.

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Khushal Nadir Hadi, Niktash Khan Hadi, Ayesha Bangash, Fawad Rahim
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引用次数: 0

Abstract

Objective: To determine the association between hypomagnesemia and chronic use of proton pump inhibitors (PPIs) among patients visiting a tertiary care hospital.

Method: This cross-sectional study was conducted in the Department of Medicine at Hayatabad Medical Complex, Peshawar, Pakistan from July 2024 to December 2024. A total of 303 patients aged 18 years and above, who had used a PPI for at least one month, were enrolled. Age, gender, body mass index, patient setting, duration and type of PPI used, and the presence of hypertension and diabetes mellitus were documented. Serum magnesium levels were measured for all participants. The data were analyzed using SPSS.

Results: Hypomagnesemia was observed in 51.5% (n=156) patients. Patients with hypomagnesemia had a significantly higher mean age compared to those without (48.9±12.3 vs 38.2±11.4 years, p <0.001). On multivariate analysis, PPI use for more than six months (AOR: 58.1, 95% CI: 22.2-152.5, p<0.001), diabetes mellitus (AOR: 23.1, 95% CI: 6.4-82.6, p<0.001), and hypertension (AOR: 3.2, 95% CI: 1.4 - 7.1, p<0.001) were identified as independent predictors of hypomagnesemia. No significant differences in serum magnesium levels were found among patients using different types of PPIs (p=0.131).

Conclusion: Hypomagnesemia was found in 51.5% of patients, irrespective of PPI type. Significant risk factors included advanced age, prolonged PPI use, diabetes mellitus, and hypertension. Raising awareness among healthcare professionals about PPI's potential adverse effects and advocating for prudent prescription practices is essential.

在巴基斯坦白沙瓦一家三级医院就诊的患者中,低镁血症与长期使用质子泵抑制剂的关系
目的:探讨三级医院患者低镁血症与质子泵抑制剂(PPIs)长期使用的关系。方法:本横断面研究于2024年7月至2024年12月在巴基斯坦白沙瓦Hayatabad综合医院医学系进行。共有303名18岁及以上的患者,他们使用PPI至少一个月。记录年龄、性别、体重指数、患者环境、使用PPI的持续时间和类型以及高血压和糖尿病的存在。测量了所有参与者的血清镁水平。数据采用SPSS统计软件进行分析。结果:51.5% (n=156)患者出现低镁血症。低镁血症患者的平均年龄明显高于无低镁血症患者(48.9±12.3岁vs 38.2±11.4岁)。结论:51.5%的患者存在低镁血症,与PPI类型无关。重要的危险因素包括高龄、长期使用PPI、糖尿病和高血压。提高医疗保健专业人员对PPI潜在副作用的认识并倡导谨慎的处方实践是至关重要的。
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来源期刊
Pakistan Journal of Medical Sciences
Pakistan Journal of Medical Sciences 医学-医学:内科
CiteScore
4.10
自引率
9.10%
发文量
363
审稿时长
3-6 weeks
期刊介绍: It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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