药学服务与研究最新文献

{"title":"Therapeutic drug monitoring of teicoplanin in a patient with bloodstream infection by Enterococcus faecium","authors":"Yifan Luo, L. Ren, Mingyan Jiang","doi":"10.5428/PCAR20200513","DOIUrl":"https://doi.org/10.5428/PCAR20200513","url":null,"abstract":"Objective： To analyze the blood concentration，efficacy and adverse drug reactions（ADRs） of teicoplanin in treatment of bloodstream infection by Enterococcus faecium.Methods： Changes in physiological and pathological indexes of the patient were closely followed and recorded，and the treatment regimen was adjusted according to the results of therapeutic drug monitoring（TDM） of teicoplanin.Results： In the light of the results of therapeutic drug monitoring of teicoplanin，bloodstream infection was cured，pathogenic microorganism was effectively eliminated and no ADRs occurred.Conclusion： With TDM，teicoplanin could be safely and effectively used in the treatment of blood stream infection.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46949256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of a case of delayed anaphylaxis induced by iohexol","authors":"Jialiang Guan, Heping Liu, Borden Ji","doi":"10.5428/PCAR20200520","DOIUrl":"https://doi.org/10.5428/PCAR20200520","url":null,"abstract":"","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44687999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the pharmacodynamics of wound repair ointment in promoting wound healing in rats","authors":"Meng Yang, Minyan Chen, Rong Wang, Han Lu, Yongfang Yuan","doi":"10.5428/PCAR20200509","DOIUrl":"https://doi.org/10.5428/PCAR20200509","url":null,"abstract":"Objective： To study pharmacodynamics of the wound repair ointment in promoting wound healing in rats.Methods： Healthy SD rats were selected to establish general wound model and burn and scald wound model.After cleaning，drugs were administrated，wound surfaces were covered with sterile gauze，fixed with medical tape，and dressing changed daily until all wounds healed.Then，healing time and healing rate were investigated.Evaluations on the wound surface healing of the affected sites were made in accordance with the inflammatory exudate，granulation tissue regeneration and epithelial regeneration.Histopathological changes of the wound surfaces were observed by hematoxylin-eosin（HE） staining.Results： The wound repair ointment could shorten the time required for wound healing and wound scabbing，reduce wound size，and alleviate skin scar hyperplasia.Conclusion： The wound repair ointment has obvious effect on the promotion of wound healing.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42853013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic and clinical research progress of psychological pharmacology： a brand-new discipline","authors":"Zhijun Guo, Zhuman Li, Weijia Cai, Yitian Chen, Jian-Qiang Guo, Feng Xu","doi":"10.5428/PCAR20200501","DOIUrl":"https://doi.org/10.5428/PCAR20200501","url":null,"abstract":"Psychological pharmacology is a brand-new discipline that studies the interaction between psychological state and drugs，explores general rules of the effects of mental state on drug activity，and promotes rational use of drugs in clinical practice.Evidence showed that depression could affect the levels of endogenous substances，drug metabolizing enzymes and drug transport protein，thus influencing drug metabolism and efficacy.In clinical practice，medication recognition might affect drug choice and medication compliance of patients.The application of placebo might achieve positive treatment outcomes in certain patients.These research results indicate that attention should be paid to the psychological state of patients in drug treatment.In accordance with changes of physiological and psychological changes of patients，therapeutic regimens should be duly adjusted.Rational drug use education and psychological support should be provided to patients，so that patients’ psychological burden could be relieved and therapeutic efficacy improved.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46761005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy comparison of concurrent chemoradiotherapy with nedaplatin and cisplatin in inoperable locally-advanced non-small cell lung cancer","authors":"Yong-lin Wu, Kuantang Chen, Jun Wang","doi":"10.5428/PCAR20200508","DOIUrl":"https://doi.org/10.5428/PCAR20200508","url":null,"abstract":"Objective： To compare the efficacy and safety of concurrent chemoradiotherapy with nedaplatin and cisplatin in inoperative locally-advanced non-small cell lung cancer（NSCLC）.Methods： Eighty patients with locally-advanced NSCLC treated in Guanyun County People’s Hospital，Lianyungang，Jiangsu Province，from January 2015 to January 2019 were enrolled as study subjects，and were randomly divided into the nedaplatin group and the cisplatin group，each consisting of 40 patients.The patients in the 2 groups were treated with linear accelerator 6 MV high energy X-ray and 3D-CRT，5 times a week for a succession of 6 weeks，with a total dosage of 55-66 Gy.Then，the patients were given paclitaxel（155 mg/m2） intravenously for 3 hours in the first day after radiotherapy，and the patients in the cisplatin group were treated with cisplatin（80 mg/m2） intravenously for 3 to 4 days，and the patients in the nedaplatin group were given nedaplatin（80 mg/m2） intravenously also for 3 to 4 days.The efficacy，the levels of such serum tumor markers as carcinoembryonic antigen（CEA），carbohydrate antigen 125（CA125），neuron specific enolase（NSE） and cytokeratin fragment antigen 21-1（CYFRA21-1），as well as the rate of adverse drug reactions（ADRs） were compared between the 2 groups.Results： There was no statistical significance in remission rate and disease control rate，when comparisons were made between the 2 groups（P>0.05）.After treatment，CEA，CA125，NSE and CYFRA21-1 levels in the 2 groups were significantly lower than those before treatment（P<0.05）.There were no significant differences in CEA and CA125 levels，when comparisons were made between the 2 groups（P>0.05）.However，NSE and CYFRA21-1 levels in the patients of the nedaplatin group were significantly lower than those of the cisplatin group（P<0.05）.The rates of leucopenia，neutropenia，nausea and vomiting，constipation or diarrhea，increase of blood urea nitrogen or creatinine，and weight loss in the nedaplatin group were significantly lower than those in the cisplatin group（P<0.05）.Conclusion： Nedaplatin has similar efficacy as cisplatin in the treatment of inoperable locally-advanced NSCLC，with higher safety，meanwhile it could decrease the levels of NSE and CYFRA21-1.For this reason，it is worthy further clinical promotion.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44942505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and evaluation of UPLC method for concentration determination of vancomycin in serum","authors":"Fashuang Li, Jing Zong, Huiying Li, Lili Zhang, Qiang Li, Linbo Li","doi":"10.5428/PCAR20200516","DOIUrl":"https://doi.org/10.5428/PCAR20200516","url":null,"abstract":"","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42148849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and application of prescription review rules of rational drug use software in Xinhua Hospital Affiliated to School of Medicine，Shanghai Jiao Tong University","authors":"Yang Shu, X. Guo, Ying Gao, Yi Yang","doi":"10.5428/PCAR20200504","DOIUrl":"https://doi.org/10.5428/PCAR20200504","url":null,"abstract":"Objective： To introduce the development method of prescription review rules of rational drug use software in Xinhua Hospital Affiliated to School of Medicine，Shanghai Jiao Tong University.Methods： Before the launch of rational drug use software，pharmacists reviewed the prescriptions from each clinical department from August 2017 to October 2017 by software.Through comparison of the differences between software review and manual review，the prescription review rules were developed and modified.With the comprehensive application of rational drug use software from April 2018，the Pharmacy Department established the maintenance procedures for routine prescription review rules and assessment method for the performance of prescription review pharmacists，so that continuous improvement of prescription review rules could be ensured from the aspects of procedures and systems.Results： The rate of prescription rationality of the hospital increased from about 77% before the application of the rational drug use software to about 97% after its application.In addition，the application of the rational drug use software in the outpatient and inpatient promoted the compliance of off-label drug use behavior in the hospital.Conclusion： Proper placement and continuous optimization of the prescription review rules could help pharmacists to review prescriptions accurately and improve the level of rational medication in the hospital.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45548019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance：a meta analysis","authors":"Jianqin Li, Xin-xin Yang, Wei-Zhou Shi","doi":"10.5428/PCAR20200503","DOIUrl":"https://doi.org/10.5428/PCAR20200503","url":null,"abstract":"Objective： To systematically evaluate the correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance（CR）.Methods： The databases，such as Wanfang Data，the Chinese Biomedical Literature Database（CBM），the Chinese Journal Fulltext Database in China National Knowledge Infrastructure（CNKI），the China Science and Technology Journal Database（VIP），Science Citation Index（SCI），PubMed and EMBase，were searched from the inception to October 2019.The quality of clinical studies which met the inclusion criteria was evaluated，and meta analysis was performed using Stata 14.0 software.Results： Ten papers were included and 2642 patients were enrolled，including 878 cases in the clopidogrel-resistance group and 1764 cases in the non-clopidogrel resistance group.Results of meta-analysis showed that due to ABCB1 C3435T gene polymorphism，the overall effect of each subgroup was statistically significant（P<0.05）： allele gene model OR=1.39，95% CI（1.07，1.81）， dominant gene model OR=1.37，95% CI（1.13，1.66），recessive gene model OR=1.62，95% CI（1.02，2.57）， homozygous gene model OR=1.92，95% CI（1.14，3.22），and heterozygous gene model OR=1.33，95% CI（1.06，1.66）.Conclusion： Current findings confirmed that ABCB1 C3435T gene polymorphism is associated with clopidogrel resistance.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41314617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of regionalization and chromatics in design of phase Ⅰ clinical trial ward","authors":"Hongya Mei, Xiangdong Zhong","doi":"10.5428/PCAR20200519","DOIUrl":"https://doi.org/10.5428/PCAR20200519","url":null,"abstract":"","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45011029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous determination of five pesticides residues in Anoectochilus roxburghii by HPLC-MS/MS method","authors":"L. Wu, Mingke Luo, Wensheng He, Wenting Chen","doi":"10.5428/PCAR20200506","DOIUrl":"https://doi.org/10.5428/PCAR20200506","url":null,"abstract":"Objective： To establish a HPLC-MS/MS method for simultaneous determination of five pesticides residues including tebuconazole，metalaxyl-M，thiophanate-methyl，oxytetracycline and abamectin in Anoectochilus roxburghii.Methods： The samples were extracted by acetonitrile solution and purified by QuEChERS method.Separation was performed on Agilent Eclipse Plus C18 column（50 mm×2.1 mm，1.8 μm） with the mobile phase consisting of 0.1% formic acid（A） and acetonitrile（B） by gradient elution（0-1.0 min，90% A；1.0-3.0 min，90%-70% A;3.0-5.0 min，70%-30% A;5.0-8.0 min，30%-10% A;8.0-14.0 min，10% A;14.0-15.0 min，10%-90% A;15.0-17.0 min，90% A）.Detection was performed on a triple quadrupole tandem mass spectrometry with electrospray ionization source operating in positive ion mode under multiple reaction monitoring（MRM） mode.Results： The calibration curves of five pesticides showed good linearity coefficients（r>0.99）.The average recoveries ranged from 72.7% to 94.9%（n=6），and the relative standard derivations（RSDs） were within 1.8%-10.3%（n=6）.The detection limits of tebuconazole，metalaxyl-M，thiophanate-methyl，oxytetracycline and abamectin were 0.6，0.2，0.3，0.2，5.0 μg/kg，and the quantitation limits of 5 pesticides were 2.0，0.5，1.0，0.6 and 10.0 μg/kg respectively.Conclusion： The established method was proved to be sensitive，simple and reliable，and could be applied for the determination of these five pesticides in Anoectochilus roxburghii and quality control in the planting process.","PeriodicalId":19943,"journal":{"name":"Pharmaceutical Care and Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42635055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}